Function: Using suppression subtractive hybridization with mouse muscle organoid cultures, Kemp et al. (2000) found that Ankrd2 expression increased 4-fold after 7 days of stretch. Ankrd2 expression also increased during myoblast fusion and decreased upon differentiation to the prefusion level.

Source Reference: [PubMed ID: 18310072] Hayashi C, Ono Y, Doi N, Kitamura F, Tagami M, Mineki R, Arai T, Taguchi H, Yanagida M, Hirner S, Labeit D, Labeit S, Sorimachi H, Multiple molecular interactions implicate the connectin/titin N2A region as a modulating scaffold for p94/calpain 3 activity in skeletal muscle. J Biol Chem. 2008 May 23;283(21):14801-14. doi: 10.1074/jbc.M708262200. Epub 2008

Summary

Top-ranked sequences

Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133

Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133
            ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133

Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133
            ||||| || | |||||||||||||||||||#||||||||||||||||||||||||+||||+
Sbjct    43 EDEKHQGAPSLALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKREALAAA  102

Query    74 EDEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAS  133
            |+||  | || |||||||||||||||||||#|||||||||||||||||||||||||||||+
Sbjct    47 EEEKRLGVQSPALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIELRKKRKQKKRDALAAA  106

Query    75 DEKHHGAQSAALQKVKGQERVRKTSLDLR#REIIDVGGIQNLIEL  118
            |||+    +  |  +|| +||||||+|||#+|||||||||||||+
Sbjct    43 DEKYQPPVNRNLANLKGDDRVRKTSVDLR#KEIIDVGGIQNLIEI   86

[PubMed ID: 22185618] ... Kojic S, Radojkovic D, Faulkner G, Muscle ankyrin repeat proteins: their role in striated muscle function in health and disease. Crit Rev Clin Lab Sci. 2011 Sep-Dec;48(5-6):269-94. doi:

[PubMed ID: 22016770] ... Belgrano A, Rakicevic L, Mittempergher L, Campanaro S, Martinelli VC, Mouly V, Valle G, Kojic S, Faulkner G, Multi-tasking role of the mechanosensing protein Ankrd2 in the signaling network of striated muscle. PLoS One. 2011;6(10):e25519. doi: 10.1371/journal.pone.0025519. Epub 2011 Oct 10.

[PubMed ID: 15677738] ... Mckoy G, Hou Y, Yang SY, Vega Avelaira D, Degens H, Goldspink G, Coulton GR, Expression of Ankrd2 in fast and slow muscles and its response to stretch are consistent with a role in slow muscle function. J Appl Physiol (1985). 2005 Jun;98(6):2337-43; discussion 2320. Epub 2005 Jan 27.

[PubMed ID: 14583192] ... Miller MK, Bang ML, Witt CC, Labeit D, Trombitas C, Watanabe K, Granzier H, McElhinny AS, Gregorio CC, Labeit S, The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. J Mol Biol. 2003 Nov 7;333(5):951-64.

[PubMed ID: 12004005] ... Tsukamoto Y, Senda T, Nakano T, Nakada C, Hida T, Ishiguro N, Kondo G, Baba T, Sato K, Osaki M, Mori S, Ito H, Moriyama M, Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation. Lab Invest. 2002 May;82(5):645-55.

[PubMed ID: 12679596] ... Nakamura K, Nakada C, Takeuchi K, Osaki M, Shomori K, Kato S, Ohama E, Sato K, Fukayama M, Mori S, Ito H, Moriyama M, Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis. Pathobiology. 2002-2003;70(4):197-203.

[PubMed ID: 11453652] ... Moriyama M, Tsukamoto Y, Fujiwara M, Kondo G, Nakada C, Baba T, Ishiguro N, Miyazaki A, Nakamura K, Hori N, Sato K, Shomori K, Takeuchi K, Satoh H, Mori S, Ito H, Identification of a novel human ankyrin-repeated protein homologous to CARP. Biochem Biophys Res Commun. 2001 Jul 20;285(3):715-23.

[PubMed ID: 11444853] ... Pallavicini A, Kojic S, Bean C, Vainzof M, Salamon M, Ievolella C, Bortoletto G, Pacchioni B, Zatz M, Lanfranchi G, Faulkner G, Valle G, Characterization of human skeletal muscle Ankrd2. Biochem Biophys Res Commun. 2001 Jul 13;285(2):378-86.

[PubMed ID: 10873377] ... Kemp TJ, Sadusky TJ, Saltisi F, Carey N, Moss J, Yang SY, Sassoon DA, Goldspink G, Coulton GR, Identification of Ankrd2, a novel skeletal muscle gene coding for a stretch-responsive ankyrin-repeat protein. Genomics. 2000 Jun 15;66(3):229-41.