CaMPDB :: Substrate

SB0100 : connectin/titin

* Basic Information

Organism	Homo sapiens (human)
Protein Names	titin isoform N2-A [Homo sapiens]; titin isoform N2-A; rhabdomyosarcoma antigen MU-RMS-40.14; Titin; 2.7.11.1; Connectin; Rhabdomyosarcoma antigen MU-RMS-40.14
Gene Names	TTN; titin
Gene Locus	2q31; chromosome 2
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_596869	NM_133378	7273	Q9Y6L9	188840	HGNC:12403	01787	hsa:7273

* Information From OMIM

Description: Titin, or connectin, is a giant muscle protein expressed in the cardiac and skeletal muscles that spans half of the sarcomere from Z line to M line. Titin plays a key role in muscle assembly, force transmission at the Z line, and maintenance of resting tension in the I band region (Itoh-Satoh et al., 2002).

» More (1) « Hide Below

* Structure Information

1. Primary Information

Length: 33423 aa

Average Mass: 3713.629 kDa

Monoisotopic Mass: 3711.359 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CD80-like C2-set immunoglobulin domain 1.	30	49	25.0	0.0
Immunoglobulin V-set domain 1.	55	97	63.0	0.0
Immunoglobulin V-set domain 2.	149	193	61.0	0.0
Titin Z 1.	384	453	2.0	12.4
Titin Z 2.	464	505	1.0	14.7
Titin Z 3.	510	549	1.0	5.6
Titin Z 4.	552	593	1.0	8.6
Titin Z 5.	599	639	2.0	1.5
Titin Z 6.	644	685	1.0	10.6
Titin Z 7.	696	717	8.0	2.3
Natural killer cell receptor 2B4 1.	974	1029	46.0	0.0
Immunoglobulin V-set domain 3.	1112	1163	46.0	0.0
Immunoglobulin V-set domain 4.	1325	1363	34.0	0.0
Immunoglobulin V-set domain 5.	1508	1547	68.0	0.0
CD80-like C2-set immunoglobulin domain 2.	1579	1592	24.0	0.0
Immunoglobulin domain 1.	1730	1781	25.0	0.0
CD80-like C2-set immunoglobulin domain 3.	1851	1885	8.0	0.0
Immunoglobulin V-set domain 6.	2117	2147	55.0	0.0
Immunoglobulin V-set domain 7.	2210	2251	53.0	0.0
Immunoglobulin V-set domain 8.	2302	2340	52.0	0.1
Immunoglobulin V-set domain 9.	2392	2429	53.0	0.0
Immunoglobulin domain 2.	2456	2517	11.0	0.0
Immunoglobulin V-set domain 10.	2568	2606	52.0	0.0
Immunoglobulin domain 3.	2634	2691	13.0	0.0
Immunoglobulin I-set domain 1.	2708	2778	2.0	0.0
Immunoglobulin V-set domain 11.	2846	2868	70.0	0.0
Immunoglobulin V-set domain 12.	2932	2958	69.0	0.0
Immunoglobulin V-set domain 13.	3007	3042	56.0	0.0
Immunoglobulin V-set domain 14.	3093	3145	52.0	0.0
Immunoglobulin domain 4.	3174	3223	28.0	0.0
Immunoglobulin V-set domain 15.	3286	3328	65.0	0.1
Natural killer cell receptor 2B4 2.	3375	3427	46.0	0.0
Immunoglobulin C1-set domain 1.	3482	3533	22.0	0.1
Immunoglobulin V-set domain 16.	3597	3627	64.0	0.0
Immunoglobulin V-set domain 17.	3673	3726	45.0	0.1
Natural killer cell receptor 2B4 3.	3769	3818	46.0	0.0
CD80-like C2-set immunoglobulin domain 4.	3845	3877	14.0	0.0
Immunoglobulin V-set domain 18.	3965	4006	57.0	0.0
Immunoglobulin V-set domain 19.	4061	4106	60.0	0.0
Immunoglobulin V-set domain 20.	4151	4194	55.0	0.0
Natural killer cell receptor 2B4 4.	4260	4292	70.0	0.0
Immunoglobulin V-set domain 21.	4339	4375	54.0	0.0
Immunoglobulin V-set domain 22.	4437	4469	60.0	0.0
Immunoglobulin V-set domain 23.	4531	4565	63.0	0.0
Natural killer cell receptor 2B4 5.	4611	4663	47.0	0.1
Immunoglobulin V-set domain 24.	4713	4764	55.0	0.0
Immunoglobulin V-set domain 25.	4812	4857	59.0	0.0
Immunoglobulin V-set domain 26.	4912	4944	68.0	0.1
CD80-like C2-set immunoglobulin domain 5.	4973	5005	18.0	0.0
Immunoglobulin V-set domain 27.	5096	5125	64.0	0.0
Immunoglobulin V-set domain 28.	5177	5218	53.0	0.1
Immunoglobulin V-set domain 29.	5279	5313	58.0	0.1
Immunoglobulin V-set domain 30.	5386	5419	74.0	0.2
Immunoglobulin V-set domain 31.	5463	5513	55.0	0.0
Immunoglobulin domain 5.	5561	5599	38.0	0.0
Immunoglobulin domain 6.	5663	5688	46.0	0.0
Natural killer cell receptor 2B4 6.	5735	5786	46.0	0.1
Immunoglobulin V-set domain 32.	5844	5874	60.0	0.0
Immunoglobulin V-set domain 33.	5944	5982	69.0	0.1
Immunoglobulin V-set domain 34.	6037	6062	69.0	0.0
Immunoglobulin domain 7.	6134	6169	49.0	0.0
CD80-like C2-set immunoglobulin domain 6.	6187	6253	13.0	0.1
Immunoglobulin domain 8.	6316	6347	39.0	0.0
Immunoglobulin domain 9.	6420	6441	49.0	0.0
Adenovirus E3 region protein CR1 1.	6480	6535	19.0	0.1
Immunoglobulin V-set domain 35.	6602	6634	68.0	0.0
Natural killer cell receptor 2B4 7.	6677	6726	47.0	0.0
CD80-like C2-set immunoglobulin domain 7.	6755	6783	14.0	0.0
Immunoglobulin V-set domain 36.	6890	6919	74.0	0.0
Immunoglobulin V-set domain 37.	6969	7001	58.0	0.0
Natural killer cell receptor 2B4 8.	7051	7104	46.0	0.0
Immunoglobulin V-set domain 38.	7161	7194	63.0	0.1
Immunoglobulin domain 10.	7262	7294	44.0	0.0
Immunoglobulin V-set domain 39.	7341	7395	50.0	0.0
Adenovirus E3 region protein CR1 2.	7419	7476	17.0	0.0
Immunoglobulin V-set domain 40.	7544	7579	69.0	0.0
Natural killer cell receptor 2B4 9.	7618	7675	47.0	0.0
