CaMPDB :: Substrate

SB0040 : [alpha]1-Globin

* Basic Information

Organism	Homo sapiens (human)
Protein Names	hemoglobin subunit alpha [Homo sapiens]; hemoglobin subunit alpha; alpha one globin; hemoglobin alpha 1 globin chain; delta globin; alpha-2 globin chain; Hemoglobin subunit alpha; Alpha-globin; Hemoglobin alpha chain
Gene Names	HBA1; HBA2; hemoglobin, alpha 1
Gene Locus	16p13.3; chromosome 16
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_000549	NM_000558	3039	P69905	141800	HGNC:4823	00784	hsa:3040

* Information From OMIM

Description: The alpha and beta loci determine the structure of the 2 types of polypeptide chains in the tetrameric adult hemoglobin, Hb A, alpha-2/beta-2. The alpha locus also determines a polypeptide chain, the alpha chain, in fetal hemoglobin (alpha-2/gamma-2), in hemoglobin A2(alpha-2/delta-2), and in embryonic hemoglobin (alpha-2/epsilon-2). The number of normal alpha genes (3, 2, 1 or none) in Asian cases of alpha-thalassemia (OMIM:604131) results in 4 different alpha-thalassemia syndromes (Kan et al., 1976). Three normal alpha genes gives a silent carrier state. Two normal alpha genes results in microcytosis (so-called heterozygous alpha-thalassemia). One normal alpha gene results in microcytosis and hemolysis (so-called Hb H disease, OMIM:613978). No normal alpha gene results in 'homozygous alpha-thalassemia' manifested as fatal hydrops fetalis.

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* Structure Information

1. Primary Information

Length: 142 aa

Average Mass: 15.257 kDa

Monoisotopic Mass: 15.248 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Globin 1.	7	107	1.0	0.2
--- cleavage 11 (inside Globin 7..107) ---

