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SB0077 : Histone H2A type 1

[ CaMP Format ]

* Basic Information

OrganismBos taurus (cattle)
Protein NamesPREDICTED: histone H2A type 1 [Bos taurus]; histone H2A type 1; Histone H2A type 1; H2A.1b
Gene NamesHIST1H2AM; Derived by automated computational analysis using gene prediction method: Gnomon. Supporting evidence includes similarity to: 1 EST, 80 Proteins, and 100% coverage of the annotated genomic feature by RNAseq alignments
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
XP_876240 XM_871147 618824 P0C0S9 N/A N/A N/A bta:618824

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 130 aa

Average Mass: 14.091 kDa

Monoisotopic Mass: 14.083 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Core histone H2A/H2B/H3/H4 1. 58945.00.0
--- cleavage 20 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 24 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 33 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 34 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 57 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 82 (inside Core histone H2A/H2B/H3/H4 5..89) ---
--- cleavage 92 ---
C-terminus of histone H2A 1. 921261.02.4
--- cleavage 92 (inside C-terminus of histone H2A 92..126) ---
--- cleavage 110 (inside C-terminus of histone H2A 92..126) ---
--- cleavage 114 (inside C-terminus of histone H2A 92..126) ---
--- cleavage 123 (inside C-terminus of histone H2A 92..126) ---

3. Sequence Information

Fasta Sequence: SB0077.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

10 [sites]

Source Reference: [PubMed ID: 3038857] Sakai K, Akanuma H, Imahori K, Kawashima S, A unique specificity of a calcium activated neutral protease indicated in histone hydrolysis. J Biochem. 1987 Apr;101(4):911-8.

Cleavage sites (±10aa)

[Site 1] ARAKAKTRSS20-RAGLQFPVGR

Ser20 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala11Arg12Ala13Lys14Ala15Lys16Thr17Arg18Ser19Ser20
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg21Ala22Gly23Leu24Gln25Phe26Pro27Val28Gly29Arg30

Sequence conservation (by blast)

[Site 2] AKTRSSRAGL24-QFPVGRVHRL

Leu24 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala15Lys16Thr17Arg18Ser19Ser20Arg21Ala22Gly23Leu24
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln25Phe26Pro27Val28Gly29Arg30Val31His32Arg33Leu34

Sequence conservation (by blast)

[Site 3] LQFPVGRVHR33-LLRKGNYAER

Arg33 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu24Gln25Phe26Pro27Val28Gly29Arg30Val31His32Arg33
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu34Leu35Arg36Lys37Gly38Asn39Tyr40Ala41Glu42Arg43

Sequence conservation (by blast)

[Site 4] QFPVGRVHRL34-LRKGNYAERV

Leu34 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln25Phe26Pro27Val28Gly29Arg30Val31His32Arg33Leu34
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu35Arg36Lys37Gly38Asn39Tyr40Ala41Glu42Arg43Val44

Sequence conservation (by blast)

[Site 5] APVYLAAVLE57-YLTAEILELA

Glu57 Tyr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala48Pro49Val50Tyr51Leu52Ala53Ala54Val55Leu56Glu57
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Tyr58Leu59Thr60Ala61Glu62Ile63Leu64Glu65Leu66Ala67

Sequence conservation (by blast)

[Site 6] DNKKTRIIPR82-HLQLAIRNDE

Arg82 His

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asp73Asn74Lys75Lys76Thr77Arg78Ile79Ile80Pro81Arg82
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
His83Leu84Gln85Leu86Ala87Ile88Arg89Asn90Asp91Glu92

Sequence conservation (by blast)

[Site 7] HLQLAIRNDE92-ELNKLLGKVT

Glu92 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
His83Leu84Gln85Leu86Ala87Ile88Arg89Asn90Asp91Glu92
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu93Leu94Asn95Lys96Leu97Leu98Gly99Lys100Val101Thr102

Sequence conservation (by blast)

[Site 8] VTIAQGGVLP110-NIQAVLLPKK

Pro110 Asn

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val101Thr102Ile103Ala104Gln105Gly106Gly107Val108Leu109Pro110
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Asn111Ile112Gln113Ala114Val115Leu116Leu117Pro118Lys119Lys120

Sequence conservation (by blast)

[Site 9] QGGVLPNIQA114-VLLPKKTESH

Ala114 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln105Gly106Gly107Val108Leu109Pro110Asn111Ile112Gln113Ala114
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val115Leu116Leu117Pro118Lys119Lys120Thr121Glu122Ser123His124

Sequence conservation (by blast)

[Site 10] AVLLPKKTES123-HHKAKGK

Ser123 His

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala114Val115Leu116Leu117Pro118Lys119Lys120Thr121Glu122Ser123
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
His124His125Lys126Ala127Lys128Gly129Lys130---

Sequence conservation (by blast)

* References

None.