SB0046 : Aquaporin-0
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | lens fiber major intrinsic protein [Homo sapiens]; lens fiber major intrinsic protein; aquaporin 0; Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26 |
| Gene Names | MIP; AQP0; major intrinsic protein of lens fiber |
| Gene Locus | 12q13; chromosome 12 |
| GO Function | Not available |
* Information From OMIM
Function: Wang et al. (1995) mapped 2 negative regulatory elements in the MIP 5-prime noncoding region and demonstrated that the promoter is active in lens cells but not in kidney epithelial cells or mouse fibroblasts.
* Structure Information
1. Primary Information
Length: 263 aa
Average Mass: 28.121 kDa
Monoisotopic Mass: 28.104 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Major intrinsic protein 1. | 3 | 219 | 1.0 | 14.5 |
3. Sequence Information
Fasta Sequence: SB0046.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
5 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 16310784] Ma H, Azuma M, Shearer TR, Degradation of human aquaporin 0 by m-calpain. FEBS Lett. 2005 Dec 19;579(30):6745-8. Epub 2005 Nov 21.
Cleavage sites (±10aa)
[Site 1] KSISERLSVL237-KGAKPDVSNG
Leu237 
Lys
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Lys228 | Ser229 | Ile230 | Ser231 | Glu232 | Arg233 | Leu234 | Ser235 | Val236 | Leu237 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys238 | Gly239 | Ala240 | Lys241 | Pro242 | Asp243 | Val244 | Ser245 | Asn246 | Gly247 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PIIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 113.00 | 11 | major intrinsic protein of lens fiber |
| 2 | Mus musculus | 101.00 | 10 | major intrinsic protein of eye lens fiber |
| 3 | Rattus norvegicus | 101.00 | 9 | major intrinsic protein of eye lens fiber |
| 4 | N/A | 101.00 | 6 | major intrinsic protein gi |
| 5 | Bos taurus | 100.00 | 4 | major intrinsic protein of lens fiber |
| 6 | Canis lupus familiaris | 100.00 | 2 | major intrinsic protein of lens fiber |
| 7 | Rattus rattus | 100.00 | 1 | MIP_RAT Lens fiber major intrinsic protein (Aquap |
| 8 | Rattus rattus | 100.00 | 1 | MIP26 (130 AA; AA 134 - 263) |
| 9 | Cavia porcellus | 98.60 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqu |
| 10 | Rana pipiens | 83.60 | 1 | CAA40291.1 |
| 11 | Tetraodon nigroviridis | 80.10 | 4 | unnamed protein product |
| 12 | Xenopus laevis | 79.70 | 4 | hypothetical protein LOC495140 |
| 13 | Danio rerio | 73.60 | 3 | mip2 protein |
| 14 | Fundulus heteroclitus | 73.20 | 1 | AF191906_1 lens major intrinsic protein |
| 15 | Homo sapiens | 53.10 | 3 | water-channel aquaporin 2; AQP2 |
| 16 | synthetic construct | 53.10 | 3 | aquaporin 2 |
| 17 | human, kidney, Peptide, 271 aa | 53.10 | 1 | hAQP-CD=collecting duct aquaporin |
| 18 | Notomys alexis | 53.10 | 1 | aquaporin 2 |
| 19 | Canis familiaris | 52.00 | 5 | PREDICTED: similar to aquaporin 2 |
| 20 | Ovis aries | 49.70 | 3 | AQP2_SHEEP Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQ |
| 21 | Xenopus tropicalis | 46.20 | 2 | aquaporin 2 (collecting duct) |
| 22 | Coturnix coturnix | 44.30 | 1 | aquaporin-2 |
| 23 | Hyla chrysoscelis | 40.80 | 2 | aquaporin 2-like |
| 24 | Equus caballus | 40.40 | 1 | aquaporin 5 |
| 25 | Anguilla anguilla | 40.00 | 2 | aquaporin 1 |
| 26 | Hyla japonica | 37.00 | 3 | water channel protein AQP-h2 |
| 27 | Bufo marinus | 37.00 | 3 | vasopressin regulated water channel |
| 28 | Danio rerio | 35.40 | 1 | hypothetical protein LOC335821 |
| 29 | Gallus gallus | 35.00 | 2 | aquaporin 1 |
| 30 | Sus scrofa | 35.00 | 1 | aquaporin 1 |
| 31 | Pongo pygmaeus | 34.70 | 1 | AQP1_PONPY Aquaporin-1 (AQP-1) (Aquaporin-CHIP) ( |
| 32 | Anguilla japonica | 33.50 | 2 | aquaporin 1 |
| 33 | Dicentrarchus labrax | 33.10 | 1 | aquaporin 1 |