3. Sequence Information

Fasta Sequence: SB0040.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A00 (X-ray; 200 A; A/C=2-142), 1A01 (X-ray; 180 A; A/C=2-142), 1A0U (X-ray; 214 A; A/C=2-142), 1A0Z (X-ray; 200 A; A/C=2-142), 1A3N (X-ray; 180 A; A/C=2-142), 1A3O (X-ray; 180 A; A/C=2-142), 1A9W (X-ray; 290 A; A/C=2-142), 1ABW (X-ray; 200 A; A=1-142), 1ABY (X-ray; 260 A; A=1-142), 1AJ9 (X-ray; 220 A; A=2-142), 1B86 (X-ray; 250 A; A/C=2-142), 1BAB (X-ray; 150 A; A/C=1-142), 1BBB (X-ray; 170 A; A/C=2-142), 1BIJ (X-ray; 230 A; A/C=2-142), 1BUW (X-ray; 190 A; A/C=2-142), 1BZ0 (X-ray; 150 A; A/C=2-142), 1BZ1 (X-ray; 159 A; A/C=1-142), 1BZZ (X-ray; 159 A; A/C=2-142), 1C7B (X-ray; 180 A; A/C=2-142), 1C7C (X-ray; 180 A; A=2-142), 1C7D (X-ray; 180 A; A=2-142), 1CLS (X-ray; 190 A; A/C=2-142), 1CMY (X-ray; 300 A; A/C=2-142), 1COH (X-ray; 290 A; A/C=2-142), 1DKE (X-ray; 210 A; A/C=2-142), 1DXT (X-ray; 170 A; A/C=2-142), 1DXU (X-ray; 170 A; A/C=2-142), 1DXV (X-ray; 170 A; A/C=2-142), 1FDH (X-ray; 250 A; A/B=2-142), 1FN3 (X-ray; 248 A; A/C=2-142), 1G9V (X-ray; 185 A; A/C=2-142), 1GBU (X-ray; 180 A; A/C=2-142), 1GBV (X-ray; 200 A; A/C=2-142), 1GLI (X-ray; 250 A; A/C=3-142), 1GZX (X-ray; 210 A; A/C=2-142), 1HAB (X-ray; 230 A; A/C=2-142), 1HAC (X-ray; 260 A; A/C=2-142), 1HBA (X-ray; 210 A; A/C=2-142), 1HBB (X-ray; 190 A; A/C=2-142), 1HBS (X-ray; 300 A; A/C/E/G=2-142), 1HCO (X-ray; 270 A; A=2-142), 1HDB (X-ray; 220 A; A/C=2-142), 1HGA (X-ray; 210 A; A/C=2-142), 1HGB (X-ray; 210 A; A/C=2-142), 1HGC (X-ray; 210 A; A/C=2-142), 1HHO (X-ray; 210 A; A=2-142), 1IRD (X-ray; 125 A; A=2-142), 1J3Y (X-ray; 155 A; A/C/E/G=2-142), 1J3Z (X-ray; 160 A; A/C/E/G=2-142), 1J40 (X-ray; 145 A; A/C/E/G=2-142), 1J41 (X-ray; 145 A; A/C/E/G=2-142), 1J7S (X-ray; 220 A; A/C=2-142), 1J7W (X-ray; 200 A; A/C=2-142), 1J7Y (X-ray; 170 A; A/C=2-142), 1JY7 (X-ray; 320 A; A/C/P/R/U/W=2-142), 1K0Y (X-ray; 187 A; A/C=2-142), 1K1K (X-ray; 200 A; A=2-142), 1KD2 (X-ray; 187 A; A/C=2-142), 1LFL (X-ray; 270 A; A/C/P/R=2-142), 1LFQ (X-ray; 260 A; A=2-142), 1LFT (X-ray; 260 A; A=2-142), 1LFV (X-ray; 280 A; A=2-142), 1LFY (X-ray; 330 A; A=2-142), 1LFZ (X-ray; 310 A; A=2-142), 1LJW (X-ray; 216 A; A=2-142), 1M9P (X-ray; 210 A; A/C=2-142), 1MKO (X-ray; 218 A; A/C=2-142), 1NEJ (X-ray; 210 A; A/C=2-142), 1NIH (X-ray; 260 A; A/C=2-142), 1NQP (X-ray; 173 A; A/C=2-142), 1O1I (X-ray; 230 A; A=2-142), 1O1J (X-ray; 190 A; A=2-142), 1O1K (X-ray; 200 A; A/C=3-142), 1O1L (X-ray; 180 A; A=2-142), 1O1M (X-ray; 185 A; A=2-142), 1O1N (X-ray; 180 A; A=2-142), 1O1O (X-ray; 180 A; A/C=2-142), 1O1P (X-ray; 180 