SB0095 : Crystallin, [beta]B3
[ CaMP Format ]
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | beta-crystallin B3 [Rattus norvegicus]; beta-crystallin B3; beta-B3 crystallin; Beta-crystallin B3; Beta-B3 crystallin; Beta-crystallin B3, N-terminally processed |
| Gene Names | Crybb3; crystallin, beta B3 |
| Gene Locus | 12; chromosome 12 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 211 aa
Average Mass: 24.276 kDa
Monoisotopic Mass: 24.261 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 5 --- | ||||
| --- cleavage 15 --- | ||||
| --- cleavage 17 --- | ||||
| Beta/Gamma crystallin 1. | 25 | 106 | 1.0 | 0.0 |
| Phage Conserved Open Reading Frame 51 1. | 145 | 176 | 24.0 | 0.2 |
3. Sequence Information
Fasta Sequence: SB0095.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 8405363] David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.
Cleavage sites (±10aa)
[Site 1] MAEQH5-GAPEQAAANK
His5 
Gly
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| - | - | - | - | - | Met1 | Ala2 | Glu3 | Gln4 | His5 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly6 | Ala7 | Pro8 | Glu9 | Gln10 | Ala11 | Ala12 | Ala13 | Asn14 | Lys15 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MAEQHGAPEQAAANKSHGGLGGSYKVTVYELENFQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 73.60 | 2 | crystallin, beta B3 |
| 2 | Rattus norvegicus | 72.00 | 1 | AF287304_1 betaB3-crystallin |
| 3 | Mus musculus | 71.60 | 1 | crystallin, beta B3 |
| 4 | Homo sapiens | 66.60 | 4 | betaB3 crystallin |
| 5 | Ovis aries | 66.60 | 1 | crystallin, beta B3 |
| 6 | Bos taurus | 65.10 | 1 | crystallin, beta B3 |
| 7 | Tetraodon nigroviridis | 47.40 | 1 | unnamed protein product |
| 8 | Danio rerio | 45.40 | 1 | beta B3-crystallin |
| 9 | Gallus gallus | 43.90 | 1 | crystallin, beta B3 |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||#|||||||||||||||||||||||||||||| Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |
| Rattus norvegicus | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||#||||||||+||||||||||||||||||||| Sbjct 1 MAEQH#GAPEQAAASKSHGGLGGSYKVTVYELENFQ 35 |
| Mus musculus | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||#|||||||| ||||||||||||||||||||| Sbjct 1 MAEQH#GAPEQAAAGKSHGGLGGSYKVTVYELENFQ 35 |
| Homo sapiens | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||#|||||||| |||| ||||||| +||||||| Sbjct 1 MAEQH#GAPEQAAAGKSHGDLGGSYKVILYELENFQ 35 |
| Ovis aries | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||# ||||||| |||||||||||| |||+|||| Sbjct 1 MAEQH#SAPEQAAAGKSHGGLGGSYKVIVYEMENFQ 35 |
| Bos taurus | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |||||# |||||| |||||||||||| |||+|||| Sbjct 1 MAEQH#STPEQAAAGKSHGGLGGSYKVIVYEMENFQ 35 |
| Tetraodon nigroviridis | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |+|+ # |||| || || || | +||| ++| |||| Sbjct 33 MSERQ#SAPEQLAAGKSQGGAGATYKVLLFEFENFQ 67 |
| Danio rerio | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 |++| #| |+| | || || | |||++|| |||+ Sbjct 1 MSDQQ#GVPDQQVAGKSQGGAGAIYKVSLYEFENFR 35 |
| Gallus gallus | Query 1 MAEQH#GAPEQAAANKSHGGLGGSYKVTVYELENFQ 35 | || # ||| + | ||+||+|+||||||| Sbjct 1 MTEQQ#SPPEQMVTGEGAGERGGNYKITIYELENFQ 35 |
