SB0041 : Gonadotropin-releasing hormone 1
[ CaMP Format ]
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | progonadoliberin-1 precursor [Rattus norvegicus]; progonadoliberin-1 precursor; progonadoliberin-1; luteinizing hormone-releasing hormone; progonadoliberin I; gonadotropin releasing hormone 1; Progonadoliberin-1; Progonadoliberin I; Gonadoliberin-1; Gonadoliberin I; Gonadotropin-releasing hormone I; GnRH-I; Luliberin I; Luteinizing hormone-releasing hormone I; LH-RH I; Prolactin release-inhibiting factor 1; Prolactin release-inhibiting factor I |
| Gene Names | Gnrh1; Gnrh; gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
| Gene Locus | 15p12; chromosome 15 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 92 aa
Average Mass: 10.500 kDa
Monoisotopic Mass: 10.493 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Gonadotropin-releasing hormone 1. | 24 | 33 | 1.0 | 3.2 |
| --- cleavage 28 (inside Gonadotropin-releasing hormone 24..33) --- | ||||
| --- cleavage 29 (inside Gonadotropin-releasing hormone 24..33) --- | ||||
| Gonadotropin-releasing hormone 2. | 66 | 67 | 2.0 | 0.6 |
3. Sequence Information
Fasta Sequence: SB0041.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites] cleaved by Calpain 1 and 2
Source Reference: [PubMed ID: 6092335] Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T, Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates. J Biol Chem. 1984 Oct 25;259(20):12489-94.
Cleavage sites (±10aa)
[Site 1] EGCSSQHWSY28-GLRPGGKRNT
Tyr28 
Gly
iTraq-117 Signal 3525.1 (
) for GLRPGGKRNT
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu19 | Gly20 | Cys21 | Ser22 | Ser23 | Gln24 | His25 | Trp26 | Ser27 | Tyr28 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly29 | Leu30 | Arg31 | Pro32 | Gly33 | Gly34 | Lys35 | Arg36 | Asn37 | Thr38 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| METIPKLMAAVVLLTVCLEGCSSQHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEP |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 123.00 | 1 | gonadotropin-releasing hormone 1 precursor |
| 2 | Mus musculus | 106.00 | 1 | gonadotropin-releasing hormone 1 precursor |
| 3 | N/A | 102.00 | 41 | gonadotropin-releasing hormone |
| 4 | Canis familiaris | 95.10 | 1 | PREDICTED: similar to Progonadoliberin I precurso |
| 5 | Homo sapiens | 88.60 | 4 | unnamed protein product |
| 6 | synthetic construct | 87.40 | 1 | gonadotropin-releasing hormone 1 |
| 7 | Sus scrofa | 81.60 | 1 | gonadotropin-releasing hormone 1 |
| 8 | Gallus gallus | 67.00 | 1 | hypothetical protein LOC770134 |
| 9 | Sus scrofa | 58.50 | 1 | gonadotropin-releasing hormone |
| 10 | Anguilla japonica | 45.80 | 2 | prepro-mGnRH |
| 11 | Oreochromis niloticus | 44.70 | 1 | AF467291_1 GnRH1 preprohormone |
| 12 | Oreochromis niloticus | 44.70 | 1 | seabream-type gonadotropin-releasing hormone prec |
| 13 | Mugil cephalus | 42.70 | 3 | salmon-type gonadotropin-releasing hormone prepro |
| 14 | Pagrus major | 41.60 | 1 | gonadotropin-releasing hormone |
| 15 | Cyprinus carpio | 40.80 | 6 | salmon-type gonadotropin-releasing hormone precur |
| 16 | Tetraodon nigroviridis | 40.40 | 2 | prepro-seabream-type gonadotropin-releasing hormo |
| 17 | Carassius auratus | 40.40 | 2 | salmon-type gonadotropin-releasing hormone precur |
| 18 | Dentex dentex | 39.70 | 1 | gonadotropin-releasing hormone |
| 19 | Coregonus clupeaformis | 39.30 | 3 | whitefish gonadotropin-releasing hormone 1 precur |
| 20 | Odontesthes bonariensis | 39.30 | 2 | prepro pejerrey-type gonadotropin-releasing hormo |
| 21 | Oncorhynchus mykiss | 39.30 | 2 | AF232212_1 pro-sGnRH-I |
| 22 | Oncorhynchus mykiss | 38.90 | 7 | AF110992_1 gonadotropin-releasing hormone |
| 23 | Oncorhynchus nerka | 38.90 | 2 | gonadotropin-releasing hormone precursor |
| 24 | Contains: Trp-8 gonadoliberin (Trp-8 gonadotropin-releasing hormone) ([Trp8 | 38.50 | 1 | GON8_RANDY Trp-8 progonadoliberin precursor |
| 25 | Micropogonias undulatus | 38.10 | 3 | seabream-type gonadotropin-releasing hormone prec |
