CaMPDB :: Substrate

SB0039 : Protein kinase C[beta]

* Basic Information

Organism	Rattus norvegicus (Norway rat)
Protein Names	protein kinase C, beta [Rattus norvegicus]; protein kinase C, beta; protein kinase C beta I; protein kinase C beta II; protein kinase C, beta 1; PKC-B; PKC-beta; protein kinase C beta type; Protein kinase C beta type; 2.7.11.13
Gene Names	Prkcb; Pkcb, Prkcb1; Pkcb; Prkcb1; protein kinase C, beta
Gene Locus	1q36; chromosome 1
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_036845	NM_012713	25023	P68403	N/A	N/A	N/A	rno:25023

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 673 aa

Average Mass: 76.925 kDa

Monoisotopic Mass: 76.876 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Putative zinc-RING and/or ribbon 1.	48	87	156.0	9.5
Putative zinc-RING and/or ribbon 2.	114	151	157.0	3.0
CEP76 C2 domain 1.	209	241	49.0	0.0
--- cleavage 311 ---
--- cleavage 320 ---
Phosphotransferase enzyme family 1.	457	488	163.0	0.0
Phosphotransferase enzyme family 2.	596	624	70.0	0.0
Protein kinase C terminal domain 1.	627	663	8.0	0.7

3. Sequence Information

Fasta Sequence: SB0039.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A25 (X-ray; 270 A; A/B=154-289), 3PFQ (X-ray; 400 A; A=1-661)

* Cleavage Information

2 [sites] cleaved by Calpain 1 and 2

Source Reference: [PubMed ID: 2537303] Kishimoto A, Mikawa K, Hashimoto K, Yasuda I, Tanaka S, Tominaga M, Kuroda T, Nishizuka Y, Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain). J Biol Chem. 1989 Mar 5;264(7):4088-92.

Cleavage sites (±10aa)

[Site 1] RQKFERAKIG³¹¹-QGTKAPEEKT

Gly³¹¹ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Arg³⁰²	Gln³⁰³	Lys³⁰⁴	Phe³⁰⁵	Glu³⁰⁶	Arg³⁰⁷	Ala³⁰⁸	Lys³⁰⁹	Ile³¹⁰	Gly³¹¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln³¹²	Gly³¹³	Thr³¹⁴	Lys³¹⁵	Ala³¹⁶	Pro³¹⁷	Glu³¹⁸	Glu³¹⁹	Lys³²⁰	Thr³²¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EGEYFNVPVPPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTD

Summary

#	organism	max score	hits	top seq
1	N/A	125.00	10	protein kinase C type II
2	Mus musculus	125.00	3	protein kinase C, beta 1
3	Rattus norvegicus	125.00	2	protein kinase C, beta
4	Oryctolagus cuniculus	122.00	3	protein kinase C, beta 1
5	Canis familiaris	119.00	3	PREDICTED: similar to Protein kinase C, beta type
6	Homo sapiens	117.00	6	protein kinase C, beta isoform 2
7	Bos taurus	116.00	2	protein kinase C, beta
8	Scyliorhinus canicula	89.00	1	protein kinase C
9	Danio rerio	72.40	2	protein kinase C, beta 1, like
10	Tetraodon nigroviridis	71.60	3	unnamed protein product
11	Danio rerio	67.40	1	protein kinase C
12	Petromyzon marinus	62.80	1	protein kinase C
13	synthetic construct	54.30	1	protein kinase C alpha
14	Rattus rattus	54.30	1	KPCA_RAT Protein kinase C alpha type (PKC-alpha)
15	Takifugu rubripes	53.10	1	protein kinase C, alpha type
16	Homo sapiens	52.00	1	aging-associated gene 6 protein
17	Myxine glutinosa	47.00	1	protein kinase C
18	Caenorhabditis briggsae AF16	38.90	1	Hypothetical protein CBG16150
19	Aplysia californica	35.80	1	KPC1_APLCA Calcium-dependent protein kinase C (AP
20	Halorhodospira halophila SL1	34.70	1	exporter, RND superfamily
21	NADPH	31.60	1	glutamate synthase
22	Anaeromyxobacter dehalogenans 2CP-C	31.60	1	RNA-3'-phosphate cyclase

