SB0114 : Filaggrin
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | filaggrin-2 [Homo sapiens]; filaggrin-2; filaggrin 2; ifapsoriasin; intermediate filament-associated and psoriasis susceptibility protein; FLG-2; intermediate filament-associated and psoriasis-susceptibility protein; Filaggrin-2; Intermediate filament-associated and psoriasis-susceptibility protein; Ifapsoriasin |
| Gene Names | FLG2; IFPS; filaggrin family member 2 |
| Gene Locus | 1q21.3; chromosome 1 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001014364 | NM_001014342 | 388698 | Q5D862 | 616284 | HGNC:33276 | 11815 | hsa:388698 |
* Information From OMIM
Description: The FLG2 gene encodes a member of the S100 fused-type protein (SFTP) family. These proteins are essential components that maintain epithelial homeostasis and barrier function (summary by Wu et al., 2009).
Function: Using RT-PCR, Wu et al. (2009) found that expression of both FLG and FLG2 increased 200-fold in cultured human foreskin keratinocytes following calcium-induced differentiation.
* Structure Information
1. Primary Information
Length: 2391 aa
Average Mass: 248.070 kDa
Monoisotopic Mass: 247.928 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| EF hand 1. | 26 | 39 | 15.0 | 0.0 |
| EF hand 2. | 54 | 80 | 2.0 | 0.5 |
| EF-hand domain pair 1. | 92 | 109 | 23.0 | 0.1 |
3. Sequence Information
Fasta Sequence: SB0114.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
4 [sites] cleaved by Calpain 1
Source Reference: [PubMed ID: 21531719] Hsu CY, Henry J, Raymond AA, Mechin MC, Pendaries V, Nassar D, Hansmann B, Balica S, Burlet-Schiltz O, Schmitt AM, Takahara H, Paul C, Serre G, Simon M, Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem. 2011 Jul 1;286(26):23222-33. doi: 10.1074/jbc.M110.197400. Epub 2011
Cleavage sites (±10aa)
[Site 1] RHAHYHHGLT1713-TQTGSRTTGR
Thr1713 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg1704 | His1705 | Ala1706 | His1707 | Tyr1708 | His1709 | His1710 | Gly1711 | Leu1712 | Thr1713 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr1714 | Gln1715 | Thr1716 | Gly1717 | Ser1718 | Arg1719 | Thr1720 | Thr1721 | Gly1722 | Arg1723 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SESIVPERHGTTHGQTGDTTRHAHYHHGLTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 33.10 | 6 | profilaggrin |
| 2 | Homo sapiens | 32.30 | 1 | filaggrin |
| 3 | Oryza sativa Japonica Group | 31.20 | 1 | amidophosphoribosyltransferase-like |
| 4 | Homo sapiens | 31.20 | 1 | filaggrin family member 2 |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ | |+ |++||| || #+ + | +| || |+ +||||+| | | Sbjct 32 SSAGERHGSHHQQSADSSRHAGIGHGQA#S-SAVRDSGHRGYRGSQATDSEGHSEDSDT 88 Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ + |+ |++||+ || #+ + | +| ||| |+ ||+||+| | | Sbjct 356 SSAGERHGSHYQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDNEGHSEDSDT 412 |
| Homo sapiens | Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ | |+ |++||+ || #+ + | +| ||| |+ |||||+| | | Sbjct 2324 SSAGERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDSEGHSEDSDT 2380 Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ | |+ |++||+ || #+ + | +| ||| |+ |||||+| | | Sbjct 3620 SSAGERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDSEGHSEDSDT 3676 Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ | |+ |++||+ || #+ + | +| || |+ ||+||+| | | Sbjct 2648 SSAGERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGYSGSQASDNEGHSEDSDT 2704 Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | ||||+ | |+ |++||+ || #+ + | +| || |+ ||+||+| | | Sbjct 2972 SSAGERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGYSGSQASDNEGHSEDSDT 3028 |
| Oryza sativa Japonica Group | Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSD 1733 ++|+|| |+|+ |+| |+|| |# ++ + || | +| | Sbjct 57 TQSLVPLLSSLTNGRIASTSRLLHHHHATT#AKSNASTTKSNNSLGNEEDD 106 |
| Homo sapiens | Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVS 1741 ||||| ||||| |||||||||||| || +#||||||||||| |||||||||||+|| | Sbjct 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 ||| | +|| |||||||||| | | || |# |||||||||||||||||||||| |||||| Sbjct 1911 SESTVHKRHQTTHGQTGDTTEHGHPSHGQT#IQTGSRTTGRRGSGHSEYSDSEGPSGVSHT 1970 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | | | |||||||||| ||||| | || +#|| |||||||| |||||||||||+|||||| Sbjct 1986 SGSSVHERHGTTHGQTADTTRHGHSGHGQS#TQRGSRTTGRRASGHSEYSDSEGHSGVSHT 2045 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | | | ||||||||||||||||||||| +#|| || ||||||||||| |||| +|| ||| Sbjct 1457 SGSTVHGRHGTTHGQTGDTTRHAHYHHGKS#TQRGSSTTGRRGSGHSESSDSEVHSGGSHT 1516 