| 34 | Sparus aurata | 32.70 | 2 | aquaporin 1-like |
| 35 | Centropristis striata | 32.70 | 1 | aquaporin 1 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||| Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 |
| Mus musculus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 208 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus norvegicus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 208 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 263 |
| N/A | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 208 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 263 |
| Bos taurus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 |+|| |||||||||||||||||+|||||+|#||++| |||||||||||||| |||| Sbjct 208 PVIGAGLGSLLYDFLLFPRLKSVSERLSIL#KGSRPSESNGQPEVTGEPVELKTQAL 263 |
| Canis lupus familiaris | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 208 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus rattus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 206 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 261 |
| Rattus rattus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|||+| |||||| ||||||| |||| Sbjct 75 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGARPSDSNGQPEGTGEPVELKTQAL 130 |
| Cavia porcellus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||+|||||+|#|| +| +||||| ||||||| |||| Sbjct 208 PIIGGGLGSLLYDFLLFPRLKSVSERLSIL#KGTRPSDNNGQPEGTGEPVELKTQAL 263 |
| Rana pipiens | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||| || |+|||+||||++ +|||||+|#|||+| || | ||||+|| ||+| Sbjct 207 PIIGGALGGLVYDFILFPRMRGLSERLSIL#KGARPAEPEGQQEATGEPIELKTQSL 262 |
| Tetraodon nigroviridis | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 |+||| +|+|||||+||||++ +||||+ |#|| +| + || | |||+|| |||| Sbjct 208 PMIGGAMGALLYDFMLFPRMRGLSERLATL#KGTRPPEAEGQQETRGEPIELKTQAL 263 |
| Xenopus laevis | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 ||||| +| |+|||+||||++ ++|| |+|#|||+| | || | |+|+|| ||+| Sbjct 209 PIIGGAVGGLVYDFILFPRMRGLNERFSIL#KGARPAVPEGQRETAGDPIELKTQSL 264 |
| Danio rerio | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 |+|| +|++ ||| ||||++ ||||+ |#||++| + | | |||+|| || | Sbjct 208 PMIGAAMGAIFYDFFLFPRMRGFSERLATL#KGSRPPEAENQQETRGEPIELKTQTL 263 |
| Fundulus heteroclitus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTGEPVELNTQAL 263 |+||| +|+||||||||||++ +||||+ |#|| + + | | || +|| |||| Sbjct 208 PMIGGAIGALLYDFLLFPRMRGLSERLATL#KGTRTPEAEAQQETRGESIELKTQAL 263 |
| Homo sapiens | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV-TGEPVELNT 260 |++| ||||||+++||| ||+||||+||#|| +|| + || + |||++ Sbjct 208 PLVGAILGSLLYNYVLFPPAKSLSERLAVL#KGLEPDTDWEEREVRRRQSVELHS 261 |
| synthetic construct | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV-TGEPVELNT 260 |++| ||||||+++||| ||+||||+||#|| +|| + || + |||++ Sbjct 208 PLVGAILGSLLYNYVLFPPAKSLSERLAVL#KGLEPDTDWEEREVRRRQSVELHS 261 |
| human, kidney, Peptide, 271 aa | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV-TGEPVELNT 260 |++| ||||||+++||| ||+||||+||#|| +|| + || + |||++ Sbjct 208 PLVGAILGSLLYNYVLFPPAKSLSERLAVL#KGLEPDTDWEEREVRRRQSVELHS 261 |
| Notomys alexis | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV 251 |++| +|||||++|||| ||+ |||+||#|| +|| + || Sbjct 88 PLVGAIIGSLLYNYLLFPSAKSLQERLAVL#KGLEPDTDWEEREV 131 |
| Canis familiaris | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV-TGEPVELNT 260 |++| ||||||+++||| ||++|||+||#|| +|| + || + |||++ Sbjct 208 PLVGAILGSLLYNYVLFPPAKSLAERLAVL#KGLEPDADWEEREVRRRQSVELHS 261 |
| Ovis aries | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEV-TGEPVELNT 260 |++| + ||||+++||| ||+||||+||#|| +|| + || + |||++ Sbjct 208 PLVGAIVASLLYNYVLFPPAKSLSERLAVL#KGLEPDTDWEEREVRRRQSVELHS 261 |