Top-ranked sequences

organism	matching
N/A	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341
Mus musculus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341
Rattus norvegicus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341
Oryctolagus cuniculus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKTPEEKTTNTISKFDNNGNRDRMKLTD 341
Canis familiaris	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 274 EGEYFNVPVPPEGSEGNEELRQKFERAKIS#QGTKAPEEKTTNTISKLDNNGNRDRMKLTD 333
Homo sapiens	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| #\|\|\|\| \|\|\|\|\| \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 282 EGEYFNVPVPPEGSEANEELRQKFERAKIS#QGTKVPEEKTTNTVSKFDNNGNRDRMKLTD 341
Bos taurus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|# \| \| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#PGPKTPEEKTTNTISKFDNNGNRDRMKLTD 341
Scyliorhinus canicula	Query 282 EGEYFNVPVPPE-GSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLT 340 \|\|\|\|+\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|# \|+\|\| \|\|\| +++ \|\| \| \|\|\|\|\|\|\|\|\| Sbjct 202 EGEYYNVPVPPEEDSEGNEELRQKFERARIG#PGSKAAEEKRSSSWSKID-NGNRDRMKLA 260 Query 341 D 341 \| Query 341 D 341
Danio rerio	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\| +\|\|\|\|\| + \|\|\|+\|\| ++\|\|\|\|\|\|\|# \|\| + + \| +\|\|+\| \|\|\|+\|\|\|\|\| \| Sbjct 278 EGVFFNVPVYVDEEEGNKELSKRFERAKIG#PGTNNTDGASKNDLSKYDANGNQDRMKLAD 337
Tetraodon nigroviridis	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|# \| \| + \|+\|\| \|+\|\|+\|\|\|+\|\|\|\|\| \| Sbjct 218 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PG-KNTDGKSANAASRFDSNGNQDRMKLAD 276
Danio rerio	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|# + ++\| \|\|\|\|\|+ \|\|\|\|\|\|\|\|+\| Sbjct 213 EGEYFNVPVPPEGEEGNEELRQKFERAKIG#PSKT--DGSSSNAISKFDSYGNRDRMKLSD 270
Petromyzon marinus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTK--APEEKTANTISKFDNNGNRDRMKL 339 \|\|\|\|+\|\|\|+ \|+ +\|+ \|+\|+\|\|\|+\|++\|# \| \| +\|+ \|\|++\| \|\| \| \|\|+\| Sbjct 212 EGEYYNVPIAPDIEDGDTEMRRKFEKARLG#PSVKPRASDERRANSLSAILNNANVDRVKA 271 Query 340 TD 341 \| Sbjct 272 DD 273
synthetic construct	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|+\|\|\|+\| \|\|\| \|\|\|\|\|\|\|+\|\|+\|# \| + + + + + \| \|\|+\|\|\|\| Sbjct 282 EGEYYNVPIPEGDEEGNMELRQKFEKAKLG#---PAGNKVISPSEDRKQPSNNLDRVKLTD 338
