CaMPDB :: Substrate

SB0032 : [beta]-Globin

* Basic Information

Organism	Homo sapiens (human)
Protein Names	hemoglobin subunit beta [Homo sapiens]; hemoglobin subunit beta; beta globin chain; Hemoglobin subunit beta; Beta-globin; Hemoglobin beta chain; LVV-hemorphin-7; Spinorphin
Gene Names	HBB; hemoglobin, beta
Gene Locus	11p15.5; chromosome 11
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_000509	NM_000518	3043	P68871	141900	HGNC:4827	00786	hsa:3043

* Information From OMIM

Description: The alpha (HBA1, OMIM:141800; HBA2, OMIM:141850) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, HbA. Mutant beta globin that sickles causes sickle cell anemia (OMIM:603903). Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. For clinical purposes, beta-thalassemia (OMIM:613985) is divided into thalassemia major (transfusion dependent), thalassemia intermedia (of intermediate severity), and thalassemia minor (asymptomatic).

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* Structure Information

1. Primary Information

Length: 147 aa

Average Mass: 15.998 kDa

Monoisotopic Mass: 15.988 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
--- cleavage 9 ---
Branched-chain amino acid ATP-binding cassette transporter 1.	51	63	7.0	0.0
Globin 1.	124	144	53.0	0.1