| Xenopus tropicalis | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGA-KPD 243 |++|| | || |+++ || ||+|+||++|#|| ||| Sbjct 208 PLVGGILASLFYNYIFFPHKKSLSDRLAIL#KGTYKPD 244 |
| Coturnix coturnix | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPD 243 |++| |++|+++|||+ |+ ||||++ #|| +|+ Sbjct 209 PLVGAAAASIIYNYILFPQSKTFSERLAIF#KGMEPE 244 |
| Hyla chrysoscelis | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KG 239 |+ | +|||+|+|+| | |+ |||+++|#+| Sbjct 213 PLFGATVGSLMYNFILIPNTKTFSERIAIL#RG 244 |
| Equus caballus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KG 239 ||+| | ++|| +|||| |+|||++++#|| Sbjct 27 PIVGAALAAILYFYLLFPNSLSLSERVAIV#KG 58 |
| Anguilla anguilla | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNGQPEVTG 253 || || + +|+||+|| |+| ++||| ||# | +| + | Sbjct 208 PISGGLVAALVYDYLLHPKLGDLTERLKVL#CYGSEDAPAQEPLLEG 253 |
| Hyla japonica | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKP 242 | +| | ||+|+++| |+ +| ||+||||# | | Sbjct 208 PFVGAILASLIYNYVLCPQEQSFSEKLSVL#LGRIP 242 |
| Bufo marinus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKP 242 |++| | ||+|+++| |+ +| ||+||| # | | Sbjct 208 PLVGAILASLIYNYVLCPQEQSFSEKLSVF#LGRMP 242 |
| Danio rerio | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL# 237 |+ || +|+|||||+|++ ||+ ||# Sbjct 207 PMCGGVAAALIYDFLLYPKMDDFPERVRVL# 236 |
| Gallus gallus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSV 236 ||||| +|+|||+| || +++|+ | Sbjct 217 PIIGGAGAALIYDFILAPRSSDLTDRVKV 245 |
| Sus scrofa | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSV 236 | ||| | |+|||+| || +++|+ | Sbjct 218 PFIGGALAVLIYDFILAPRSSDLTDRVKV 246 |
| Pongo pygmaeus | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSV 236 | ||| | |+|||+| || ++|+ | Sbjct 216 PFIGGALAVLIYDFILAPRSSDFTDRVKV 244 |
| Anguilla japonica | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL# 237 |+ || +|+||||| |+ ||+ ||# Sbjct 210 PMCGGVAAALVYDFLLHPKFDDFPERMKVL# 239 |
| Dicentrarchus labrax | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL# 237 |+ || +|+||||| |+ ||+ ||# Sbjct 143 PMCGGVAAALIYDFLLSPKFDDFPERMKVL# 172 |
| Sparus aurata | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL#KGAKPDVSNG 247 |+ || +|+||||| || ++ | +||# | | Sbjct 205 PMCGGIAAALIYDFLLCPRAQNFRTRRNVL#LNGSEDEDAG 244 |
| Centropristis striata | Query 208 PIIGGGLGSLLYDFLLFPRLKSISERLSVL# 237 |+ || +|+||||| |+ ||+ ||# Sbjct 144 PMCGGVAAALIYDFLLSPKFDDFPERVKVL# 173 |
[Site 2] SISERLSVLK238-GAKPDVSNGQ
Lys238 Gly
iTraq-117 Signal 795.2 (
) for GAKPDVSNGQ
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser229 | Ile230 | Ser231 | Glu232 | Arg233 | Leu234 | Ser235 | Val236 | Leu237 | Lys238 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly239 | Ala240 | Lys241 | Pro242 | Asp243 | Val244 | Ser245 | Asn246 | Gly247 | Gln248 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| IIGGGLGSLLYDFLLFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 110.00 | 11 | major intrinsic protein of lens fiber |
| 2 | Mus musculus | 98.20 | 10 | major intrinsic protein of eye lens fiber |
| 3 | N/A | 98.20 | 6 | major intrinsic protein gi |
| 4 | Rattus norvegicus | 98.20 | 5 | major intrinsic protein of eye lens fiber |
| 5 | Canis lupus familiaris | 98.20 | 2 | major intrinsic protein of lens fiber |
| 6 | Rattus rattus | 97.80 | 1 | MIP_RAT Lens fiber major intrinsic protein (Aquap |
| 7 | Rattus rattus | 97.80 | 1 | MIP26 (130 AA; AA 134 - 263) |
| 8 | Bos taurus | 97.40 | 4 | major intrinsic protein of lens fiber |
| 9 | Cavia porcellus | 95.90 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqu |
| 10 | Rana pipiens | 80.50 | 1 | CAA40291.1 |
| 11 | Tetraodon nigroviridis | 77.40 | 4 | unnamed protein product |
| 12 | Xenopus laevis | 77.00 | 4 | hypothetical protein LOC495140 |
| 13 | Danio rerio | 70.90 | 3 | Mip2 protein |