Immunoglobulin V-set domain 41.	7720	7758	55.0	0.1
Immunoglobulin V-set domain 42.	7815	7864	56.0	0.1
Immunoglobulin V-set domain 43.	7908	7947	57.0	0.0
Natural killer cell receptor 2B4 10.	7992	8047	46.0	0.0
Immunoglobulin V-set domain 44.	8097	8140	56.0	0.0
Immunoglobulin domain 11.	8207	8241	48.0	0.0
Immunoglobulin V-set domain 45.	8295	8327	61.0	0.0
Natural killer cell receptor 2B4 11.	8387	8430	56.0	0.0
Immunoglobulin V-set domain 46.	8492	8544	53.0	0.0
--- cleavage 8563 ---
--- cleavage 8651 ---
--- cleavage 8652 ---
Immunoglobulin V-set domain 47.	8694	8732	53.0	0.0
Immunoglobulin domain 12.	8797	8825	47.0	0.0
Immunoglobulin domain 13.	8847	8908	12.0	0.0
PPAK motif 1.	9205	9224	4.0	6.6
PPAK motif 2.	9261	9283	5.0	5.7
PPAK motif 3.	9284	9310	1.0	26.5
PPAK motif 4.	9312	9338	1.0	33.8
PPAK motif 5.	9341	9366	2.0	28.0
PPAK motif 6.	9368	9393	1.0	4.0
PPAK motif 7.	9395	9419	1.0	24.8
PPAK motif 8.	9423	9445	1.0	24.6
PPAK motif 9.	9466	9483	10.0	0.3
PPAK motif 10.	9528	9548	6.0	3.7
PPAK motif 11.	9576	9602	1.0	27.8
PPAK motif 12.	9604	9625	1.0	27.2
PPAK motif 13.	9633	9657	2.0	1.1
PPAK motif 14.	9660	9686	1.0	17.2
PPAK motif 15.	9688	9714	1.0	12.0
PPAK motif 16.	9810	9831	1.0	18.0
PPAK motif 17.	9835	9860	1.0	13.3
PPAK motif 18.	9866	9888	1.0	17.0
PPAK motif 19.	9892	9907	1.0	12.2
PPAK motif 20.	9947	9972	2.0	28.8
PPAK motif 21.	9974	9998	1.0	24.0
PPAK motif 22.	10000	10026	1.0	31.7
PPAK motif 23.	10028	10054	1.0	31.1
PPAK motif 24.	10056	10082	1.0	25.3
PPAK motif 25.	10184	10206	2.0	18.8
PPAK motif 26.	10208	10231	1.0	17.3
PPAK motif 27.	10266	10289	2.0	19.0
PPAK motif 28.	10291	10312	1.0	16.1
PPAK motif 29.	10314	10336	1.0	21.8
PPAK motif 30.	10344	10354	11.0	0.2
PPAK motif 31.	10465	10485	1.0	19.6
PPAK motif 32.	10491	10519	1.0	28.8
PPAK motif 33.	10521	10547	1.0	33.7
PPAK motif 34.	10549	10575	1.0	25.7
PPAK motif 35.	10577	10603	1.0	30.1
PPAK motif 36.	10606	10631	2.0	29.4
PPAK motif 37.	10633	10659	1.0	26.7
PPAK motif 38.	10690	10715	2.0	20.1
PPAK motif 39.	10717	10743	1.0	29.2
PPAK motif 40.	10745	10769	1.0	27.0
PPAK motif 41.	10771	10797	1.0	23.3
PPAK motif 42.	10835	10859	1.0	24.0
Immunoglobulin V-set domain 48.	11163	11199	59.0	0.0
Immunoglobulin V-set domain 49.	11268	11286	74.0	0.2
Immunoglobulin V-set domain 50.	11350	11383	59.0	0.0
Immunoglobulin I-set domain 2.	11400	11476	4.0	0.0
Immunoglobulin V-set domain 51.	11524	11574	57.0	0.0
Immunoglobulin domain 14.	11584	11639	11.0	0.0
Immunoglobulin V-set domain 52.	11703	11739	58.0	0.0
Immunoglobulin I-set domain 3.	11752	11831	2.0	0.0
Natural killer cell receptor 2B4 12.	11878	11915	57.0	0.0
CD80-like C2-set immunoglobulin domain 8.	11950	11983	23.0	0.0
Immunoglobulin V-set domain 53.	12073	12091	74.0	0.1
Immunoglobulin I-set domain 4.	12109	12184	3.0	0.0
Immunoglobulin domain 15.	12208	12269	11.0	0.0
Immunoglobulin domain 16.	12293	12356	11.0	0.0
Immunoglobulin C1-set domain 2.	12401	12448	24.0	0.0
Immunoglobulin V-set domain 54.	12495	12538	48.0	0.0
Natural killer cell receptor 2B4 13.	12582	12628	46.0	0.0
Immunoglobulin V-set domain 55.	12691	12723	70.0	0.0
Immunoglobulin V-set domain 56.	12753	12808	32.0	0.0
Immunoglobulin V-set domain 57.	12861	12896	55.0	0.0
Immunoglobulin domain 17.	12951	12987	34.0	0.0
Immunoglobulin domain 18.	13010	13077	10.0	0.0
Y_Y_Y domain 1.	13133	13178	18.0	0.0
Purple acid Phosphatase, N-terminal domain 1.	13241	13269	55.0	0.0
Purple acid Phosphatase, N-terminal domain 2.	13296	13376	4.0	0.0
Immunoglobulin V-set domain 58.	13433	13471	54.0	0.0
Tissue factor 1.	13486	13537	20.0	0.0
Purple acid Phosphatase, N-terminal domain 3.	13637	13669	55.0	0.0
Natural killer cell receptor 2B4 14.	13748	13772	73.0	0.0
Tissue factor 2.	13796	13860	33.0	0.0
Fibronectin type III domain 1.	13934	13964	48.0	0.0
CRISPR associated protein 1.	14039	14059	79.0	0.0
Tissue factor 3.	14102	14167	39.0	0.0
Fibronectin type III domain 2.	14186	14270	2.0	0.0
Tissue factor 4.	14283	14366	20.0	0.0
Immunoglobulin V-set domain 59.	14425	14466	54.0	0.0
SusE outer membrane protein 1.	14494	14543	43.0	0.0
Y_Y_Y domain 2.	14544	14566	36.0	0.0
Purple acid Phosphatase, N-terminal domain 4.	14586	14665	6.0	0.0
CD80-like C2-set immunoglobulin domain 9.	14704	14720	25.0	0.0
SusE outer membrane protein 2.	14814	14856	41.0	0.0
Purple acid Phosphatase, N-terminal domain 5.	14914	14992	11.0	0.0
Fibronectin type III domain 3.	15005	15087	3.0	0.0
Natural killer cell receptor 2B4 15.	15160	15184	72.0	0.0
Purple acid Phosphatase, N-terminal domain 6.	15251	15273	61.0	0.0
Immunoglobulin I-set domain 5.	15350	15386	54.0	0.0
Immunoglobulin V-set domain 60.	15429	15493	30.0	0.0
Y_Y_Y domain 3.	15560	15583	32.0	0.1
Fibronectin type III domain 4.	15601	15690	2.0	0.0
Y_Y_Y domain 4.	15776	15796	40.0	0.0