Rattus rattus	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|+\|\|\|+\| \|\|\| \|\|\|\|\|\|\|+\|\|+\|# \| + + + + + \| \|\|+\|\|\|\| Sbjct 282 EGEYYNVPIPEGDEEGNVELRQKFEKAKLG#---PAGNKVISPSEDRKQPSNNLDRVKLTD 338
Takifugu rubripes	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTK--APEEKTANTISKFDNNGNRDRMKL 339 \|\|\|\|+\|\|\|+\| \| + \| \|\|\|\|\|\|\|+\|\|+\|#\|\| \| \| + ++ +\|\| \|\|++\| Sbjct 280 EGEYYNVPIP-EVDDVNLELRQKFEKAKLG#QGKKVITPSDHRRFSLP----SGNMDRVRL 334 Query 340 TD 341 \| Sbjct 335 ND 336
Homo sapiens	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QG---TKAPEEKTANTISKFDNNGNRDRMK 338 \|\|\|\|+\|\|\|+\| \|\|\| \|\|\|\|\|\|\|+\|\|+\|# +\| \| + \| \|\|+\| Sbjct 282 EGEYYNVPIPEGDEEGNMELRQKFEKAKLG#PAGNKVISPSEDRKQP------SNNLDRVK 335 Query 339 LTD 341 \|\|\| Query 339 LTD 341
Myxine glutinosa	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMKLTD 341 \|\|\|\|+\|\|\|\| \|\|\| \|\| \|\|\|\|+ +\|++\| #+ \| + + \| + \|\|+ \| \| Sbjct 203 EGEYYNVPVAPEGEEG-LELRQRLQRSQIA#RSDKNKQSPAKDQPSDSASLSGLDRVNLED 261
Caenorhabditis briggsae AF16	Query 282 EGEYFNVPVPPEGSEGNEELRQKF-ERAKIG#QGTKA--PEEKTANTISKFDNNGNRDRMK 338 \|\|\|++\|+ + \|\| \| \|++\|+\| + \|\| #+ + \| \| \| \| \| \| \|\|\| +\| Sbjct 352 EGEFYNINITPEYDEDMEKVRKKMNDNFKIS#RDSSAGKPRESTPRATSTSLTNTNRDVIK 411 Query 339 LTD 341 +\| Sbjct 412 ASD 414
Aplysia californica	Query 282 EGEYFNVPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTISKFD 329 \|\|\|++ \|\|\| + +\| +\|++ \| \|+ \| # + \|\| +\|\| \| Sbjct 266 EGEFYGVPVTDDITESIQEIKSKMHRSSIS#SEKRYPEPDKVQNMSKQD 313
Halorhodospira halophila SL1	Query 288 VPVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTANTI 325 +\| \|\|\| \| + +\| \|\| + #\|\|\| \| \|+ \|\| \| Sbjct 130 IPTPPETQEEADRIRAAVERLPMY#QGTLASEDGTAAGI 167
NADPH	Query 289 PVPPEGSEGNEELRQKFERAKIG#QGTKAPEEKTA-----NTISKFDNNG 332 \|+\| \| \| \|\|\| ++\|+ \| + # \| +\|\| \| \|\|+ \| \|+\| Sbjct 858 PLPIEEVEPAEELFKRFDTAAMS#IGALSPEAHEALAEAMNTLGGFSNSG 906
Anaeromyxobacter dehalogenans 2CP-C	Query 288 VPVPPEGSEGNEELR-QKFERAKIG#QGTKAPEEKTANTISKFDNNGNRDRMK 338 \|\|\|\| \| \| \| \|\|\| + \|# \| + \|+\| ++ \| \|\| ++ Sbjct 231 VPVPSRASRGGHVLLVSTFERTRAG#HGAVSARERTPEEVADLAVGGLRDHLR 282