| 14 | Fundulus heteroclitus | 70.10 | 1 | AF191906_1 lens major intrinsic protein |
| 15 | Homo sapiens | 50.40 | 3 | water-channel aquaporin 2; AQP2 |
| 16 | synthetic construct | 50.40 | 3 | aquaporin 2 |
| 17 | human, kidney, Peptide, 271 aa | 50.40 | 1 | hAQP-CD=collecting duct aquaporin |
| 18 | Notomys alexis | 50.40 | 1 | aquaporin 2 |
| 19 | Canis familiaris | 49.30 | 5 | PREDICTED: similar to aquaporin 2 |
| 20 | Ovis aries | 47.00 | 2 | AQP2_SHEEP Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQ |
| 21 | Xenopus tropicalis | 43.50 | 2 | aquaporin 2 (collecting duct) |
| 22 | Coturnix coturnix | 41.20 | 1 | aquaporin-2 |
| 23 | Hyla chrysoscelis | 37.70 | 2 | aquaporin 2-like |
| 24 | Equus caballus | 37.70 | 1 | aquaporin 5 |
| 25 | Anguilla anguilla | 37.00 | 2 | aquaporin 1 |
| 26 | Hyla japonica | 34.30 | 3 | water channel protein AQP-h2 |
| 27 | Bufo marinus | 33.90 | 2 | vasopressin regulated water channel |
| 28 | Danio rerio | 32.70 | 1 | hypothetical protein LOC335821 |
| 29 | Sus scrofa | 32.00 | 1 | aquaporin 1 |
| 30 | Gallus gallus | 32.00 | 1 | aquaporin 1 |
| 31 | Pongo pygmaeus | 31.60 | 1 | AQP1_PONPY Aquaporin-1 (AQP-1) (Aquaporin-CHIP) ( |
| 32 | Anguilla japonica | 30.40 | 2 | aquaporin 1 |
| 33 | Dicentrarchus labrax | 30.40 | 1 | aquaporin 1 |
| 34 | Rhodopirellula baltica SH 1 | 30.40 | 1 | similar to serine proteinase HtrA |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||| Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |
| Mus musculus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| N/A | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus norvegicus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Canis lupus familiaris | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 263 |
| Rattus rattus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 207 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 261 |
| Rattus rattus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#||+| |||||| ||||||| |||| Sbjct 76 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GARPSDSNGQPEGTGEPVELKTQAL 130 |
| Bos taurus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 +|| |||||||||||||||||+|||||+||#|++| |||||||||||||| |||| Sbjct 209 VIGAGLGSLLYDFLLFPRLKSVSERLSILK#GSRPSESNGQPEVTGEPVELKTQAL 263 |
| Cavia porcellus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||||||||||||||||||||+|||||+||#| +| +||||| ||||||| |||| Sbjct 209 IIGGGLGSLLYDFLLFPRLKSVSERLSILK#GTRPSDNNGQPEGTGEPVELKTQAL 263 |
| Rana pipiens | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||| || |+|||+||||++ +|||||+||#||+| || | ||||+|| ||+| Sbjct 208 IIGGALGGLVYDFILFPRMRGLSERLSILK#GARPAEPEGQQEATGEPIELKTQSL 262 |
| Tetraodon nigroviridis | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 +||| +|+|||||+||||++ +||||+ ||#| +| + || | |||+|| |||| Sbjct 209 MIGGAMGALLYDFMLFPRMRGLSERLATLK#GTRPPEAEGQQETRGEPIELKTQAL 263 |
| Xenopus laevis | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 |||| +| |+|||+||||++ ++|| |+||#||+| | || | |+|+|| ||+| Sbjct 210 IIGGAVGGLVYDFILFPRMRGLNERFSILK#GARPAVPEGQRETAGDPIELKTQSL 264 |
| Danio rerio | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 +|| +|++ ||| ||||++ ||||+ ||#|++| + | | |||+|| || | Sbjct 209 MIGAAMGAIFYDFFLFPRMRGFSERLATLK#GSRPPEAENQQETRGEPIELKTQTL 263 |
| Fundulus heteroclitus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 +||| +|+||||||||||++ +||||+ ||#| + + | | || +|| |||| Sbjct 209 MIGGAIGALLYDFLLFPRMRGLSERLATLK#GTRTPEAEAQQETRGESIELKTQAL 263 |
| Homo sapiens | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV-TGEPVELNT 260 ++| ||||||+++||| ||+||||+|||#| +|| + || + |||++ Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEPDTDWEEREVRRRQSVELHS 261 |
