SB0083 : p19INK4d, Cyclin-dependent kinase inhibitor 2D
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | cyclin-dependent kinase 4 inhibitor D [Homo sapiens]; cyclin-dependent kinase 4 inhibitor D; CDK inhibitor p19INK4d; cyclin-dependent kinase 4 inhibitor D p19; inhibitor of cyclin-dependent kinase 4d; cell cycle inhibitor, Nur77 associating protein; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d |
| Gene Names | CDKN2D; cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| Gene Locus | 19p13; chromosome 19 |
| GO Function | Not available |
* Information From OMIM
Description: Cyclins are important in regulating the cell cycle through their formation of enzymatic complexes with various cyclin-dependent kinases. The D type cyclins complex with CDK4 (OMIM:123829) and CDK6 (OMIM:603368) to govern progression through the G1 phase of the cell cycle and later are involved with inactivating phosphorylation of the RB1 protein (OMIM:614041), which results in release of RB1-associated transcription factors that are needed for entry into S phase (Okuda et al., 1995). The activity of the cyclin D-dependent kinases is, in part, controlled by inhibitors such as the INK4 family, which includes INK4a (CDKN2A; OMIM:600160), 4b (CDKN2B; OMIM:600431), 4c (CDKN2C; OMIM:603369), and 4d (CDKN2D). INK4a has been shown to act by competing with CDK4 and CDK6 and functions as a tumor suppressor in a variety of cancers.
Function: The mouse INK4d protein interacts with Cdk6. In fibroblasts and macrophages it is rapidly induced at the G1-to-S transition. Overexpression of INK4d caused NIH 3T3 cells to arrest in G1 phase and inhibited cyclin D1-CDK4 kinase activity (Hirai et al., 1995).
* Structure Information
1. Primary Information
Length: 166 aa
Average Mass: 17.700 kDa
Monoisotopic Mass: 17.689 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Ankyrin repeats (many copies) 1. | 15 | 47 | 23.0 | 0.0 |
| --- cleavage 25 (inside Ankyrin repeats (many copies) 15..47) --- | ||||
| --- cleavage 29 (inside Ankyrin repeats (many copies) 15..47) --- | ||||
| --- cleavage 47 (inside Ankyrin repeats (many copies) 15..47) --- | ||||
| --- cleavage 47 --- | ||||
| Ankyrin repeats (many copies) 2. | 49 | 94 | 9.0 | 0.0 |
| --- cleavage 64 (inside Ankyrin repeats (many copies) 49..94) --- | ||||
| --- cleavage 113 --- | ||||
| --- cleavage 127 --- | ||||
| Ankyrin repeats (many copies) 3. | 131 | 151 | 26.0 | 0.0 |
3. Sequence Information
Fasta Sequence: SB0083.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
6 [sites] cleaved by Calpain 1
Source Reference: [PubMed ID: 16542156] Joy J, Nalabothula N, Ghosh M, Popp O, Jochum M, Machleidt W, Gil-Parrado S, Holak TA, Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d). Biol Chem. 2006 Mar;387(3):329-35.
Cleavage sites (±10aa)
[Site 1] AARGDVQEVR25-RLLHRELVHP
Arg25 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala16 | Ala17 | Arg18 | Gly19 | Asp20 | Val21 | Gln22 | Glu23 | Val24 | Arg25 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg26 | Leu27 | Leu28 | His29 | Arg30 | Glu31 | Leu32 | Val33 | His34 | Pro35 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTA |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 111.00 | 17 | cyclin-dependent kinase inhibitor 2D |
| 2 | N/A | 111.00 | 14 | p19 protein |
| 3 | synthetic construct | 111.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Canis familiaris | 108.00 | 2 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 5 | Rattus norvegicus | 106.00 | 5 | similar to cyclin-dependent kinase inhibitor 2D |
| 6 | Mus musculus | 105.00 | 14 | cyclin-dependent kinase inhibitor 2D |
| 7 | Bos taurus | 102.00 | 5 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 8 | Monodelphis domestica | 47.00 | 1 | cyclin-dependent kinase inhibitor 2A isoform 1 |
| 9 | Monodelphis domestica | 47.00 | 1 | tumor suppressor CDKN2A |
| 10 | Mesocricetus auratus | 46.60 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 11 | Tetraodon nigroviridis | 46.20 | 4 | unnamed protein product |
| 12 | human, brain tumors, Peptide, 156 aa | 42.70 | 1 | cyclin D-dependent kinases 4 and 6-binding protei |
| 13 | Danio rerio | 41.60 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 14 | Sus scrofa | 41.20 | 4 | cyclin dependant kinase inhibitor |
| 15 | Takifugu rubripes | 40.80 | 2 | p19 |
| 16 | Gallus gallus | 37.00 | 1 | cyclin-dependent kinase inhibitor 2B |
| 17 | Xenopus tropicalis | 35.80 | 1 | cyclin-dependent kinase inhibitor 2B (p15, inhibi |
| 18 | Xiphophorus maculatus | 35.40 | 1 | 13CDKN2X protein |
| 19 | Xiphophorus helleri | 35.40 | 1 | p13CDKN2X |
| 20 | Apis mellifera | 34.30 | 1 | PREDICTED: similar to MYPT-75D CG6896-PA |
| 21 | Populus tremula x Populus tremuloides | 33.90 | 1 | potassium channel 2 |
| 22 | Canis lupus familiaris | 33.10 | 1 | uveal autoantigen with coiled-coil domains and an |
| 23 | Artemisia desertorum | 32.00 | 1 | ring zinc finger protein |
| 24 | Mus musculus | 31.20 | 1 | cyclin-dependent kinase inhibitor |
| 25 | Leishmania major strain Friedlin | 30.40 | 1 | hypothetical protein, conserved |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |
| N/A | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |
| synthetic construct | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |
| Canis familiaris | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGS 53 |||||||||||||||||||||||||#|||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGS 53 |
| Rattus norvegicus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |||||| |||||||||||||||||#|||||||||||||||||||||||||||| | Sbjct 1 MLLEEVSVGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSPA 55 |
| Mus musculus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 |||||| |||||||||||||||||#|||||||||||||||||||||||||||| | Sbjct 1 MLLEEVCVGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSPA 55 |
| Bos taurus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGS 53 |||||| ||||||||||||||||||#|||| |||||| |||||||||||||||| Sbjct 1 MLLEEVHAGDRLSGAAARGDVQEVR#RLLHSELVHPDVLNRFGKTALQVMMFGS 53 |
| Monodelphis domestica | Query 4 EEVRAGDRLSGAAARGDVQEVR#RLLHREL-VHPDALNRFGKTALQVMMFGS 53 || +|++|+ ||||| + | # || || +|+|+||||++|+|||| |+ Sbjct 42 EESFSGEKLTEAAARGRTEVVT#ELL--ELGTNPNAVNRFGRSAIQVMMMGN 90 |
| Monodelphis domestica | Query 4 EEVRAGDRLSGAAARGDVQEVR#RLLHREL-VHPDALNRFGKTALQVMMFGS 53 || +|++|+ ||||| + | # || || +|+|+||||++|+|||| |+ Sbjct 8 EESFSGEKLTEAAARGRTEVVT#ELL--ELGTNPNAVNRFGRSAIQVMMMGN 56 |
| Mesocricetus auratus | Query 12 LSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 |+ ||||| |+ ||#+|| | |+|+||||+ +|||| ||| Sbjct 10 LATAAARGQVETVR#QLLEAG-VDPNAVNRFGRRPIQVMMMGST 51 |
| Tetraodon nigroviridis | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 | |+ |||+|| +||# || + +||||+||||||| |||+ Sbjct 5 DELTAAAAKGDTAQVR#LLLGAG-AQVNGVNRFGRTALQVMMMGSTS 49 |
| human, brain tumors, Peptide, 156 aa | Query 8 AGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 + | |+ ||||| |+|||# || + |+| | +|+ +|||| || Sbjct 12 SADWLATAAARGRVEEVR#ALLE-AVALPNAPNSYGRRPIQVMMMGSA 57 |
| Danio rerio | Query 3 LEEVRAGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGSTA 55 + | | |||| ||| ||+ || #+ | |+ + |++|+|||||| | + Sbjct 1 MAEDTALDRLSTAAAIGDLMEVE#QTLQSN-VNVNEKNKYGRTALQVMKLGCPS 52 |
| Sus scrofa | Query 8 AGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 + | |+ ||||| |||# || + +| ||+|+| +|||| ||| Sbjct 4 SADWLASAAARGREGEVR#ALLEAGAL-ANAPNRYGRTPIQVMMMGST 49 |
| Takifugu rubripes | Query 23 EVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 ||+#|+| | || | |||||||||| |+ Sbjct 23 EVQ#RILEECRVPPDTRNEFGKTALQVMMLGNC 54 |
| Gallus gallus | Query 18 RGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 |||+ |+# || |+|+| ||+| +|||| || Sbjct 19 RGDLLRVK#ELLD-GAADPNAVNSFGRTPIQVMMLGSP 54 |
| Xenopus tropicalis | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 + | | ||||| |#++| + +| | |+| +|||| || Sbjct 6 NTLCSACARGDVDLAR#QMLQSG-IPVNATNSHGRTPIQVMMMGSP 49 |
| Xiphophorus maculatus | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 | |+ |||+| || # || + + +| ||+ |+|||| ||+ Sbjct 5 DELTTAAAKGHTAEVE#ALLLQG-APVNGVNSFGRRAIQVMMMGSS 48 |
| Xiphophorus helleri | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMMFGST 54 | |+ |||+| || # || + + +| ||+ |+|||| ||+ Sbjct 5 DELTTAAAKGHTAEVE#ALLLQG-APVNGVNSFGRRAIQVMMMGSS 48 |
| Apis mellifera | Query 15 AAARGDVQEVR#RLLHRELVHPDALNRFGKTALQ 47 |||| |+ |||#||| + |+||+ | | ||| Sbjct 68 AAARNDIDEVR#RLLKKG-VNPDSTNEDGLTALH 99 |
| Populus tremula x Populus tremuloides | Query 8 AGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMM 50 ||| | || + |+ ++# || + | + |+ +| ||||||| | Sbjct 623 AGDLLCTAAKQNDLMVMK#ELLKQGL-NVDSKDRHGKTALQVAM 664 |