Immunoglobulin domain 19.	15834	15895	22.0	0.0
Purple acid Phosphatase, N-terminal domain 7.	15968	15989	62.0	0.0
Y_Y_Y domain 5.	16084	16103	38.0	0.0
Immunoglobulin I-set domain 6.	16126	16213	10.0	0.0
Y_Y_Y domain 6.	16262	16300	19.0	0.0
Y_Y_Y domain 7.	16379	16401	30.0	0.0
Tissue factor 5.	16439	16470	39.0	0.0
CD80-like C2-set immunoglobulin domain 10.	16549	16573	25.0	0.0
Immunoglobulin V-set domain 61.	16576	16608	71.0	0.0
Purple acid Phosphatase, N-terminal domain 8.	16629	16695	12.0	0.0
Immunoglobulin I-set domain 7.	16761	16800	44.0	0.0
CD80-like C2-set immunoglobulin domain 11.	16843	16859	25.0	0.0
Natural killer cell receptor 2B4 16.	16873	16899	70.0	0.0
Fibronectin-III type domain 1.	16925	16993	14.0	0.0
Purple acid Phosphatase, N-terminal domain 9.	17020	17090	8.0	0.0
Fibronectin type III domain 5.	17160	17197	42.0	0.0
Immunoglobulin V-set domain 62.	17273	17294	74.0	0.0
Fibronectin-III type domain 2.	17371	17391	73.0	0.0
Purple acid Phosphatase, N-terminal domain 10.	17459	17486	56.0	0.0
Immunoglobulin V-set domain 63.	17549	17600	54.0	0.1
Purple acid Phosphatase, N-terminal domain 11.	17615	17683	10.0	0.0
Purple acid Phosphatase, N-terminal domain 12.	17712	17786	8.0	0.0
Fibronectin type III domain 6.	17806	17890	2.0	0.0
Natural killer cell receptor 2B4 17.	17964	17992	71.0	0.0
Purple acid Phosphatase, N-terminal domain 13.	18062	18083	67.0	0.0
SusE outer membrane protein 3.	18113	18148	41.0	0.0
Natural killer cell receptor 2B4 18.	18260	18285	72.0	0.0
Purple acid Phosphatase, N-terminal domain 14.	18310	18375	13.0	0.0
Tissue factor 6.	18398	18473	22.0	0.0
Purple acid Phosphatase, N-terminal domain 15.	18560	18582	62.0	0.0
Immunoglobulin domain 20.	18629	18681	21.0	0.0
CRISPR associated protein 2.	18728	18775	54.0	0.0
CRISPR associated protein 3.	18848	18877	72.0	0.0
Immunoglobulin V-set domain 64.	18940	18988	57.0	0.0
Purple acid Phosphatase, N-terminal domain 16.	19043	19076	56.0	0.0
Fibronectin type III domain 7.	19093	19178	1.0	0.0
Fibronectin type III domain 8.	19191	19278	1.0	0.0
CD80-like C2-set immunoglobulin domain 12.	19320	19340	25.0	0.0
Immunoglobulin V-set domain 65.	19346	19386	66.0	0.0
Tissue factor 7.	19389	19464	22.0	0.0
Y_Y_Y domain 8.	19525	19575	15.0	0.0
Purple acid Phosphatase, N-terminal domain 17.	19645	19674	60.0	0.1
CD80-like C2-set immunoglobulin domain 13.	19718	19734	25.0	0.0
Adenovirus E3 region protein CR1 3.	19755	19782	66.0	0.1
Tissue factor 8.	19787	19863	22.0	0.0
Purple acid Phosphatase, N-terminal domain 18.	19937	19960	61.0	0.0
Immunoglobulin V-set domain 66.	20018	20069	51.0	0.0
Y_Y_Y domain 9.	20118	20158	16.0	0.0
Fibronectin type III domain 9.	20226	20252	47.0	0.0
Purple acid Phosphatase, N-terminal domain 19.	20331	20353	62.0	0.0
Natural killer cell receptor 2B4 19.	20436	20460	72.0	0.0
Fibronectin type III domain 10.	20475	20557	2.0	0.1
Purple acid Phosphatase, N-terminal domain 20.	20582	20651	10.0	0.0
Fibronectin type III domain 11.	20675	20759	2.0	0.1
CD80-like C2-set immunoglobulin domain 14.	20802	20820	26.0	0.0
Purple acid Phosphatase, N-terminal domain 21.	20907	20946	44.0	0.1
Purple acid Phosphatase, N-terminal domain 22.	21020	21047	62.0	0.0
Immunoglobulin V-set domain 67.	21099	21138	49.0	0.0
SusE outer membrane protein 4.	21171	21245	40.0	0.0
Fibronectin type III domain 12.	21266	21341	9.0	0.0
Fibronectin type III domain 13.	21367	21439	12.0	0.0
Natural killer cell receptor 2B4 20.	21513	21551	69.0	0.0
Tissue factor 9.	21570	21633	35.0	0.0
Purple acid Phosphatase, N-terminal domain 23.	21663	21736	8.0	0.0
Purple acid Phosphatase, N-terminal domain 24.	21814	21833	62.0	0.0
Natural killer cell receptor 2B4 21.	21914	21939	72.0	0.0
SusE outer membrane protein 5.	21956	22015	33.0	0.1
SusE outer membrane protein 6.	22054	22098	32.0	0.0
Y_Y_Y domain 10.	22104	22138	29.0	0.0
Immunoglobulin V-set domain 68.	22184	22229	52.0	0.0
SusE outer membrane protein 7.	22252	22279	37.0	0.0
Fibronectin type III domain 14.	22365	22416	25.0	0.0
Purple acid Phosphatase, N-terminal domain 25.	22453	22525	14.0	0.0
Natural killer cell receptor 2B4 22.	22575	22625	46.0	0.0
Fibronectin-III type domain 3.	22683	22718	54.0	0.0
Purple acid Phosphatase, N-terminal domain 26.	22745	22821	8.0	0.0
Fibronectin type III domain 15.	22843	22914	5.0	0.0
Natural killer cell receptor 2B4 23.	22997	23021	72.0	0.0
Natural killer cell receptor 2B4 24.	23031	23071	9.0	0.0
CRISPR associated protein 4.	23169	23205	60.0	0.0
Natural killer cell receptor 2B4 25.	23261	23311	46.0	0.0
SusE outer membrane protein 8.	23333	23366	38.0	0.1
Y_Y_Y domain 11.	23381	23405	30.0	0.0
Purple acid Phosphatase, N-terminal domain 27.	23434	23501	11.0	0.0
Purple acid Phosphatase, N-terminal domain 28.	23573	23603	57.0	0.0
Natural killer cell receptor 2B4 26.	23659	23706	48.0	0.0