| synthetic construct | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV-TGEPVELNT 260 ++| ||||||+++||| ||+||||+|||#| +|| + || + |||++ Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEPDTDWEEREVRRRQSVELHS 261 |
| human, kidney, Peptide, 271 aa | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV-TGEPVELNT 260 ++| ||||||+++||| ||+||||+|||#| +|| + || + |||++ Sbjct 209 LVGAILGSLLYNYVLFPPAKSLSERLAVLK#GLEPDTDWEEREVRRRQSVELHS 261 |
| Notomys alexis | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV 251 ++| +|||||++|||| ||+ |||+|||#| +|| + || Sbjct 89 LVGAIIGSLLYNYLLFPSAKSLQERLAVLK#GLEPDTDWEEREV 131 |
| Canis familiaris | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV-TGEPVELNT 260 ++| ||||||+++||| ||++|||+|||#| +|| + || + |||++ Sbjct 209 LVGAILGSLLYNYVLFPPAKSLAERLAVLK#GLEPDADWEEREVRRRQSVELHS 261 |
| Ovis aries | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEV-TGEPVELNT 260 ++| + ||||+++||| ||+||||+|||#| +|| + || + |||++ Sbjct 209 LVGAIVASLLYNYVLFPPAKSLSERLAVLK#GLEPDTDWEEREVRRRQSVELHS 261 |
| Xenopus tropicalis | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GA-KPD 243 ++|| | || |+++ || ||+|+||++||#| ||| Sbjct 209 LVGGILASLFYNYIFFPHKKSLSDRLAILK#GTYKPD 244 |
| Coturnix coturnix | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPD 243 ++| |++|+++|||+ |+ ||||++ |#| +|+ Sbjct 210 LVGAAAASIIYNYILFPQSKTFSERLAIFK#GMEPE 244 |
| Hyla chrysoscelis | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#G 239 + | +|||+|+|+| | |+ |||+++|+#| Sbjct 214 LFGATVGSLMYNFILIPNTKTFSERIAILR#G 244 |
| Equus caballus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#G 239 |+| | ++|| +|||| |+|||++++|#| Sbjct 28 IVGAALAAILYFYLLFPNSLSLSERVAIVK#G 58 |
| Anguilla anguilla | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKPDVSNGQPEVTG 253 | || + +|+||+|| |+| ++||| || # | +| + | Sbjct 209 ISGGLVAALVYDYLLHPKLGDLTERLKVLC#YGSEDAPAQEPLLEG 253 |
| Hyla japonica | Query 210 IGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKP 242 +| | ||+|+++| |+ +| ||+|||| #| | Sbjct 210 VGAILASLIYNYVLCPQEQSFSEKLSVLL#GRIP 242 |
| Bufo marinus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSVLK#GAKP 242 ++| | ||+|+++| |+ +| ||+||| #| | Sbjct 209 LVGAILASLIYNYVLCPQEQSFSEKLSVFL#GRMP 242 |
| Danio rerio | Query 211 GGGLGSLLYDFLLFPRLKSISERLSVL 237 || +|+|||||+|++ ||+ || Sbjct 210 GGVAAALIYDFLLYPKMDDFPERVRVL 236 |
| Sus scrofa | Query 210 IGGGLGSLLYDFLLFPRLKSISERLSV 236 ||| | |+|||+| || +++|+ | Sbjct 220 IGGALAVLIYDFILAPRSSDLTDRVKV 246 |
| Gallus gallus | Query 209 IIGGGLGSLLYDFLLFPRLKSISERLSV 236 |||| +|+|||+| || +++|+ | Sbjct 218 IIGGAGAALIYDFILAPRSSDLTDRVKV 245 |
| Pongo pygmaeus | Query 210 IGGGLGSLLYDFLLFPRLKSISERLSV 236 ||| | |+|||+| || ++|+ | Sbjct 218 IGGALAVLIYDFILAPRSSDFTDRVKV 244 |
| Anguilla japonica | Query 211 GGGLGSLLYDFLLFPRLKSISERLSVL 237 || +|+||||| |+ ||+ || Sbjct 213 GGVAAALVYDFLLHPKFDDFPERMKVL 239 |
| Dicentrarchus labrax | Query 211 GGGLGSLLYDFLLFPRLKSISERLSVL 237 || +|+||||| |+ ||+ || Sbjct 146 GGVAAALIYDFLLSPKFDDFPERMKVL 172 |
| Rhodopirellula baltica SH 1 | Query 224 FPRLKSISERLSVLK#GAKPDVSNGQPEVTGEPVELNTQAL 263 ||| ++| + # | ||||| ||| |+ + ++ Sbjct 78 FPRTNPSTDRRAPTT#QRNPTASNGQPTVTGRSGEIASDSI 117 |
[Site 3] DVSNGQPEVT252-GEPVELNTQA
Thr252 Gly
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp243 | Val244 | Ser245 | Asn246 | Gly247 | Gln248 | Pro249 | Glu250 | Val251 | Thr252 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly253 | Glu254 | Pro255 | Val256 | Glu257 | Leu258 | Asn259 | Thr260 | Gln261 | Ala262 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LFPRLKSISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 87.00 | 4 | major intrinsic protein of lens fiber |
| 2 | Bos taurus | 75.90 | 2 | major intrinsic protein of lens fiber |
| 3 | N/A | 75.50 | 4 | MIP_SHEEP Lens fiber major intrinsic protein (Aqu |
| 4 | Mus musculus | 74.70 | 4 | major intrinsic protein of eye lens fiber |