A; A=2-142), 1QI8 (X-ray; 180 A; A/C=3-142), 1QSH (X-ray; 170 A; A/C=2-142), 1QSI (X-ray; 170 A; A/C=2-142), 1QXD (X-ray; 225 A; A/C=2-142), 1QXE (X-ray; 185 A; A/C=2-142), 1R1X (X-ray; 215 A; A=2-142), 1R1Y (X-ray; 180 A; A/C=2-142), 1RPS (X-ray; 211 A; A/C=2-142), 1RQ3 (X-ray; 191 A; A/C=2-142), 1RQ4 (X-ray; 211 A; A/C=2-142), 1RQA (X-ray; 211 A; A/C=2-142), 1RVW (X-ray; 250 A; A=2-142), 1SDK (X-ray; 180 A; A/C=2-142), 1SDL (X-ray; 180 A; A/C=2-142), 1SHR (X-ray; 188 A; A/C=2-142), 1SI4 (X-ray; 220 A; A/C=2-142), 1THB (X-ray; 150 A; A/C=2-142), 1UIW (X-ray; 150 A; A/C/E/G=2-142), 1VWT (X-ray; 190 A; A/C=2-142), 1XXT (X-ray; 191 A; A/C=2-142), 1XY0 (X-ray; 199 A; A/C=2-142), 1XYE (X-ray; 213 A; A/C=3-142), 1XZ2 (X-ray; 190 A; A/C=2-142), 1XZ4 (X-ray; 200 A; A/C=3-142), 1XZ5 (X-ray; 211 A; A/C=2-142), 1XZ7 (X-ray; 190 A; A/C=2-142), 1XZU (X-ray; 216 A; A/C=2-142), 1XZV (X-ray; 211 A; A/C=2-142), 1Y01 (X-ray; 280 A; B=1-142), 1Y09 (X-ray; 225 A; A/C=2-142), 1Y0A (X-ray; 222 A; A/C=2-140), 1Y0C (X-ray; 230 A; A/C=2-140), 1Y0D (X-ray; 210 A; A/C=2-141), 1Y0T (X-ray; 214 A; A/C=2-142), 1Y0W (X-ray; 214 A; A/C=2-142), 1Y22 (X-ray; 216 A; A/C=2-142), 1Y2Z (X-ray; 207 A; A/C=2-142), 1Y31 (X-ray; 213 A; A/C=2-142), 1Y35 (X-ray; 212 A; A/C=2-142), 1Y45 (X-ray; 200 A; A/C=2-142), 1Y46 (X-ray; 222 A; A/C=2-142), 1Y4B (X-ray; 210 A; A/C=2-142), 1Y4F (X-ray; 200 A; A/C=2-142), 1Y4G (X-ray; 191 A; A/C=2-142), 1Y4P (X-ray; 198 A; A/C=2-142), 1Y4Q (X-ray; 211 A; A/C=2-142), 1Y4R (X-ray; 222 A; A/C=2-142), 1Y4V (X-ray; 184 A; A/C=2-142), 1Y5F (X-ray; 214 A; A/C=2-142), 1Y5J (X-ray; 203 A; A/C=2-142), 1Y5K (X-ray; 220 A; A/C=2-142), 1Y7C (X-ray; 210 A; A/C=2-142), 1Y7D (X-ray; 190 A; A/C=2-142), 1Y7G (X-ray; 210 A; A/C=2-142), 1Y7Z (X-ray; 198 A; A/C=2-142), 1Y83 (X-ray; 190 A; A/C=2-142), 1Y85 (X-ray; 213 A; A/C=2-142), 1Y8W (X-ray; 290 A; A/C=2-142), 1YDZ (X-ray; 330 A; A/C=2-140), 1YE0 (X-ray; 250 A; A/C=2-142), 1YE1 (X-ray; 450 A; A/C=2-142), 1YE2 (X-ray; 180 A; A/C=2-142), 1YEN (X-ray; 280 A; A/C=2-142), 1YEO (X-ray; 222 A; A/C=2-142), 1YEQ (X-ray; 275 A; A/C=2-142), 1YEU (X-ray; 212 A; A/C=2-142), 1YEV (X-ray; 211 A; A/C=2-142), 1YFF (X-ray; 240 A; A/C/E/G=2-142), 1YG5 (X-ray; 270 A; A/C=2-142), 1YGD (X-ray; 273 A; A/C=2-142), 1YGF (X-ray; 270 A; A/C=2-142), 1YH9 (X-ray; 220 A; A/C=2-142), 1YHE (X-ray; 210 A; A/C=2-142), 1YHR (X-ray; 260 A; A/C=2-142), 1YIE (X-ray; 240 A; A/C=2-142), 1YIH (X-ray; 200 A; A/C=2-142), 1YVQ (X-ray; 180 A; A/C=2-142), 1YVT (X-ray; 180 A; A=2-142), 1YZI (X-ray; 207 A; A=2-142), 1Z8U (X-ray; 240 A; B/D=1-142), 2D5Z (X-ray; 