Purple acid Phosphatase, N-terminal domain 29.	23730	23797	10.0	0.1
Fibronectin type III domain 16.	23824	23900	7.0	0.0
SusE outer membrane protein 9.	23931	23969	40.0	0.0
Natural killer cell receptor 2B4 27.	24078	24103	71.0	0.0
Purple acid Phosphatase, N-terminal domain 30.	24129	24193	13.0	0.0
CRISPR associated protein 5.	24230	24287	43.0	0.0
Natural killer cell receptor 2B4 28.	24367	24403	71.0	0.0
Fibronectin-III type domain 4.	24445	24490	48.0	0.0
Fibronectin type III domain 17.	24556	24580	48.0	0.0
Purple acid Phosphatase, N-terminal domain 31.	24658	24689	60.0	0.0
Natural killer cell receptor 2B4 29.	24740	24789	47.0	0.0
Purple acid Phosphatase, N-terminal domain 32.	24852	24880	55.0	0.0
Y_Y_Y domain 12.	24936	24989	12.0	0.0
Purple acid Phosphatase, N-terminal domain 33.	25057	25082	58.0	0.0
Immunoglobulin V-set domain 69.	25151	25195	61.0	0.0
Y_Y_Y domain 13.	25256	25292	30.0	0.0
SusE outer membrane protein 10.	25301	25345	32.0	0.1
Immunoglobulin V-set domain 70.	25430	25472	51.0	0.0
Tissue factor 10.	25506	25571	39.0	0.9
Fibronectin type III domain 18.	25640	25668	50.0	0.0
Tissue factor 11.	25702	25763	38.0	0.0
Natural killer cell receptor 2B4 30.	25820	25870	45.0	0.0
Fibronectin-III type domain 5.	25886	25964	4.0	0.0
Purple acid Phosphatase, N-terminal domain 34.	25989	26062	6.0	0.0
Tissue factor 12.	26116	26163	51.0	0.0
Natural killer cell receptor 2B4 31.	26240	26262	71.0	0.0
Tissue factor 13.	26274	26344	18.0	0.1
SusE outer membrane protein 11.	26387	26424	41.0	0.0
Natural killer cell receptor 2B4 32.	26528	26561	67.0	0.0
SusE outer membrane protein 12.	26583	26612	41.0	0.0
Purple acid Phosphatase, N-terminal domain 35.	26679	26748	9.0	0.1
Tissue factor 14.	26769	26844	23.0	0.0
Natural killer cell receptor 2B4 33.	26904	26960	46.0	0.0
Fibronectin-III type domain 6.	26979	27047	14.0	0.0
Purple acid Phosphatase, N-terminal domain 36.	27076	27157	10.0	0.0
SusE outer membrane protein 13.	27178	27230	40.0	0.0
Adenovirus E3 region protein CR1 4.	27322	27349	55.0	0.0
Tissue factor 15.	27383	27441	38.0	0.0
SusE outer membrane protein 14.	27460	27511	24.0	0.0
Natural killer cell receptor 2B4 34.	27595	27640	46.0	0.0
Y_Y_Y domain 14.	27725	27741	39.0	0.0
Y_Y_Y domain 15.	27826	27851	40.0	0.0
Purple acid Phosphatase, N-terminal domain 37.	27886	27933	53.0	0.1
Immunoglobulin V-set domain 71.	28001	28048	60.0	0.0
Fibronectin type III domain 19.	28057	28136	4.0	0.0
Y_Y_Y domain 16.	28192	28233	15.0	0.0
Purple acid Phosphatase, N-terminal domain 38.	28309	28331	60.0	0.0
Natural killer cell receptor 2B4 35.	28412	28446	72.0	0.0
Fibronectin type III domain 20.	28455	28522	8.0	0.0
Purple acid Phosphatase, N-terminal domain 39.	28599	28630	60.0	0.0
Natural killer cell receptor 2B4 36.	28691	28728	61.0	0.0
Purple acid Phosphatase, N-terminal domain 40.	28787	28825	53.0	0.1
Fibronectin type III domain 21.	28842	28927	1.0	0.1
Y_Y_Y domain 17.	28997	29023	25.0	0.0
Natural killer cell receptor 2B4 37.	29081	29128	48.0	0.0
Tissue factor 16.	29158	29218	38.0	0.1
Purple acid Phosphatase, N-terminal domain 41.	29253	29324	13.0	0.0
CRISPR associated protein 6.	29381	29425	61.0	0.0
Natural killer cell receptor 2B4 38.	29497	29527	69.0	0.0
Purple acid Phosphatase, N-terminal domain 42.	29547	29613	9.0	0.0
SusE outer membrane protein 15.	29647	29679	41.0	0.0
Purple acid Phosphatase, N-terminal domain 43.	29689	29725	59.0	0.0
Natural killer cell receptor 2B4 39.	29795	29830	72.0	0.0
Purple acid Phosphatase, N-terminal domain 44.	29885	29910	58.0	0.0
Purple acid Phosphatase, N-terminal domain 45.	29945	30008	13.0	0.1
Tissue factor 17.	30032	30110	21.0	0.0
Immunoglobulin V-set domain 72.	30180	30211	61.0	0.0
Purple acid Phosphatase, N-terminal domain 46.	30243	30312	14.0	0.0
Tissue factor 18.	30346	30406	37.0	0.0
Tissue factor 19.	30431	30490	22.0	0.0
Natural killer cell receptor 2B4 40.	30580	30618	63.0	0.0
Immunoglobulin domain 21.	30664	30725	30.0	0.0
Tissue factor 20.	30740	30801	37.0	0.0
Tissue factor 21.	30838	30910	34.0	0.0
Natural killer cell receptor 2B4 41.	30957	31012	44.0	0.0
CD80-like C2-set immunoglobulin domain 15.	31053	31066	26.0	0.0
Tissue factor 22.	31124	31195	24.0	0.0
Protein tyrosine kinase 1.	31253	31494	3.0	0.3
Immunoglobulin domain 22.	31589	31645	15.0	0.2
Natural killer cell receptor 2B4 42.	31721	31772	46.0	0.0
Immunoglobulin V-set domain 73.	31852	31885	74.0	0.1
Immunoglobulin V-set domain 74.	32400	32457	51.0	0.1
Natural killer cell receptor 2B4 43.	32615	32648	70.0	0.0
Immunoglobulin domain 23.	32775	32806	50.0	0.0
Natural killer cell receptor 2B4 44.	32897	32935	61.0	0.0
Immunoglobulin V-set domain 75.	33088	33113	69.0	0.0
Natural killer cell receptor 2B4 45.	33167	33223	48.0	0.0
Immunoglobulin V-set domain 76.	33363	33414	49.0	0.0