| 5 | Rattus norvegicus | 74.70 | 3 | major intrinsic protein of eye lens fiber |
| 6 | Rattus rattus | 74.30 | 1 | MIP_RAT Lens fiber major intrinsic protein (Aquap |
| 7 | Canis lupus familiaris | 74.30 | 1 | major intrinsic protein of lens fiber |
| 8 | Rattus rattus | 73.20 | 1 | MIP26 (130 AA; AA 134 - 263) |
| 9 | Cavia porcellus | 71.60 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqu |
| 10 | Rana pipiens | 62.40 | 1 | CAA40291.1 |
| 11 | Xenopus laevis | 58.50 | 2 | hypothetical protein LOC495140 |
| 12 | Tetraodon nigroviridis | 58.20 | 3 | unnamed protein product |
| 13 | Danio rerio | 53.50 | 2 | Mip2 protein |
| 14 | Fundulus heteroclitus | 48.90 | 1 | AF191906_1 lens major intrinsic protein |
| 15 | Homo sapiens | 35.40 | 2 | water-channel aquaporin 2; AQP2 |
| 16 | human, kidney, Peptide, 271 aa | 35.40 | 1 | hAQP-CD=collecting duct aquaporin |
| 17 | synthetic construct | 35.40 | 1 | aquaporin 2 |
| 18 | Ovis aries | 35.40 | 1 | AQP2_SHEEP Aquaporin-2 (AQP-2) (Aquaporin-CD) (AQ |
| 19 | Notomys alexis | 34.70 | 1 | aquaporin 2 |
| 20 | Canis familiaris | 34.30 | 1 | PREDICTED: similar to aquaporin 2 |
| 21 | Coturnix coturnix | 30.00 | 1 | aquaporin-2 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||||||||||||||||||||||||||||#||||||||||| Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |
| Bos taurus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+|||++| ||||||||#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGSRPSESNGQPEVT#GEPVELKTQAL 263 |
| N/A | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||| +| ||||||||#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGTRPSESNGQPEVT#GEPVELKTQAL 263 |
| Mus musculus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||||+| |||||| |#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGARPSDSNGQPEGT#GEPVELKTQAL 263 |
| Rattus norvegicus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||||+| |||||| |#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGARPSDSNGQPEGT#GEPVELKTQAL 263 |
| Rattus rattus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||||+| |||||| |#|||||| |||| Sbjct 221 LFPRLKSVSERLSILKGARPSDSNGQPEGT#GEPVELKTQAL 261 |
| Canis lupus familiaris | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||||+| |||||| |#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGARPSDSNGQPEGT#GEPVELKTQAL 263 |
| Rattus rattus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||||+| |||||| |#|||||| |||| Sbjct 90 LFPRLKSVSERLSILKGARPSDSNGQPEGT#GEPVELKTQAL 130 |
| Cavia porcellus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 |||||||+|||||+||| +| +||||| |#|||||| |||| Sbjct 223 LFPRLKSVSERLSILKGTRPSDNNGQPEGT#GEPVELKTQAL 263 |
| Rana pipiens | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||++ +|||||+||||+| || | |#|||+|| ||+| Sbjct 222 LFPRMRGLSERLSILKGARPAEPEGQQEAT#GEPIELKTQSL 262 |
| Xenopus laevis | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||++ ++|| |+||||+| | || | #|+|+|| ||+| Sbjct 224 LFPRMRGLNERFSILKGARPAVPEGQRETA#GDPIELKTQSL 264 |
| Tetraodon nigroviridis | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||++ +||||+ ||| +| + || | #|||+|| |||| Sbjct 223 LFPRMRGLSERLATLKGTRPPEAEGQQETR#GEPIELKTQAL 263 |
| Danio rerio | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||++ ||||+ |||++| + | | #|||+|| || | Sbjct 223 LFPRMRGFSERLATLKGSRPPEAENQQETR#GEPIELKTQTL 263 |
| Fundulus heteroclitus | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEVT#GEPVELNTQAL 263 ||||++ +||||+ ||| + + | | #|| +|| |||| Sbjct 223 LFPRMRGLSERLATLKGTRTPEAEAQQETR#GESIELKTQAL 263 |
| Homo sapiens | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV-T#GEPVELNT 260 ||| ||+||||+|||| +|| + || # + |||++ Sbjct 223 LFPPAKSLSERLAVLKGLEPDTDWEEREVRR#RQSVELHS 261 |