| Canis lupus familiaris | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVM 49 ||| || ||||++| # +| ++ ++| |+ |++| |+ Sbjct 38 DRLMKAAERGDVEKVS#SILAKKGINPGKLDVEGRSAFHVV 77 |
| Artemisia desertorum | Query 15 AAARGDVQEVR#RLLHRELVHPDALNRFGKTALQV-MMFGSTA 55 ||| | ++ | # || + |+|||||| +| | + | | | Sbjct 54 AAANGQIEIVN#LLLDKSSVNPDALNRRKQTPLMLAAMHGKIA 95 |
| Mus musculus | Query 8 AGDRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQ 47 | |||+ ||+| | +||# || | |+| | ||+| +| Sbjct 4 AADRLA-RAAQGRVHDVR#ALLEAG-VSPNAPNSFGRTPIQ 41 |
| Leishmania major strain Friedlin | Query 10 DRLSGAAARGDVQEVR#RLLHRELVHPDALNRFGKTALQVMM-FGS 53 +++ || +| |||#||+ | | |||| ||| + || Sbjct 18 EKIHVAARKGQTDEVR#RLIETG-VSPTIQNRFGCTALHLACKFGC 61 |
[Site 2] DVQEVRRLLH29-RELVHPDALN
His29 Arg
iTraq-117 Signal 623.5 (
) for DVQEVRRLLH
iTraq-117 Signal 5802.3 () for RELVHPDALN
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp20 | Val21 | Gln22 | Glu23 | Val24 | Arg25 | Arg26 | Leu27 | Leu28 | His29 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg30 | Glu31 | Leu32 | Val33 | His34 | Pro35 | Asp36 | Ala37 | Leu38 | Asn39 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MLLEEVRAGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 118.00 | 17 | cyclin-dependent kinase inhibitor 2D |
| 2 | N/A | 118.00 | 14 | p19 protein |
| 3 | synthetic construct | 118.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Canis familiaris | 114.00 | 2 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 5 | Rattus norvegicus | 112.00 | 5 | similar to cyclin-dependent kinase inhibitor 2D |
| 6 | Mus musculus | 111.00 | 13 | cyclin-dependent kinase inhibitor 2D |
| 7 | Bos taurus | 109.00 | 5 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 8 | Tetraodon nigroviridis | 48.90 | 4 | unnamed protein product |
| 9 | Mesocricetus auratus | 48.90 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 10 | Monodelphis domestica | 48.10 | 1 | cyclin-dependent kinase inhibitor 2A isoform 1 |
| 11 | Monodelphis domestica | 47.80 | 1 | tumor suppressor CDKN2A |
| 12 | Danio rerio | 44.70 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 13 | Takifugu rubripes | 43.90 | 2 | p19 |
| 14 | human, brain tumors, Peptide, 156 aa | 43.90 | 1 | cyclin D-dependent kinases 4 and 6-binding protei |
| 15 | Sus scrofa | 42.70 | 4 | cyclin dependant kinase inhibitor |
| 16 | Gallus gallus | 38.50 | 1 | cyclin-dependent kinase inhibitor 2B |
| 17 | Xenopus tropicalis | 37.40 | 1 | cyclin-dependent kinase inhibitor 2B (p15, inhibi |
| 18 | Xiphophorus helleri | 37.00 | 1 | p13CDKN2X |
| 19 | Xiphophorus maculatus | 37.00 | 1 | 13CDKN2X protein |
| 20 | Apis mellifera | 34.30 | 1 | PREDICTED: similar to MYPT-75D CG6896-PA |
| 21 | Populus tremula x Populus tremuloides | 33.90 | 1 | potassium channel 2 |
| 22 | Canis lupus familiaris | 33.10 | 1 | uveal autoantigen with coiled-coil domains and an |
| 23 | Artemisia desertorum | 32.00 | 1 | ring zinc finger protein |
| 24 | Gallus gallus | 31.60 | 1 | ankyrin repeat domain 52 |
| 25 | Mus musculus | 31.20 | 1 | cyclin-dependent kinase inhibitor |
| 26 | Leishmania major strain Friedlin | 31.20 | 1 | hypothetical protein, conserved |
| 27 | Equus caballus | 29.30 | 1 | cyclin-dependent kinase 2A inhibitor |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |
| N/A | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |
| synthetic construct | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |
| Canis familiaris | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||| |||| Sbjct 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSPTIALE 59 |
| Rattus norvegicus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||| |||||||||||||||||||||#|||||||||||||||||||||||| |+||| Sbjct 1 MLLEEVSVGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSPAVALE 59 |
| Mus musculus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||| |||||||||||||||||||||#|||||||||||||||||||||||| |+||| Sbjct 1 MLLEEVCVGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSPAVALE 59 |
| Bos taurus | Query 1 MLLEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIALE 59 |||||| ||||||||||||||||||||||# |||||| |||||||||||||||| |||| Sbjct 1 MLLEEVHAGDRLSGAAARGDVQEVRRLLH#SELVHPDVLNRFGKTALQVMMFGSPTIALE 59 |
| Tetraodon nigroviridis | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 | |+ |||+|| +|| || # + +||||+||||||| |||++| Sbjct 5 DELTAAAAKGDTAQVRLLLG#AG-AQVNGVNRFGRTALQVMMMGSTSVA 51 |
| Mesocricetus auratus | Query 12 LSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 |+ ||||| |+ ||+|| # | |+|+||||+ +|||| ||| +| Sbjct 10 LATAAARGQVETVRQLLE#AG-VDPNAVNRFGRRPIQVMMMGSTQVA 54 |
| Monodelphis domestica | Query 4 EEVRAGDRLSGAAARGDVQEVRRLLH#REL-VHPDALNRFGKTALQVMMFGSTAIA 57 || +|++|+ ||||| + | || # || +|+|+||||++|+|||| |+ +| Sbjct 42 EESFSGEKLTEAAARGRTEVVTELL-#-ELGTNPNAVNRFGRSAIQVMMMGNVRLA 94 |
| Monodelphis domestica | Query 4 EEVRAGDRLSGAAARGDVQEVRRLLH#REL-VHPDALNRFGKTALQVMMFGSTAIA 57 || +|++|+ ||||| + | || # || +|+|+||||++|+|||| |+ +| Sbjct 8 EESFSGEKLTEAAARGRTEVVTELL-#-ELGTNPNAVNRFGRSAIQVMMMGNVRLA 60 |
| Danio rerio | Query 3 LEEVRAGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 + | | |||| ||| ||+ || + | # |+ + |++|+|||||| | +|| Sbjct 1 MAEDTALDRLSTAAAIGDLMEVEQTLQ#SN-VNVNEKNKYGRTALQVMKLGCPSIA 54 |
| Takifugu rubripes | Query 23 EVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 ||+|+| # | || | |||||||||| |+ || Sbjct 23 EVQRILE#ECRVPPDTRNEFGKTALQVMMLGNCKIA 57 |
| human, brain tumors, Peptide, 156 aa | Query 8 AGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 + | |+ ||||| |+||| || # + |+| | +|+ +|||| || +| Sbjct 12 SADWLATAAARGRVEEVRALLE#-AVALPNAPNSYGRRPIQVMMMGSARVA 60 |
| Sus scrofa | Query 8 AGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 + | |+ ||||| ||| || # + +| ||+|+| +|||| ||| +| Sbjct 4 SADWLASAAARGREGEVRALLE#AGAL-ANAPNRYGRTPIQVMMMGSTRVA 52 |
| Gallus gallus | Query 18 RGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 |||+ |+ || # |+|+| ||+| +|||| || +| Sbjct 19 RGDLLRVKELLD#-GAADPNAVNSFGRTPIQVMMLGSPRVA 57 |
| Xenopus tropicalis | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 + | | ||||| |++| # + +| | |+| +|||| || +| Sbjct 6 NTLCSACARGDVDLARQMLQ#SGIPV-NATNSHGRTPIQVMMMGSPKMA 52 |
| Xiphophorus helleri | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 | |+ |||+| || || #+ + +| ||+ |+|||| ||+ +| Sbjct 5 DELTTAAAKGHTAEVEALLL#QG-APVNGVNSFGRRAIQVMMMGSSEVA 51 |
| Xiphophorus maculatus | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMFGSTAIA 57 | |+ |||+| || || #+ + +| ||+ |+|||| ||+ +| Sbjct 5 DELTTAAAKGHTAEVEALLL#QG-APVNGVNSFGRRAIQVMMMGSSEVA 51 |
| Apis mellifera | Query 15 AAARGDVQEVRRLLH#RELVHPDALNRFGKTALQ 47 |||| |+ |||||| #++ |+||+ | | ||| Sbjct 68 AAARNDIDEVRRLL-#KKGVNPDSTNEDGLTALH 99 |
| Populus tremula x Populus tremuloides | Query 8 AGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMM 50 ||| | || + |+ ++ || #+ | + |+ +| ||||||| | Sbjct 623 AGDLLCTAAKQNDLMVMKELLK#QGL-NVDSKDRHGKTALQVAM 664 |
| Canis lupus familiaris | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVM 49 ||| || ||||++| +| #++ ++| |+ |++| |+ Sbjct 38 DRLMKAAERGDVEKVSSILA#KKGINPGKLDVEGRSAFHVV 77 |
| Artemisia desertorum | Query 15 AAARGDVQEVRRLLH#RELVHPDALNRFGKTALQV-MMFGSTA 55 ||| | ++ | || #+ |+|||||| +| | + | | | Sbjct 54 AAANGQIEIVNLLLD#KSSVNPDALNRRKQTPLMLAAMHGKIA 95 |
| Gallus gallus | Query 12 LSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQVMMF-GSTAIALE 59 | ||| | ++ || || #| | | | || ||| + + | |+| | Sbjct 210 LHTAAASGQIEVVRHLL-#RLGVEIDEPNSFGNTALHIACYMGQDAVANE 257 |
| Mus musculus | Query 8 AGDRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQ 47 | |||+ ||+| | +|| || # | |+| | ||+| +| Sbjct 4 AADRLA-RAAQGRVHDVRALLE#-AGVSPNAPNSFGRTPIQ 41 |
| Leishmania major strain Friedlin | Query 10 DRLSGAAARGDVQEVRRLLH#RELVHPDALNRFGKTALQV-MMFGSTAIA 57 +++ || +| |||||+ # | | |||| ||| + || | Sbjct 18 EKIHVAARKGQTDEVRRLIE#TG-VSPTIQNRFGCTALHLACKFGCVDTA 65 |
| Equus caballus | Query 35 PDALNRFGKTALQVMMFGSTAIA 57 |+ +| ||+ +|||| || +| Sbjct 5 PNGVNGFGRRPIQVMMMGSVHVA 27 |
[Site 3] LNRFGKTALQ47-VMMFGSTAIA
Gln47 Val
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu38 | Asn39 | Arg40 | Phe41 | Gly42 | Lys43 | Thr44 | Ala45 | Leu46 | Gln47 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Val48 | Met49 | Met50 | Phe51 | Gly52 | Ser53 | Thr54 | Ala55 | Ile56 | Ala57 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| RGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSP |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 124.00 | 17 | p19 protein |
| 2 | Homo sapiens | 124.00 | 10 | cyclin-dependent kinase inhibitor 2D |