[Site 2] GAPEQAAANK15-SHGGLGGSYK
Lys15 Ser
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly6 | Ala7 | Pro8 | Glu9 | Gln10 | Ala11 | Ala12 | Ala13 | Asn14 | Lys15 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser16 | His17 | Gly18 | Gly19 | Leu20 | Gly21 | Gly22 | Ser23 | Tyr24 | Lys25 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MAEQHGAPEQAAANKSHGGLGGSYKVTVYELENFQGKRCELSAEC |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 95.50 | 8 | crystallin, beta B3 |
| 2 | Mus musculus | 93.60 | 10 | crystallin, beta B3 |
| 3 | Rattus norvegicus | 91.70 | 2 | AF287304_1 betaB3-crystallin |
| 4 | Homo sapiens | 88.20 | 7 | betaB3 crystallin |
| 5 | Ovis aries | 87.40 | 1 | crystallin, beta B3 |
| 6 | Bos taurus | 86.30 | 5 | crystallin, beta B3 |
| 7 | Danio rerio | 62.00 | 8 | beta B3-crystallin |
| 8 | Gallus gallus | 58.20 | 4 | crystallin, beta B3 |
| 9 | Tetraodon nigroviridis | 57.00 | 12 | unnamed protein product |
| 10 | Pan troglodytes | 40.80 | 1 | PREDICTED: crystallin, beta B1 isoform 2 |
| 11 | synthetic construct | 40.80 | 1 | crystallin beta B1 |
| 12 | Xenopus laevis | 40.40 | 3 | crystallin, beta A1 |
| 13 | Xenopus laevis | 40.00 | 2 | hypothetical protein LOC494645 |
| 14 | Canis familiaris | 40.00 | 1 | PREDICTED: similar to crystallin, beta B1 |
| 15 | N/A | 39.30 | 9 | beta-B1-crystallin |
| 16 | Rana catesbeiana | 37.70 | 4 | CRB12_RANCA Beta-crystallin A1-2 gi |
| 17 | Cynops pyrrhogaster | 36.60 | 3 | newt beta B1-crystallin |
| 18 | Canis lupus familiaris | 36.20 | 2 | crystallin, beta A1 |
| 19 | Cavia porcellus | 35.80 | 2 | beta A3-crystallin |
| 20 | Rana temporaria | 35.80 | 2 | CRBA1_RANTE Beta-crystallin A1 gi |
| 21 | Macropus fuliginosus | 35.80 | 1 | CRBA2_MACFL Beta-crystallin A2 (Beta-A2 crystalli |
| 22 | Oryctolagus cuniculus | 35.80 | 1 | beta A3-crystallin |
| 23 | Oryctolagus cuniculus | 35.80 | 1 | beta A1-crystallin |
| 24 | Contains: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form | 35.00 | 1 | CRBA1_BOVIN Beta-crystallin A3 |
| 25 | Xenopus tropicalis | 33.90 | 1 | crystallin, beta B1 |
| 26 | Petenia splendida x Cichlasoma synspilum | 32.70 | 1 | AAA50959.1 |
| 27 | Dicentrarchus labrax | 31.60 | 1 | crystallin beta B1 |
| 28 | Pan troglodytes | 31.60 | 1 | PREDICTED: crystallin, beta A4 |
| 29 | Cyprinus carpio | 31.20 | 1 | CRGM2_CYPCA Gamma-crystallin M2 (Gamma-M2) gi |
| 30 | Clarias fuscus | 31.20 | 1 | CAA57215.1 |
| 31 | Danio rerio | 30.80 | 3 | crystallin, gamma M2b |
| 32 | Iguana iguana | 30.40 | 1 | betaA2-crystallin |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |
| Mus musculus | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 ||||||||||||| |#|||||||||||||||||||||||||||||| Sbjct 1 MAEQHGAPEQAAAGK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |
| Rattus norvegicus | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |||||||||||||+|#|||||||||||||||||||||||||| ||| Sbjct 1 MAEQHGAPEQAAASK#SHGGLGGSYKVTVYELENFQGKRCELLAEC 45 |
| Homo sapiens | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 ||||||||||||| |#||| ||||||| +||||||||||||||||| Sbjct 1 MAEQHGAPEQAAAGK#SHGDLGGSYKVILYELENFQGKRCELSAEC 45 |