| human, kidney, Peptide, 271 aa | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV-T#GEPVELNT 260 ||| ||+||||+|||| +|| + || # + |||++ Sbjct 223 LFPPAKSLSERLAVLKGLEPDTDWEEREVRR#RQSVELHS 261 |
| synthetic construct | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV-T#GEPVELNT 260 ||| ||+||||+|||| +|| + || # + |||++ Sbjct 223 LFPPAKSLSERLAVLKGLEPDTDWEEREVRR#RQSVELHS 261 |
| Ovis aries | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV-T#GEPVELNT 260 ||| ||+||||+|||| +|| + || # + |||++ Sbjct 223 LFPPAKSLSERLAVLKGLEPDTDWEEREVRR#RQSVELHS 261 |
| Notomys alexis | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV 251 ||| ||+ |||+|||| +|| + || Sbjct 103 LFPSAKSLQERLAVLKGLEPDTDWEEREV 131 |
| Canis familiaris | Query 223 LFPRLKSISERLSVLKGAKPDVSNGQPEV-T#GEPVELNT 260 ||| ||++|||+|||| +|| + || # + |||++ Sbjct 223 LFPPAKSLAERLAVLKGLEPDADWEEREVRR#RQSVELHS 261 |
| Coturnix coturnix | Query 223 LFPRLKSISERLSVLKGAKPD 243 |||+ |+ ||||++ || +|+ Sbjct 224 LFPQSKTFSERLAIFKGMEPE 244 |
[Site 4] EVTGEPVELN259-TQAL
Asn259 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu250 | Val251 | Thr252 | Gly253 | Glu254 | Pro255 | Val256 | Glu257 | Leu258 | Asn259 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr260 | Gln261 | Ala262 | Leu263 | - | - | - | - | - | - |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| ISERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 73.60 | 2 | major intrinsic protein of lens fiber |
| 2 | Bos taurus | 62.40 | 1 | major intrinsic protein of lens fiber |
| 3 | N/A | 62.00 | 3 | MIP_SHEEP Lens fiber major intrinsic protein (Aqu |
| 4 | Rattus norvegicus | 60.50 | 1 | major intrinsic protein of eye lens fiber |
| 5 | Rattus rattus | 60.50 | 1 | MIP26 (130 AA; AA 134 - 263) |
| 6 | Canis lupus familiaris | 60.50 | 1 | major intrinsic protein of lens fiber |
| 7 | Mus musculus | 60.50 | 1 | major intrinsic protein of eye lens fiber |
| 8 | Rattus rattus | 60.50 | 1 | MIP_RAT Lens fiber major intrinsic protein (Aquap |
| 9 | Cavia porcellus | 57.40 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqu |
| 10 | Rana pipiens | 51.20 | 1 | CAA40291.1 |
| 11 | Xenopus laevis | 47.40 | 1 | hypothetical protein LOC495140 |
| 12 | Tetraodon nigroviridis | 47.00 | 3 | unnamed protein product |
| 13 | Danio rerio | 42.70 | 2 | Mip2 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 ||||||||||||||||||||||||||||||#|||| Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 |
| Bos taurus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+|||++| |||||||||||||| #|||| Sbjct 230 VSERLSILKGSRPSESNGQPEVTGEPVELK#TQAL 263 |
| N/A | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||| +| |||||||||||||| #|||| Sbjct 230 VSERLSILKGTRPSESNGQPEVTGEPVELK#TQAL 263 |
| Rattus norvegicus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| |||||| ||||||| #|||| Sbjct 230 VSERLSILKGARPSDSNGQPEGTGEPVELK#TQAL 263 |
| Rattus rattus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| |||||| ||||||| #|||| Sbjct 97 VSERLSILKGARPSDSNGQPEGTGEPVELK#TQAL 130 |
| Canis lupus familiaris | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| |||||| ||||||| #|||| Sbjct 230 VSERLSILKGARPSDSNGQPEGTGEPVELK#TQAL 263 |
| Mus musculus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| |||||| ||||||| #|||| Sbjct 230 VSERLSILKGARPSDSNGQPEGTGEPVELK#TQAL 263 |
| Rattus rattus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| |||||| ||||||| #|||| Sbjct 228 VSERLSILKGARPSDSNGQPEGTGEPVELK#TQAL 261 |
| Cavia porcellus | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||| +| +||||| ||||||| #|||| Sbjct 230 VSERLSILKGTRPSDNNGQPEGTGEPVELK#TQAL 263 |
| Rana pipiens | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +|||||+||||+| || | ||||+|| #||+| Sbjct 229 LSERLSILKGARPAEPEGQQEATGEPIELK#TQSL 262 |