[Site 2] GQGTKAPEEK³²⁰-TANTISKFDN

Lys³²⁰ Thr

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Gly³¹¹	Gln³¹²	Gly³¹³	Thr³¹⁴	Lys³¹⁵	Ala³¹⁶	Pro³¹⁷	Glu³¹⁸	Glu³¹⁹	Lys³²⁰

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Thr³²¹	Ala³²²	Asn³²³	Thr³²⁴	Ile³²⁵	Ser³²⁶	Lys³²⁷	Phe³²⁸	Asp³²⁹	Asn³³⁰

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
PPEGSEGNEELRQKFERAKIGQGTKAPEEKTANTISKFDNNGNRDRMKLTDFNFLMVLGK

Summary

#	organism	max score	hits	top seq
1	N/A	125.00	11	KPCB_RAT Protein kinase C beta type (PKC-beta) (P
2	Rattus norvegicus	125.00	2	unnamed protein product
3	Mus musculus	124.00	3	protein kinase C, beta 1
4	Oryctolagus cuniculus	121.00	3	protein kinase C, beta 1
5	Canis familiaris	119.00	2	PREDICTED: similar to Protein kinase C, beta type
6	Homo sapiens	117.00	5	protein kinase C, beta isoform 2
7	Bos taurus	116.00	2	protein kinase C, beta
8	Scyliorhinus canicula	90.90	1	protein kinase C
9	Danio rerio	77.00	2	protein kinase C, beta 1, like
10	Tetraodon nigroviridis	75.10	2	unnamed protein product
11	Danio rerio	70.10	1	protein kinase C
12	Petromyzon marinus	63.90	1	protein kinase C
13	synthetic construct	56.60	1	protein kinase C alpha
14	Homo sapiens	56.20	1	aging-associated gene 6 protein
15	Rattus rattus	56.20	1	KPCA_RAT Protein kinase C alpha type (PKC-alpha)
16	Takifugu rubripes	54.70	1	protein kinase C, alpha type
17	Caenorhabditis briggsae AF16	43.10	1	Hypothetical protein CBG16150
18	Myxine glutinosa	41.60	1	protein kinase C
19	Aplysia californica	36.60	1	KPC1_APLCA Calcium-dependent protein kinase C (AP
20	Branchiostoma lanceolatum	35.00	1	protein kinase C