| Ovis aries | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 ||||| ||||||| |#||||||||||| |||+||||||||||+||| Sbjct 1 MAEQHSAPEQAAAGK#SHGGLGGSYKVIVYEMENFQGKRCELTAEC 45 |
| Bos taurus | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 ||||| |||||| |#||||||||||| |||+||||||||||+||| Sbjct 1 MAEQHSTPEQAAAGK#SHGGLGGSYKVIVYEMENFQGKRCELTAEC 45 |
| Danio rerio | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |++| | |+| | |#| || | |||++|| |||+||+ |||||| Sbjct 1 MSDQQGVPDQQVAGK#SQGGAGAIYKVSLYEFENFRGKKLELSAEC 45 |
| Gallus gallus | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAE 44 | || ||| +# | ||+||+|+||||||||+||||| | Sbjct 1 MTEQQSPPEQMVTGE#GAGERGGNYKITIYELENFQGRRCELSEE 44 |
| Tetraodon nigroviridis | Query 1 MAEQHGAPEQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 |+|+ |||| || |#| || | +||| ++| ||||| + | |++| Sbjct 33 MSERQSAPEQLAAGK#SQGGAGATYKVLLFEFENFQGCKAEFSSDC 77 |
| Pan troglodytes | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |+|++ |+|||||||+| | | || Sbjct 57 GNYRLVVFELENFQGRRAEFSGEC 80 |
| synthetic construct | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |+|++ |+|||||||+| | | || Sbjct 57 GNYRLVVFELENFQGRRAEFSGEC 80 |
| Xenopus laevis | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 ||+|+|||+ ||||||| | |+ | Sbjct 28 GSWKITVYDQENFQGKRMEFSSSC 51 |
| Xenopus laevis | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 ||+|+|||+ ||||||| | |+ | Sbjct 12 GSWKITVYDQENFQGKRMEFSSSC 35 |
| Canis familiaris | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 ||||+ |+| |||||+| | | || Sbjct 53 GSYKLVVFEQENFQGRRVEFSGEC 76 |
| N/A | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ |+| |||||+| | | || Sbjct 54 GSYRLVVFEQENFQGRRVEFSGEC 77 |
| Rana catesbeiana | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 | +|+|||+ ||||||| | ++ | Sbjct 12 GPWKITVYDQENFQGKRMEFTSSC 35 |
| Cynops pyrrhogaster | Query 2 AEQHGAPEQ---AAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 +++ | | + ||#+ |+||+ ++| |||||+ || || Sbjct 23 SKEKGVPPSVPISKPNK#AGDSSVGTYKIIIFEQENFQGRHLELVNEC 69 |
| Canis lupus familiaris | Query 19 GLGGSYKVTVYELENFQGKRCELSAEC 45 | | +|+|+|+ ||||||| | ++ | Sbjct 26 GSAGPWKITIYDQENFQGKRMEFTSSC 52 |
| Cavia porcellus | Query 9 EQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 + | | # | || +|+|+|+ ||||||| | ++ | Sbjct 17 KMAQTNP#MPGSLG-PWKITIYDQENFQGKRMEFTSSC 52 |
| Rana temporaria | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 | +|+|||+ ||||||| | ++ | Sbjct 12 GPWKITVYDQENFQGKRMEFTSSC 35 |
| Macropus fuliginosus | Query 25 KVTVYELENFQGKRCELSAEC 45 ++|++| |||||+|||| ++| Sbjct 13 RLTLWEEENFQGRRCELMSDC 33 |
| Oryctolagus cuniculus | Query 9 EQAAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 + | | # | || +|+|+|+ ||||||| | ++ | Sbjct 17 KMAQTNP#MPGSLG-PWKITIYDQENFQGKRMEFTSSC 52 |
| Oryctolagus cuniculus | Query 11 AAANK#SHGGLGGSYKVTVYELENFQGKRCELSAEC 45 | | # | || +|+|+|+ ||||||| | ++ | Sbjct 2 AQTNP#MPGSLG-PWKITIYDQENFQGKRMEFTSSC 35 |
| Contains: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 | +|+|+|+ ||||||| | ++ | Sbjct 29 GPWKITIYDQENFQGKRMEFTSSC 52 |
| Xenopus tropicalis | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 ||+|+ ++| |||||+ || || Sbjct 35 GSFKIVLFEQENFQGRHVELLNEC 58 |