| 26 | Sparus aurata | 37.40 | 3 | sbGnRH |
| 27 | Scleropages jardinii | 37.00 | 2 | prepro-salmon-type gonadotropin-releasing hormone |
| 28 | Oryzias latipes | 36.20 | 6 | prepro-gonadotropin-releasing hormone |
| 29 | Acanthopagrus latus | 35.40 | 1 | gonadotropin-releasing hormone |
| 30 | Monopterus albus | 34.70 | 3 | pejerrey-type gonadotropin-releasing hormone prec |
| 31 | Odontesthes bonariensis | 34.70 | 2 | gonadotropin-releasing hormone |
| 32 | Oreochromis mossambicus | 34.30 | 1 | gonadotropin-releasing hormone III precursor |
| 33 | Morone chrysops | 34.30 | 1 | GnRH-1 precursor |
| 34 | Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIB | 33.50 | 1 | GON2B_CARAU Progonadoliberin IIB precursor |
| 35 | Eublepharis macularius | 33.10 | 1 | prepro-chicken-II-type gonadotropin-releasing hor |
| 36 | Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIA | 33.10 | 1 | GON2A_CARAU Progonadoliberin IIA precursor |
| 37 | Alosa sapidissima | 32.30 | 1 | gonadotropin-releasing hormone precursor |
| 38 | Tetraodon nigroviridis | 32.00 | 1 | unnamed protein product |
| 39 | Geotria australis | 32.00 | 1 | preprogonadotropin-releasing hormone III |
| 40 | Clarias gariepinus | 32.00 | 1 | catfish gonadotropin-releasing hormone and catfis |
| 41 | Danio rerio | 31.60 | 3 | gonadotropin-releasing hormone 3 |
| 42 | Agrobacterium tumefaciens str. C58 | 31.20 | 1 | nitric oxide reductase NorD protein |
| 43 | Ciona intestinalis | 30.80 | 2 | preprogonadotropin-releasing hormone 2 |
| 44 | Lampetra tridentatus | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 45 | Ichthyomyzon unicuspis | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 46 | Paralichthys olivaceus | 30.40 | 1 | chicken-type gonadotropin-releasing hormone 2 pre |
| 47 | Lampetra appendix | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 48 | Ichthyomyzon fossor | 30.00 | 1 | preprogonadotropin-releasing hormone III |
| 49 | Rana esculenta | 30.00 | 1 | mGnRH precursor |
| 50 | Shewanella oneidensis MR-1 | 30.00 | 1 | hypothetical protein SO_3790 |
| 51 | Typhlonectes natans | 29.60 | 1 | AF167558_1 gonadotropin-releasing hormone II prec |
| 52 | Lampetra richardsoni | 29.30 | 1 | preprogonadotropin-releasing hormone III |
| 53 | Petromyzon marinus | 29.30 | 1 | gonadotropin-releasing hormone III precursor |
| 54 | Trichosurus vulpecula | 28.90 | 1 | AF193516_1 type II gonadotrophin releasing hormon |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |
| Mus musculus | Query 4 IPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 | |||| ++||||||||||||||||#||||||||||||||+|||||||| |||||| Sbjct 2 ILKLMAGILLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVESFQEMGKEVDQMAEP 56 |
| N/A | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 ||||||||||||||||||||||||||||#|||||||||||||||||||+ Sbjct 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEV 48 |
| Canis familiaris | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || ||||+| ++||| |+ || |||||#||||||||| |||+|||||| || || ||| Sbjct 1 MEPIPKLVAGLLLLTFCVVSCSGQHWSY#GLRPGGKRNAEHLIDSFQEMAKELDQPAEP 58 |
| Homo sapiens | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAE 57 |+ | ||+| ++||| |+||||||||||#||||||||+ |+|+|||||+ || |+|| Sbjct 1 MKPIQKLLAGLILLTSCVEGCSSQHWSY#GLRPGGKRDAENLIDSFQEIVKEVGQLAE 57 |
| synthetic construct | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAE 57 |+ | ||+| ++||| |+||||||||||#||||||||+ |+|+|||||+ || |+|| Sbjct 1 MKPIQKLLAGLILLTWCVEGCSSQHWSY#GLRPGGKRDAENLIDSFQEIVKEVGQLAE 57 |
| Sus scrofa | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || ||||+| ++|||+|+ |||||||||#||||||||| |+++|||||| || ++||| Sbjct 1 MEPIPKLLAGLLLLTLCVVGCSSQHWSY#GLRPGGKRNAENVIDSFQEMAKEVARLAEP 58 |
| Gallus gallus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAE 57 || |++ |+| | + | +|||||#||+|||||| |+||+||||+ | + + | Sbjct 1 MEKSRKILVGVLLFTASVAICLAQHWSY#GLQPGGKRNAENLVESFQEIANEMESLGE 57 |