| Xenopus laevis | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 ++|| |+||||+| | || | |+|+|| #||+| Sbjct 231 LNERFSILKGARPAVPEGQRETAGDPIELK#TQSL 264 |
| Tetraodon nigroviridis | Query 230 ISERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 +||||+ ||| +| + || | |||+|| #|||| Sbjct 230 LSERLATLKGTRPPEAEGQQETRGEPIELK#TQAL 263 |
| Danio rerio | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELN#TQAL 263 ||||+ |||++| + | | |||+|| #|| | Sbjct 231 SERLATLKGSRPPEAENQQETRGEPIELK#TQTL 263 |
[Site 5] VTGEPVELNT260-QAL
Thr260 Gln
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val251 | Thr252 | Gly253 | Glu254 | Pro255 | Val256 | Glu257 | Leu258 | Asn259 | Thr260 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln261 | Ala262 | Leu263 | - | - | - | - | - | - | - |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SERLSVLKGAKPDVSNGQPEVTGEPVELNTQAL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 71.60 | 2 | major intrinsic protein of lens fiber |
| 2 | Bos taurus | 61.20 | 1 | major intrinsic protein of lens fiber |
| 3 | N/A | 60.80 | 3 | MIP_SHEEP Lens fiber major intrinsic protein (Aqu |
| 4 | Rattus norvegicus | 59.30 | 1 | major intrinsic protein of eye lens fiber |
| 5 | Canis lupus familiaris | 59.30 | 1 | major intrinsic protein of lens fiber |
| 6 | Mus musculus | 59.30 | 1 | major intrinsic protein of eye lens fiber |
| 7 | Rattus rattus | 59.30 | 1 | MIP_RAT Lens fiber major intrinsic protein (Aquap |
| 8 | Rattus rattus | 58.90 | 1 | MIP26 (130 AA; AA 134 - 263) |
| 9 | Cavia porcellus | 56.20 | 1 | MIP_CAVPO Lens fiber major intrinsic protein (Aqu |
| 10 | Rana pipiens | 50.40 | 1 | CAA40291.1 |
| 11 | Xenopus laevis | 46.60 | 1 | hypothetical protein LOC495140 |
| 12 | Tetraodon nigroviridis | 46.20 | 3 | unnamed protein product |
| 13 | Danio rerio | 42.70 | 2 | Mip2 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 ||||||||||||||||||||||||||||||#||| Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |
| Bos taurus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+|||++| |||||||||||||| |#||| Sbjct 231 SERLSILKGSRPSESNGQPEVTGEPVELKT#QAL 263 |
| N/A | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||| +| |||||||||||||| |#||| Sbjct 231 SERLSILKGTRPSESNGQPEVTGEPVELKT#QAL 263 |
| Rattus norvegicus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| |||||| ||||||| |#||| Sbjct 231 SERLSILKGARPSDSNGQPEGTGEPVELKT#QAL 263 |
| Canis lupus familiaris | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| |||||| ||||||| |#||| Sbjct 231 SERLSILKGARPSDSNGQPEGTGEPVELKT#QAL 263 |
| Mus musculus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| |||||| ||||||| |#||| Sbjct 231 SERLSILKGARPSDSNGQPEGTGEPVELKT#QAL 263 |
| Rattus rattus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| |||||| ||||||| |#||| Sbjct 229 SERLSILKGARPSDSNGQPEGTGEPVELKT#QAL 261 |
| Rattus rattus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| |||||| ||||||| |#||| Sbjct 98 SERLSILKGARPSDSNGQPEGTGEPVELKT#QAL 130 |
| Cavia porcellus | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||| +| +||||| ||||||| |#||| Sbjct 231 SERLSILKGTRPSDNNGQPEGTGEPVELKT#QAL 263 |
| Rana pipiens | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 |||||+||||+| || | ||||+|| |#|+| Sbjct 230 SERLSILKGARPAEPEGQQEATGEPIELKT#QSL 262 |
| Xenopus laevis | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 +|| |+||||+| | || | |+|+|| |#|+| Sbjct 232 NERFSILKGARPAVPEGQRETAGDPIELKT#QSL 264 |
| Tetraodon nigroviridis | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 ||||+ ||| +| + || | |||+|| |#||| Sbjct 231 SERLATLKGTRPPEAEGQQETRGEPIELKT#QAL 263 |
| Danio rerio | Query 231 SERLSVLKGAKPDVSNGQPEVTGEPVELNT#QAL 263 ||||+ |||++| + | | |||+|| |#| | Sbjct 231 SERLATLKGSRPPEAENQQETRGEPIELKT#QTL 263 |
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