logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0080 : Crystallin, [beta]A4

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namesbeta-crystallin A4 [Rattus norvegicus]; beta-crystallin A4; beta-A4 crystallin; Beta-crystallin A4; Beta-A4 crystallin
Gene NamesCryba4; crystallin, beta A4
Gene Locus12; chromosome 12
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_113877 NM_031689 64348 P56374 N/A N/A N/A rno:64348

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 196 aa

Average Mass: 22.381 kDa

Monoisotopic Mass: 22.368 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 4 ---
Protein of unknown function (DUF2914) 1. 72939.00.2
Beta/Gamma crystallin 1. 1071942.00.5

3. Sequence Information

Fasta Sequence: SB0080.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 8405363] David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.

Cleavage sites (±10aa)

[Site 1] MTLQ4-CTKSAGHWRV

Gln4 Cys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
------Met1Thr2Leu3Gln4
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Cys5Thr6Lys7Ser8Ala9Gly10His11Trp12Arg13Val14

Sequence conservation (by blast)

* References

[PubMed ID: 11773034] Lampi KJ, Shih M, Ueda Y, Shearer TR, David LL, Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci. 2002 Jan;43(1):216-24.

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