3. Sequence Information

Fasta Sequence: SB0032.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A00 (X-ray; 200 A; B/D=3-147), 1A01 (X-ray; 180 A; B/D=3-147), 1A0U (X-ray; 214 A; B/D=3-147), 1A0Z (X-ray; 200 A; B/D=3-147), 1A3N (X-ray; 180 A; B/D=2-147), 1A3O (X-ray; 180 A; B/D=2-147), 1ABW (X-ray; 200 A; B/D=3-147), 1ABY (X-ray; 260 A; B/D=3-147), 1AJ9 (X-ray; 220 A; B=2-147), 1B86 (X-ray; 250 A; B/D=2-147), 1BAB (X-ray; 150 A; B/D=2-147), 1BBB (X-ray; 170 A; B/D=2-147), 1BIJ (X-ray; 230 A; B/D=2-147), 1BUW (X-ray; 190 A; B/D=2-147), 1BZ0 (X-ray; 150 A; B/D=2-147), 1BZ1 (X-ray; 159 A; B/D=2-147), 1BZZ (X-ray; 159 A; B/D=2-147), 1C7B (X-ray; 180 A; B/D=2-147), 1C7C (X-ray; 180 A; B/D=2-147), 1C7D (X-ray; 180 A; B/D=2-147), 1CBL (X-ray; 180 A; A/B/C/D=2-147), 1CBM (X-ray; 174 A; A/B/C/D=2-147), 1CH4 (X-ray; 250 A; A/B/C/D=2-146), 1CLS (X-ray; 190 A; B/D=2-147), 1CMY (X-ray; 300 A; B/D=2-147), 1COH (X-ray; 290 A; B/D=2-147), 1DKE (X-ray; 210 A; B/D=2-147), 1DXT (X-ray; 170 A; B/D=1-147), 1DXU (X-ray; 170 A; B/D=3-147), 1DXV (X-ray; 170 A; B/D=3-147), 1FN3 (X-ray; 248 A; B/D=2-147), 1G9V (X-ray; 185 A; B/D=2-147), 1GBU (X-ray; 180 A; B/D=2-147), 1GBV (X-ray; 200 A; B/D=2-147), 1GLI (X-ray; 250 A; B/D=3-147), 1GZX (X-ray; 210 A; B/D=2-147), 1HAB (X-ray; 230 A; B/D=2-147), 1HAC (X-ray; 260 A; B/D=2-147), 1HBA (X-ray; 210 A; B/D=2-147), 1HBB (X-ray; 190 A; B/D=2-147), 1HBS (X-ray; 300 A; B/D/F/H=2-147), 1HCO (X-ray; 270 A; B=2-147), 1HDB (X-ray; 220 A; B/D=2-147), 1HGA (X-ray; 210 A; B/D=2-147), 1HGB (X-ray; 210 A; B/D=2-147), 1HGC (X-ray; 210 A; B/D=2-147), 1HHO (X-ray; 210 A; B=2-147), 1IRD (X-ray; 125 A; B=2-147), 1J3Y (X-ray; 155 A; B/D/F/H=2-147), 1J3Z (X-ray; 160 A; B/D/F/H=2-147), 1J40 (X-ray; 145 A; B/D/F/H=2-147), 1J41 (X-ray; 145 A; B/D/F/H=2-147), 1J7S (X-ray; 220 A; B/D=2-147), 1J7W (X-ray; 200 A; B/D=2-147), 1J7Y (X-ray; 170 A; B/D=2-147), 1JY7 (X-ray; 320 A; B/D/Q/S/V/X=2-147), 1K0Y (X-ray; 187 A; B/D=2-147), 1K1K (X-ray; 200 A; B=2-147), 1KD2 (X-ray; 187 A; B/D=2-147), 1LFL (X-ray; 270 A; B/D/Q/S=2-147), 1LFQ (X-ray; 260 A; B=2-147), 1LFT (X-ray; 260 A; B=2-147), 1LFV (X-ray; 280 A; B=2-147), 1LFY (X-ray; 330 A; B=2-147), 1LFZ (X-ray; 310 A; B=2-147), 1LJW (X-ray; 216 A; B=2-147), 1M9P (X-ray; 210 A; B/D=2-147), 1MKO (X-ray; 218 A; B/D=2-147), 1NEJ (X-ray; 210 A; B/D=2-147), 1NIH (X-ray; 260 A; B/D=2-147), 1NQP (X-ray; 173 A; B/D=2-147), 1O1I (X-ray; 230 A; B=1-147), 1O1J (X-ray; 190 A; B/D=1-147), 1O1K (X-ray; 200 A; B/D=1-147), 1O1L (X-ray; 180 