Function: Development as well as maintenance of many adult tissues is achieved by several dynamically regulated processes that include cell proliferation, differentiation, and programmed cell death. Oltvai et al. (1993) noted that, in the latter process, cells are eliminated by a highly characteristic suicide program called apoptosis. The best-defined genetic pathway of cell death exists in the nematode Caenorhabditis elegans. Two autosomal recessive death effector genes, ced-3 and ced-4, are required for the death of all 131 cells destined to die during worm development. One autosomal dominant death repressor gene, ced-9, can save those cells in its gain-of-function form. This implies that both effector and repressor genes also exist within each mammalian cell death pathway. BCL2 is one such mammalian gene that has been identified; it functions as a repressor of programmed cell death.

Source Reference: [PubMed ID: 12490315] Toyota H, Yanase N, Yoshimoto T, Moriyama M, Sudo T, Mizuguchi J, Calpain-induced Bax-cleavage product is a more potent inducer of apoptotic cell death than wild-type Bax. Cancer Lett. 2003 Jan 28;189(2):221-30.

Summary

Top-ranked sequences

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
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Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            ||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            ||||||||||||||||||||||||||||#||||||||||||| ||| |+ |||||||||
Sbjct     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGETPELGLEQVPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||||||||| |||||||||||||||#||||||||||||| |||||+ |||||||||
Sbjct     1 MDGSGEQPRGGGHTSSEQIMKTGALLLQ#GFIQDRAGRMGGETPELALEQVPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            ||||||||||||||||||||||||||||#||||||||||||| ||| |+ |||||||||
Sbjct     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGETPELPLEQVPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||||   |||||||||||||| |||#|||||||||| || ||| |+  ||||||||
Sbjct     1 MDGSGEQLGSGGPTSSEQIMKTGAFLLQ#GFIQDRAGRMAGETPELTLEQPPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||+|  ||||||||| ||||| |||#||||||| || || ||| |+  ||||||||
Sbjct     1 MDGSGDQLGGGGPTSSEQFMKTGAFLLQ#GFIQDRAERMAGETPELTLEQPPQDASTKK   58

Query     1 MDGSGEQPRGGGPTSSEQIMKTGALLLQ#GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||||  ||||||||| ||||| |||#||||||| || || ||| |+  ||||||||
Sbjct     1 MDGSGEQLGGGGPTSSEQFMKTGAFLLQ#GFIQDRAERMAGETPELTLEQPPQDASTKK   58

Query    29 GFIQDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||| |||||| ||| |+ |||||||||
Sbjct     1 GFIQDRDGRMGGETPELGLEQVPQDASTKK   30

Query    32 QDRAGRMGGEAPELALDPVPQDASTKK   58
            |||||||||| |||||+ |||||||||
Sbjct     1 QDRAGRMGGETPELALEQVPQDASTKK   27

Query     9 RGGGPTSSEQIMKTGALLLQ#GFIQDR   34
            | |   |+|||++|| ||| #||| ||
Sbjct    36 RSGTGVSTEQILETGELLLN#GFISDR   61

Query    37 RMGGEAPELALDPVPQDASTKK   58
            || || ||| |+  ||||||||
Sbjct     1 RMAGETPELTLEQPPQDASTKK   22

[PubMed ID: 24786774] ... Fresquet V, Rieger M, Carolis C, Garcia-Barchino MJ, Martinez-Climent JA, Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma. Blood. 2014 Jun 26;123(26):4111-9. doi: 10.1182/blood-2014-03-560284. Epub 2014

[PubMed ID: 24434006] ... Yao S, Westphal D, Babon JJ, Thompson GV, Robin AY, Adams JM, Colman PM, Czabotar PE, NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS. Arch Biochem Biophys. 2014 Mar 1;545:33-43. doi: 10.1016/j.abb.2014.01.003. Epub

[PubMed ID: 24402682] ... Park GB, Choi Y, Kim YS, Lee HK, Kim D, Hur DY, ROS-mediated JNK/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells. Int J Oncol. 2014 Mar;44(3):977-85. doi: 10.3892/ijo.2014.2252. Epub 2014 Jan 9.

[PubMed ID: 24402374] ... Zhang HH, Pang M, Dong W, Xin JX, Li YJ, Zhang ZC, Yu L, Wang PY, Li BS, Xie SY, miR-511 induces the apoptosis of radioresistant lung adenocarcinoma cells by triggering BAX. Oncol Rep. 2014 Mar;31(3):1473-9. doi: 10.3892/or.2014.2973. Epub 2014 Jan 9.

[PubMed ID: 9645350] ... Salomons GS, Buitenhuis CK, Martinez Munoz C, Verwijs-Jassen M, Behrendt H, Zsiros J, Smets LA, Mutational analysis of Bax and Bcl-2 in childhood acute lymphoblastic leukaemia. Int J Cancer. 1998 Jun 19;79(3):273-7.

[PubMed ID: 7566098] ... Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O, et al., Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. Nature. 1995 Sep 28;377(6547 Suppl):3-174.

[PubMed ID: 7607685] ... Apte SS, Mattei MG, Olsen BR, Mapping of the human BAX gene to chromosome 19q13.3-q13.4 and isolation of a novel alternatively spliced transcript, BAX delta. Genomics. 1995 Apr 10;26(3):592-4.

[PubMed ID: 7834749] ... Miyashita T, Reed JC, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 1995 Jan 27;80(2):293-9.

[PubMed ID: 8358790] ... Oltvai ZN, Milliman CL, Korsmeyer SJ, Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19.