| Sus scrofa | Query 26 WSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |||#||||||||| |+++|||||| || ++||| Sbjct 1 WSY#GLRPGGKRNAENVIDSFQEMAKEVARLAEP 33 |
| Anguilla japonica | Query 7 LMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKE 51 | + + || +|| |||||#|||||||| + | |+ |++ +| Sbjct 8 LWLGLAVALVC-QGCC-QHWSY#GLRPGGKRGADSLQDTLQDIIEE 50 |
| Oreochromis niloticus | Query 6 KLMAAVVLL--TVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |++| +|| || +|| |||||#|| |||||+ ++ |+ | +| ++ | Sbjct 4 KILALWLLLAGTVFPQGCC-QHWSY#GLSPGGKRDLDNFSDTLGNMVEEFPRVEAP 57 |
| Oreochromis niloticus | Query 6 KLMAAVVLL--TVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |++| +|| || +|| |||||#|| |||||+ ++ |+ | +| ++ | Sbjct 4 KILALWLLLAGTVFPQGCC-QHWSY#GLSPGGKRDLDNFSDTLGNMVEEFPRVEAP 57 |
| Mugil cephalus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMG 49 || ++| |+| + ++ ||||||#| |||||+ | + + || Sbjct 1 MEASSRVMVQVLLRALVVQVSLSQHWSY#GWLPGGKRSVGELEATIRMMG 49 |
| Pagrus major | Query 11 VVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +|++ | +|| |||||#|| |||||+ + | |+ ++ Sbjct 3 LVVMMVMSQGCC-QHWSY#GLSPGGKRDLDSLSDTLGDI 39 |
| Cyprinus carpio | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || +++ +++| || |||||#| |||||+| + +|+ | + ++ | Sbjct 1 MEWKGRVLVQLLMLVCVLEVSLCQHWSY#GWLPGGKRSTGEVEATFRMMDPGDAVLSIP 58 |
| Tetraodon nigroviridis | Query 23 SQHWSY#GLRPGGKRNTEHLVD 43 ||||||#|| |||||+ +|| + Sbjct 22 SQHWSY#GLSPGGKRDVDHLSN 42 |
| Carassius auratus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || +|+ +++| || |||||#| |||||+ + +|+ | + ++ | Sbjct 1 MEWNGRLLVQLLMLVCVLEVSLCQHWSY#GWLPGGKRSVGEVEATFKMMDAGDAVLSIP 58 |
| Dentex dentex | Query 11 VVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 +|++ | +|| |||||#|| |||||+ + |+ + + + | Sbjct 3 LVVMMVMSQGCC-QHWSY#GLSPGGKRDLDSFSDTLGNIIERFPHVDSP 49 |
| Coregonus clupeaformis | Query 19 EGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKE 51 +|| |||||#|+ ||||| | | |+ | ++ Sbjct 20 QGCC-QHWSY#GMNPGGKRATGSLSDTQDNMAED 51 |
| Odontesthes bonariensis | Query 5 PKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 | |+ +|+| | ||||+#|| |||||+ + |+ + + | | Sbjct 10 PLLVGSVLLQVTC------QHWSF#GLSPGGKRDLDTFSDTLDNVVEGFPHMDAP 57 |
| Oncorhynchus mykiss | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 |+ | + ||+| + + ||||||#| |||||+ | + + | Sbjct 1 MDLSSKTVVQVVMLALIAQVTFSQHWSY#GWLPGGKRSVGELEATIRMM 48 |
| Oncorhynchus mykiss | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 |+ | ||+| + + ||||||#| |||||+ | + + | Sbjct 1 MDLSSKTFVQVVMLALIAQVTFSQHWSY#GWLPGGKRSVGELEATIRMM 48 |
| Oncorhynchus nerka | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 |+ | + ||+| + + ||||||#| |||||+ | + + | Sbjct 1 MDLSSKTVVQVVMLALIAQVTFSQHWSY#GWLPGGKRSVGELEATIRMM 48 |
| Contains: Trp-8 gonadoliberin (Trp-8 gonadotropin-releasing hormone) ([Trp8 | Query 24 QHWSY#GLRPGGKRNTEHLVDSFQEMGKE 51 |||||#|| ||||| | | +|+ |+ | Sbjct 25 QHWSY#GLWPGGKREVEGLQESYSEVPNE 52 |
| Micropogonias undulatus | Query 5 PKLMAAVVLLTVCLEGC--SSQHWSY#GLRPGGKRN----TEHLVDSF 45 |+ | ++|| + | |||||#|| |||||+ ++ +|||| Sbjct 3 PQTSAMLLLLVGSVLWCHGCCQHWSY#GLSPGGKRDLDGRSDTMVDSF 49 |
| Sparus aurata | Query 19 EGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 +|| |||||#|| |||||+ + | |+ + + + | Sbjct 17 QGCC-QHWSY#GLSPGGKRDLDSLSDTLGNIIERFPHVDSP 55 |
| Scleropages jardinii | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNT 38 || | + +|+| + ||||||#| |||||+| Sbjct 1 MELTGKSVLHLVVLAHVAQIGFSQHWSY#GWLPGGKRST 38 |
| Oryzias latipes | Query 4 IPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQE 47 + | +++ +| +|| ||||+#|| ||||| ++ ++ + Sbjct 3 VKTWMPWLLVSSVLSQGCC-QHWSF#GLSPGGKRELKYFPNTLEN 45 |
| Acanthopagrus latus | Query 19 EGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 || |||||#|| |||||+ | |+ + Sbjct 15 RGCC-QHWSY#GLSPGGKRDLGSLSDTLGNI 43 |
| Monopterus albus | Query 3 TIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEM 48 |+ + ++|+ + ||||+#|| ||||| | |+ + Sbjct 6 TVKTMALWLLLVGTLVPQLYCQHWSF#GLSPGGKRELNSLSDTLGNI 51 |