145 A; A/C=2-142), 2D60 (X-ray; 170 A; A/C=2-142), 2DN1 (X-ray; 125 A; A=2-142), 2DN2 (X-ray; 125 A; A/C=2-142), 2DN3 (X-ray; 125 A; A=2-142), 2DXM (Neutron; 210 A; A/C=2-142), 2H35 (NMR; -; A/C=2-142), 2HBC (X-ray; 210 A; A=2-142), 2HBD (X-ray; 220 A; A=2-142), 2HBE (X-ray; 200 A; A=2-142), 2HBF (X-ray; 220 A; A=2-142), 2HBS (X-ray; 205 A; A/C/E/G=2-142), 2HCO (X-ray; 270 A; A=2-142), 2HHB (X-ray; 174 A; A/C=2-142), 2HHD (X-ray; 220 A; A/C=2-142), 2HHE (X-ray; 220 A; A/C=2-142), 2M6Z (NMR; -; A/C=2-142), 2W6V (X-ray; 180 A; A/C=2-142), 2W72 (X-ray; 107 A; A=2-142, C=3-142), 2YRS (X-ray; 230 A; A/C/I/M=2-142), 3B75 (X-ray; 230 A; A/C/E/G/S=2-142), 3D17 (X-ray; 280 A; A/C=2-142), 3D7O (X-ray; 180 A; A=2-142), 3DUT (X-ray; 155 A; A/C=2-142), 3HHB (X-ray; 174 A; A/C=2-142), 3HXN (X-ray; 200 A; A/C=2-142), 3IA3 (X-ray; 320 A; B/D=1-142), 3IC0 (X-ray; 180 A; A/C=2-142), 3IC2 (X-ray; 240 A; A/C=2-142), 3KMF (Neutron; 200 A; A/E=2-142), 3NL7 (X-ray; 180 A; A=2-142), 3NMM (X-ray; 160 A; A/C=2-142), 3ODQ (X-ray; 310 A; A/C=2-142), 3ONZ (X-ray; 209 A; A=2-142), 3OO4 (X-ray; 190 A; A=2-142), 3OO5 (X-ray; 210 A; A=2-142), 3OVU (X-ray; 283 A; C=2-142), 3P5Q (X-ray; 200 A; A=2-142), 3QJB (X-ray; 180 A; A=2-142), 3QJC (X-ray; 200 A; A=2-142), 3QJD (X-ray; 156 A; A/C=2-142), 3QJE (X-ray; 180 A; A/C=2-142), 3R5I (X-ray; 220 A; A/C=2-142), 3S48 (X-ray; 305 A; C/D=2-142), 3S65 (X-ray; 180 A; A/C=2-142), 3S66 (X-ray; 140 A; A=2-142), 3SZK (X-ray; 301 A; A/D=2-142), 3WCP (X-ray; 194 A; A/C=2-142), 3WHM (X-ray; 185 A; A/E=2-142), 4FC3 (X-ray; 226 A; A=2-142), 4HHB (X-ray; 174 A; A/C=2-142), 4IJ2 (X-ray; 424 A; A/C=2-142), 4L7Y (X-ray; 180 A; A/C=2-142), 4M4A (X-ray; 205 A; A=2-142), 4M4B (X-ray; 200 A; A=2-142), 4MQC (X-ray; 220 A; A=2-142), 4MQG (X-ray; 168 A; A=2-142), 4MQH (X-ray; 250 A; A=2-140), 4MQI (X-ray; 192 A; A=2-141), 4MQJ (X-ray; 180 A; A/C/E/G=2-142), 4MQK (X-ray; 224 A; A/C/E/G=2-142), 4N7N (X-ray; 275 A; A/C/E/G/I/K=2-142), 4N7O (X-ray; 250 A; A/C/E/G/I/K=2-142), 4N7P (X-ray; 281 A; A/C/E/G/I/K=2-142), 4N8T (X-ray; 190 A; A=2-142), 4NI0 (X-ray; 215 A; A=2-142), 4NI1 (X-ray; 190 A; A=2-142), 4WJG (X-ray; 310 A; A/F/K/P/U/Z=2-142), 4X0I (X-ray; 309 A; A=2-142), 4X0L (X-ray; 205 A; A=2-142), 6HBW (X-ray; 200 A; A/C=2-142)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 6331510] Melloni E, Salamino F, Sparatore B, Michetti M, Pontremoli S, Characterization of the single peptide generated from the amino-terminus end of alpha- and beta-hemoglobin chains by the Ca2+-dependent neutral proteinase. Biochim Biophys Acta. 1984 Jul 17;788(1):11-6.