| 3 | synthetic construct | 124.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Mus musculus | 119.00 | 18 | cyclin-dependent kinase inhibitor 2D |
| 5 | Rattus norvegicus | 119.00 | 8 | similar to cyclin-dependent kinase inhibitor 2D |
| 6 | Canis familiaris | 116.00 | 3 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 7 | Bos taurus | 113.00 | 3 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 8 | Tetraodon nigroviridis | 67.00 | 3 | unnamed protein product |
| 9 | Takifugu rubripes | 65.10 | 2 | p19 |
| 10 | Mesocricetus auratus | 54.30 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 11 | Gallus gallus | 49.70 | 1 | cyclin-dependent kinase inhibitor 2B |
| 12 | Monodelphis domestica | 48.50 | 1 | cyclin-dependent kinase inhibitor 2A isoform 1 |
| 13 | human, brain tumors, Peptide, 156 aa | 48.50 | 1 | cyclin D-dependent kinases 4 and 6-binding protei |
| 14 | Monodelphis domestica | 48.50 | 1 | tumor suppressor CDKN2A |
| 15 | Sus scrofa | 47.80 | 2 | cyclin dependant kinase inhibitor |
| 16 | Danio rerio | 47.80 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 17 | Xiphophorus maculatus | 45.10 | 1 | 13CDKN2X protein |
| 18 | Xiphophorus helleri | 45.10 | 1 | p13CDKN2X |
| 19 | Xenopus tropicalis | 42.40 | 1 | cyclin-dependent kinase inhibitor 2B (p15, inhibi |
| 20 | Solibacter usitatus Ellin6076 | 39.30 | 1 | ankyrin-related protein |
| 21 | Apis mellifera | 38.90 | 1 | PREDICTED: similar to MYPT-75D CG6896-PA |
| 22 | Equus caballus | 38.90 | 1 | cyclin-dependent kinase 2A inhibitor |
| 23 | Schistosoma japonicum | 38.90 | 1 | SJCHGC04635 protein |
| 24 | Drosophila melanogaster | 38.50 | 1 | CG3104 CG3104-PA, isoform A |
| 25 | Gallus gallus | 37.40 | 1 | ankyrin repeat domain 52 |
| 26 | Cryptosporidium hominis TU502 | 37.40 | 1 | proteasome 26S subunit |
| 27 | Aspergillus oryzae RIB40 | 36.60 | 1 | hypothetical protein |
| 28 | Egeria densa | 36.60 | 1 | inward potassium channel alpha subunit |
| 29 | Rickettsia felis URRWXCal2 | 36.20 | 1 | Ankyrin repeat |
| 30 | Bordetella parapertussis 12822 | 36.20 | 1 | hypothetical protein BPP0952 |
| 31 | Bordetella pertussis Tohama I | 36.20 | 1 | hypothetical protein BP2881 |
| 32 | Xenopus laevis | 35.80 | 3 | AF465262_1 inversin |
| 33 | Rattus norvegicus | 35.80 | 1 | 190 kDa ankyrin isoform; AnkG190 |
| 34 | Methanosarcina barkeri str. Fusaro | 35.40 | 1 | hypothetical protein Mbar_A2380 |
| 35 | Dictyostelium discoideum AX4 | 35.00 | 1 | ankyrin repeat-containing protein |
| 36 | Caenorhabditis briggsae AF16 | 34.70 | 1 | Hypothetical protein CBG03811 |
| 37 | Orf virus | 34.30 | 1 | Ankyrin/F-box protein |
| 38 | Wolbachia endosymbiont of Drosophila melanogaster | 34.30 | 1 | ankyrin repeat domain protein |
| 39 | Caenorhabditis elegans | 33.90 | 2 | GEI-4(Four) Interacting protein family member (gf |
| 40 | Neurospora crassa OR74A | 33.90 | 1 | hypothetical protein NCU04881 |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 |
| Homo sapiens | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 |
| synthetic construct | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 |
| Mus musculus | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||| |+||||||||||||||| ||||| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPAVALELLKQGASPNVQDASGTSP 77 |
| Rattus norvegicus | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||| |+||||||||||||||| ||||| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPAVALELLKQGASPNVQDASGTSP 77 |
| Canis familiaris | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||||||||||||||||||||||||||||#|||||| |||||||||||||||| +||+| Sbjct 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSPTIALELLKQGASPNVQDATGTTP 77 |
| Bos taurus | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 |||||||||||| |||||| ||||||||||#|||||| |||||||||||||||| |||+| Sbjct 18 RGDVQEVRRLLHSELVHPDVLNRFGKTALQ#VMMFGSPTIALELLKQGASPNVQDASGTTP 77 |
| Tetraodon nigroviridis | Query 23 EVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||||+| | || | |||||||#||| |+ || ||++|| ||||| | +| Sbjct 23 EVRRILEECRVPPDTPNEFGKTALQ#VMMLGNCKIASLLLEKGADPNVQDKHGIAP 77 |
| Takifugu rubripes | Query 23 EVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTSGTSP 77 ||+|+| | || | |||||||#||| |+ || ||++|| ||||| | +| Sbjct 23 EVQRILEECRVPPDTRNEFGKTALQ#VMMLGNCKIASLLLEKGADPNVQDKHGIAP 77 |
| Mesocricetus auratus | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 71 || |+ ||+|| | |+|+||||+ +|#||| ||| +| || || || | Sbjct 16 RGQVETVRQLLEAG-VDPNAVNRFGRRPIQ#VMMMGSTQVAELLLLHGAEPNCAD 68 |
| Gallus gallus | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDT-SGTS 76 |||+ |+ || |+|+| ||+| +|#||| || +| ||++|| || | +| Sbjct 19 RGDLLRVKELLD-GAADPNAVNSFGRTPIQ#VMMLGSPRVAELLLQRGADPNRPDPRTGCR 77 Query 77 P 77 | Query 77 P 77 |
| Monodelphis domestica | Query 18 RGDVQEVRRLLHREL-VHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 71 || + | || || +|+|+||||++|+|#||| |+ +| ||+ || || | Sbjct 56 RGRTEVVTELL--ELGTNPNAVNRFGRSAIQ#VMMMGNVRLAAILLQYGAEPNTPD 108 |
| human, brain tumors, Peptide, 156 aa | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTS 73 || |+||| || + |+| | +|+ +|#||| || +| || || || | + Sbjct 22 RGRVEEVRALLE-AVALPNAPNSYGRRPIQ#VMMMGSARVAELLLLHGAEPNCADPA 76 |
| Monodelphis domestica | Query 18 RGDVQEVRRLLHREL-VHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 71 || + | || || +|+|+||||++|+|#||| |+ +| ||+ || || | Sbjct 22 RGRTEVVTELL--ELGTNPNAVNRFGRSAIQ#VMMMGNVRLAAILLQYGAEPNTPD 74 |
| Sus scrofa | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTS 73 || ||| || + +| ||+|+| +|#||| ||| +| || || || +| + Sbjct 14 RGREGEVRALLEAGAL-ANAPNRYGRTPIQ#VMMMGSTRVAELLLLHGADPNCEDPA 68 |
| Danio rerio | Query 19 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 71 ||+ || + | |+ + |++|+||||#|| | +|| ||+ || |||+| Sbjct 17 GDLMEVEQTLQSN-VNVNEKNKYGRTALQ#VMKLGCPSIAETLLQAGADPNVRD 68 |
| Xiphophorus maculatus | Query 36 DALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTS-GTSP 77 + +| ||+ |+|#||| ||+ +| || +|| ||| | | | +| Sbjct 30 NGVNSFGRRAIQ#VMMMGSSEVARLLLTRGADPNVTDKSTGATP 72 |
| Xiphophorus helleri | Query 36 DALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQDTS-GTSP 77 + +| ||+ |+|#||| ||+ +| || +|| ||| | | | +| Sbjct 30 NGVNSFGRRAIQ#VMMMGSSEVARLLLTRGADPNVTDKSTGATP 72 |
| Xenopus tropicalis | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD-TSGTS 76 |||| |++| + +| | |+| +|#||| || +| || || | + | +| Sbjct 14 RGDVDLARQMLQSG-IPVNATNSHGRTPIQ#VMMMGSPKMAQLLLDHGADPKLPDPCTGAC 72 Query 77 P 77 | Query 77 P 77 |
| Solibacter usitatus Ellin6076 | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQ-GASPNVQDTSGTS 76 | | |+ ||| + +|+| ||+| | | #+ | +||| | || || | + Sbjct 62 RQDDLEMSRLLLKAGANPNAANRYGMTVLA#LACTNGNAAIVELLLQAGADPNAALPGGET 121 Query 77 P 77 | Query 77 P 77 |
| Apis mellifera | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELLKQ-GASPNVQDTSGTS 76 | |+ |||||| ++ |+||+ | | ||| # ++|| + ||+ | +|+ + Sbjct 71 RNDIDEVRRLL-KKGVNPDSTNEDGLTALH#QCCIDDNEEMMKLLIEFGANVNAEDSEKWT 129 Query 77 P 77 | Query 77 P 77 |
| Equus caballus | Query 35 PDALNRFGKTALQ#VMMFGSTAIALELLKQGASPNVQD 71 |+ +| ||+ +|#||| || +| || || || | Sbjct 5 PNGVNGFGRRPIQ#VMMMGSVHVAELLLLHGADPNRAD 41 |
| Schistosoma japonicum | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 76 |||+ ||| || | || | | |+| |# + + + ||+ ||+|| +|| + Sbjct 94 RGDLDEVRELLSSG-VCPDVANEDGLTSLHQ#CCIDNNLEMCRLLLRYGANPNSRDTELWT 152 Query 77 P 77 | Query 77 P 77 |
| Drosophila melanogaster | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGS-TAIALELLKQGASPNVQDTSGTS 76 ||| + |+| || | + | | | #+ | | +||| ||| || + +||+ Sbjct 19 RGDEVALLRVLDSGKVHVDCKDEDGTTPLI#LAAAGGHTYCVMELLDQGADPNSRRLTGTT 78 Query 77 P 77 | Query 77 P 77 |
| Gallus gallus | Query 19 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 77 | ++ || || | | | | || ||| #+ + | |+| ||+ ||+ | + | +| Sbjct 217 GQIEVVRHLL-RLGVEIDEPNSFGNTALH#IACYMGQDAVANELVNYGANVNQPNEKGFTP 275 |
| Cryptosporidium hominis TU502 | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMM-FGSTAIALELLKQGASPNVQDTSGTS 76 + +|+ ++++| | ++ + | || #+ | + ||| ||| ||+|||+| | | Sbjct 159 KNEVEFLKKILERYPFLSNSRSSEGSYALH#LACDKGYSEIALLLLKNGANPNVKDNFGDS 218 Query 77 P 77 | Query 77 P 77 |
| Aspergillus oryzae RIB40 | Query 23 EVRRLLHRELVHPDALNRFGKTALQ#V-MMFGSTAIALELLKQGASPNVQDTSGTSP 77 | ||| |+|+| | ||| #| +| |+ + |||++|| | + + +| | Sbjct 167 SVMRLLLSYGADPNAVNSEGATALH#VGVMNGNYTMVAELLQRGADPTLTNAAGWLP 222 |
| Egeria densa | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTALQ#VMM-FGSTAIALELLKQGASPNVQDTSGTS 76 ||| | +|| |+ + |+||| #+ || || || +||+|| +|+ |++ Sbjct 433 RGDYMLVDKLLECG-SDPNEADSKGRTALH#IAARNGSERCALLLLDRGANPNSKDSDGST 491 Query 77 P 77 | Query 77 P 77 |