| Odontesthes bonariensis | Query 24 QHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 ||||+#|| |||||+ + |+ + + | | Sbjct 1 QHWSF#GLSPGGKRDLDTFSDTLDNVVEGFPHMDAP 35 |
| Oreochromis mossambicus | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEMG 49 ||||||#| |||||+ | + + || Sbjct 23 SQHWSY#GWLPGGKRSVGELEATIRMMG 49 |
| Morone chrysops | Query 24 QHWSY#GLRPGGKRNTEHLVDSFQEM 48 |||||#|| ||||| + | ++ + Sbjct 23 QHWSY#GLSPGGKRELDGLSETLANI 47 |
| Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIB | Query 12 VLLTVCLEGCSSQHWSY#GLRPGGKRNTE 39 +|+ + ++ ||||||+#| ||||| + Sbjct 13 MLMFLSVQFASSQHWSH#GWYPGGKREID 40 |
| Eublepharis macularius | Query 5 PKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTE 39 | |+ +++ + +||||+#| ||||| + Sbjct 6 PLLLFLCIMIIATIHLSKAQHWSH#GWYPGGKREVD 40 |
| Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIA | Query 12 VLLTVCLEGCSSQHWSY#GLRPGGKRNTE 39 +|| + + ||||||+#| ||||| + Sbjct 13 MLLCLSAQFASSQHWSH#GWYPGGKREID 40 |
| Alosa sapidissima | Query 22 SSQHWSY#GLRPGGKRNTEHLVDSFQEMGK 50 |+||||+#|| ||||| | + + + | Sbjct 21 SAQHWSH#GLSPGGKREAHTLSEVMEGLPK 49 |
| Tetraodon nigroviridis | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHL 41 || ++| |+|| + |+ ||||||#| |||||+ | Sbjct 1 MEANSRVMVQVLLLALALQVALSQHWSY#GWLPGGKRSVGEL 41 |
| Geotria australis | Query 23 SQHWSY#GLRPGGKRNTE 39 |||||+# +|||||| | Sbjct 25 SQHWSH#DWKPGGKRNLE 41 |
| Clarias gariepinus | Query 22 SSQHWSY#GLRPGGKR 36 |+||||+#|| ||||| Sbjct 20 SAQHWSH#GLNPGGKR 34 |
| Danio rerio | Query 24 QHWSY#GLRPGGKRNTEHLVDSFQ 46 |||||#| |||||+ + +|+ Sbjct 24 QHWSY#GWLPGGKRSVGEMEATFR 46 |
| Agrobacterium tumefaciens str. C58 | Query 6 KLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || +||+| | +| + # + | | + | + | || |+++|+| Sbjct 34 KLEDMQAVLTICFRGFGGEH-AV#QIAPARARTSTHRLRLRQRMGLGEEKLAQP 85 |
| Ciona intestinalis | Query 24 QHWSY#GLRPGGKR 36 |||||# | ||||| Sbjct 65 QHWSY#ALSPGGKR 77 |
| Lampetra tridentatus | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +||||+# +|||||+ | + +|+ Sbjct 24 TQHWSH#DWKPGGKRDLEAMRPLLEEL 49 |
| Ichthyomyzon unicuspis | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +||||+# +|||||+ | + +|+ Sbjct 24 TQHWSH#DWKPGGKRDLEAMRPLLEEL 49 |
| Paralichthys olivaceus | Query 22 SSQHWSY#GLRPGGKRNTEHLVDSF 45 | ||||+#| ||||| +||| Sbjct 22 SGQHWSH#GWYPGGKRE----LDSF 41 |
| Lampetra appendix | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +||||+# +|||||+ | + +|+ Sbjct 24 TQHWSH#DWKPGGKRDLEAMRPLLEEL 49 |
| Ichthyomyzon fossor | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +||||+# +|||||+ | + +|+ Sbjct 24 TQHWSH#DWKPGGKRDLEAMRPLLEEL 49 |
| Rana esculenta | Query 29 GLRPGGKRNTEHLVDSFQEMGKE 51 |||||||| | | +|+ |+ | Sbjct 1 GLRPGGKREVESLQESYAEVPNE 23 |
| Shewanella oneidensis MR-1 | Query 2 ETIPKLMAAVVLLTVCLEGCSSQHWSY#GLRPGGKRNTEHLVDS 44 +|+| | | | + ++|| | | |# + ||| +| || Sbjct 44 KTLPTLADAFRLESAQVKGCESDAWLY#HIEQGGKHY--YLADS 84 |
| Typhlonectes natans | Query 16 VCLEGCSSQHWSY#GLRPGGKRNTE 39 | ++ +||||+#| ||||| + Sbjct 17 VGIQASYAQHWSH#GWYPGGKRELD 40 |
| Lampetra richardsoni | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQEM 48 +||||+# +||||| | + +|+ Sbjct 24 TQHWSH#DWKPGGKRGLEAMRPLLEEL 49 |
| Petromyzon marinus | Query 23 SQHWSY#GLRPGGKRNTEHLVDSFQE 47 +||||+# +|||||+ | + +| Sbjct 24 TQHWSH#DWKPGGKRDLEAMRPLLEE 48 |
| Trichosurus vulpecula | Query 23 SQHWSY#GLRPGGKRNTE 39 +||||+#| |||||+ + Sbjct 22 AQHWSH#GWYPGGKRDLD 38 |
[Site 2] GCSSQHWSYG29-LRPGGKRNTE
Gly29 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly20 | Cys21 | Ser22 | Ser23 | Gln24 | His25 | Trp26 | Ser27 | Tyr28 | Gly29 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu30 | Arg31 | Pro32 | Gly33 | Gly34 | Lys35 | Arg36 | Asn37 | Thr38 | Glu39 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| METIPKLMAAVVLLTVCLEGCSSQHWSYGLRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 125.00 | 1 | gonadotropin-releasing hormone 1 precursor |
| 2 | Mus musculus | 108.00 | 1 | gonadotropin-releasing hormone 1 precursor |
| 3 | N/A | 102.00 | 41 | gonadotropin-releasing hormone |