Cleavage sites (±10aa)

[Site 1] VLSPADKTNV¹¹-KAAWGKVGAH

Val¹¹ Lys

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val²	Leu³	Ser⁴	Pro⁵	Ala⁶	Asp⁷	Lys⁸	Thr⁹	Asn¹⁰	Val¹¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Lys¹²	Ala¹³	Ala¹⁴	Trp¹⁵	Gly¹⁶	Lys¹⁷	Val¹⁸	Gly¹⁹	Ala²⁰	His²¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTK

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	88.20	7	hemoglobin alpha-2
2	synthetic construct	88.20	1	hemoglobin alpha 2
3	Homo sapiens	87.40	1	hemoglobin alpha-2 globin mutant
4	Hylobates lar	87.00	2	HBA1_HYLLA Hemoglobin subunit alpha-1 (Hemoglobin
5	N/A	85.90	141	A Chain A, Artificial Mutant (Alpha Y42h) Of Deox
6	Pongo pygmaeus	85.50	3	alpha-2 globin
7	alpha V96w	85.10	1	A Chain A, R State Human Hemoglobin
8	Macaca mulatta	84.70	1	theta 1 globin
9	Pipistrellus abramus	82.80	1	HBA_PIPAB Hemoglobin subunit alpha (Hemoglobin al
10	Papio anubis	80.10	1	HBA_PAPAN Hemoglobin subunit alpha (Hemoglobin al
11	Taphozous georgianus=tomb bats, erythrocytes, Peptide, 141 aa	79.70	1	HBA_TAPGE Hemoglobin subunit alpha (Hemoglobin al
12	Equus caballus	78.60	4	alpha 2 globin
13	Bubalus bubalis	78.20	4	HBA4_BUBBU Hemoglobin subunit alpha-4 (Hemoglobin
14	Bos taurus	77.80	2	hemoglobin alpha chain
15	Bos taurus	77.80	1	hemoglobin alpha chain
16	Oryctolagus cuniculus	76.60	1	alpha-hemoglobin
17	Equus burchelli	76.30	2	HBA2_EQUBU Hemoglobin subunit alpha-2 (Hemoglobin
18	Bubalus bubalis=river buffalo, Peptide, 141 aa	76.30	2	hemoglobin alpha 3 chain
19	Ovis aries	75.90	3	alpha globin chain
20	Equus hemionus	75.90	2	alpha 2 hemoglobin
21	Bubalus bubalis=river buffaloes, Peptide, 142 aa	74.30	1	hemoglobin AA phenotype alpha 1 chain
22	Equus grevyi	73.90	1	HBA1_EQUGR Hemoglobin subunit alpha-1 (Hemoglobin
23	Mus musculus	72.00	6	hemoglobin alpha, adult chain 2
24	Lynx lynx=European lynx, blood, Peptide, 141 aa	71.60	1	HBA_LYNLY Hemoglobin subunit alpha (Hemoglobin al
25	Proteles cristatus=aardwolves, Peptide, 141 aa	68.20	1	HBA_PROCR Hemoglobin subunit alpha (Hemoglobin al