| Rickettsia felis URRWXCal2 | Query 19 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTS 76 ||+ ||+ || + + | |+||| # +| | | ||| ||||+ | || + Sbjct 17 GDLSEVQALLKSGVNIDEHKNERGETALY#NTLFTGYMDRAAFLLKHKASPNIPDNSGQT 75 |
| Bordetella parapertussis 12822 | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTA-LQ#VMMFGST-----AIALELLKQGASPNVQD 71 || |+ | || | | || +|| | | |+# ++ | || |++ || |+ | Sbjct 145 RGHVEVVDMLL-RAGVDPDHVNRLGWTGLLE#AIILGDGGTRHQAIVARLIEGGADVNLAD 203 Query 72 TSGTSP 77 | || Sbjct 204 GDGVSP 209 |
| Bordetella pertussis Tohama I | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTA-LQ#VMMFGST-----AIALELLKQGASPNVQD 71 || |+ | || | | || +|| | | |+# ++ | || |++ || |+ | Sbjct 139 RGHVEVVDMLL-RAGVDPDHVNRLGWTGLLE#AIILGDGGTRHQAIVARLIEGGADVNLAD 197 Query 72 TSGTSP 77 | || Sbjct 198 GDGVSP 203 |
| Xenopus laevis | Query 24 VRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALE-LLKQGASPNVQDTSG 74 | ++| ++||| + |+| ||# +| +| |++ | ||+|| +| Sbjct 434 VCQILIENNINPDAQDYEGRTPLQ#CAAYGGYIGCMEVLMENKADPNIQDKNG 485 |
| Rattus norvegicus | Query 23 EVRRLLHRELVHPDALNRFGKTALQ#VMM-FGSTAIALELLKQGASPNVQDTSGTSP 77 || || ++ ||| + | | | #| + + +|| || |||||+ +| +| Sbjct 573 EVASLLLQKSASPDAAGKSGLTPLH#VAAHYDNQKVALLLLDQGASPHAAAKNGYTP 628 |
| Methanosarcina barkeri str. Fusaro | Query 19 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMFGSTAIALELL-KQGASPNVQDTSGTS 76 | ++ | + | + | ++ + +||||| # + +||| | || ||+|| +| + Sbjct 23 GQIENVEKFLKSDKVDINSQDAYGKTALN#YAVNKGYRDVVELLIKGGADPNIQDENGDT 81 |
| Dictyostelium discoideum AX4 | Query 19 GDVQEVRRLLHRELVHPDALNRFGKTALQ#VMMF-GSTAIALELLKQGASPNVQDTSGTSP 77 ||++++ ||+ || + +| | # | || | || + |+ |++|++| +| Sbjct 46 GDIEKLSNLLNNSATSPDTPDSEKRTPLH#HAAFCGSAACVNFLLDKKANANIKDSAGNTP 105 |
| Caenorhabditis briggsae AF16 | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 76 | | || |||+ | +|+ | | | | |# + + | | || +||+ | ||| + Sbjct 67 RADYAEVERLLN-ENANPNLHNDDGLTPLHQ#CAIDDNQQIMLLLLDRGANVNAQDTEQWT 125 Query 77 P 77 | Query 77 P 77 |
| Orf virus | Query 34 HPDALNRFGKTALQ#VMM---FGSTAIALELLKQGASPNVQDTSGTSP 77 | +| + |+| | #+ + | | +|| |+ ||+|| | | +| Sbjct 143 HVNAKDDLGRTPLH#IYLSGFFVSAPVALALIALGANPNATDAYGRTP 189 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 18 RGDVQEVRRLLHRELVHPDALNR--FGKTALQ-#VMMFGSTAIALELLKQGASPNVQDTSG 74 +| + +| |+ | |+ +||+| | + || # | + ||++||+||++| | Sbjct 77 KGCLDIIRFLIEEEKVNINALDRNAFKRIALHH#AAGEGHLEVIKFLLEKGANPNIRDIDG 136 Query 75 TSP 77 +| Sbjct 137 KNP 139 |
| Caenorhabditis elegans | Query 18 RGDVQEVRRLLHRELVHPDALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 76 | | || |||+ + +|+ | | | | |# + + | | ||++||+ | ||| + Sbjct 67 RADYAEVERLLN-DNANPNLHNDDGLTPLHQ#CAIDDNQQIMLLLLERGANVNAQDTEQWT 125 Query 77 P 77 | Query 77 P 77 |
| Neurospora crassa OR74A | Query 36 DALNRFGKTAL-Q#VMMFGSTAIALELLKQGASPNVQDTSGTS 76 | |++|+||| |# + |+| |+++|| ||+|| | | Sbjct 939 DMANKYGETALMQ#AVSTRRWALAKLLIEKGADPNLQDGQGES 980 |
[Site 4] AIALELLKQG64-ASPNVQDTSG
Gly64 Ala
iTraq-117 Signal 302.2 () for AIALELLKQG
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala55 | Ile56 | Ala57 | Leu58 | Glu59 | Leu60 | Leu61 | Lys62 | Gln63 | Gly64 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala65 | Ser66 | Pro67 | Asn68 | Val69 | Gln70 | Asp71 | Thr72 | Ser73 | Gly74 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PDALNRFGKTALQVMMFGSTAIALELLKQGASPNVQDTSGTSPVHDAARTGFLDTLKVLV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 123.00 | 20 | A Chain A, Structure Of Cdk Inhibitor P19ink4d |
| 2 | Homo sapiens | 123.00 | 20 | cyclin-dependent kinase inhibitor 2D |
| 3 | synthetic construct | 123.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Mus musculus | 118.00 | 21 | cyclin-dependent kinase inhibitor 2D |
| 5 | Rattus norvegicus | 118.00 | 5 | similar to cyclin-dependent kinase inhibitor 2D |
| 6 | Canis familiaris | 112.00 | 8 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 7 | Bos taurus | 112.00 | 3 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 8 | Takifugu rubripes | 90.90 | 2 | p19 |
| 9 | Tetraodon nigroviridis | 90.10 | 6 | unnamed protein product |
| 10 | Xiphophorus maculatus | 73.60 | 1 | 13CDKN2X protein |
| 11 | Xiphophorus helleri | 73.20 | 1 | p13CDKN2X |
| 12 | Monodelphis domestica | 73.20 | 1 | tumor suppressor CDKN2A |
| 13 | Mesocricetus auratus | 72.80 | 3 | p15INK4b cyclin-dependent kinase inhibitor |
| 14 | Monodelphis domestica | 72.80 | 1 | cyclin-dependent kinase inhibitor 2A isoform 1 |
| 15 | Sus scrofa | 70.90 | 4 | cyclin dependant kinase inhibitor |
| 16 | Gallus gallus | 70.10 | 1 | cyclin-dependent kinase inhibitor 2B |
| 17 | human, brain tumors, Peptide, 156 aa | 66.60 | 1 | cyclin D-dependent kinases 4 and 6-binding protei |
| 18 | Danio rerio | 65.10 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 19 | Xenopus tropicalis | 63.90 | 3 | cyclin-dependent kinase inhibitor 2B (p15, inhibi |
| 20 | Equus caballus | 56.20 | 1 | cyclin-dependent kinase 2A inhibitor |
| 21 | Felis catus | 53.50 | 2 | p16/CDKN2A/MTS1 |
| 22 | Mus spretus | 51.20 | 1 | cyclin-dependent kinase inhibitor protein |
| 23 | Rattus sp. | 45.80 | 1 | AAP31998.1 |
| 24 | Arabidopsis thaliana | 44.70 | 1 | EMB506 (EMBRYO DEFECTIVE 506); protein binding |
| 25 | Ustilago maydis 521 | 44.30 | 1 | hypothetical protein UM02100.1 |
| 26 | Theileria annulata strain Ankara | 43.90 | 1 | Ankyrin repeat protein, putative |
| 27 | Dictyostelium discoideum | 43.50 | 1 | homeobox-containing protein Wariai |
| 28 | Drosophila melanogaster | 43.10 | 1 | CG3104 CG3104-PA, isoform A |
| 29 | Samanea saman | 43.10 | 1 | pulvinus inward-rectifying channel for potassium |
| 30 | Dictyostelium discoideum AX4 | 43.10 | 1 | putative homeobox transcription factor |
| 31 | Oryza sativa Japonica Group | 43.10 | 1 | ankyrin repeat protein chloroplast precursor-like |
| 32 | Leifsonia xyli subsp. xyli str. CTCB07 | 42.00 | 1 | hypothetical protein Lxx18600 |
| 33 | Canis lupus familiaris | 35.40 | 1 | inversin |
| 34 | Wolbachia endosymbiont of Drosophila melanogaster | 35.00 | 1 | ankyrin repeat domain protein |
| 35 | Wolbachia pipientis | 34.70 | 1 | ankyrin domain protein |
| 36 | Xenopus laevis | 33.50 | 4 | inv2 |
| 37 | Apis mellifera | 33.50 | 1 | PREDICTED: similar to no mechanoreceptor potentia |
| 38 | Caenorhabditis elegans | 33.10 | 7 | AO13 ankyrin |
| 39 | synthetic construct | 33.10 | 3 | ankyrin repeat protein E2_17 |
| 40 | Treponema denticola ATCC 35405 | 33.10 | 1 | ankyrin repeat protein |
| 41 | Caenorhabditis briggsae AF16 | 32.30 | 1 | Hypothetical protein CBG09456 |
| 42 | Hemicentrotus pulcherrimus | 31.60 | 1 | inv-like protein |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 |
| Homo sapiens | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 |
| synthetic construct | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 |
| Mus musculus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||| |+||||||||#||||||| |||||||||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPAVALELLKQG#ASPNVQDASGTSPVHDAARTGFLDTLKVLV 94 |
| Rattus norvegicus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||| |+||||||||#||||||| |||||||||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPAVALELLKQG#ASPNVQDASGTSPVHDAARTGFLDTLKVLV 94 |
| Canis familiaris | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ||||||||||||||||||| |||||||||#||||||| +||+| |||||||||||||||| Sbjct 35 PDALNRFGKTALQVMMFGSPTIALELLKQG#ASPNVQDATGTTPAHDAARTGFLDTLKVLV 94 |
| Bos taurus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || |||||||||||||||| |||||||||#||||||| |||+| |||||||||||||||| Sbjct 35 PDVLNRFGKTALQVMMFGSPTIALELLKQG#ASPNVQDASGTTPAHDAARTGFLDTLKVLV 94 |
| Takifugu rubripes | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || | |||||||||| |+ || ||++|#| ||||| | +||||||||||||||+||| Sbjct 35 PDTRNEFGKTALQVMMLGNCKIASLLLEKG#ADPNVQDKHGIAPVHDAARTGFLDTLQVLV 94 |
| Tetraodon nigroviridis | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || | |||||||||| |+ || ||++|#| ||||| | +||||||||||||||+||| Sbjct 35 PDTPNEFGKTALQVMMLGNCKIASLLLEKG#ADPNVQDKHGIAPVHDAARTGFLDTLQVLV 94 |
| Xiphophorus maculatus | Query 36 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTS-GTSPVHDAARTGFLDTLKVLV 94 + +| ||+ |+|||| ||+ +| || +|#| ||| | | | +|+|||||||||||+++|| Sbjct 30 NGVNSFGRRAIQVMMMGSSEVARLLLTRG#ADPNVTDKSTGATPLHDAARTGFLDTVQLLV 89 |
| Xiphophorus helleri | Query 36 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTS-GTSPVHDAARTGFLDTLKVLV 94 + +| ||+ |+|||| ||+ +| || +|#| ||| | | | +|+|||||||||||+++|| Sbjct 30 NGVNSFGRRAIQVMMMGSSEVARLLLTRG#ADPNVTDKSTGATPLHDAARTGFLDTVQLLV 89 |