| 4 | Canis familiaris | 97.10 | 1 | PREDICTED: similar to Progonadoliberin I precurso |
| 5 | Homo sapiens | 89.70 | 3 | unnamed protein product |
| 6 | synthetic construct | 89.40 | 1 | gonadotropin-releasing hormone 1 |
| 7 | Sus scrofa | 83.20 | 1 | gonadotropin-releasing hormone 1 |
| 8 | Gallus gallus | 68.60 | 1 | hypothetical protein LOC770134 |
| 9 | Sus scrofa | 60.50 | 1 | gonadotropin-releasing hormone |
| 10 | Anguilla japonica | 45.40 | 2 | prepro-mGnRH |
| 11 | Oreochromis niloticus | 44.70 | 1 | AF467291_1 GnRH1 preprohormone |
| 12 | Oreochromis niloticus | 44.70 | 1 | seabream-type gonadotropin-releasing hormone prec |
| 13 | Mugil cephalus | 42.70 | 3 | salmon-type gonadotropin-releasing hormone prepro |
| 14 | Pagrus major | 41.60 | 1 | gonadotropin-releasing hormone |
| 15 | Cyprinus carpio | 41.20 | 6 | salmon-type gonadotropin-releasing hormone precur |
| 16 | Tetraodon nigroviridis | 40.40 | 2 | prepro-seabream-type gonadotropin-releasing hormo |
| 17 | Carassius auratus | 40.40 | 2 | salmon-type gonadotropin-releasing hormone precur |
| 18 | Dentex dentex | 39.70 | 1 | gonadotropin-releasing hormone |
| 19 | Coregonus clupeaformis | 39.30 | 3 | whitefish gonadotropin-releasing hormone 1 precur |
| 20 | Odontesthes bonariensis | 39.30 | 2 | prepro pejerrey-type gonadotropin-releasing hormo |
| 21 | Oncorhynchus mykiss | 39.30 | 2 | AF232212_1 pro-sGnRH-I |
| 22 | Oncorhynchus mykiss | 38.90 | 7 | AF110992_1 gonadotropin-releasing hormone |
| 23 | Oncorhynchus nerka | 38.90 | 2 | gonadotropin-releasing hormone precursor |
| 24 | Contains: Trp-8 gonadoliberin (Trp-8 gonadotropin-releasing hormone) ([Trp8 | 38.50 | 1 | GON8_RANDY Trp-8 progonadoliberin precursor |
| 25 | Micropogonias undulatus | 38.10 | 3 | seabream-type gonadotropin-releasing hormone prec |
| 26 | Sparus aurata | 37.40 | 3 | sbGnRH |
| 27 | Scleropages jardinii | 37.00 | 2 | prepro-salmon-type gonadotropin-releasing hormone |
| 28 | Oryzias latipes | 36.20 | 6 | prepro-gonadotropin-releasing hormone |
| 29 | Acanthopagrus latus | 35.80 | 1 | gonadotropin-releasing hormone |
| 30 | Monopterus albus | 34.70 | 3 | pejerrey-type gonadotropin-releasing hormone prec |
| 31 | Odontesthes bonariensis | 34.70 | 2 | gonadotropin-releasing hormone |
| 32 | Oreochromis mossambicus | 34.30 | 1 | gonadotropin-releasing hormone III precursor |
| 33 | Morone chrysops | 34.30 | 1 | GnRH-1 precursor |
| 34 | Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIB | 33.50 | 1 | GON2B_CARAU Progonadoliberin IIB precursor |
| 35 | Eublepharis macularius | 33.10 | 1 | prepro-chicken-II-type gonadotropin-releasing hor |
| 36 | Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIA | 33.10 | 1 | GON2A_CARAU Progonadoliberin IIA precursor |
| 37 | Alosa sapidissima | 32.30 | 1 | gonadotropin-releasing hormone precursor |
| 38 | Tetraodon nigroviridis | 32.00 | 1 | unnamed protein product |
| 39 | Geotria australis | 32.00 | 1 | preprogonadotropin-releasing hormone III |
| 40 | Clarias gariepinus | 32.00 | 1 | catfish gonadotropin-releasing hormone and catfis |
| 41 | Danio rerio | 31.60 | 3 | gonadotropin-releasing hormone 3 |
| 42 | Agrobacterium tumefaciens str. C58 | 31.20 | 1 | nitric oxide reductase NorD protein |
| 43 | Rana esculenta | 31.20 | 1 | mGnRH precursor |
| 44 | Ciona intestinalis | 30.80 | 2 | preprogonadotropin-releasing hormone 2 |
| 45 | Lampetra tridentatus | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 46 | Paralichthys olivaceus | 30.40 | 1 | chicken-type gonadotropin-releasing hormone 2 pre |
| 47 | Lampetra appendix | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 48 | Ichthyomyzon unicuspis | 30.40 | 1 | preprogonadotropin-releasing hormone III |
| 49 | Ichthyomyzon fossor | 30.00 | 1 | preprogonadotropin-releasing hormone III |
| 50 | Shewanella oneidensis MR-1 | 30.00 | 1 | hypothetical protein SO_3790 |
| 51 | Typhlonectes natans | 29.60 | 1 | AF167558_1 gonadotropin-releasing hormone II prec |
