logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0092 : Filamin C

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namesfilamin-C isoform a [Homo sapiens]; filamin-C isoform a; actin binding protein 280; ABP-L, gamma filamin; filamin-2; ABP-280-like protein; Filamin-C; FLN-C; FLNc; ABP-L; Actin-binding-like protein; Filamin-2; Gamma-filamin
Gene NamesFLNC; ABPL, FLN2; ABPL; FLN2; filamin C, gamma
Gene Locus7q32-q35; chromosome 7
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001449 NM_001458 2318 Q14315 102565 HGNC:3756 N/A hsa:2318

* Information From OMIM

Description: Filamins, such as FLNC, are a family of actin (see ACTA1; OMIM:102610)-binding proteins involved in reshaping of the cytoskeleton. See FLN1 (FLNA; OMIM:300017) for background information on the filamin gene family.

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* Structure Information

1. Primary Information

Length: 2725 aa

Average Mass: 291.019 kDa

Monoisotopic Mass: 290.841 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CAMSAP CH domain 1. 5611312.00.0
CAMSAP CH domain 2. 17620211.00.0
Bacterial Ig-like domain (group 3) 1. 30835726.00.1
YtkA-like 1. 40945239.00.0
YtkA-like 2. 51454945.00.1
YtkA-like 3. 61164254.00.0
Filamin/ABP280 repeat 1. 6657552.00.0
Bacterial Ig-like domain (group 3) 2. 82684746.00.0
Chagasin family peptidase inhibitor I42 1. 92794653.00.0
Filamin/ABP280 repeat 2. 96510523.00.0
YtkA-like 4. 1123113563.00.0
PapC N-terminal domain 1. 1180121154.00.0
Chagasin family peptidase inhibitor I42 2. 1304133040.00.0
Bacterial Ig-like domain (group 3) 3. 1401142545.00.0
YtkA-like 5. 1489151757.00.0
YtkA-like 6. 1576161442.00.0
Chagasin family peptidase inhibitor I42 3. 1662168752.00.0
Y_Y_Y domain 1. 1703171930.00.0
Filamin/ABP280 repeat 3. 1795185041.00.0
YtkA-like 7. 1900193055.00.0
Filamin/ABP280 repeat 4. 1975203042.00.0
Bacterial Ig-like domain (group 3) 4. 2093211646.00.0
emp24/gp25L/p24 family/GOLD 1. 2244229134.00.0
YtkA-like 8. 2376238864.00.0
Bacterial Ig-like domain (group 3) 5. 2463248548.00.0
Putative Ig domain 1. 2530254417.00.0
Chagasin family peptidase inhibitor I42 4. 2558257853.00.0
--- cleavage 2626 ---
YtkA-like 9. 2680270857.00.2

3. Sequence Information

Fasta Sequence: SB0092.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1V05 (X-ray; 143 A; A=2633-2725), 2D7M (NMR; -; A=1536-1637), 2D7N (NMR; -; A=1782-1861), 2D7O (NMR; -; A=1856-1953), 2D7P (NMR; -; A=2405-2503), 2D7Q (NMR; -; A=2502-2599), 2K9U (NMR; -; A=2302-2415), 2NQC (X-ray; 205 A; A=2495-2598), 3V8O (X-ray; 280 A; A/B=569-761), 4MGX (X-ray; 316 A; A=572-756)

* Cleavage Information

1 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 16297652] Raynaud F, Jond-Necand C, Marcilhac A, Furst D, Benyamin Y, Calpain 1-gamma filamin interaction in muscle cells: a possible in situ regulation by PKC-alpha. Int J Biochem Cell Biol. 2006 Mar;38(3):404-13. Epub 2005 Oct 27.

Cleavage sites (±10aa)

[Site 1] SSSSRGSSYS2626-SIPKFSSDAS

Ser2626 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser2617Ser2618Ser2619Ser2620Arg2621Gly2622Ser2623Ser2624Tyr2625Ser2626
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser2627Ile2628Pro2629Lys2630Phe2631Ser2632Ser2633Asp2634Ala2635Ser2636

Sequence conservation (by blast)

* References

[PubMed ID: 24469451] Sethi R, Seppala J, Tossavainen H, Ylilauri M, Ruskamo S, Pentikainen OT, Pentikainen U, Permi P, Ylanne J, A novel structural unit in the N-terminal region of filamins. J Biol Chem. 2014 Mar 21;289(12):8588-98. doi: 10.1074/jbc.M113.537456. Epub 2014

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