| Petenia splendida x Cichlasoma synspilum | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ +|| |||||+ || +| Sbjct 86 GSYRMRIYERENFQGQNHELMNDC 109 |
| Dicentrarchus labrax | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ +++ |||||+ |+ || Sbjct 38 GSYRIMMFDQENFQGRMIEVQNEC 61 |
| Pan troglodytes | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 | +|+ |++ + |||+| | +||| Sbjct 10 GPWKMVVWDEDGFQGRRHEFTAEC 33 |
| Cyprinus carpio | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ +|| ||| |+ |++ +| Sbjct 86 GSYRMRIYERENFMGQMYEMADDC 109 |
| Clarias fuscus | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |+|++ +|| ||| |+ |+| +| Sbjct 88 GAYRMKIYERENFLGQMMEISDDC 111 |
| Danio rerio | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ +|| ||| |+ || +| Sbjct 88 GSYRIKIYERENFGGQMYELMDDC 111 |
| Iguana iguana | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 | +|+||+| |||||+||| || Sbjct 3 GQFKITVWEEENFQGERCEFLMEC 26 Query 25 KVTVYELENFQGKRCELSAE 44 |||+|| |||||++ ||| + Sbjct 99 KVTLYEGENFQGRKFELSDD 118 |
[Site 3] PEQAAANKSH17-GGLGGSYKVT
His17 Gly
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Pro8 | Glu9 | Gln10 | Ala11 | Ala12 | Ala13 | Asn14 | Lys15 | Ser16 | His17 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly18 | Gly19 | Leu20 | Gly21 | Gly22 | Ser23 | Tyr24 | Lys25 | Val26 | Thr27 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MAEQHGAPEQAAANKSHGGLGGSYKVTVYELENFQGKRCELSAECPN |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 100.00 | 10 | crystallin, beta B3 |
| 2 | Mus musculus | 99.00 | 13 | crystallin, beta B3 |
| 3 | Rattus norvegicus | 97.10 | 2 | AF287304_1 betaB3-crystallin |
| 4 | Ovis aries | 92.80 | 1 | crystallin, beta B3 |
| 5 | Homo sapiens | 91.30 | 8 | betaB3 crystallin |
| 6 | Bos taurus | 91.30 | 8 | crystallin, beta B3 |
| 7 | Gallus gallus | 62.80 | 6 | crystallin, beta B3 |
| 8 | Danio rerio | 62.40 | 16 | beta B3-crystallin |
| 9 | Tetraodon nigroviridis | 57.40 | 16 | unnamed protein product |
| 10 | Xenopus laevis | 45.40 | 4 | hypothetical protein LOC494645 |
| 11 | N/A | 43.10 | 21 | beta crystallin subunit beta-A3 |
| 12 | Xenopus laevis | 42.00 | 4 | crystallin, beta A1 |
| 13 | synthetic construct | 42.00 | 1 | crystallin beta B1 |
| 14 | Pan troglodytes | 42.00 | 1 | PREDICTED: crystallin, beta B1 isoform 2 |
| 15 | Canis lupus familiaris | 41.20 | 4 | crystallin, beta A1 |
| 16 | Canis familiaris | 40.80 | 2 | PREDICTED: similar to crystallin, beta B1 |
| 17 | Oryctolagus cuniculus | 40.80 | 1 | beta A3-crystallin |
| 18 | Oryctolagus cuniculus | 40.80 | 1 | beta A1-crystallin |
| 19 | Contains: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form | 40.00 | 1 | CRBA1_BOVIN Beta-crystallin A3 |
| 20 | Rana catesbeiana | 39.30 | 4 | CRB32_RANCA Beta-crystallin A3-2 gi |
| 21 | Rana temporaria | 37.70 | 2 | CRBA1_RANTE Beta-crystallin A1 gi |
| 22 | Cavia porcellus | 37.70 | 2 | beta A3-crystallin |
| 23 | Cynops pyrrhogaster | 36.20 | 4 | newt beta B1-crystallin |
| 24 | Xenopus tropicalis | 35.40 | 1 | crystallin, beta B1 |
| 25 | Pan troglodytes | 34.70 | 1 | PREDICTED: crystallin, beta A4 |