| 52 | Lampetra richardsoni | 29.30 | 1 | preprogonadotropin-releasing hormone III |
| 53 | Petromyzon marinus | 29.30 | 1 | gonadotropin-releasing hormone III precursor |
| 54 | Trichosurus vulpecula | 28.90 | 1 | AF193516_1 type II gonadotrophin releasing hormon |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 |
| Mus musculus | Query 4 IPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 | |||| ++|||||||||||||||||#|||||||||||||+|||||||| ||||||| Sbjct 2 ILKLMAGILLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVESFQEMGKEVDQMAEPQ 57 |
| N/A | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 |||||||||||||||||||||||||||||#||||||||||||||||||+ Sbjct 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEV 48 |
| Canis familiaris | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 || ||||+| ++||| |+ || ||||||#|||||||| |||+|||||| || || |||| Sbjct 1 MEPIPKLVAGLLLLTFCVVSCSGQHWSYG#LRPGGKRNAEHLIDSFQEMAKELDQPAEPQ 59 |
| Homo sapiens | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 |+ | ||+| ++||| |+|||||||||||#|||||||+ |+|+|||||+ || |+|| | Sbjct 1 MKPIQKLLAGLILLTSCVEGCSSQHWSYG#LRPGGKRDAENLIDSFQEIVKEVGQLAETQ 59 |
| synthetic construct | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 |+ | ||+| ++||| |+|||||||||||#|||||||+ |+|+|||||+ || |+|| | Sbjct 1 MKPIQKLLAGLILLTWCVEGCSSQHWSYG#LRPGGKRDAENLIDSFQEIVKEVGQLAETQ 59 |
| Sus scrofa | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 || ||||+| ++|||+|+ ||||||||||#|||||||| |+++|||||| || ++|||| Sbjct 1 MEPIPKLLAGLLLLTLCVVGCSSQHWSYG#LRPGGKRNAENVIDSFQEMAKEVARLAEPQ 59 |
| Gallus gallus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 || |++ |+| | + | +||||||#|+|||||| |+||+||||+ | + + | | Sbjct 1 MEKSRKILVGVLLFTASVAICLAQHWSYG#LQPGGKRNAENLVESFQEIANEMESLGEGQ 59 |
| Sus scrofa | Query 26 WSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 ||||#|||||||| |+++|||||| || ++|||| Sbjct 1 WSYG#LRPGGKRNAENVIDSFQEMAKEVARLAEPQ 34 |
| Anguilla japonica | Query 7 LMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKE 51 | + + || +|| ||||||#||||||| + | |+ |++ +| Sbjct 8 LWLGLAVALVC-QGCC-QHWSYG#LRPGGKRGADSLQDTLQDIIEE 50 |
| Oreochromis niloticus | Query 6 KLMAAVVLL--TVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |++| +|| || +|| ||||||#| |||||+ ++ |+ | +| ++ | Sbjct 4 KILALWLLLAGTVFPQGCC-QHWSYG#LSPGGKRDLDNFSDTLGNMVEEFPRVEAP 57 |
| Oreochromis niloticus | Query 6 KLMAAVVLL--TVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 |++| +|| || +|| ||||||#| |||||+ ++ |+ | +| ++ | Sbjct 4 KILALWLLLAGTVFPQGCC-QHWSYG#LSPGGKRDLDNFSDTLGNMVEEFPRVEAP 57 |
| Mugil cephalus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMG 49 || ++| |+| + ++ |||||||# |||||+ | + + || Sbjct 1 MEASSRVMVQVLLRALVVQVSLSQHWSYG#WLPGGKRSVGELEATIRMMG 49 |
| Pagrus major | Query 11 VVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +|++ | +|| ||||||#| |||||+ + | |+ ++ Sbjct 3 LVVMMVMSQGCC-QHWSYG#LSPGGKRDLDSLSDTLGDI 39 |
| Cyprinus carpio | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 || +++ +++| || ||||||# |||||+| + +|+ | + ++ |+ Sbjct 1 MEWKGRVLVQLLMLVCVLEVSLCQHWSYG#WLPGGKRSTGEVEATFRMMDPGDAVLSIPE 59 |
| Tetraodon nigroviridis | Query 23 SQHWSYG#LRPGGKRNTEHLVD 43 |||||||#| |||||+ +|| + Sbjct 22 SQHWSYG#LSPGGKRDVDHLSN 42 |
| Carassius auratus | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || +|+ +++| || ||||||# |||||+ + +|+ | + ++ | Sbjct 1 MEWNGRLLVQLLMLVCVLEVSLCQHWSYG#WLPGGKRSVGEVEATFKMMDAGDAVLSIP 58 |
| Dentex dentex | Query 11 VVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 +|++ | +|| ||||||#| |||||+ + |+ + + + | Sbjct 3 LVVMMVMSQGCC-QHWSYG#LSPGGKRDLDSFSDTLGNIIERFPHVDSP 49 |
| Coregonus clupeaformis | Query 19 EGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKE 51 +|| ||||||#+ ||||| | | |+ | ++ Sbjct 20 QGCC-QHWSYG#MNPGGKRATGSLSDTQDNMAED 51 |
| Odontesthes bonariensis | Query 5 PKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 | |+ +|+| | ||||+|#| |||||+ + |+ + + | | Sbjct 10 PLLVGSVLLQVTC------QHWSFG#LSPGGKRDLDTFSDTLDNVVEGFPHMDAP 57 |