Top-ranked sequences

organism	matching
Homo sapiens	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41
synthetic construct	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41
Homo sapiens	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41
Hylobates lar	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSPADKTNV#KAAWGKVGAHAGDYGAEALERMFLSFPTTK 41
N/A	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41
Pongo pygmaeus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\| \|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSPADKTNV#KTAWGKVGAHAGDYGAEALERMFLSFPTTK 41
alpha V96w	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41
Macaca mulatta	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|+\|\|#\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSPADKSNV#KAAWGKVGGHAGEYGAEALERMFLSFPTTK 41
Pipistrellus abramus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|\|#\|\|\|\| \|\|\| \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSPADKTNV#KAAWDKVGGHAGDYGAEALERMFLSFPTTK 41
Papio anubis	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\| \|\| +\|#\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSPDDKKHV#KAAWGKVGEHAGEYGAEALERMFLSFPTTK 41
Taphozous georgianus=tomb bats, erythrocytes, Peptide, 141 aa	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|#\|\|\|\| \|\|\| \|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VLSPADKTNV#KAAWEKVGGHAGDYGAEALERMFLSFPTTK 40
Equus caballus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|\|\|\|#\|\|\|\| \|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 1 MVLSAADKTNV#KAAWSKVGGHAGEYGAEALERMFLGFPTTK 41
Bubalus bubalis	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|+\|\|#\|\|\|\|\|\|\|\| \|\| +\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSAADKSNV#KAAWGKVGGHAADYGAEALERMFLSFPTTK 41
Bos taurus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\| \|\|#\|\|\|\|\|\|\|\| \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSAADKGNV#KAAWGKVGGHAAEYGAEALERMFLSFPTTK 41
Bos taurus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\| \|\|#\|\|\|\|\|\|\|\| \|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSAADKGNV#KAAWGKVGGHAAEYGAEALERMFLSFPTTK 41
Oryctolagus cuniculus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\|\|\|\|\|\|\|+#\| \|\| \|+\|+\| \|\|\|\|\|\|\|+\|\|\|\|\| \|\|\|\|\| Sbjct 1 MVLSPADKTNI#KTAWEKIGSHGGEYGAEAVERMFLGFPTTK 41
Equus burchelli	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|\|\|\|#\|\|\|\|\|\|\|\| +\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 1 MVLSAADKTNV#KAAWGKVGGNAGEFGAEALERMFLGFPTTK 41
Bubalus bubalis=river buffalo, Peptide, 141 aa	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\| \|\|\|+\|\|#\|\|\|\|\|\|\|\| \|\| +\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VLSAADKSNV#KAAWGKVGGHAADYGAEALERMFLSFPTTK 40
Ovis aries	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|+\|\|#\|\|\|\|\|\|\|\| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MVLSAADKSNV#KAAWGKVGGNAGAYGAEALERMFLSFPTTK 41
Equus hemionus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|\|\|\|#\|\|\|\| \|\|\| \|\|\|++\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 1 MVLSAADKTNV#KAAWSKVGGHAGDFGAEALERMFLGFPTTK 41
Bubalus bubalis=river buffaloes, Peptide, 142 aa	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\| \|\|\| \|\|#\|\|\|\|\|\|\|\| \|\| +\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 VLSAADKGNV#KAAWGKVGGHAADYGAEALERMFLSFPTTK 40
Equus grevyi	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|\|\|\|\|#\|\|\|\| \|\|\| +\|\|\|+\|\|\|\|\|\|\|\|\|\| \|\|\|\|\| Sbjct 1 MVLSAADKTNV#KAAWSKVGGNAGEFGAEALERMFLGFPTTK 41
Mus musculus	Query 1 MVLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\|\| \|\|+\|+#\|\|\|\|\|\|+\| \| \|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| Sbjct 1 MVLSGEDKSNI#KAAWGKIGGHGAEYGAEALERMFASFPTTK 41
Lynx lynx=European lynx, blood, Peptide, 141 aa	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\| \|\|\|+\|\|#\|\| \|\|\|+\|+\|\|\|+\|\| \|\|\|\|\| \| \|\|\|\|\|\| Sbjct 1 VLSAADKSNV#KACWGKIGSHAGDYGTEALERTFCSFPTTK 40
Proteles cristatus=aardwolves, Peptide, 141 aa	Query 2 VLSPADKTNV#KAAWGKVGAHAGEYGAEALERMFLSFPTTK 41 \|\|\| \|\|\| \|+#\|\| \| \|+\| \| \|\|\|\|\|\|\|\|\|\| \|\| \|\|\|\|\| Sbjct 1 VLSSADKANI#KATWDKIGGHGGEYGAEALERTFLCFPTTK 40