| Monodelphis domestica | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVL 93 |+|+||||++|+|||| |+ +| ||+ |#| || | |+ | ||||||| |||||| +| Sbjct 38 PNAVNRFGRSAIQVMMMGNVRLAAILLQYG#AEPNTPDPTTLTLPVHDAAREGFLDTLMLL 97 |
| Mesocricetus auratus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 93 |+|+||||+ +|||| ||| +| || |#| || | + | ||||||| |||||| || Sbjct 32 PNAVNRFGRRPIQVMMMGSTQVAELLLLHG#AEPNCADPNTLTRPVHDAAREGFLDTLVVL 91 |
| Monodelphis domestica | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVL 93 |+|+||||++|+|||| |+ +| ||+ |#| || | |+ | ||||||| |||||| +| Sbjct 72 PNAVNRFGRSAIQVMMMGNVRLAAILLQYG#AEPNTPDPTTLTLPVHDAAREGFLDTLMLL 131 |
| Sus scrofa | Query 36 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 93 +| ||+|+| +|||| ||| +| || |#| || +| + | ||||||| |||||| || Sbjct 31 NAPNRYGRTPIQVMMMGSTRVAELLLLHG#ADPNCEDPATLTRPVHDAAREGFLDTLVVL 89 |
| Gallus gallus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDT-SGTSPVHDAARTGFLDTLKVL 93 |+|+| ||+| +|||| || +| ||++|#| || | +| | ||||| |||||| | Sbjct 35 PNAVNSFGRTPIQVMMLGSPRVAELLLQRG#ADPNRPDPRTGCRPAHDAARAGFLDTLAAL 94 |
| human, brain tumors, Peptide, 156 aa | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 93 |+| | +|+ +|||| || +| || |#| || | + | ||||||| |||||| || Sbjct 38 PNAPNSYGRRPIQVMMMGSARVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLDTLVVL 97 |
| Danio rerio | Query 39 NRFGKTALQVMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVL 93 |++|+|||||| | +|| ||+ |#| |||+| | + +||||| |+|||| || Sbjct 36 NKYGRTALQVMKLGCPSIAETLLQAG#ADPNVRDPILGLTVIHDAARDGYLDTLHVL 91 |
| Xenopus tropicalis | Query 36 DALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVLV 94 +| | |+| +|||| || +| || |#| | + | +| ||||||| |||||| ||+ Sbjct 31 NATNSHGRTPIQVMMMGSPKMAQLLLDHG#ADPKLPDPCTGACPVHDAAREGFLDTLLVLL 90 |
| Equus caballus | Query 35 PDALNRFGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFL 87 |+ +| ||+ +|||| || +| || |#| || | | ||||||| ||| Sbjct 5 PNGVNGFGRRPIQVMMMGSVHVAELLLLHG#ADPNRADPDTLTRPVHDAAREGFL 58 |
| Felis catus | Query 48 VMMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLDTLKVL 93 ||| || +| || |#| || | + | ||||||| |||||| || Sbjct 1 VMMMGSARVAELLLLHG#ADPNCADPATLTRPVHDAAREGFLDTLVVL 47 |
| Mus spretus | Query 48 VMMFGSTAIALELLKQG#ASPNVQD-TSGTSPVHDAARTGFLDTLKVL 93 ||| |+ +| || |#| | +| |+ + ||||||| |||||| || Sbjct 1 VMMMGNVHVAALLLNYG#ADSNCEDPTTFSRPVHDAAREGFLDTLVVL 47 |
| Rattus sp. | Query 49 MMFGSTAIALELLKQG#ASPNVQDTSG-TSPVHDAARTGFLD 88 || || +| || |#| || | + | ||||||| |||| Sbjct 1 MMMGSAQVAELLLLHG#AEPNCADPATLTRPVHDAAREGFLD 41 |
| Arabidopsis thaliana | Query 36 DALNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 | +++ +||| + | |+ ||++|#|+|++|| | +|+| | + | | |+|+| Sbjct 179 DDVDKDNQTALHKAIIGKKEAVISHLLRKG#ANPHLQDRDGAAPIHYAVQVGALQTVKLL 237 |
| Ustilago maydis 521 | Query 39 NRFGKTAL-QVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +| |+||| + | | ++| || |#| | || | + +|+| |+|| +++|| Sbjct 398 DREGETALHKAAMAGKLSVASLLLSHG#ADANAQDADGWTALHNACSRGYLDLVRLLV 454 |
| Theileria annulata strain Ankara | Query 52 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 |+| + +||+ |#| ||+ |+ | +|+| |+ +|+| |+|+ Sbjct 253 GNTGLVKKLLENG#ADPNICDSQGWTPLHCASESGYLSVCKLLI 295 |
| Dictyostelium discoideum | Query 36 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +|++ | | | + | | ||+ |#| ||+||+ | +|+| | | ++|+| |+ Sbjct 532 NAIDIDGHTPLHTSSLMGQYLITRLLLENG#ADPNIQDSEGYTPIHYAVRESRIETVKFLI 591 |
| Drosophila melanogaster | Query 52 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | | +||| ||#| || + +||+|+ ||+ | || +|+|+ Sbjct 54 GHTYCVMELLDQG#ADPNSRRLTGTTPLFFAAQGGHLDVVKILI 96 |
| Samanea saman | Query 46 LQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | | |+ | |||| |# |+| |+ | +|+| || | | +|||+ Sbjct 548 LTVASTGNAAFLEELLKAG#LDPDVGDSKGKTPLHIAASNGHEDCVKVLL 596 |
| Dictyostelium discoideum AX4 | Query 36 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +|++ | | | + | | ||+ |#| ||+||+ | +|+| | | ++|+| |+ Sbjct 535 NAIDIDGHTPLHTSSLMGHDLITRLLLENG#ADPNIQDSEGYTPIHYAVRESRIETVKFLI 594 |
| Oryza sativa Japonica Group | Query 38 LNRFGKTALQVMMFGS-TAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 |++ | | | + | |+ ||++|#|+|+|+| | +|+| | + | | |+|+|+ Sbjct 190 LDKDGFTPLHKAVIGKKEAVISHLLRRG#ANPHVRDRDGATPLHYAVQVGALQTVKLLI 247 |
| Leifsonia xyli subsp. xyli str. CTCB07 | Query 36 DALNRFGKTALQVMMF------GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGF 86 | +|| | |||| + |+ + +|| |#| |+++| | +|+ +| | || Sbjct 179 DHVNRLGGTALQEAIVMGDGGRGAQDVVRQLLTAG#ADPDIRDADGRTPLCNAERNGF 235 |
| Canis lupus familiaris | Query 35 PDALNRFGKTALQVMMFGSTAIALE-LLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 |+ + |+| || +| + |++ #| ||+|| | + +| + |+|| +|+| Sbjct 449 PNVQDYAGRTPLQCAAYGGYINCMAVLMENN#ADPNIQDKEGRTALHWSCNNGYLDAIKLL 508 Query 94 V 94 + Sbjct 509 L 509 Query 36 DALNRFGKTALQVMMFGSTAIALELLKQG#A-SPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | +++ | + | | | ++| + # +||||| +| +|+ || |+++ + ||+ Sbjct 417 DLVDQDGHSLLHWAALGGNADVCQILIEN#KINPNVQDYAGRTPLQCAAYGGYINCMAVLM 476 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 36 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | ||+|+| | +| | + || + # + ||| | +|+|||| | ++ +| |+ Sbjct 140 DLKNRYGETPLHYAAKYGHTQVLENLLGRS#TNVNVQSEVGRTPLHDAANNGHIEVVKHLI 199 Query 52 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | + |+|+|#| ||| | +|+|+||+ | ++||+ Sbjct 190 GHIEVVKHLIKKG#ADVNVQSKVGRTPLHNAAKHGHTQVVEVLL 232 Query 39 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ++ |+| | | | + |||+|#| |+|| | +|+| | + + |+|+ Sbjct 209 SKVGRTPLHNAAKHGHTQVVEVLLKKG#ADVNIQDRGGRTPLHYAVQRRYPKLAKLLL 265 |
| Wolbachia pipientis | Query 36 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | ||+|+| | +| | + || + # + ||| | +|+|||| | ++ +| |+ Sbjct 139 DLKNRYGETPLHYAAKYGHTQVLENLLGRS#TNVNVQSEVGRTPLHDAANNGHIEVVKHLI 198 Query 52 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | + |+|+|#| ||| | +|+|+|| |+++ +| |+ Sbjct 189 GHIEVVKHLIKKG#ADVNVQSKVGRTPLHNAANNGYIEVVKHLI 231 Query 39 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ++ |+| | | | + |||+|#| |+|| | +|+| | + |+ |+|+ Sbjct 274 SKVGRTPLHNAAKHGHTQVVEVLLKKG#ADVNIQDRGGRTPLHYAVQRGYPKLAKLLL 330 Query 36 DALNRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 + ++++|+| | | + |+++ #| ||| | +|+|+||+ | ++||+ Sbjct 238 NVVDQYGRTPLHDAAKHGRIEVVKHLIEKE#ADVNVQSKVGRTPLHNAAKHGHTQVVEVLL 297 Query 39 NRFGKTALQ-VMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 ++ |+| | | + |+|+ #| || | | +|+||||+ | ++ +| |+ Sbjct 208 SKVGRTPLHNAANNGYIEVVKHLIKKE#ADVNVVDQYGRTPLHDAAKHGRIEVVKHLI 264 |
| Xenopus laevis | Query 35 PDALNRFGKTALQVMMFGSTAIALE-LLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 ||| + |+| || +| +| |++ #| ||+|| +| + +| + |+|| +|+| Sbjct 445 PDAQDYEGRTPLQCAAYGGYIGCMEVLMENK#ADPNIQDKNGRTALHWSCNNGYLDAVKLL 504 Query 94 V 94 + Sbjct 505 L 505 Query 50 MFGSTAIALELLKQG#ASPNV-QDTSGTSPVHDAARTGFLDTLKVLV 94 + | | || ||++ # |||+ |+ | +|+| ||+ ||++||+ Sbjct 260 LLGHTPIAHLLLERN#NSPNIPSDSQGATPLHYAAQGNCPDTVRVLL 305 Query 36 DALNRFGKTALQVMMFGST-AIALELLKQG#ASPNVQDTSGTSPVHDAARTG 85 | ++ |+| | + | + | ||| |#| | | || + +| ||+|| Sbjct 38 DQEDQLGRTPLMYSVLGDRRSCAEALLKHG#AKVNRPDRSGRTALHLAAQTG 88 |
| Apis mellifera | Query 39 NRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +|+||| | + | + || ||#| | | +| +|+| ||| |+|| +|+|| Sbjct 1025 DRYGKTGLHIAATHGHYQMVEVLLGQG#AEINATDKNGWTPLHCAARAGYLDVVKLLV 1081 Query 56 IALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDT 89 || ||| |#| ||+ | +||| || | | | Sbjct 468 CALMLLKSG#AGPNLTTDDGQTPVHVAASHGNLAT 501 |
| Caenorhabditis elegans | Query 36 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +| | | | | | |+ | + ||+||#|+|+|+ | +|+| ||| | ++||+ Sbjct 419 EATTESGLTPLHVAAFMGAINIVIYLLQQG#ANPDVETVRGETPLHLAARANQTDVVRVLI 478 Query 36 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || | | ||| + + | + | |++ |#|+ ||| +| +|++ ||+ + +| |+ Sbjct 93 DAATRKGNTALHIASLAGQSLIVTILVENG#ANVNVQSVNGFTPLYMAAQENHEEVVKYLL 152 Query 60 LLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 ||+ |#|||| | +| +|+ | | |++ ++ | Sbjct 774 LLENG#ASPNEQTATGQTPLSIAQRLGYVSVVETL 807 |
| synthetic construct | Query 36 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +|++ +| | | + + | | ||| |#| | +| | +|+| || | |+ ++||+ Sbjct 41 NAMDYYGSTPLHLAAYNGHLEIVEVLLKNG#ADVNAKDFQGETPLHLAANNGHLEIVEVLL 100 Query 41 FGKTALQVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || |+ | |+ |#| | | |++|+| || | |+ ++||+ Sbjct 14 LGKKLLEAARAGQDDEVRILMANG#ADVNAMDYYGSTPLHLAAYNGHLEIVEVLL 67 |