3. Sequence Information

Fasta Sequence: SB0100.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1BPV (NMR; -; A=22283-22385), 1G1C (X-ray; 210 A; A/B=2073-2171), 1NCT (NMR; -; A=33483-33579), 1NCU (NMR; -; A=33483-33579), 1TIT (NMR; -; A=12680-12765), 1TIU (NMR; -; A=12680-12765), 1TKI (X-ray; 200 A; A/B=32172-32492), 1TNM (NMR; -; A=33489-33579), 1TNN (NMR; -; A=33489-33579), 1WAA (X-ray; 180 A; A/B/C/D/E/F=12677-12765), 1YA5 (X-ray; 244 A; A/B=1-196), 2A38 (X-ray; 200 A; A/B/C=1-194), 2BK8 (X-ray; 169 A; A=32497-32590), 2F8V (X-ray; 275 A; A/B/C/D=1-196), 2ILL (X-ray; 220 A; A=31854-32047), 2J8H (X-ray; 199 A; A=31854-32047), 2J8O (X-ray; 249 A; A/B=31854-32047), 2NZI (X-ray; 290 A; A/B=31854-32155), 2RQ8 (NMR; -; A=12677-12765), 2WP3 (X-ray; 148 A; T=34252-34350), 2WWK (X-ray; 170 A; T=34252-34350), 2WWM (X-ray; 230 A; D/T=34252-34350), 2Y9R (X-ray; 190 A; T=34252-34350), 3B43 (X-ray; 330 A; A=7945-8511), 3KNB (X-ray; 140 A; A=34253-34350), 3LCY (X-ray; 250 A; A/B/C/D=31456-31649), 3LPW (X-ray; 165 A; A/B=22877-23070), 3PUC (X-ray; 096 A; A=33774-33871), 3Q5O (X-ray; 205 A; A/B=34253-34350), 3QP3 (X-ray; 200 A; A/B/C=33294-33395), 4C4K (X-ray; 195 A; T=34252-34350), 4JNW (X-ray; 206 A; A/B=32172-32492), 4O00 (X-ray; 185 A; A/B=14217-14319), 4UOW (X-ray; 330 A; 1/3/5/7/9/B/D/F/H/J/L/N/P/R/T/V/X/Z=7-99)