* References

[PubMed ID: 25284125] Farra C, Badra R, Fares F, Muwakkit S, Dbaibo G, Dabbous I, Ashkar H, Mounsef C, Abboud MR, Alpha thalassemia allelic frequency in Lebanon. Pediatr Blood Cancer. 2015 Jan;62(1):120-2. doi: 10.1002/pbc.25242. Epub 2014 Oct

» More (12) « Hide Below

[PubMed ID: 25139985] ... Viappiani C, Abbruzzetti S, Ronda L, Bettati S, Henry ER, Mozzarelli A, Eaton WA, Experimental basis for a new allosteric model for multisubunit proteins. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12758-63. doi:

[PubMed ID: 25079862] ... Ok ES, Asci G, Toz H, Ritz E, Kircelli F, Sever MS, Ozkahya M, Sipahi S, Dheir H, Bozkurt D, Omer Z, Sahin OZ, Ertilav M, Ok E, Glycated hemoglobin predicts overall and cardiovascular mortality in non-diabetic hemodialysis patients. Clin Nephrol. 2014 Sep;82(3):173-80.

[PubMed ID: 25123009] ... Tatu T, Sritong W, Sa-Nguansermsri T, The associations of SEA-alpha thalassemia 1, XmnI-Ggamma polymorphism and beta-globin gene mutations with the clinical severity of beta-thalassemia syndrome in northern Thailand. J Med Assoc Thai. 2014 Mar;97(3):300-7.

[PubMed ID: 22738435] ... Ghassemifar R, Forster L, Qadah T, Finlayson J, Identification and characterization of two novel and differentially expressed isoforms of human alpha2- and alpha1-globin genes. Hemoglobin. 2012;36(5):421-32.

[PubMed ID: 18083107] ... Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ, Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203.

[PubMed ID: 11499613] ... Zhang X, Medzihradszky KF, Cunningham J, Lee PD, Rognerud CL, Ou CN, Harmatz P, Witkowska HE, Characterization of glycated hemoglobin in diabetic patients: usefulness of electrospray mass spectrometry in monitoring the extent and distribution of glycation. J Chromatogr B Biomed Sci Appl. 2001 Aug 5;759(1):1-15.

[PubMed ID: 20301608] ... Origa R, Moi P, Galanello R, Cao A, Alpha-Thalassemia

[PubMed ID: 7358733] ... Shapiro R, McManus MJ, Zalut C, Bunn HF, Sites of nonenzymatic glycosylation of human hemoglobin A. J Biol Chem. 1980 Apr 10;255(7):3120-7.

[PubMed ID: 108887] ... Knuth A, Pribilla W, Marti HR, Winterhalter KH, Hemoglobin Moabit: alpha 86 (F7) Leu leads to Arg: a new unstable abnormal hemoglobin. Acta Haematol. 1979;61(3):121-4.

[PubMed ID: 31339] ... Moo-Penn WF, Jue DL, Baine RM, Hemoglobin J Rovigo (alpha53 Ala replaced by Asp) in association with beta-thalassemia. Hemoglobin. 1978;2(5):443-5.

[PubMed ID: 270752] ... Chang JC, Temple GF, Poon R, Neumann KH, Kan YW, The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs. Proc Natl Acad Sci U S A. 1977 Nov;74(11):5145-9.

[PubMed ID: 234399] ... Cohen-Solal M, Manesse B, Thillet J, Rosa J, Haemoglobin G Norfolk alpha 85 (F6) Asp leads to Asn. Structural characterization by sequenator analysis and functional properties of a new variant with high oxygen affinity. FEBS Lett. 1975 Feb 1;50(2):163-7.