logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0096 : Crystallin, [beta]A1/A3

[ CaMP Format ]

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesPREDICTED: beta-crystallin A3 [Rattus norvegicus]; beta-crystallin A3; Beta-crystallin A3; Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form
Gene NamesCryba1; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 8 mRNAs, 37 ESTs, 19 Proteins
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
XP_001080813 XM_001080813 25583 P14881 N/A N/A N/A rno:25583

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 215 aa

Average Mass: 25.270 kDa

Monoisotopic Mass: 25.254 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 11 ---
Beta/Gamma crystallin 1. 321161.00.4
Beta/Gamma crystallin 2. 1252131.01.5

3. Sequence Information

Fasta Sequence: SB0096.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 8405363] David LL, Shearer TR, Beta-crystallins insolubilized by calpain II in vitro contain cleavage sites similar to beta-crystallins insolubilized during cataract. FEBS Lett. 1993 Jun 21;324(3):265-70.

Cleavage sites (±10aa)

[Site 1] ETQTVQRELE11-TLPTTKMAQT

Glu11 Thr

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu2Thr3Gln4Thr5Val6Gln7Arg8Glu9Leu10Glu11
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Thr12Leu13Pro14Thr15Thr16Lys17Met18Ala19Gln20Thr21

Sequence conservation (by blast)

* References

None.