| Treponema denticola ATCC 35405 | Query 35 PDALNRFGKTALQVMMFGSTAIAL--ELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTL 90 |++ | | ||| ++| ++ | ||+ |#|+||++| | +|+| ||| | | + Sbjct 307 PNSRNSSGNTALHLVMPEASRSKLFNELITAG#ANPNLKDNYGETPLHVAARIGMNDDI 364 Query 44 TALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVH----DAARTGFLDTL 90 ||+| ++ |+| |+ ||+ |#| || +++|| + +| +|+|+ + | Sbjct 283 TAMQEAVYNGNTEAAILLLQAG#ADPNSRNSSGNTALHLVMPEASRSKLFNEL 334 |
| Caenorhabditis briggsae AF16 | Query 36 DALNRFGKTALQVMMF-GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 +| | | | | | |+ | + ||+||#|+|+|+ | +|+| ||| | ++||+ Sbjct 420 EATTESGLTPLHVAAFMGAINIVIYLLQQG#ANPDVETVRGETPLHLAARANQTDVVRVLI 479 Query 36 DALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 || | | ||| + + | + | |++ |#|+ ||| +| +|++ ||+ | ++ |+ Sbjct 94 DAATRKGNTALHIASLAGQSLIVTILVENG#ANVNVQSVNGFTPLYMAAQENHEDVVRYLL 153 Query 35 PDALNRFGKTALQVM-MFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 || ++ | | | + +| + || +|#|+ | | ||+| | + | ++ || Sbjct 221 PDVTSKSGFTPLHIAAHYGHENVGTLLLDKG#ANVNYQARHNISPLHVATKWGRINMANVL 280 Query 94 V 94 + Sbjct 281 L 281 Query 47 QVMMFGSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 | | ||+ |#|||| | +| +|+ | | |++ ++ | Sbjct 762 QAAQQGHNNCVRYLLENG#ASPNEQTATGQTPLAIAQRLGYVSVVETL 808 |
| Hemicentrotus pulcherrimus | Query 35 PDALNRFGKTALQVMMFGSTAIALELL-KQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVL 93 |+ + |+| || +| + || + |#| ||+|| | + +| | ||+|| ++| Sbjct 499 PNVQDNAGRTPLQCAAYGGFIRCMTLLLEHG#ADPNLQDNEGMTALHWACSTGYLDATRLL 558 Query 94 V 94 + Sbjct 559 L 559 Query 52 GSTAIALELLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLKVLV 94 | | + |+ # |||||| +| +|+ || ||+ + +|+ Sbjct 484 GHTCVCYHLMTHD#ISPNVQDNAGRTPLQCAAYGGFIRCMTLLL 526 Query 36 DALNRFGKTALQVMMFGSTAIALE----LLKQG#ASPNVQDTSGTSPVHDAARTGFLDTLK 91 | ++||+| | || | |+ |+|+|#|+ + +| | + +| | | | Sbjct 92 DQADQFGRTPL---MFAVLADRLDCAEVLIKKG#ANVDAKDNGGRTALHWATYKGVFRLCK 148 Query 92 VLV 94 +|| Sbjct 149 LLV 151 |
[Site 5] DGTGALPIHL113-AVQEGHTAVV
Leu113 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Asp104 | Gly105 | Thr106 | Gly107 | Ala108 | Leu109 | Pro110 | Ile111 | His112 | Leu113 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala114 | Val115 | Gln116 | Glu117 | Gly118 | His119 | Thr120 | Ala121 | Val122 | Val123 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| TGFLDTLKVLVEHGADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 121.00 | 16 | A Chain A, Structure Of Cdk Inhibitor P19ink4d |
| 2 | Homo sapiens | 121.00 | 9 | cyclin-dependent kinase inhibitor 2D |
| 3 | synthetic construct | 121.00 | 2 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Canis familiaris | 113.00 | 7 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 5 | Bos taurus | 109.00 | 4 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 6 | Mus musculus | 100.00 | 14 | cyclin-dependent kinase inhibitor 2D |
| 7 | Rattus norvegicus | 100.00 | 3 | similar to cyclin-dependent kinase inhibitor 2D |
| 8 | Takifugu rubripes | 77.40 | 1 | p19 |
| 9 | Tetraodon nigroviridis | 60.10 | 3 | unnamed protein product |
| 10 | Danio rerio | 56.60 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 11 | Caenorhabditis elegans | 47.40 | 1 | TRPA cation channel homolog family member (trpa-1 |
| 12 | Plasmodium berghei strain ANKA | 47.40 | 1 | hypothetical protein PB000903.01.0 |
| 13 | Plasmodium falciparum 3D7 | 47.40 | 1 | hypothetical protein PF11_0197 |
| 14 | synthetic construct | 43.90 | 6 | ankyrin repeat protein E4_8 |
| 15 | Strongylocentrotus purpuratus | 33.50 | 3 | PREDICTED: similar to ankyrin 2,3/unc44 |
| 16 | Wolbachia endosymbiont of Drosophila ananassae | 32.70 | 1 | ankyrin repeat domain protein |
| 17 | Arabidopsis thaliana | 31.20 | 3 | SPIK (SHAKER POLLEN INWARD K+ CHANNEL); cyclic nu |
| 18 | Xiphophorus maculatus | 31.20 | 1 | 13CDKN2X protein |
| 19 | Xiphophorus helleri | 30.80 | 1 | p13CDKN2X |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |
| Homo sapiens | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |
| synthetic construct | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |
| Canis familiaris | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |||||||||||||||||| |||||||||||#||+||||||||||| ||||| ||||||||| Sbjct 84 TGFLDTLKVLVEHGADVNAPDGTGALPIHL#AVREGHTAVVSFLATESDLHHRDARGLTPL 143 |
| Bos taurus | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |||||||||||||||||| |||||||||||#||+||||+|||||| ||||| ||| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNAPDGTGALPIHL#AVREGHTSVVSFLATESDLHHRDATGLTPL 143 |
| Mus musculus | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |||||||||||||||||| | ||+|||||#|++|||++|||||| ||||| ||| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNALDSTGSLPIHL#AIREGHSSVVSFLAPESDLHHRDASGLTPL 143 |
| Rattus norvegicus | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 |||||||||||||||||| | ||+|||||#|++|||++|||||| ||||| +|| ||||| Sbjct 84 TGFLDTLKVLVEHGADVNTLDSTGSLPIHL#AIREGHSSVVSFLAPESDLHHKDASGLTPL 143 |
| Takifugu rubripes | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLT 141 |||||||+||||+|| ||+|| +||||||+#|++||| || ||| ||| + | | Sbjct 84 TGFLDTLQVLVEYGASVNLPDQSGALPIHI#AIREGHRDVVEFLAPRSDLKHANKSGQT 141 |
| Tetraodon nigroviridis | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPI-HL#AVQEGHTAVVSFLA 127 |||||||+||||+|| ||+|| +||||| | # ++|| || ||| Sbjct 84 TGFLDTLQVLVEYGASVNLPDQSGALPIPHC#QSEKGHRDVVEFLA 128 |
| Danio rerio | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE--SDLHRRDARGLTP 142 |+|||| || ++|||||+ | | ||+||#| +||| || || + +|+| || Sbjct 83 GYLDTLHVLAQNGADVNLLDNDGNLPLHL#AAREGHLDVVQFLVTHCVTQPFLANAKGYTP 142 |
| Caenorhabditis elegans | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAES--DLHRRDARGLTP 142 |||+ || ||| | + | + |+|+|+#| | |||+| | ++ | +|||| Sbjct 305 GFLEVLKALVEAGGNKNELNEVKAVPLHV#AAQMNQLEVVSYLIEEEKDNIDVVDEQGLTP 364 Query 143 L 143 | Query 143 L 143 |
| Plasmodium berghei strain ANKA | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLT 141 |||| +| |++ ||++| | | +|+#| | ++ || | ++|+++| ||| Sbjct 251 GFLDIVKFLIKAGANINEEDSLGDSVLHI#AAYSGKMEIIKFLINAGVNIHKKNAEGLT 308 |
| Plasmodium falciparum 3D7 | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL-AAESDLHRRDARGLT 141 |++| +| || ||++|| | | |+|+#| || || + +|+++ ++ ||| Sbjct 306 GYIDIVKYLVNQGANINVEDSYGDTPLHM#AAYSEKLNVVDFLKSVGADINKTNSEGLT 363 |
| synthetic construct | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 143 | |+ ++||+++||||| | | |+||#| || +| | +|++ | |+||| Sbjct 91 GHLEIVEVLLKNGADVNAIDTIGYTPLHL#AANNGHLEIVEVLLKNGADVNAHDTNGVTPL 150 Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 143 | |+ ++||+++||||| | || |+||#| || +| | +|++ | | ||| Sbjct 58 GHLEIVEVLLKNGADVNADDVTGFTPLHL#AAVWGHLEIVEVLLKNGADVNAIDTIGYTPL 117 Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVS-FLAAESDLHRRDARGLTP 142 | |+ ++||+++||||| | | |+||#| ||| +| | +|++ +| | | Sbjct 123 NGHLEIVEVLLKNGADVNAHDTNGVTPLHL#AAHEGHLEIVEVLLKYGADVNAQDKFGKTA 182 Query 143 L 143 Sbjct 183 F 183 Query 88 DTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 143 | +++|+ +||||| | | |+||#| || +| | +|++ | | ||| Sbjct 28 DEVRILMANGADVNARDRDGNTPLHL#AADMGHLEIVEVLLKNGADVNADDVTGFTPL 84 |
| Strongylocentrotus purpuratus | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTP 142 +| +|++| |||| | | |+|+#| +||| +| || |+ |++|+ |+|| Sbjct 67 SGHASIVKLVVSKGADVEGIDDDGLTPLHV#ACREGHLEIVQFLFAKGGDINRQTFDGMTP 126 Query 143 L 143 | Query 143 L 143 Query 87 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTPL 143 || +| |+ |||+| | | |+|+#| | ++ +| ++ +|| + + | | | Sbjct 202 LDVIKSLLSAGADLNWLDKDGTTPLHV#ACYNYRTQILKYLLSKGADLQKAELDGTTSL 259 Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAES-DLHRRDARGLTPL 143 | |+ ++ | | |+| | |+ +#| + || |+ +| ++ ++ | | +| || Sbjct 101 GHLEIVQFLFAKGGDINRQTFDGMTPLAM#ATKRGHVEVLKYLISKGVEIERSDKKGCPPL 160 Query 97 GADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRR 135 | || || | |+|+#| | |+++ | + |+| Sbjct 272 GELVNRPDARGETPLHV#ATSNGFTSIIDILVSRGGSHQR 310 |
| Wolbachia endosymbiont of Drosophila ananassae | Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAESDLHRRDARGLTPL 143 | | +| |+|| || || | |+| #|+ || | + ++ +| | ||| Sbjct 35 GDLVGVKSLLEHEADFNVVDNENRNPLHY#AIMHGHKKVAKLFVNQLTINSKDKNGFTPL 93 Query 93 LVEHGADVNVPDGTGALPIHL#AVQEGH-TAVVSFLAAESDLHRRDARGLTPL 143 |||+| |+| | +| +| # +|| | | | |+| + | || Sbjct 10 LVENGFDINSKDASGITLLHK#FTKEGDLVGVKSLLEHEADFNVVDNENRNPL 61 |
| Arabidopsis thaliana | Query 87 LDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLAAE-SDLHRRDARGLTP 142 || || ++++| || +||| | +| #|| ||| +| || + +|| |+ | || Sbjct 654 LDALKDIIKYGGDVTLPDGNGTTALHR#AVSEGHLEIVKFLLDQGADLDWPDSYGWTP 710 Query 92 VLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFLA 127 +|+||||| |+ | | +|+ #|+ | + || Sbjct 595 LLLEHGADPNIRDSEGNVPLWE#AIIGRHREIAKLLA 630 Query 85 GFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL 126 | |+ +| |++ |||++ || | | |#| +|+ + + Sbjct 685 GHLEIVKFLLDQGADLDWPDSYGWTPRGL#ADHQGNEEIKTLF 726 |