| Oncorhynchus mykiss | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 |+ | + ||+| + + |||||||# |||||+ | + + | Sbjct 1 MDLSSKTVVQVVMLALIAQVTFSQHWSYG#WLPGGKRSVGELEATIRMM 48 |
| Oncorhynchus mykiss | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 |+ | ||+| + + |||||||# |||||+ | + + | Sbjct 1 MDLSSKTFVQVVMLALIAQVTFSQHWSYG#WLPGGKRSVGELEATIRMM 48 |
| Oncorhynchus nerka | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 |+ | + ||+| + + |||||||# |||||+ | + + | Sbjct 1 MDLSSKTVVQVVMLALIAQVTFSQHWSYG#WLPGGKRSVGELEATIRMM 48 |
| Contains: Trp-8 gonadoliberin (Trp-8 gonadotropin-releasing hormone) ([Trp8 | Query 24 QHWSYG#LRPGGKRNTEHLVDSFQEMGKE 51 ||||||#| ||||| | | +|+ |+ | Sbjct 25 QHWSYG#LWPGGKREVEGLQESYSEVPNE 52 |
| Micropogonias undulatus | Query 5 PKLMAAVVLLTVCLEGC--SSQHWSYG#LRPGGKRN----TEHLVDSF 45 |+ | ++|| + | ||||||#| |||||+ ++ +|||| Sbjct 3 PQTSAMLLLLVGSVLWCHGCCQHWSYG#LSPGGKRDLDGRSDTMVDSF 49 |
| Sparus aurata | Query 19 EGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 +|| ||||||#| |||||+ + | |+ + + + | Sbjct 17 QGCC-QHWSYG#LSPGGKRDLDSLSDTLGNIIERFPHVDSP 55 |
| Scleropages jardinii | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNT 38 || | + +|+| + |||||||# |||||+| Sbjct 1 MELTGKSVLHLVVLAHVAQIGFSQHWSYG#WLPGGKRST 38 |
| Oryzias latipes | Query 3 TIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQE 47 + | +++ +| +|| ||||+|#| ||||| ++ ++ + Sbjct 2 VVKTWMPWLLVSSVLSQGCC-QHWSFG#LSPGGKRELKYFPNTLEN 45 |
| Acanthopagrus latus | Query 19 EGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 || ||||||#| |||||+ | |+ + Sbjct 15 RGCC-QHWSYG#LSPGGKRDLGSLSDTLGNI 43 |
| Monopterus albus | Query 3 TIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEM 48 |+ + ++|+ + ||||+|#| ||||| | |+ + Sbjct 6 TVKTMALWLLLVGTLVPQLYCQHWSFG#LSPGGKRELNSLSDTLGNI 51 |
| Odontesthes bonariensis | Query 24 QHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 ||||+|#| |||||+ + |+ + + | | Sbjct 1 QHWSFG#LSPGGKRDLDTFSDTLDNVVEGFPHMDAP 35 |
| Oreochromis mossambicus | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEMG 49 |||||||# |||||+ | + + || Sbjct 23 SQHWSYG#WLPGGKRSVGELEATIRMMG 49 |
| Morone chrysops | Query 24 QHWSYG#LRPGGKRNTEHLVDSFQEM 48 ||||||#| ||||| + | ++ + Sbjct 23 QHWSYG#LSPGGKRELDGLSETLANI 47 |
| Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIB | Query 12 VLLTVCLEGCSSQHWSYG#LRPGGKRNTE 39 +|+ + ++ ||||||+|# ||||| + Sbjct 13 MLMFLSVQFASSQHWSHG#WYPGGKREID 40 |
| Eublepharis macularius | Query 5 PKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTE 39 | |+ +++ + +||||+|# ||||| + Sbjct 6 PLLLFLCIMIIATIHLSKAQHWSHG#WYPGGKREVD 40 |
| Contains: Gonadoliberin II (Luteinizing hormone-releasing hormone II) (LH-RH II) (Gonadotropin-releasing hormone II) (GnRH II) (Luliberin II); GnRH-associated peptide IIA | Query 1 METIPKLMAAV-VLLTVCLEGCSSQHWSYG#LRPGGKRNTE 39 | | +| + +|| + + ||||||+|# ||||| + Sbjct 1 MVHICRLFVVMGMLLCLSAQFASSQHWSHG#WYPGGKREID 40 |
| Alosa sapidissima | Query 22 SSQHWSYG#LRPGGKRNTEHLVDSFQEMGK 50 |+||||+|#| ||||| | + + + | Sbjct 21 SAQHWSHG#LSPGGKREAHTLSEVMEGLPK 49 |
| Tetraodon nigroviridis | Query 1 METIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHL 41 || ++| |+|| + |+ |||||||# |||||+ | Sbjct 1 MEANSRVMVQVLLLALALQVALSQHWSYG#WLPGGKRSVGEL 41 |
| Geotria australis | Query 23 SQHWSYG#LRPGGKRNTE 39 |||||+ # +|||||| | Sbjct 25 SQHWSHD#WKPGGKRNLE 41 |
| Clarias gariepinus | Query 22 SSQHWSYG#LRPGGKR 36 |+||||+|#| ||||| Sbjct 20 SAQHWSHG#LNPGGKR 34 |
| Danio rerio | Query 24 QHWSYG#LRPGGKRNTEHLVDSFQ 46 ||||||# |||||+ + +|+ Sbjct 24 QHWSYG#WLPGGKRSVGEMEATFR 46 |
| Agrobacterium tumefaciens str. C58 | Query 6 KLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDSFQEMGKEEDQMAEP 58 || +||+| | +| + #+ | | + | + | || |+++|+| Sbjct 34 KLEDMQAVLTICFRGFGGEH-AVQ#IAPARARTSTHRLRLRQRMGLGEEKLAQP 85 |
| Rana esculenta | Query 29 G#LRPGGKRNTEHLVDSFQEMGKEEDQMAEPQ 59 |#||||||| | | +|+ |+ | | ||| Sbjct 1 G#LRPGGKREVESLQESYAEVPNEVSFM-EPQ 30 |
| Ciona intestinalis | Query 24 QHWSYG#LRPGGKR 36 ||||| #| ||||| Sbjct 65 QHWSYA#LSPGGKR 77 |
