SB0044 : [beta]-COP, [beta]-subunit of coatomer protein complex
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | coatomer subunit beta [Homo sapiens]; coatomer subunit beta; beta-cop; beta coat protein; beta-coat protein; Coatomer subunit beta; Beta-coat protein; Beta-COP |
| Gene Names | COPB1; MSTP026; COPB; coatomer protein complex, subunit beta 1 |
| Gene Locus | 11p15.2; chromosome 11 |
| GO Function | Not available |
* Information From OMIM
Function: Olivos-Glander et al. (1995) demonstrated that the protein deficient in oculocerebral renal syndrome (OMIM:300535), OCRL1, is localized to the Golgi complex by using a monoclonal antibody against the Golgi-specific coat protein, beta-COP.
* Structure Information
1. Primary Information
Length: 953 aa
Average Mass: 107.141 kDa
Monoisotopic Mass: 107.074 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Dos2-interacting transcription regulator of RNA-Pol-II 1. | 37 | 66 | 119.0 | 0.0 |
| non-SMC mitotic condensation complex subunit 1 1. | 131 | 159 | 21.0 | 0.0 |
| Dos2-interacting transcription regulator of RNA-Pol-II 2. | 235 | 261 | 92.0 | 0.0 |
| Dos2-interacting transcription regulator of RNA-Pol-II 3. | 380 | 450 | 188.0 | 0.0 |
| HEAT-like repeat 1. | 456 | 474 | 5.0 | 0.0 |
| --- cleavage 528 --- | ||||
| HEAT repeats 1. | 537 | 565 | 31.0 | 0.0 |
| HEAT-like repeat 2. | 570 | 589 | 14.0 | 0.0 |
| non-SMC mitotic condensation complex subunit 1 2. | 617 | 652 | 105.0 | 0.1 |
| Coatomer beta C-terminal region 1. | 667 | 807 | 1.0 | 0.3 |
| Adaptin AP4 complex epsilon appendage platform 1. | 832 | 877 | 1.0 | 0.0 |
3. Sequence Information
Fasta Sequence: SB0044.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites] cleaved by Calpain 1
Source Reference: [PubMed ID: 16476741] Hata S, Koyama S, Kawahara H, Doi N, Maeda T, Toyama-Sorimachi N, Abe K, Suzuki K, Sorimachi H, Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP. J Biol Chem. 2006 Apr 21;281(16):11214-24. Epub 2006 Feb 13.
Cleavage sites (±10aa)
[Site 1] GTYATQSALS528-SSRPTKKEED
Ser528 
Ser
iTraq-117 Signal 8568.3 (
) for SSRPTKKEED
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly519 | Thr520 | Tyr521 | Ala522 | Thr523 | Gln524 | Ser525 | Ala526 | Leu527 | Ser528 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser529 | Ser530 | Arg531 | Pro532 | Thr533 | Lys534 | Lys535 | Glu536 | Glu537 | Asp538 |
Sequence conservation (by blast)
* References
[PubMed ID: 18556652] Burman JL, Bourbonniere L, Philie J, Stroh T, Dejgaard SY, Presley JF, McPherson PS, Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. J Biol Chem. 2008 Aug 15;283(33):22774-86. doi: 10.1074/jbc.M801869200. Epub 2008