| Xiphophorus maculatus | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL 126 ||||||+++||+ ||| | ||| |#| | ||| ||+ | Sbjct 79 TGFLDTVQLLVKAGADPQARDKDNCLPIDL#ARQNGHTDVVAVL 121 Query 85 GFLDTLKVLVEHGADVNVPD-GTGALPIHL#AVQEGHTAVVSFL-AAESDLHRRDARGLTP 142 | + ++|+ ||| || | ||| |+| #| + | | | | +| || | Sbjct 46 GSSEVARLLLTRGADPNVTDKSTGATPLHD#AARTGFLDTVQLLVKAGADPQARDKDNCLP 105 Query 143 L 143 + Sbjct 106 I 106 |
| Xiphophorus helleri | Query 84 TGFLDTLKVLVEHGADVNVPDGTGALPIHL#AVQEGHTAVVSFL 126 ||||||+++||| ||| | ||| |#| | ||| ||+ | Sbjct 79 TGFLDTVQLLVEAGADPQARDKDNCLPIDL#ARQNGHTDVVAVL 121 Query 85 GFLDTLKVLVEHGADVNVPD-GTGALPIHL#AVQEGHTAVVSFLA-AESDLHRRDARGLTP 142 | + ++|+ ||| || | ||| |+| #| + | | | | +| || | Sbjct 46 GSSEVARLLLTRGADPNVTDKSTGATPLHD#AARTGFLDTVQLLVEAGADPQARDKDNCLP 105 Query 143 L 143 + Sbjct 106 I 106 |
[Site 6] GHTAVVSFLA127-AESDLHRRDA
Ala127 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly118 | His119 | Thr120 | Ala121 | Val122 | Val123 | Ser124 | Phe125 | Leu126 | Ala127 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala128 | Glu129 | Ser130 | Asp131 | Leu132 | His133 | Arg134 | Arg135 | Asp136 | Ala137 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| ADVNVPDGTGALPIHLAVQEGHTAVVSFLAAESDLHRRDARGLTPLELALQRGAQDLVDI |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 119.00 | 14 | p19 protein |
| 2 | Homo sapiens | 119.00 | 10 | cyclin-dependent kinase inhibitor 2D |
| 3 | synthetic construct | 119.00 | 2 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 4 | Canis familiaris | 102.00 | 9 | PREDICTED: similar to Cyclin-dependent kinase 4 i |
| 5 | Bos taurus | 100.00 | 2 | cyclin-dependent kinase inhibitor 2D (p19, inhibi |
| 6 | Mus musculus | 94.70 | 15 | unnamed protein product |
| 7 | Rattus norvegicus | 94.00 | 4 | similar to cyclin-dependent kinase inhibitor 2D |
| 8 | Takifugu rubripes | 56.60 | 1 | p19 |
| 9 | Drosophila pseudoobscura | 48.90 | 1 | GA19105-PA |
| 10 | Drosophila melanogaster | 48.90 | 1 | ANKTM1 |
| 11 | Arabidopsis thaliana | 46.60 | 3 | AKT6_ARATH Potassium channel AKT6 (Shaker pollen |
| 12 | Tetraodon nigroviridis | 45.80 | 3 | unnamed protein product |
| 13 | synthetic construct | 44.30 | 7 | ankyrin repeat protein mbp3_16 |
| 14 | Wolbachia endosymbiont of Drosophila melanogaster | 43.90 | 2 | ankyrin repeat domain protein |
| 15 | Wolbachia endosymbiont of Drosophila ananassae | 43.90 | 1 | ankyrin repeat domain protein |
| 16 | Egeria densa | 43.90 | 1 | inward potassium channel alpha subunit |
| 17 | Gallus gallus | 43.90 | 1 | mindbomb homolog 2 |
| 18 | Danio rerio | 43.10 | 1 | PREDICTED: similar to Chain A, Structure Of P18in |
| 19 | Paramecium bursaria Chlorella virus 1 | 43.10 | 1 | hypothetical protein PBCV1_A8L |
| 20 | Xenopus tropicalis | 40.80 | 1 | HECT domain and ankyrin repeat containing, E3 ubi |
| 21 | Wolbachia pipientis | 33.90 | 2 | ankyrin domain protein |
| 22 | Wolbachia endosymbiont of Drosophila simulans | 33.90 | 1 | ankyrin repeat domain protein |
| 23 | Aspergillus nidulans FGSC A4 | 33.10 | 1 | hypothetical protein AN8767.2 |
| 24 | Strongylocentrotus purpuratus | 32.30 | 3 | PREDICTED: similar to ankyrin 2,3/unc44, partial |
| 25 | Xenopus laevis | 32.30 | 1 | putative transient receptor potential channel |
| 26 | Geobacter metallireducens GS-15 | 32.30 | 1 | Ankyrin |
| 27 | Caenorhabditis elegans | 31.60 | 1 | TRP (transient receptor potential) channel family |
| 28 | Caenorhabditis briggsae AF16 | 30.80 | 1 | Hypothetical protein CBG13617 |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |
| Homo sapiens | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |
| synthetic construct | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |
| Canis familiaris | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| |||||||||||||+|||||||||||# ||||| |||||||||||| |||||+|| Sbjct 98 ADVNAPDGTGALPIHLAVREGHTAVVSFLA#TESDLHHRDARGLTPLELAQGIGAQDLMDI 157 |
| Bos taurus | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| |||||||||||||+||||+||||||# ||||| ||| |||||||| ||||+|+|| Sbjct 98 ADVNAPDGTGALPIHLAVREGHTSVVSFLA#TESDLHHRDATGLTPLELARGRGAQELMDI 157 |
| Mus musculus | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | ||+||||||++|||++||||||# ||||| ||| |||||||| |||||+|+|| Sbjct 77 ADVNALDSTGSLPIHLAIREGHSSVVSFLA#PESDLHHRDASGLTPLELARQRGAQNLMDI 136 |
| Rattus norvegicus | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | ||+||||||++|||++||||||# ||||| +|| |||||||| |||||+|+|| Sbjct 98 ADVNTLDSTGSLPIHLAIREGHSSVVSFLA#PESDLHHKDASGLTPLELARQRGAQNLMDI 157 |
| Takifugu rubripes | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 | ||+|| +||||||+|++||| || |||# ||| + | | ++| |++|+ Sbjct 98 ASVNLPDQSGALPIHIAIREGHRDVVEFLA#PRSDLKHANKSGQTAADVARASRVPDMMDL 157 |
| Drosophila pseudoobscura | Query 100 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +| || | |+|++ |+||| || | # | || | ||+|| | + +++ Sbjct 519 INESDGAGMTPLHISSQQGHTRVVQLLL#NRGALLHRDHTGRNPLQLAAMSGYTETIEL 576 |
| Drosophila melanogaster | Query 100 VNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +| || | |+|++ |+||| || | # | || | ||+|| | + +++ Sbjct 506 INESDGAGMTPLHISSQQGHTRVVQLLL#NRGALLHRDHTGRNPLQLAAMSGYTETIEL 563 |
| Arabidopsis thaliana | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDL 154 || +||| | +| || ||| +| || # + +|| |+ | || || +| +++ Sbjct 665 GDVTLPDGNGTTALHRAVSEGHLEIVKFLL#DQGADLDWPDSYGWTPRGLADHQGNEEI 722 |
| Tetraodon nigroviridis | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDL-HRRDARGLTPLELALQRGAQDLV 155 || |+ | | ||+||| +||| || | # ++ |+ +| | |+|| +|| | | Sbjct 95 ADANMADRRGNLPLHLAAEEGHPEVVRLLM#EHTENPQSRNKQGATALQLAGRRGRVDTV 153 |
| synthetic construct | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | || |+||| + |+ +| | # +|++ +| | | ++++ | +|| + Sbjct 71 ADVNASDATGDTPLHLAAKWGYLGIVEVLLK#YGADVNAQDKFGKTAFDISIDNGNEDLAE 130 Query 157 I 157 | Query 157 I 157 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | | |+||| || +| | # +|++ || | ||| || + | +|+ Sbjct 38 ADVNAMDNFGVTPLHLAAYWGHFEIVEVLLK#YGADVNASDATGDTPLHLAAKWGYLGIVE 97 Query 157 I 157 + Sbjct 98 V 98 |
| Wolbachia endosymbiont of Drosophila melanogaster | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 |
| Wolbachia endosymbiont of Drosophila ananassae | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 |
| Egeria densa | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDL 154 ||+|+| +|+ +| || +|+ +|||| # +| | | | || | | |+| |+ Sbjct 544 ADINLPKRSGSTALHSAVCDGNVEIVSFLL#QHGADPDRPDINGWTPREYADQQGHHDI 601 |
| Gallus gallus | Query 99 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQR 149 |||| + |+|||+ +|| +| | #+| ||++ | | | + +||+| Sbjct 658 DVNVKNNRNQTPLHLAIIQGHVGLVQLLV#SEGSDVNAEDEDGDTAMHIALER 709 |
| Danio rerio | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE--SDLHRRDARGLTPLELAL 147 ||||+ | | ||+||| +||| || || # + +|+| || +|| Sbjct 96 ADVNLLDNDGNLPLHLAAREGHLDVVQFLV#THCVTQPFLANAKGYTPRDLAF 147 |
| Paramecium bursaria Chlorella virus 1 | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA-#AESDLHRRDARGLTPLELALQRGAQDLV 155 |++|| | | |+|+|+ | || | #| ++|+ | || ||+ +| | | Sbjct 57 ANLNVRDDEGRTPLHIAIIEWHTICFKLLVN#AGANLNVGKKYGFAPLHLAITKGCTDYV 115 |
| Xenopus tropicalis | Query 99 DVNVPDGTGALPIHLAVQEGH-TAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +|+| | | +|+| | || | |+ | #+ +|++| + | ||| | | +| | Sbjct 156 NVDVEDAMGQTALHVACQNGHKTTVLCLLD#SGADINRPNVSGATPLYFACSHGQRDTAQI 215 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 ||+| |+ +|| |++ | | | # + | |+|||+| +| | + || Sbjct 188 ADINRPNVSGATPLYFACSHGQRDTAQILL#LRGAKYLPDKNGVTPLDLCVQGGYGETCDI 247 |
| Wolbachia pipientis | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 30 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 88 Query 110 PIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |+ |||++||| +| | # ++++ + +| || ||+|+ |+ + Sbjct 289 PLLLAVKKGHTQIVKMLLE#VRANMNICEQQGFAPLHLAVQKDYFDIAQL 337 |
| Wolbachia endosymbiont of Drosophila simulans | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 || || | |+| |+ || | # + ++ +| | ||| || + +|+| Sbjct 48 ADFNVVDNENRNPLHYAIMHGHKKVAKLFV#NQLTINSKDKNGFTPLHLAALQDDTELID 106 Query 110 PIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |+ |||++||| +| | # ++++ + +| || ||+|+ |+ + Sbjct 307 PLLLAVKKGHTQIVKMLLE#VRANMNICEQQGFAPLHLAVQKDYFDIAQL 355 |