A; B/D=1-147), 1O1M (X-ray; 185 A; B/D=1-147), 1O1N (X-ray; 180 A; B/D=1-147), 1O1O (X-ray; 180 A; B/D=1-147), 1O1P (X-ray; 180 A; B/D=1-147), 1QI8 (X-ray; 180 A; B/D=3-147), 1QSH (X-ray; 170 A; B/D=2-147), 1QSI (X-ray; 170 A; B/D=2-147), 1QXD (X-ray; 225 A; B/D=2-147), 1QXE (X-ray; 185 A; B/D=2-147), 1R1X (X-ray; 215 A; B=2-147), 1R1Y (X-ray; 180 A; B/D=2-147), 1RPS (X-ray; 211 A; B/D=2-147), 1RQ3 (X-ray; 191 A; B/D=2-147), 1RQ4 (X-ray; 211 A; B/D=2-147), 1RQA (X-ray; 211 A; B/D=2-147), 1RVW (X-ray; 250 A; B=2-147), 1SDK (X-ray; 180 A; B/D=2-147), 1SDL (X-ray; 180 A; B/D=2-147), 1THB (X-ray; 150 A; B/D=2-147), 1UIW (X-ray; 150 A; B/D/F/H=2-147), 1VWT (X-ray; 190 A; B/D=2-147), 1XXT (X-ray; 191 A; B/D=2-147), 1XY0 (X-ray; 199 A; B/D=2-147), 1XYE (X-ray; 213 A; B/D=2-147), 1XZ2 (X-ray; 190 A; B/D=2-147), 1XZ4 (X-ray; 200 A; B/D=2-147), 1XZ5 (X-ray; 211 A; B/D=2-147), 1XZ7 (X-ray; 190 A; B/D=2-147), 1XZU (X-ray; 216 A; B/D=2-147), 1XZV (X-ray; 211 A; B/D=2-147), 1Y09 (X-ray; 225 A; B/D=2-147), 1Y0A (X-ray; 222 A; B/D=2-147), 1Y0C (X-ray; 230 A; B/D=2-147), 1Y0D (X-ray; 210 A; B/D=2-147), 1Y0T (X-ray; 214 A; B/D=2-147), 1Y0W (X-ray; 214 A; B/D=2-147), 1Y22 (X-ray; 216 A; B/D=2-147), 1Y2Z (X-ray; 207 A; B/D=2-147), 1Y31 (X-ray; 213 A; B/D=2-147), 1Y35 (X-ray; 212 A; B/D=2-147), 1Y45 (X-ray; 200 A; B/D=2-147), 1Y46 (X-ray; 222 A; B/D=2-147), 1Y4B (X-ray; 210 A; B/D=2-147), 1Y4F (X-ray; 200 A; B/D=2-147), 1Y4G (X-ray; 191 A; B/D=2-147), 1Y4P (X-ray; 198 A; B/D=2-147), 1Y4Q (X-ray; 211 A; B/D=2-147), 1Y4R (X-ray; 222 A; B/D=2-147), 1Y4V (X-ray; 184 A; B/D=2-147), 1Y5F (X-ray; 214 A; B/D=2-147), 1Y5J (X-ray; 203 A; B/D=2-147), 1Y5K (X-ray; 220 A; B/D=2-147), 1Y7C (X-ray; 210 A; B/D=2-147), 1Y7D (X-ray; 190 A; B/D=2-147), 1Y7G (X-ray; 210 A; B/D=2-147), 1Y7Z (X-ray; 198 A; B/D=2-147), 1Y83 (X-ray; 190 A; B/D=2-145), 1Y85 (X-ray; 213 A; B/D=2-146), 1Y8W (X-ray; 290 A; B/D=2-147), 1YDZ (X-ray; 330 A; B/D=2-147), 1YE0 (X-ray; 250 A; B/D=2-147), 1YE1 (X-ray; 450 A; B/D=2-147), 1YE2 (X-ray; 180 A; B/D=2-147), 1YEN (X-ray; 280 A; B/D=2-147), 1YEO (X-ray; 222 A; B/D=2-147), 1YEQ (X-ray; 275 A; B/D=2-147), 1YEU (X-ray; 212 A; B/D=2-147), 1YEV (X-ray; 211 A; B/D=2-147), 1YFF (X-ray; 240 A; B/D/F/H=2-147), 1YG5 (X-ray; 270 A; B/D=2-147), 1YGD (X-ray; 273 A; B/D=2-147), 1YGF (X-ray; 270 A; B/D=2-147), 1YH9 (X-ray; 220 A; B/D=2-147), 1YHE (X-ray; 210 A; B/D=2-147), 1YHR (X-ray; 260 A; B/D=2-147), 1YIE (X-ray; 240 A; B/D=2-147), 1YIH (X-ray; 200 A; B/D=2-147), 1YVQ (X-ray; 180 A; B/D=2-147), 1YVT (X-ray; 180 A; B=2-147), 1YZI (X-ray; 207 A; B=2-147), 2D5Z (X-ray; 145 A; B/D=2-147), 2D60 (X-ray; 170 A; B/D=2-147), 2DN1 (X-ray; 125 A; B=2-147), 2DN2 (X-ray; 125 A; B/D=2-147), 2DN3 (X-ray; 125 A; B=2-147), 2DXM (Neutron; 210 A; B/D=2-147), 2H35 (NMR; -; B/D=2-147), 2HBC (X-ray; 210 A; B=2-147), 2HBD (X-ray; 220 A; B=2-147), 2HBE (X-ray; 200 A; B=2-147), 2HBF (X-ray; 220 A; B=2-147), 2HBS (X-ray; 205 A; B/D/F/H=2-147), 2HCO (X-ray; 270 A; B=2-147), 2HHB (X-ray; 174 A; B/D=2-147), 2HHD (X-ray; 220 A; B/D=2-147), 2HHE (X-ray; 220 A; B/D=4-147), 2M6Z (NMR; -; B/D=2-147), 2W6V (X-ray; 180 A; B/D=2-147), 2W72 (X-ray; 107 A; B/D=3-147), 2YRS (X-ray; 230 A; B/D/K/O=2-147), 3B75 (X-ray; 230 A; B/D/F/H/T=2-147), 3D17 (X-ray; 280 A; B/D=2-147), 3D7O (X-ray; 180 A; B=2-147), 3DUT (X-ray; 155 A; B/D=2-147), 3HHB (X-ray; 174 A; B/D=2-147), 3HXN (X-ray; 200 A; B/D=2-147), 3IC0 (X-ray; 180 A; B/D=2-147), 3IC2 (X-ray; 240 A; B/D=2-147), 3KMF (Neutron; 200 A; C/G=2-147), 3NL7 (X-ray; 180 A; B=2-147), 3NMM (X-ray; 160 A; B/D=2-147), 3ODQ (X-ray; 310 A; B/D=2-147), 3ONZ (X-ray; 209 A; B=2-147), 3OO4 (X-ray; 190 A; B=2-147), 3OO5 (X-ray; 210 A; B=2-147), 3P5Q (X-ray; 200 A; B=2-147), 3QJB (X-ray; 180 A; B=2-147), 3QJC (X-ray; 200 A; B=2-147), 3QJD (X-ray; 156 A; B/D=2-147), 3QJE (X-ray; 180 A; B/D=2-147), 3R5I (X-ray; 220 A; B/D=2-147), 3S65 (X-ray; 180 A; B/D=2-147), 3S66 (X-ray; 140 A; B=2-147), 3SZK (X-ray; 301 A; B/E=2-147), 3W4U (X-ray; 195 A; B/D/F=2-147), 3WCP (X-ray; 194 A; B/D=2-147), 3WHM (X-ray; 185 A; B/F=2-147), 4FC3 (X-ray; 226 A; B=2-147), 4HHB (X-ray; 174 A; B/D=2-147), 4IJ2 (X-ray; 424 A; B/D=2-147), 4L7Y (X-ray; 180 A; B/D=2-147), 4M4A (X-ray; 205 A; B=2-147), 4M4B (X-ray; 200 A; B=2-147), 4MQC (X-ray; 220 A; B=2-147), 4MQG (X-ray; 168 A; B=2-147), 4MQH (X-ray; 250 A; B=2-147), 4MQI (X-ray; 192 A; B=2-147), 4N7N (X-ray; 275 A; B/D/F/H/J/L=2-147), 4N7O (X-ray; 250 A; B/D/F/H/J/L=2-147), 4N7P (X-ray; 281 A; B/D/F/H/J/L=2-147), 4N8T (X-ray; 190 A; B=2-147), 4NI0 (X-ray; 215 A; B=2-147), 4NI1 (X-ray; 190 A; B=2-147), 4WJG (X-ray; 310 A; 1/B/G/L/Q/V=2-147), 4X0I (X-ray; 309 A; B=2-147), 4X0L (X-ray; 205 A; B=2-147), 6HBW (X-ray; 200 A; B/D=2-147)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 6331510] Melloni E, Salamino F, Sparatore B, Michetti M, Pontremoli S, Characterization of the single peptide generated from the amino-terminus end of alpha- and beta-hemoglobin chains by the Ca2+-dependent neutral proteinase. Biochim Biophys Acta. 1984 Jul 17;788(1):11-6.