* Cleavage Information

3 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 18310072] Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H, Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem. 2008 May 23;283(21):14801-14. doi: 10.1074/jbc.M708262200. Epub 2008

Cleavage sites (±10aa)

[Site 1] EGDLRAMLKK⁸⁵⁶³-TPILKKGAGE

Lys⁸⁵⁶³ Thr

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Glu⁸⁵⁵⁴	Gly⁸⁵⁵⁵	Asp⁸⁵⁵⁶	Leu⁸⁵⁵⁷	Arg⁸⁵⁵⁸	Ala⁸⁵⁵⁹	Met⁸⁵⁶⁰	Leu⁸⁵⁶¹	Lys⁸⁵⁶²	Lys⁸⁵⁶³

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Thr⁸⁵⁶⁴	Pro⁸⁵⁶⁵	Ile⁸⁵⁶⁶	Leu⁸⁵⁶⁷	Lys⁸⁵⁶⁸	Lys⁸⁵⁶⁹	Gly⁸⁵⁷⁰	Ala⁸⁵⁷¹	Gly⁸⁵⁷²	Glu⁸⁵⁷³

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
GEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEK

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	119.00	12	Titin
2	Canis familiaris	117.00	13	cardiac titin
3	Rattus norvegicus	115.00	1	cardiac titin N2BA isoform
4	Tetraodon nigroviridis	70.10	2	unnamed protein product
5	Danio rerio	52.40	1	novel protein similar to human titin (TTN)
6	Chaetomium globosum CBS 148.51	31.60	1	hypothetical protein CHGG_00312
7	Mycoplasma pulmonis UAB CTIP	31.60	1	LIPOPROTEIN
8	Xenopus laevis	30.80	1	Unknown (protein for MGC:114614)
9	Xenopus laevis	30.80	1	cardiac myosin-binding protein C

Top-ranked sequences

organism	matching
Homo sapiens	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593
Canis familiaris	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|+\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2592 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPVLKKGTGEEEEIDIMELLKNVDPKEYEK 2651
Rattus norvegicus	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2437 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPALKKGSGEEEEIDIMELLKNVDPKEYEK 2496
Tetraodon nigroviridis	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593 \|\|\|\| + +\| \|+\|+\|+ +\|\|\|\|\|\| \|\|\|#\|\| +\| \|\|++\|\|\|+\|\|\|+\|\|\|\|\|\|\|\|\| Sbjct 9880 GEIECSSDLLVEEKKESAVLEGDLRAKLKK#TPSKQKSPKEEKDIDIVELLRNVDPKEYEK 9939
Danio rerio	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPKEYEK 8593 \|\|\|\| + +\| \|\|\|+\|+ \| \|\|\|#\|\| +\| \|+++\|\|\|+\|\|\|+\|\|\| \|\|\|\|\| Sbjct 5215 GEIECSTDLNVDEKKES----GPEVVKLKK#TPSKQKSPKEDKDIDIVELLRNVDTKEYEK 5270
Chaetomium globosum CBS 148.51	Query 8553 IEGDLRAMLKK#TPILKKGAGEEEEIDIMELLKNVDPK 8589 +\|\|\|+ \|++\|+# +\| \|+ \|+\|\| \|\| \|+\| \|+ Sbjct 257 VEGDVDAVVKR#GLEWFQGTGDGGELDIEELWKHVGPE 293
Mycoplasma pulmonis UAB CTIP	Query 8535 EIESNVNLQVDERKKQEKIEGDLRAM--LKK#TPILKKGAGEEEEIDIMELLKNV 8586 \|+\| \| + \| \| + \| \|\|\| \|+\|+ \|\| # \| \| \| ++++ + + +\|\| Sbjct 234 ELEINSSYQEDPKTNQFKIERDIRSFPYLKS#YPKLLKSTNKKKDFSLSDYIKNT 287
Xenopus laevis	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGA-------GEEEEIDIMELLKNV 8586 \| + \|++ +\| \| \| \|+\|\|\|# + \| \| ++\|+ \|+\|\| Sbjct 285 GAAKRRVSIAFSGDGTEEAGELDFSALLKK#RDSFLRSVNRNEPKQGTEPDVDVWEILKKA 344 Query 8587 DPKEYEK 8593 \| \|\|\|\| Sbjct 345 PPSEYEK 351
Xenopus laevis	Query 8534 GEIESNVNLQVDERKKQEKIEGDLRAMLKK#TPILKKGA-------GEEEEIDIMELLKNV 8586 \| + \|++ +\| \| \| \|+\|\|\|# + \| \| ++\|+ \|+\|\| Sbjct 283 GAAKRRVSIAFSGDGTEEAGELDFSALLKK#RDSFLRSVNRNEPKQGTEPDVDVWEILKKA 342 Query 8587 DPKEYEK 8593 \| \|\|\|\| Sbjct 343 PPSEYEK 349

[Site 2] LVSFIQQRLS⁸⁶⁵¹-QTEPVTLIKD

Ser⁸⁶⁵¹ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Leu⁸⁶⁴²	Val⁸⁶⁴³	Ser⁸⁶⁴⁴	Phe⁸⁶⁴⁵	Ile⁸⁶⁴⁶	Gln⁸⁶⁴⁷	Gln⁸⁶⁴⁸	Arg⁸⁶⁴⁹	Leu⁸⁶⁵⁰	Ser⁸⁶⁵¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln⁸⁶⁵²	Thr⁸⁶⁵³	Glu⁸⁶⁵⁴	Pro⁸⁶⁵⁵	Val⁸⁶⁵⁶	Thr⁸⁶⁵⁷	Leu⁸⁶⁵⁸	Ile⁸⁶⁵⁹	Lys⁸⁶⁶⁰	Asp⁸⁶⁶¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
HRLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKI

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	120.00	2	Titin
2	Rattus norvegicus	115.00	1	cardiac titin N2BA isoform
3	Canis familiaris	94.40	1	cardiac titin
4	Tetraodon nigroviridis	45.10	2	unnamed protein product
5	Danio rerio	34.30	1	novel protein similar to human titin (TTN)
6	Trypanosoma cruzi strain CL Brener	32.00	2	hypothetical protein Tc00.1047053506181.70
7	Bacillus clausii KSM-K16	31.20	1	hypothetical protein ABC0905
8	Yersinia pseudotuberculosis IP 32953	30.80	1	ABC transporter, periplasmic oligo-dipeptide/nicke

Top-ranked sequences

organism	matching
Homo sapiens	Query 8622 HRLEIEEIERSERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 8622 HRLEIEEIERSERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681
Rattus norvegicus	Query 8622 HRLEIEEIERSERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681 \|\|\|\|\|\|\|+\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\| Sbjct 2525 HRLEIEELEKSERDEKEFEELVSFIQQRLT#QTEPVTLIKDIENQTVLKDNDAIFEIDIKI 2584
Canis familiaris	Query 8622 HRLEIEEIERSERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681 \|\|\|\|\|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|++\|\|\|\|\|\|\|\|\| Sbjct 2680 HRLEIEEIEKSEKDEKEFEELISFIQQRLS#QTEPVTLIKDIENQTVLKDDEAVFEIDIKI 2739
Tetraodon nigroviridis	Query 8628 EIERSERDEKE-FEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681 \|+\|\|+\|\|+ \| \|\|+ +\|+\|+ #+\|\|\|\|\|++ \|\| +\|+\| +\| \|+ ++ \| Sbjct 9971 ELERAERESDEDMARLVADLQKRME#RTEPVTVLSDISDQSVFTGKEAEFQCEVTI10025
Danio rerio	Query 8651 S#QTEPVTLIKDIENQTVLKDNDAVFEIDIKI 8681 +# \|\|\|\|+\|\|\| +\|\| + +\|\|\|\| +\|\|+ Sbjct 5331 T#TASPVTLLKDITDQTTQLNKEAVFECEIKV 5361
Trypanosoma cruzi strain CL Brener	Query 8624 LEIEEIERSERDEKEFE-ELVSFIQQRLS#QTEPVTLIKDIENQTVLKDN 8671 \|+ \|\|+\| \|\|\| \| +++ +\|\| #+\| +\|+ + \| \| \|+\|\| Sbjct 712 LDEEEMENIERDYHSLEGRVIATAVERLR#KTAAASLLSSVPNSTRLRDN 760
Bacillus clausii KSM-K16	Query 8628 EIERSERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDNDAVFEIDI 8679 +\| \|\|\|\| \| ++ +\|\| + \|#+\| \|+ + \| +\| \| ++++ \|+ Sbjct 669 DIYIGERDESEIDDYLSFYLRNNS#ETAPLFQLTVNEFKTSRKSRESIYRTDV 720
Yersinia pseudotuberculosis IP 32953	Query 8632 SERDEKEFEELVSFIQQRLS#QTEPVTLIKDIENQTVLKDN 8671 +\| \| ++ +\| + +\|\| \| #\| \| \| + \| \|\|+\|\| Sbjct 467 AEADPEKRTQLYTQLQQELQ#QNSPYIFIDQAKAQVVLRDN 506

[Site 3] VSFIQQRLSQ⁸⁶⁵²-TEPVTLIKDI

Gln⁸⁶⁵² Thr

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val⁸⁶⁴³	Ser⁸⁶⁴⁴	Phe⁸⁶⁴⁵	Ile⁸⁶⁴⁶	Gln⁸⁶⁴⁷	Gln⁸⁶⁴⁸	Arg⁸⁶⁴⁹	Leu⁸⁶⁵⁰	Ser⁸⁶⁵¹	Gln⁸⁶⁵²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Thr⁸⁶⁵³	Glu⁸⁶⁵⁴	Pro⁸⁶⁵⁵	Val⁸⁶⁵⁶	Thr⁸⁶⁵⁷	Leu⁸⁶⁵⁸	Ile⁸⁶⁵⁹	Lys⁸⁶⁶⁰	Asp⁸⁶⁶¹	Ile⁸⁶⁶²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
RLEIEEIERSERDEKEFEELVSFIQQRLSQTEPVTLIKDIENQTVLKDNDAVFEIDIKIN

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	119.00	2	Titin
2	Rattus norvegicus	115.00	1	cardiac titin N2BA isoform
3	Canis familiaris	93.20	1	cardiac titin
4	Tetraodon nigroviridis	47.40	2	unnamed protein product
5	Danio rerio	37.00	1	novel protein similar to human titin (TTN)
6	Trypanosoma cruzi strain CL Brener	32.00	2	hypothetical protein Tc00.1047053506181.70
7	Bacillus clausii KSM-K16	31.20	1	hypothetical protein ABC0905
8	Yersinia pseudotuberculosis IP 32953	30.80	1	ABC transporter, periplasmic oligo-dipeptide/nicke