Top-ranked sequences

organism	matching
N/A	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350
Rattus norvegicus	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350
Mus musculus	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350
Oryctolagus cuniculus	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|#\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PPEGSEGNEELRQKFERAKIGQGTKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350
Canis familiaris	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\| \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 283 PPEGSEGNEELRQKFERAKISQGTKAPEEK#TTNTISKLDNNGNRDRMKLTDFNFLMVLGK 342
Homo sapiens	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\| \|\|\|\|#\| \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PPEGSEANEELRQKFERAKISQGTKVPEEK#TTNTVSKFDNNGNRDRMKLTDFNFLMVLGK 350
Bos taurus	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \| \| \|\|\|\|#\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PPEGSEGNEELRQKFERAKIGPGPKTPEEK#TTNTISKFDNNGNRDRMKLTDFNFLMVLGK 350
Scyliorhinus canicula	Query 291 PPEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \| \| \|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\| \|+\|\| \|\|\|# +++ \|\| \| \|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 212 PEEDSEGNEELRQKFERARIGPGSKAAEEK#RSSSWSKID-NGNRDRMKLADFNFLMVLGK 270
Danio rerio	Query 296 EGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|+\|\| ++\|\|\|\|\|\|\| \|\| + #+ \| +\|\|+\| \|\|\|+\|\|\|\|\| \|\|\|\|+\|\|\|\|\| Sbjct 292 EGNKELSKRFERAKIGPGTNNTDGA#SKNDLSKYDANGNQDRMKLADFNFIMVLGK 346
Tetraodon nigroviridis	Query 301 LRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\| \| \| + \|#+\|\| \|+\|\|+\|\|\|+\|\|\|\|\| \|\|\|\|\|\|\|\|\|\| Sbjct 237 LRQKFERAKIGPG-KNTDGK#SANAASRFDSNGNQDRMKLADFNFLMVLGK 285
Danio rerio	Query 301 LRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\|\|\|\|\|\|\|\|\| + #++\| \|\|\|\|\|+ \|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\| Sbjct 232 LRQKFERAKIGPSKT--DGS#SSNAISKFDSYGNRDRMKLSDFNFLMVLGK 279
Petromyzon marinus	Query 292 PEGSEGNEELRQKFERAKIGQGTK--APEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLG 349 \|+ +\|+ \|+\|+\|\|\|+\|++\| \| \| +\|+# \|\|++\| \|\| \| \|\|+\| \|\|\|\|\|\|\|\|\| Sbjct 222 PDIEDGDTEMRRKFEKARLGPSVKPRASDER#RANSLSAILNNANVDRVKADDFNFLMVLG 281 Query 350 K 350 \| Query 350 K 350
synthetic construct	Query 292 PEG-SEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\| \|\|\| \|\|\|\|\|\|\|+\|\|+\| \| + # + + + + \| \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PEGDEEGNMELRQKFEKAKLG---PAGNKV#ISPSEDRKQPSNNLDRVKLTDFNFLMVLGK 347
Homo sapiens	Query 292 PEG-SEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\| \|\|\| \|\|\|\|\|\|\|+\|\|+\| \| + # + + + + \| \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PEGDEEGNMELRQKFEKAKLG---PAGNKV#ISPSEDRKQPSNNLDRVKLTDFNFLMVLGK 347
Rattus rattus	Query 292 PEG-SEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\| \|\|\| \|\|\|\|\|\|\|+\|\|+\| \| + # + + + + \| \|\|+\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 291 PEGDEEGNVELRQKFEKAKLG---PAGNKV#ISPSEDRKQPSNNLDRVKLTDFNFLMVLGK 347
Takifugu rubripes	Query 292 PEGSEGNEELRQKFERAKIGQGTK--APEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLG 349 \|\| + \| \|\|\|\|\|\|\|+\|\|+\|\|\| \| \| + # ++ +\|\| \|\|++\| \|\|\|\|\| +\|\| Sbjct 289 PEVDDVNLELRQKFEKAKLGQGKKVITPSDH#RRFSLP----SGNMDRVRLNDFNFLALLG 344 Query 350 K 350 \| Query 350 K 350
Caenorhabditis briggsae AF16	Query 292 PEGSEGNEELRQKF-ERAKIGQGTKA--PEEK#TANTISKFDNNGNRDRMKLTDFNFLMVL 348 \|\| \| \|++\|+\| + \|\| + + \| \| \| #\| \| \| \|\|\| +\| +\|\|\|\|\| \|\| Sbjct 362 PEYDEDMEKVRKKMNDNFKISRDSSAGKPRES#TPRATSTSLTNTNRDVIKASDFNFLTVL 421 Query 349 GK 350 \|\| Query 349 GK 350
Myxine glutinosa	Query 292 PEGSEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \|\|\| \|\| \|\|\|\|+ +\|++\| + \| + # + \| + \|\|+ \| \|\| \|\| \|\|\|\| Sbjct 213 PEGEEG-LELRQRLQRSQIARSDKNKQSP#AKDQPSDSASLSGLDRVNLEDFVFLTVLGK 270
Aplysia californica	Query 295 SEGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 +\| +\|++ \| \|+ \| + \|\| # +\|\| +\| ++ +\|\|\|\|\| \|\|\|\| Sbjct 279 TESIQEIKSKMHRSSISSEKRYPEPD#KVQNMSK------QDIVRASDFNFLTVLGK 328
Branchiostoma lanceolatum	Query 296 EGNEELRQKFERAKIGQGTKAPEEK#TANTISKFDNNGNRDRMKLTDFNFLMVLGK 350 \| +\|++ ++ \|+ + \| ++#+ \| \|+ \| \|\| \|\|\|\|\|\|\|\|\|\| Sbjct 226 ENVAKLKEHLQKQKLDEQRKQKSKR#SEEC-----NIGSLDHMKAADFNFLMVLGK 275

* References

[PubMed ID: 19587355] Nagareddy PR, Soliman H, Lin G, Rajput PS, Kumar U, McNeill JH, MacLeod KM, Selective inhibition of protein kinase C beta(2) attenuates inducible nitric oxide synthase-mediated cardiovascular abnormalities in streptozotocin-induced diabetic rats. Diabetes. 2009 Oct;58(10):2355-64. doi: 10.2337/db09-0432. Epub 2009 Jul 8.

» More (9) « Hide Below

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