Function: Fraser et al. (2000) found that IGFBP3 mRNA is expressed in the endothelium of the human corpus luteum and that the levels of message change during luteal development and rescue by human chorionic gonadotropin (CG; see OMIM:118860). The signal was strong during the early luteal phase, but showed significant reduction during the mid- and late luteal phases. Administration of human CG caused a marked increase in the levels of IGFBP3 mRNA in luteal endothelial cells that was comparable to that observed during the early luteal phase. The authors concluded that endothelial cell IGFBP3 expression is a physiologic property of the corpus luteum of menstruation and pregnancy, and they speculated that the regulated expression of endothelial IGFBP3 may play a role in controlling angiogenesis and cell responses in the human corpus luteum by autocrine/paracrine mechanisms.

Source Reference: [PubMed ID: 17655506] Berg U, Bang P, Carlsson-Skwirut C, Calpain proteolysis of insulin-like growth factor binding protein (IGFBP) -2 and -3, but not of IGFBP-1. Biol Chem. 2007 Aug;388(8):859-63.

Summary

Top-ranked sequences

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            |||+ +||||||  | |||||+| ||||||#+|+ +||||||+||||||||||||||||||
Sbjct    59 SEEEHNAGSVESQVVPSTHRVTDSKFHPLH#AKMDVIKKGHARDSQRYKVDYESQSTDTQN  118

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            |||| |||||++ +| ||| + ||||| +|#+|+ +|||||||||||||||||||||||||
Sbjct     8 SEEDHSAGSVDNQAVPSTHCMPDPKFHTIH#TKMDVIKKGHAKDSQRYKVDYESQSTDTQN   67

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            |||| +||||||  | |||||+| ||||||#||+ +| || |+||||||||||||||||||
Sbjct   140 SEEDHNAGSVESQVVPSTHRVTDSKFHPLH#SKMEVIIKGQARDSQRYKVDYESQSTDTQN  199

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            |||| +||||||  | |||||+| ||||||#||+ +| || |+||||||||||||||||||
Sbjct   141 SEEDHNAGSVESQVVPSTHRVTDSKFHPLH#SKMEVIIKGQARDSQRYKVDYESQSTDTQN  200

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            |||| | || |+ +  |||||   ||||+|#+|+ +|||||||||||||||||||||||||
Sbjct   140 SEEDHSMGSTENQAGPSTHRVPVSKFHPIH#TKMDVIKKGHAKDSQRYKVDYESQSTDTQN  199

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||||  |+|+ ++ ||||| | | | +|#+|+ +|||||||||||||||||||||||||
Sbjct   142 SEEDRSVDSMENQALPSTHRVPDSKLHSIH#TKMDVIKKGHAKDSQRYKVDYESQSTDTQN  201

Query   146 SEEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||  ||  ++  +  |||| | |  |||#+|+ +|||||||||||||||||||||||||
Sbjct   414 SEEDHGAGGAQA--LPGTHRVPDAKLQPLH#TKMDVIKKGHAKDSQRYKVDYESQSTDTQN  471

Query   147 EEDRSAGSVESPSVSSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||+  |+|+ ++ |  || | |||| |#+|+ ||+|| |||+||||++||||||||||
Sbjct    94 EEDRNTSSMENQAIPSVPRVPDSKFHPHH#TKLDIIRKGQAKDTQRYKMEYESQSTDTQN  152

Query   170 KFHPLH#SKIIIIKKGHAKDSQRYKVDYESQSTDTQN  205
            ||||+|#+|+ +|||||||||||||||||||||||||
Sbjct     1 KFHPIH#TKMDVIKKGHAKDSQRYKVDYESQSTDTQN   36

Query   161 SSTHRVSDPKFHPLH#SKIIIIKKGHAKDSQRYKVDYESQST  201
            |+ + ||  ++| | #     ++ | | |++ ++ |||++ |
Sbjct     6 STKYNVSFEEWHELL#MDYAELRGGSAADAEAWRDDYEAEKT   46

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[PubMed ID: 8843739] ... Booth BA, Boes M, Bar RS, IGFBP-3 proteolysis by plasmin, thrombin, serum: heparin binding, IGF binding, and structure of fragments. Am J Physiol. 1996 Sep;271(3 Pt 1):E465-70.

[PubMed ID: 7538844] ... Fielder PJ, Rosenfeld RG, Graves HC, Grandbois K, Maack CA, Sawamura S, Ogawa Y, Sommer A, Cohen P, Biochemical analysis of prostate specific antigen-proteolyzed insulin-like growth factor binding protein-3. Growth Regul. 1994 Dec;4(4):164-72.

[PubMed ID: 7523391] ... Fowlkes JL, Enghild JJ, Suzuki K, Nagase H, Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. J Biol Chem. 1994 Oct 14;269(41):25742-6.

[PubMed ID: 1280211] ... Gargosky SE, Pham HM, Wilson KF, Liu F, Giudice LC, Rosenfeld RG, Measurement and characterization of insulin-like growth factor binding protein-3 in human biological fluids: discrepancies between radioimmunoassay and ligand blotting. Endocrinology. 1992 Dec;131(6):3051-60.

[PubMed ID: 1293182] ... Takahashi T, Monica-Masuda L, Ito S, Katsumoto T, Ishibashi Y, Onodera K, Biochemical study of cells cultured from a patient with tuberous sclerosis. J Dermatol. 1992 Nov;19(11):909-13.

[PubMed ID: 1383255] ... Cohen P, Graves HC, Peehl DM, Kamarei M, Giudice LC, Rosenfeld RG, Prostate-specific antigen (PSA) is an insulin-like growth factor binding protein-3 protease found in seminal plasma. J Clin Endocrinol Metab. 1992 Oct;75(4):1046-53.

[PubMed ID: 1373120] ... Ehrenborg E, Larsson C, Stern I, Janson M, Powell DR, Luthman H, Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7. Genomics. 1992 Mar;12(3):497-502.

[PubMed ID: 1695633] ... Cubbage ML, Suwanichkul A, Powell DR, Insulin-like growth factor binding protein-3. Organization of the human chromosomal gene and demonstration of promoter activity. J Biol Chem. 1990 Jul 25;265(21):12642-9.