| Lampetra tridentatus | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +||||+ # +|||||+ | + +|+ Sbjct 24 TQHWSHD#WKPGGKRDLEAMRPLLEEL 49 |
| Paralichthys olivaceus | Query 22 SSQHWSYG#LRPGGKRNTEHLVDSF 45 | ||||+|# ||||| +||| Sbjct 22 SGQHWSHG#WYPGGKRE----LDSF 41 |
| Lampetra appendix | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +||||+ # +|||||+ | + +|+ Sbjct 24 TQHWSHD#WKPGGKRDLEAMRPLLEEL 49 |
| Ichthyomyzon unicuspis | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +||||+ # +|||||+ | + +|+ Sbjct 24 TQHWSHD#WKPGGKRDLEAMRPLLEEL 49 |
| Ichthyomyzon fossor | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +||||+ # +|||||+ | + +|+ Sbjct 24 TQHWSHD#WKPGGKRDLEAMRPLLEEL 49 |
| Shewanella oneidensis MR-1 | Query 2 ETIPKLMAAVVLLTVCLEGCSSQHWSYG#LRPGGKRNTEHLVDS 44 +|+| | | | + ++|| | | | #+ ||| +| || Sbjct 44 KTLPTLADAFRLESAQVKGCESDAWLYH#IEQGGKHY--YLADS 84 |
| Typhlonectes natans | Query 16 VCLEGCSSQHWSYG#LRPGGKRNTE 39 | ++ +||||+|# ||||| + Sbjct 17 VGIQASYAQHWSHG#WYPGGKRELD 40 |
| Lampetra richardsoni | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQEM 48 +||||+ # +||||| | + +|+ Sbjct 24 TQHWSHD#WKPGGKRGLEAMRPLLEEL 49 |
| Petromyzon marinus | Query 23 SQHWSYG#LRPGGKRNTEHLVDSFQE 47 +||||+ # +|||||+ | + +| Sbjct 24 TQHWSHD#WKPGGKRDLEAMRPLLEE 48 |
| Trichosurus vulpecula | Query 23 SQHWSYG#LRPGGKRNTEHL 41 +||||+|# |||||+ + + Sbjct 22 AQHWSHG#WYPGGKRDLDGI 40 |
* References
[PubMed ID: 23736294] True C, Verma S, Grove KL, Smith MS, Cocaine- and amphetamine-regulated transcript is a potent stimulator of GnRH and kisspeptin cells and may contribute to negative energy balance-induced reproductive inhibition in females. Endocrinology. 2013 Aug;154(8):2821-32. doi: 10.1210/en.2013-1156. Epub 2013 Jun
[PubMed ID: 23518222] ... Donato J Jr, Lee C, Ratra DV, Franci CR, Canteras NS, Elias CF, Lesions of the ventral premammillary nucleus disrupt the dynamic changes in Kiss1 and GnRH expression characteristic of the proestrus-estrus transition. Neuroscience. 2013 Jun 25;241:67-79. doi: 10.1016/j.neuroscience.2013.03.013.
[PubMed ID: 23668015] ... Cheng M, Ye XD, Miao YP, Chen AY, Zheng GL, [Experimental study on therapeutic effect of Dabuyin Wan on true precocious puberty in female rats]. Zhongguo Zhong Yao Za Zhi. 2013 Feb;38(3):386-90.
[PubMed ID: 23197165] ... Foradori CD, Zimmerman AD, Hinds LR, Zuloaga KL, Breckenridge CB, Handa RJ, Atrazine inhibits pulsatile gonadotropin-releasing hormone (GnRH) release without altering GnRH messenger RNA or protein levels in the female rat. Biol Reprod. 2013 Jan 10;88(1):9. doi: 10.1095/biolreprod.112.102277. Print 2013
[PubMed ID: 23452939] ... Li X, Kang X, Deng Q, Cai J, Wang Z, Combination of a GnRH agonist with an antagonist prevents flare-up effects and protects primordial ovarian follicles in the rat ovary from cisplatin-induced toxicity: a controlled experimental animal study. Reprod Biol Endocrinol. 2013 Mar 1;11:16. doi: 10.1186/1477-7827-11-16.
[PubMed ID: 11145576] ... Dalkin AC, Burger LL, Aylor KW, Haisenleder DJ, Workman LJ, Cho S, Marshall JC, Regulation of gonadotropin subunit gene transcription by gonadotropin-releasing hormone: measurement of primary transcript ribonucleic acids by quantitative reverse transcription-polymerase chain reaction assays. Endocrinology. 2001 Jan;142(1):139-46.
[PubMed ID: 1468115] ... Maier CC, Marchetti B, LeBoeuf RD, Blalock JE, Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA. Cell Mol Neurobiol. 1992 Oct;12(5):447-54.
[PubMed ID: 2476669] ... Bond CT, Hayflick JS, Seeburg PH, Adelman JP, The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression. Mol Endocrinol. 1989 Aug;3(8):1257-62.
[PubMed ID: 3547652] ... Adelman JP, Bond CT, Douglass J, Herbert E, Two mammalian genes transcribed from opposite strands of the same DNA locus. Science. 1987 Mar 20;235(4795):1514-7.
[PubMed ID: 2867548] ... Adelman JP, Mason AJ, Hayflick JS, Seeburg PH, Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat. Proc Natl Acad Sci U S A. 1986 Jan;83(1):179-83.