Cleavage sites (±10aa)

[Site 1] MVHLTPEEK⁹-SAVTALWGKV

Lys⁹ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

-	Met¹	Val²	His³	Leu⁴	Thr⁵	Pro⁶	Glu⁷	Glu⁸	Lys⁹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser¹⁰	Ala¹¹	Val¹²	Thr¹³	Ala¹⁴	Leu¹⁵	Trp¹⁶	Gly¹⁷	Lys¹⁸	Val¹⁹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWT

Summary

#	organism	max score	hits	top seq
1	N/A	82.40	141	HBB_GORGO Hemoglobin subunit beta (Hemoglobin bet
2	Homo sapiens	82.40	24	beta globin chain variant
3	Homo sapiens	82.40	6	AF083883_1 mutant beta-globin
4	synthetic construct	82.40	2	hemoglobin beta
5	Gorilla gorilla	82.00	1	beta-globin
6	Macaca mulatta	79.70	1	PREDICTED: similar to beta globin
7	Callithrix jacchus	78.60	1	HBB_CALJA Hemoglobin subunit beta (Hemoglobin bet
8	Aotus azarai	77.80	1	HBB_AOTAZ Hemoglobin subunit beta (Hemoglobin bet
9	Pithecia pithecia	77.80	1	HBB_PITPI Hemoglobin subunit beta (Hemoglobin bet
10	Cebus apella	77.80	1	HBB_CEBAP Hemoglobin subunit beta (Hemoglobin bet
11	Lagothrix lagotricha	77.80	1	HBB_LAGLA Hemoglobin subunit beta (Hemoglobin bet
12	Oryctolagus cuniculus	77.40	1	beta-globin
13	Oryctolagus cuniculus	77.00	1	hemoglobin, beta
14	Ateles paniscus	77.00	1	HBB_ATEPA Hemoglobin subunit beta (Hemoglobin bet
15	Callimico goeldii	77.00	1	HBB_CALGO Hemoglobin subunit beta (Hemoglobin bet
16	Macaca fascicularis	77.00	1	beta-globin
17	Alouatta belzebul	76.60	1	HBB_ALOBE Hemoglobin subunit beta (Hemoglobin bet
18	Pan troglodytes	76.30	1	beta-globin
19	Tarsius syrichta	75.10	1	HBE_TARSY Hemoglobin subunit epsilon (Hemoglobin
20	Callicebus torquatus	75.10	1	HBB_CALTO Hemoglobin subunit beta (Hemoglobin bet
21	Canis familiaris	74.70	2	PREDICTED: similar to beta globin
22	Lepus europaeus	74.30	1	HBB_LEPEU Hemoglobin subunit beta (Hemoglobin bet
23	Ailuropoda melanoleuca	73.90	2	hemoglobin beta
24	Taphozous georgianus=tomb bats, erythrocytes, Peptide, 146 aa	73.60	1	HBB_TAPGE Hemoglobin subunit beta (Hemoglobin bet
25	Saimiri sciureus	73.60	1	HBB_SAISC Hemoglobin subunit beta (Hemoglobin bet
26	Sus scrofa	73.20	1	HBB_PIG Hemoglobin subunit beta (Hemoglobin beta
27	Mus musculus	72.40	6	unnamed protein product
28	Callithrix geoffroyi	72.00	1	HBE_CALGE Hemoglobin subunit epsilon (Hemoglobin
29	Macroderma gigas=Australian ghost bats, Microchiroptera, Peptide, 146 aa	72.00	1	HBB_MACGG Hemoglobin subunit beta (Hemoglobin bet
30	Bos taurus	72.00	1	hemoglobin, epsilon 1
31	Callithrix mauesi	71.20	1	epsilon-globin
32	Elephas maximus	71.20	1	HBG_ELEMA Hemoglobin subunit gamma (Hemoglobin ga
33	Callithrix argentata	71.20	1	epsilon-globin
34	Macropus eugenii	71.20	1	HBE_MACEU Hemoglobin subunit epsilon (Hemoglobin
35	Ceratotherium simum	70.10	1	AF139502_1 epsilon globin
36	Equus caballus	70.10	1	epsilon-1 globin