| Aspergillus nidulans FGSC A4 | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 ||||+|| | |+ ||+ || ||| | # |+ + | | ||| |+ +| |++| Sbjct 106 ADVNIPDSKGQTPLSWAVENGHQAVVQLLL#GHGSNPNTPDPGGQTPLSCAVSKGNQEIVK 165 Query 157 I 157 + Sbjct 166 L 166 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRD--ARGLTPLELALQRGAQDLV 155 ++ | || | |+ || +|+ +| | #+ ||| ||||| |+ | +++| Sbjct 139 SNPNTPDPGGQTPLSCAVSKGNQEIVKLLL#SSSDLECNTPHPNGLTPLCWAVNEGQEEIV 198 Query 156 DI 157 + Sbjct 199 QL 200 Query 99 DVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDL--HRRDARGLTPLELALQRGAQDLV 155 + | | | |+ || || +| | # ||+ ++ | | || |+++ + +| Sbjct 174 ECNTPHPNGLTPLCWAVNEGQEEIVQLLL#DRSDVDPNKPDTDGYAPLSRAVEKNSLAMV 232 |
| Strongylocentrotus purpuratus | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRG 150 |||| | | +|+| | +|+ |+ +| # + ||+++ || | || |+| | Sbjct 556 ADVNEKDEEGEIPLHGAANDGNVEVIKYLI#QQGSDVNKMDAEGWTPFNAAVQEG 609 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRG 150 |||| | +|+| | ||| |+ +| # + || ++ || | || |+| | Sbjct 944 ADVNEEHDKGMIPLHGAACEGHLEVMEYLI#QQGSDTNKCDAEGWTPFNAAVQYG 997 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRG 150 |||| | +|+| | ||| |+ +| # + || ++ || | || |+| | Sbjct 653 ADVNEEDDRRKIPLHGAACEGHLEVMEYLI#QQGSDTNKCDAEGWTPFNAAVQYG 706 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRG 150 |||| | | +|+| | +|+ |+++| # + || ++ || | || |+| | Sbjct 459 ADVNEEDEEGEIPLHGAAIDGNVEVMAYLI#QQGSDTNKCDADGWTPFNAAIQYG 512 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | +|+| | || |+ +| # + +|++++| | ||| |+ | ++| Sbjct 1332 ADVNEEHDKGMIPLHGAAHRGHLEVMEYLI#QQGADVNKKDNTGWTPLHAAVSNGHLEVVK 1391 Query 157 I 157 + Sbjct 1392 V 1392 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRG 150 |||| | | +|+| | || |+ +| # + |++++ ++ | || |+| | Sbjct 264 ADVNEEDEKGEIPLHGAASGGHLEVMKYLI#QQGSNVNKANSEGWTPFNAAVQYG 317 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +||| | | | + ||||| | +| # + |+ |+||| | | | |+| Sbjct 589 SDVNKMDAEGWTPFNAAVQEGQLEAVKYLM#TKGAKQNRN-DGMTPLYAAAQSGRLDIVKF 647 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 | ||| | | |+ | |||| || |||# + +| | || ||+ | | + |+ Sbjct 1448 AHVNVQDDEGWTPLEAAAQEGHEDVVDFLA#LDGADTDVNDIDGLAPLQAAANAGHPNAVE 1507 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | | + ||| || | +| # + | |+||| | | | |+| Sbjct 880 ADVNKADAKGGTSFNAAVQGGHLEAVEYLM#TKGAKQNR-YDGMTPLYAAAQSGCLDIVKF 938 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | | + ||| || | +| # + | |+||| | | | |+| Sbjct 1074 ADVNKADAKGGTSFNAAVQGGHLEAVEYLM#TKGAKQNR-YDGMTPLYAAAQSGCLDIVKF 1132 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | | + ||| || | +| # + | |+||| | | | |+| Sbjct 1268 ADVNKADAKGGTSFNAAVQGGHLEAVEYLM#TKGAKQNR-YDGMTPLYAAAQSGCLDIVKF 1326 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +| | | | | + ||| || | +| # + | | |+||| | | | |+| Sbjct 686 SDTNKCDAEGWTPFNAAVQYGHLESVKYLI#TKGAKRNRYA-GMTPLYAAAQSGHLDIVKF 744 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +| | | | | + ||| || | +| # + | | |+||| | | | |+| Sbjct 977 SDTNKCDAEGWTPFNAAVQYGHLESVKYLI#TKGAKRNRYA-GMTPLYAAAQSGHLDIVKF 1035 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 |||| | | + ||| || | +| # + | |+||| | | | |+| Sbjct 1171 ADVNKADAKGGTSFNAAVQGGHLEAVEYLM#TKGAKQNR-FDGMTPLYAAAQSGCLDIVKF 1229 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | +|+| | || |+ +| # + +|+++ ||+| | |+| | + |+ Sbjct 1235 ADVNEEHDKGMIPLHGAAHRGHLEVMEYLI#QQGADVNKADAKGGTSFNAAVQGGHLEAVE 1294 Query 157 I 157 Sbjct 1295 Y 1295 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 +||| | | + ||| || | +| # + | |+||| | | | |+| Sbjct 783 SDVNKADAKGGTSFNAAVQGGHLEAVEYLM#TKGAKQNR-YDGMTPLYAAAQSGCLDIVKF 841 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 | || | | | + ||| || | +| # + | | | ||| | | | |+| Sbjct 200 AYVNKADSKGCTPFNAAVQYGHLEAVEYLM#TKGAKQNRYA-GRTPLYAAAQLGHLDIVKF 258 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AES------------------DLHRRDARG 139 |||| | || |+| || || || | #|+ |++ |+ | Sbjct 1365 ADVNKKDNTGWTPLHAAVSNGHLEVVKVLL#AKGAQGTMFEGLTLVLVSNGFDVNERNECG 1424 Query 140 LTPLELALQRGAQDLVDI 157 +|| | |++ + Sbjct 1425 KSPLHAGCYNGNIDILKL 1442 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLVDI 157 ++|| + | | + ||| || | +| # + | |+||| | | | ++| Sbjct 297 SNVNKANSEGWTPFNAAVQYGHLEAVKYLM#TKGATQNR-YNGMTPLYAAAQSGHLNIVQF 355 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLV 155 +| | | | | + |+| || | +| # + | | | ||| | | | |+| Sbjct 492 SDTNKCDADGWTPFNAAIQYGHLESVKYLI#TKGAKQNRYA-GRTPLYAAAQLGHLDIV 548 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | | +|+ | | |+ +| # + ||+++ ||+| | |+| | + |+ Sbjct 750 ADVNEEDEEGMIPLRGAAAGGQLEVMEYLI#QQGSDVNKADAKGGTSFNAAVQGGHLEAVE 809 Query 157 I 157 Sbjct 810 Y 810 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 |||| | | +|+ | | |+ +| # + +|+++ ||+| | |+| | + |+ Sbjct 1041 ADVNEEDEEGMIPLRGAAAGGQLEVMEYLI#QQGADVNKADAKGGTSFNAAVQGGHLEAVE 1100 Query 157 I 157 Sbjct 1101 Y 1101 Query 107 GALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 157 | |++ | | || +| | #+| +|++ | |+ || | | ++++ Sbjct 726 GMTPLYAAAQSGHLDIVKFFI#SEGADVNEEDEEGMIPLRGAAAGGQLEVMEY 777 Query 107 GALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 157 | |++ | | || +| | #+| +|++ | |+ || | | ++++ Sbjct 1017 GMTPLYAAAQSGHLDIVKFFI#SEGADVNEEDEEGMIPLRGAAAGGQLEVMEY 1068 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVD 156 |||| +|+| | | |+ +| # + +|+++ ||+| | |+| | + |+ Sbjct 1138 ADVNEEHARRMIPLHGAAHRGQLEVMEYLI#QQGADVNKADAKGGTSFNAAVQGGHLEAVE 1197 Query 157 I 157 Sbjct 1198 Y 1198 |
| Xenopus laevis | Query 107 GALPIHLAVQEGHTAVVSFLA#AE--SDLHRRDARGLTPLELALQRGAQDLV 155 |+ ||||| | |||||| | #++ | || +| || | | || | +++ Sbjct 857 GSTPIHLAAQNGHTAVVGLLL#SKSTSQLHMKDKRGRTCLHLAAANGHIEMM 907 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFL---A#AESDLHRRDARGLTPLELALQRGAQDL 154 |++|| | | |+| | + | | || #| | +| | | ++ | + ||+ Sbjct 915 AEINVTDKNGWCPLHFAARSGFLDTVRFLVECG#ANPTLECKD--GKTAIQYAAAKNHQDV 972 Query 155 VDI 157 | Sbjct 973 VSF 975 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 | |+| | | +||| + || + | # ++ ++ + ||||| | | | || Sbjct 528 ARVDVFDEHGKAALHLAAENGHDKIADILLK#HKAFVNAKTKLGLTPLHLCAQNGFNHLVK 587 Query 157 I 157 + Sbjct 588 L 588 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFL-A#AESDLHRRDARGLTPLELALQRGAQDLVD 156 |+|+ + | |+|+ | ++ || # +++ + | ||| +| +|| ++|+ Sbjct 136 ANVDCQNDEGQTPLHIVAWAGDEMMLKFLHQ#CKTNANITDKMERTPLHVAAERGNTNVVE 195 Query 157 I 157 | Query 157 I 157 |
| Geobacter metallireducens GS-15 | Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRRDARGLTPLELALQRGAQDLVD 156 ||+|+ | |+| || |+ | |||# +| |+ ||||| +|| +|| +|+ Sbjct 218 ADINIAGRYGDTPLHYAVGLGYEEFVRLFLA#RGADPTIRNDRGLTPRQLAEERGFASIVE 277 Query 157 I 157 + Sbjct 278 L 278 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA-#AESDLHRRDARGLTPLELALQRGAQDLV 155 | || +| | |+ || ||| | | #| +|+ ++ ||| | +|| +| Sbjct 119 ARVNAVNGEGNTPLFAAVHEGHDDVARILLD#AGADVTIANSYWYTPLREACRRGNTGMV 177 Query 98 ADVNVPDGTGALPIHLAVQ-EGHTAVVSFLA#AESDLHRRDARGLTPLELALQRGAQDLV 155 ||||+ | | |+| || | | | #+ +|++ | ||| |+ | ++ | Sbjct 185 ADVNITDNKGFTPLHAAVSAEALEAATLILD#SGADINIAGRYGDTPLHYAVGLGYEEFV 243 |
| Caenorhabditis elegans | Query 109 LPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLVDI 157 +|+||| |+|| ||| | #+ | | +| || ||| || | | ++| + Sbjct 1194 IPLHLAAQQGHIAVVGMLL#SRSTQQQHAKDWRGRTPLHLAAQNGHYEMVSL 1244 Query 104 DGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 157 | | |+||| | || +|| | #|+ |+++ | | | | | + | +| + Sbjct 1223 DWRGRTPLHLAAQNGHYEMVSLLI#AQGSNINVMDQNGWTGLHFATRAGHLSVVKL 1277 Query 104 DGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRR--DARGLTPLELALQRG 150 || |+|||||| + |+ +| |+# || | | | | | || + | Sbjct 407 DGDGSLPIHLAFKFGNVNIVELLLS#GPSDEQTRKADGNGDTLLHLAARSG 456 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFL 126 | || || |+||| | || ||+ | Sbjct 897 AFVNSKSKTGEAPLHLAAQHGHVKVVNVL 925 |
| Caenorhabditis briggsae AF16 | Query 109 LPIHLAVQEGHTAVVSFLA#AES--DLHRRDARGLTPLELALQRGAQDLVDI 157 +|+||| |+|| ||| | #+ | | +| || ||| || | | ++| + Sbjct 1211 IPLHLAAQQGHIAVVGMLL#SRSTQQQHAKDWRGRTPLHLAAQNGHYEMVSL 1261 Query 104 DGTGALPIHLAVQEGHTAVVSFLA#AE-SDLHRRDARGLTPLELALQRGAQDLVDI 157 | | |+||| | || +|| | #|+ |+++ | | | | | + | +| + Sbjct 1240 DWRGRTPLHLAAQNGHYEMVSLLI#AQGSNINVMDQNGWTGLHFATRAGHLSVVKL 1294 Query 104 DGTGALPIHLAVQEGHTAVVS-FLA#AESDLHRR--DARGLTPLELALQRGAQDLV 155 || |+|||||| + |+ +| |+# || | | | | | || + |+ + | Sbjct 423 DGEGSLPIHLAFKFGNVNIVELLLS#GPSDEQTRKADGNGDTLLHLAARSGSIEAV 477 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFL 126 | || || |+||| | || ||+ | Sbjct 914 AFVNSKSKTGEAPLHLAAQHGHVKVVNVL 942 Query 98 ADVNVPDGTGALPIHLAVQEGHTAVVSFLA#A-ESDLHRRDARGLTPLELALQRGAQDLVD 156 | ++| | | +||| || ++| | # ++ ++ + | || || | | +|+ Sbjct 881 ARIDVFDEMGRTALHLAAFNGHLSIVHLLL#QHKAFVNSKSKTGEAPLHLAAQHGHVKVVN 940 Query 157 I 157 + Sbjct 941 V 941 |
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