| 26 | Petenia splendida x Cichlasoma synspilum | 34.70 | 1 | AAA50959.1 |
| 27 | Iguana iguana | 33.50 | 1 | betaA2-crystallin |
| 28 | Danio rerio | 33.10 | 4 | crystallin, gamma M2b |
| 29 | Macropus fuliginosus | 33.10 | 1 | CRBA2_MACFL Beta-crystallin A2 (Beta-A2 crystalli |
| 30 | Dicentrarchus labrax | 32.30 | 1 | crystallin beta B1 |
| 31 | Cyprinus carpio | 31.20 | 1 | CRGM2_CYPCA Gamma-crystallin M2 (Gamma-M2) gi |
| 32 | Clarias fuscus | 31.20 | 1 | CAA57215.1 |
| 33 | Xenopus tropicalis | 30.80 | 1 | MGC89845 protein |
| 34 | human, lens, Peptide, 204 aa | 30.00 | 1 | A Chain A, Structure Of Native Human Beta B2 Crys |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |
| Mus musculus | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 ||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 1 MAEQHGAPEQAAAGKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |
| Rattus norvegicus | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |||||||||||||+|||#|||||||||||||||||||||||| ||||| Sbjct 1 MAEQHGAPEQAAASKSH#GGLGGSYKVTVYELENFQGKRCELLAECPN 47 |
| Ovis aries | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 ||||| ||||||| |||#||||||||| |||+||||||||||+||||| Sbjct 1 MAEQHSAPEQAAAGKSH#GGLGGSYKVIVYEMENFQGKRCELTAECPN 47 |
| Homo sapiens | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 ||||||||||||| |||#| ||||||| +||||||||||||||||||+ Sbjct 1 MAEQHGAPEQAAAGKSH#GDLGGSYKVILYELENFQGKRCELSAECPS 47 |
| Bos taurus | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 ||||| |||||| |||#||||||||| |||+||||||||||+||||| Sbjct 1 MAEQHSTPEQAAAGKSH#GGLGGSYKVIVYEMENFQGKRCELTAECPN 47 |
| Gallus gallus | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 | || ||| + #| ||+||+|+||||||||+||||| | || Sbjct 1 MTEQQSPPEQMVTGEGA#GERGGNYKITIYELENFQGRRCELSEELPN 47 |
| Danio rerio | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |++| | |+| | || #|| | |||++|| |||+||+ |||||| + Sbjct 1 MSDQQGVPDQQVAGKSQ#GGAGAIYKVSLYEFENFRGKKLELSAECKD 47 |
| Tetraodon nigroviridis | Query 1 MAEQHGAPEQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 |+|+ |||| || || #|| | +||| ++| ||||| + | |++| + Sbjct 33 MSERQSAPEQLAAGKSQ#GGAGATYKVLLFEFENFQGCKAEFSSDCKD 79 |
| Xenopus laevis | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 ||+|+|||+ ||||||| | |+ ||| Sbjct 12 GSWKITVYDQENFQGKRMEFSSSCPN 37 |
| N/A | Query 19 GLGGSYKVTVYELENFQGKRCELSAECPN 47 | | +|+|+|+ ||||||| | ++ ||| Sbjct 26 GSVGPWKITIYDQENFQGKRMEFTSSCPN 54 |
| Xenopus laevis | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 ||+|+|||+ ||||||| | |+ | | Sbjct 28 GSWKITVYDQENFQGKRMEFSSSCQN 53 |
| synthetic construct | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 |+|++ |+|||||||+| | | || | Sbjct 57 GNYRLVVFELENFQGRRAEFSGECSN 82 |
| Pan troglodytes | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 |+|++ |+|||||||+| | | || | Sbjct 57 GNYRLVVFELENFQGRRAEFSGECSN 82 |
| Canis lupus familiaris | Query 19 GLGGSYKVTVYELENFQGKRCELSAECPN 47 | | +|+|+|+ ||||||| | ++ ||| Sbjct 26 GSAGPWKITIYDQENFQGKRMEFTSSCPN 54 |
| Canis familiaris | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 ||||+ |+| |||||+| | | || | Sbjct 53 GSYKLVVFEQENFQGRRVEFSGECLN 78 |