Top-ranked sequences

organism	matching
N/A	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Homo sapiens	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Homo sapiens	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
synthetic construct	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Gorilla gorilla	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Macaca mulatta	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#+\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTPEEK#NAVTTLWGKVNVDEVGGEALGRLLVVYPWT 39
Callithrix jacchus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Aotus azarai	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#AAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Pithecia pithecia	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#AAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Cebus apella	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTAEEK#SAVTTLWGKVNVDEVGGEALGRLLVVYPWT 39
Lagothrix lagotricha	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#AAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Oryctolagus cuniculus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|+ \|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLSSEEK#SAVTALWGKVNVEEVGGEALGRLLVVYPWT 39
Oryctolagus cuniculus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|+ \|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLSSEEK#SAVTALWGKVNVEEVGGEALGRLLVVYPWT 39
Ateles paniscus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#SAVTTLWGKVNVDEVGGEALGRLLVVYPWT 39
Callimico goeldii	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#SAVTTLWGKVNVDEVGGEALGRLLVVYPWT 39
Macaca fascicularis	Query 2 VHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\|\|\|\|#+\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VHLTPEEK#NAVTTLWGKVNVDEVGGEALGRLLVVYPWT 38
Alouatta belzebul	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| +\|\|#+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGDEK#AAVTALWGKVNVDEVGGEALGRLLVVYPWT 39
Pan troglodytes	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALG----RLLVVYPWT 39 \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLVSRLLVVYPWT 43
Tarsius syrichta	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\|+\|\|+\|\|\|\|+\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTAEEK#SSVTSLWGKMNVDEAGGEALGRLLVVYPWT 39
Callicebus torquatus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#+\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#AAVTALWGKVNVXEVGGEALGRLLVVYPWT 39
Canis familiaris	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#\| \|+ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\| Sbjct 1 MVHLTAEEK#SLVSGLWGKVNVDEVGGEALGRLLIVYPWT 39
Lepus europaeus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|+ \|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLSGEEK#SAVTALWGKVNVEEVGGETLGRLLVVYPWT 39
Ailuropoda melanoleuca	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| \|\|\|#+\|\|\| \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGEEK#AAVTGLWSKVNVDEVGGEALGRLLVVYPWT 39
Taphozous georgianus=tomb bats, erythrocytes, Peptide, 146 aa	Query 2 VHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\| +\|\|#+\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VHLTADEK#AAVTGLWGKVNVDEVGGEALGRLLVVYPWT 38
Saimiri sciureus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|\| +\|\|#+\|\|\|\|\|\|\|\|\|\|\|++\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTGDEK#AAVTALWGKVNVEDVGGEALGRLLVVYPWT 39
Sus scrofa	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\|+ \|\|\|# \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLSAEEK#EAVLGLWGKVNVDEVGGEALGRLLVVYPWT 39
Mus musculus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPW 38 \|\|\|\|\| \|\|#+\|\|+ \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHLTDAEK#AAVSGLWGKVNADEVGGEALGRLLVVYPW 38
Callithrix geoffroyi	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\|+\|\|\|\|+\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITSLWGKMNVEEAGGEALGRLLVVYPWT 39
Macroderma gigas=Australian ghost bats, Microchiroptera, Peptide, 146 aa	Query 2 VHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\|\| \|\|\|#+\|\|\| \|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VHLTGEEK#AAVTGLWGKVNVEEVGGEALGRLLVVYPWT 38
Bos taurus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\| \|\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITGLWGKVNVEEAGGEALGRLLVVYPWT 39
Callithrix mauesi	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\|+\|\|\|\|+\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITSLWGKMNVEEAGGEALGRLLVVYPWT 39
Elephas maximus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\|+\|\|\|+\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITSLWGQVNVEETGGEALGRLLVVYPWT 39
Callithrix argentata	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\|+\|\|\|\|+\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITSLWGKMNVEEAGGEALGRLLVVYPWT 39
Macropus eugenii	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\|++\|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#TAITSVWGKVNVEETGGEALGRLLVVYPWT 39
Ceratotherium simum	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\| \|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITNAWGKVNVEEAGGEALGRLLVVYPWT 39
Equus caballus	Query 1 MVHLTPEEK#SAVTALWGKVNVDEVGGEALGRLLVVYPWT 39 \|\|\| \| \|\|\|#+\|+\| \|\|\|\|\|\|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVHFTAEEK#AAITNAWGKVNVEEAGGEALGRLLVVYPWT 39