Top-ranked sequences

organism	matching
Homo sapiens	Query 8623 RLEIEEIERSERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 8623 RLEIEEIERSERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682
Rattus norvegicus	Query 8623 RLEIEEIERSERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682 \|\|\|\|\|\|+\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\| Sbjct 2526 RLEIEELEKSERDEKEFEELVSFIQQRLTQ#TEPVTLIKDIENQTVLKDNDAIFEIDIKIN 2585
Canis familiaris	Query 8623 RLEIEEIERSERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682 \|\|\|\|\|\|\|\|+\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|++\|\|\|\|\|\|\|\|\|\| Sbjct 2681 RLEIEEIEKSEKDEKEFEELISFIQQRLSQ#TEPVTLIKDIENQTVLKDDEAVFEIDIKIN 2740
Tetraodon nigroviridis	Query 8628 EIERSERDEKE-FEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682 \|+\|\|+\|\|+ \| \|\|+ +\|+\|+ +#\|\|\|\|\|++ \|\| +\|+\| +\| \|+ ++ \|\| Sbjct 9971 ELERAERESDEDMARLVADLQKRMER#TEPVTVLSDISDQSVFTGKEAEFQCEVTIN10026
Danio rerio	Query 8651 SQ#TEPVTLIKDIENQTVLKDNDAVFEIDIKIN 8682 + # \|\|\|\|+\|\|\| +\|\| + +\|\|\|\| +\|\|+\| Sbjct 5331 TT#ASPVTLLKDITDQTTQLNKEAVFECEIKVN 5362
Trypanosoma cruzi strain CL Brener	Query 8624 LEIEEIERSERDEKEFE-ELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDN 8671 \|+ \|\|+\| \|\|\| \| +++ +\|\| +#\| +\|+ + \| \| \|+\|\| Sbjct 712 LDEEEMENIERDYHSLEGRVIATAVERLRK#TAAASLLSSVPNSTRLRDN 760
Bacillus clausii KSM-K16	Query 8628 EIERSERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDNDAVFEIDI 8679 +\| \|\|\|\| \| ++ +\|\| + \|+#\| \|+ + \| +\| \| ++++ \|+ Sbjct 669 DIYIGERDESEIDDYLSFYLRNNSE#TAPLFQLTVNEFKTSRKSRESIYRTDV 720
Yersinia pseudotuberculosis IP 32953	Query 8632 SERDEKEFEELVSFIQQRLSQ#TEPVTLIKDIENQTVLKDN 8671 +\| \| ++ +\| + +\|\| \| \|# \| \| + \| \|\|+\|\| Sbjct 467 AEADPEKRTQLYTQLQQELQQ#NSPYIFIDQAKAQVVLRDN 506

* References

[PubMed ID: 19679839] Hidalgo C, Hudson B, Bogomolovas J, Zhu Y, Anderson B, Greaser M, Labeit S, Granzier H, PKC phosphorylation of titin's PEVK element: a novel and conserved pathway for modulating myocardial stiffness. Circ Res. 2009 Sep 25;105(7):631-8, 17 p following 638. doi:

» More (12) « Hide Below

[PubMed ID: 19622741] ... Bertz M, Wilmanns M, Rief M, The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13307-133310. doi:

[PubMed ID: 19651040] ... Grutzner A, Garcia-Manyes S, Kotter S, Badilla CL, Fernandez JM, Linke WA, Modulation of titin-based stiffness by disulfide bonding in the cardiac titin N2-B unique sequence. Biophys J. 2009 Aug 5;97(3):825-34. doi: 10.1016/j.bpj.2009.05.037.

[PubMed ID: 20031603] ... Marroni F, Pfeufer A, Aulchenko YS, Franklin CS, Isaacs A, Pichler I, Wild SH, Oostra BA, Wright AF, Campbell H, Witteman JC, Kaab S, Hicks AA, Gyllensten U, Rudan I, Meitinger T, Pattaro C, van Duijn CM, Wilson JF, Pramstaller PP, A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project. Circ Cardiovasc Genet. 2009 Aug;2(4):322-8. doi: 10.1161/CIRCGENETICS.108.833806.

[PubMed ID: 19608031] ... Arimura T, Bos JM, Sato A, Kubo T, Okamoto H, Nishi H, Harada H, Koga Y, Moulik M, Doi YL, Towbin JA, Ackerman MJ, Kimura A, Cardiac ankyrin repeat protein gene (ANKRD1) mutations in hypertrophic cardiomyopathy. J Am Coll Cardiol. 2009 Jul 21;54(4):334-42. doi: 10.1016/j.jacc.2008.12.082.

[PubMed ID: 17525332] ... Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, Shiloh Y, Gygi SP, Elledge SJ, ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 2007 May 25;316(5828):1160-6.

[PubMed ID: 11717165] ... Bang ML, Centner T, Fornoff F, Geach AJ, Gotthardt M, McNabb M, Witt CC, Labeit D, Gregorio CC, Granzier H, Labeit S, The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res. 2001 Nov 23;89(11):1065-72.

[PubMed ID: 9804419] ... Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Furst DO, Wilmanns M, Gautel M, Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature. 1998 Oct 29;395(6705):863-9.

[PubMed ID: 8404852] ... Gautel M, Leonard K, Labeit S, Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts. EMBO J. 1993 Oct;12(10):3827-34.

[PubMed ID: 1429890] ... Furst DO, Vinkemeier U, Weber K, Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA. J Cell Sci. 1992 Aug;102 ( Pt 4):769-78.

[PubMed ID: 1582406] ... Labeit S, Gautel M, Lakey A, Trinick J, Towards a molecular understanding of titin. EMBO J. 1992 May;11(5):1711-6.

[PubMed ID: 2129545] ... Labeit S, Barlow DP, Gautel M, Gibson T, Holt J, Hsieh CL, Francke U, Leonard K, Wardale J, Whiting A, et al., A regular pattern of two types of 100-residue motif in the sequence of titin. Nature. 1990 May 17;345(6272):273-6.

[PubMed ID: 3397062] ... Zeviani M, Darras BT, Rizzuto R, Salviati G, Betto R, Bonilla E, Miranda AF, Du J, Samitt C, Dickson G, et al., Cloning and expression of human nebulin cDNAs and assignment of the gene to chromosome 2q31-q32. Genomics. 1988 Apr;2(3):249-56.