| Oryctolagus cuniculus | Query 9 EQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 + | | #| || +|+|+|+ ||||||| | ++ ||| Sbjct 17 KMAQTNPMP#GSLG-PWKITIYDQENFQGKRMEFTSSCPN 54 |
| Oryctolagus cuniculus | Query 11 AAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 | | #| || +|+|+|+ ||||||| | ++ ||| Sbjct 2 AQTNPMP#GSLG-PWKITIYDQENFQGKRMEFTSSCPN 37 |
| Contains: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | +|+|+|+ ||||||| | ++ ||| Sbjct 29 GPWKITIYDQENFQGKRMEFTSSCPN 54 |
| Rana catesbeiana | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | +|+|||+ ||||||| | ++ | | Sbjct 29 GPWKITVYDQENFQGKRMEFTSSCAN 54 |
| Rana temporaria | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | +|+|||+ ||||||| | ++ | | Sbjct 12 GPWKITVYDQENFQGKRMEFTSSCAN 37 |
| Cavia porcellus | Query 9 EQAAANKSH#GGLGGSYKVTVYELENFQGKRCELSAECPN 47 + | | #| || +|+|+|+ ||||||| | ++ | | Sbjct 17 KMAQTNPMP#GSLG-PWKITIYDQENFQGKRMEFTSSCSN 54 |
| Cynops pyrrhogaster | Query 2 AEQHGAPEQ---AAANKSH#GGLGGSYKVTVYELENFQGKRCELSAEC 45 +++ | | + ||+ # |+||+ ++| |||||+ || || Sbjct 23 SKEKGVPPSVPISKPNKAG#DSSVGTYKIIIFEQENFQGRHLELVNEC 69 |
| Xenopus tropicalis | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 ||+|+ ++| |||||+ || || | Sbjct 35 GSFKIVLFEQENFQGRHVELLNECGN 60 |
| Pan troglodytes | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | +|+ |++ + |||+| | +||||+ Sbjct 10 GPWKMVVWDEDGFQGRRHEFTAECPS 35 |
| Petenia splendida x Cichlasoma synspilum | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 |||++ +|| |||||+ || +| | Sbjct 86 GSYRMRIYERENFQGQNHELMNDCDN 111 |
| Iguana iguana | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | +|+||+| |||||+||| |||+ Sbjct 3 GQFKITVWEEENFQGERCEFLMECPS 28 Query 25 KVTVYELENFQGKRCELSAECPN 47 |||+|| |||||++ ||| + |+ Sbjct 99 KVTLYEGENFQGRKFELSDDYPS 121 |
| Danio rerio | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 |||++ +|| ||| |+ || +| | Sbjct 88 GSYRIKIYERENFGGQMYELMDDCDN 113 |
| Macropus fuliginosus | Query 25 KVTVYELENFQGKRCELSAEC 45 ++|++| |||||+|||| ++| Sbjct 13 RLTLWEEENFQGRRCELMSDC 33 |
| Dicentrarchus labrax | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 |||++ +++ |||||+ |+ || | Sbjct 38 GSYRIMMFDQENFQGRMIEVQNECMN 63 |
| Cyprinus carpio | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |||++ +|| ||| |+ |++ +| Sbjct 86 GSYRMRIYERENFMGQMYEMADDC 109 |
| Clarias fuscus | Query 22 GSYKVTVYELENFQGKRCELSAEC 45 |+|++ +|| ||| |+ |+| +| Sbjct 88 GAYRMKIYERENFLGQMMEISDDC 111 |
| Xenopus tropicalis | Query 22 GSYKVTVYELENFQGKRCELSAECPN 47 | ||+ +|| +|||+ | +||| Sbjct 87 GQYKMRIYEKGDFQGQMMEFFDDCPN 112 |
| human, lens, Peptide, 204 aa | Query 25 KVTVYELENFQGKRCELSAECPN 47 |+ ++| ||||| ||+ ||| Sbjct 17 KIIIFEQENFQGHSHELNGPCPN 39 |
* References
[PubMed ID: 11773034] Lampi KJ, Shih M, Ueda Y, Shearer TR, David LL, Lens proteomics: analysis of rat crystallin sequences and two-dimensional electrophoresis map. Invest Ophthalmol Vis Sci. 2002 Jan;43(1):216-24.
[PubMed ID: 8405363] ... David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.
[PubMed ID: 3879970] ... den Dunnen JT, Moormann RJ, Schoenmakers JG, Rat lens beta-crystallins are internally duplicated and homologous to gamma-crystallins. Biochim Biophys Acta. 1985 Apr 19;824(4):295-303.