* References

[PubMed ID: 25898735] Pereverzev AP, Markina NM, Ianushevich IuG, Gorodnicheva TV, Minasian BE, Luk'ianov KA, Gurskaia NG, [Intron 2 of human beta-globin in 3'-untranslated region enhances expression of chimeric genes]. Bioorg Khim. 2014 May-Jun;40(3):293-6.

» More (14) « Hide Below

[PubMed ID: 25271992] ... Vovor A, Feteke L, Kueviakoe IM, Kpatarou L, Mawussi K, Magnang H, Segbena AY, Blood typing profile of a school-aged population of a North Togo township. Hemoglobin. 2014;38(5):316-8. doi: 10.3109/03630269.2014.963234.

[PubMed ID: 25238043] ... Charoenkwan P, Teerachaimahit P, Sanguansermsri T, The correlation of alpha-globin gene mutations and the XmnI polymorphism with clinical severity of Hb E/beta-thalassemia. Hemoglobin. 2014;38(5):335-8. doi: 10.3109/03630269.2014.952744. Epub 2014 Sep

[PubMed ID: 25222044] ... Patel AP, Patel RB, Patel SA, Vaniawala SN, Patel DS, Shrivastava NS, Sharma NP, Zala JV, Parmar PH, Naik MR, beta-Thalassemia mutations in Western India: outcome of prenatal diagnosis in a hemoglobinopathies project. Hemoglobin. 2014;38(5):329-34. doi: 10.3109/03630269.2014.951889. Epub 2014 Sep

[PubMed ID: 19372376] ... Calvo SE, Pagliarini DJ, Mootha VK, Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7507-12. doi:

[PubMed ID: 18083107] ... Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ, Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.

[PubMed ID: 11499613] ... Zhang X, Medzihradszky KF, Cunningham J, Lee PD, Rognerud CL, Ou CN, Harmatz P, Witkowska HE, Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation. J Chromatogr B Biomed Sci Appl. 2001 Aug 5;759(1):1-15.

[PubMed ID: 10954746] ... Gladwin MT, Ognibene FP, Pannell LK, Nichols JS, Pease-Fye ME, Shelhamer JH, Schechter AN, Relative role of heme nitrosylation and beta-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):9943-8.

[PubMed ID: 9006104] ... Ferranti P, Sannolo N, Mamone G, Fiume I, Carbone V, Tornqvist M, Bergman A, Malorni A, Structural characterization by mass spectrometry of hemoglobin adducts formed after in vivo exposure to methyl bromide. Carcinogenesis. 1996 Dec;17(12):2661-71.

[PubMed ID: 20301599] ... Origa R, Beta-Thalassemia

[PubMed ID: 20301551] ... Bender MA, Douthitt Seibel G, Sickle Cell Disease

[PubMed ID: 7358733] ... Shapiro R, McManus MJ, Zalut C, Bunn HF, Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem. 1980 Apr 10;255(7):3120-7.

[PubMed ID: 429365] ... Adams JG, Steinberg MH, Boxer LA, Baehner RL, Forget BG, Tsistrakis GA, The structure of hemoglobin Indianapolis [beta112(G14) arginine]. An unstable variant detectable only by isotopic labeling. J Biol Chem. 1979 May 10;254(9):3479-82.

[PubMed ID: 68958] ... Marotta CA, Wilson JT, Forget BG, Weissman SM, Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA. J Biol Chem. 1977 Jul 25;252(14):5040-53.

[PubMed ID: 67897] ... Proudfoot NJ, Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNAs. Cell. 1977 Apr;10(4):559-70.