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | | | |||||||||||||||||| || +#|| |||| ||||||||| |||| +|||||| Sbjct 2061 SGSSVHERHGTTHGQTGDTTRHAHSGHGQS#TQRGSRTAGRRGSGHSESSDSEVHSGVSHT 2120 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 ||||| |||||||||||||+ |+ || +#||+|| ||||| ||||| |||| +|| ||| Sbjct 1836 SESIVDERHGTTHGQTGDTSGHSQSGHGQS#TQSGSSTTGRRRSGHSESSDSEVHSGGSHT 1895 Query 1691 RHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | |||||||||||||||| +| +#|| |||||||||||||| |||| +| ||| Sbjct 2218 RQGTTHGQTGDTTRHAHYGYGQS#TQRGSRTTGRRGSGHSESSDSEVHSWGSHT 2270 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSH 1742 ||| | ||| ||+||||+ | | | || +#|| |||||||||||||| |||| +|| || Sbjct 1380 SESTVHERHETTYGQTGEATGHGHSGHGQS#TQRGSRTTGRRGSGHSESSDSEVHSGGSH 1438 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSH 1742 ||||+ +|| |||||||||||++ | |#||||||||||+ + ||| +||| +|| || Sbjct 1532 SESIIHDRHRITHGQTGDTTRHSYSGHEQT#TQTGSRTTGRQRTSHSESTDSEVHSGGSH 1590 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSH 1742 | | | | |||||| |||||| | || +#|||||||+||+ ||+ +||| +||||| Sbjct 1303 SGSTVRRRQGTTHGQRGDTTRHGHSGHGQS#TQTGSRTSGRQRFSHSDATDSEVHSGVSH 1361 Query 1685 ESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSHT 1743 | | ||||||||| |||| |+| || +#|| |||||||+ | ||| |||| +|||||| Sbjct 1610 EFTVHERHGTTHGQIGDTTGHSHSGHGQS#TQRGSRTTGRQRSSHSESSDSEVHSGVSHT 1668 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRR 1724 | | + | || |||||||||| || +#||||||||||+ Sbjct 2136 SGSAIHGRQGTIHGQTGDTTRHGQSGHGQS#TQTGSRTTGRQ 2176 Query 1686 SIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTT 1721 | | | |||||||||||| | +| +#||||||++ Sbjct 2288 STVHGRLETTHGQTGDTTRHGHSGYGQS#TQTGSRSS 2323 Query 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVSH 1742 | | | | |||||| +||||+ | +#|||||| | || | || |||| +| ||| Sbjct 1228 SGSTVHGRQETTHGQTINTTRHSQSGQGQS#TQTGSRVTRRRRSSQSENSDSEVHSKVSH 1286 |
[Site 2] SDSEGYSGVS1741-HTHSGHTHGQ
Ser1741 His
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ser1732 | Asp1733 | Ser1734 | Glu1735 | Gly1736 | Tyr1737 | Ser1738 | Gly1739 | Val1740 | Ser1741 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| His1742 | Thr1743 | His1744 | Ser1745 | Gly1746 | His1747 | Thr1748 | His1749 | Gly1750 | Gln1751 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LTTQTGSRTTGRRGSGHSEYSDSEGYSGVSHTHSGHTHGQARSQHGESESIVHERHGTIH |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 42.40 | 1 | filaggrin family member 2 |
| 2 | Mus musculus | 32.70 | 1 | filaggrin family member 2 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1712 LTTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1712 LTTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +|| |||||||| |||||||||||+||||#|||||| |||| |||||| | ||||||| | Sbjct 2015 STQRGSRTTGRRASGHSEYSDSEGHSGVS#HTHSGHAHGQAGSQHGESGSSVHERHGTTH 2073 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 | |||||||||||||||||||||| ||||#||||||||||| | + || | ||||||| | Sbjct 1940 TIQTGSRTTGRRGSGHSEYSDSEGPSGVS#HTHSGHTHGQAGSHYPESGSSVHERHGTTH 1998 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +|| |||| ||||||||| |||| +||||#|||||||+|||||||||| | +| | |||| Sbjct 2090 STQRGSRTAGRRGSGHSESSDSEVHSGVS#HTHSGHTYGQARSQHGESGSAIHGRQGTIH 2148 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#H-THS-GHTHGQARSQHGESESIVHERHGTI 1770 +||||||||||| |||||||||||+|| |# || ||||||| |||||||||| ||||| Sbjct 1788 STQTGSRTTGRRSSGHSEYSDSEGHSGFS#QRPHSRGHTHGQAGSQHGESESIVDERHGTT 1847 Query 1771 H 1771 | Query 1771 H 1771 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +|| || ||||||||||| |||| +|| |#||||||||||+ |||||||||+|+|| | Sbjct 1486 STQRGSSTTGRRGSGHSESSDSEVHSGGS#HTHSGHTHGQSGSQHGESESIIHDRHRITH 1544 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +||+|| ||||| ||||| |||| +|| |#|||||||| ||||||||||| ||+|| | | Sbjct 1865 STQSGSSTTGRRRSGHSESSDSEVHSGGS#HTHSGHTHSQARSQHGESESTVHKRHQTTH 1923 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSG--HTHGQARSQHGESESIVHERHGTI 1770 +|| |||||||||||||| |||| +|| |#| ||||| |||||| | || |||| Sbjct 1409 STQRGSRTTGRRGSGHSESSDSEVHSGGS#HRPQSQEQTHGQAGSQHGESGSTVHGRHGTT 1468 Query 1771 H 1771 | Query 1771 H 1771 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +|| |||||||+ | ||| |||| +||||#|||+||||||| ||||+||||| ||||| | Sbjct 1638 STQRGSRTTGRQRSSHSESSDSEVHSGVS#HTHTGHTHGQAGSQHGQSESIVPERHGTTH 1696 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +|| |||||||||||||| |||| +| |#|||||| ||| || + | || | | | Sbjct 2240 STQRGSRTTGRRGSGHSESSDSEVHSWGS#HTHSGHIQGQAGSQQRQPGSTVHGRLETTH 2298 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#H-THS-GHTHGQARSQHGESESIVHERHGTI 1770 |||||||||||+ + ||| +||| +|| |#| || ||+||| ||| | | ||||||| Sbjct 1561 TTQTGSRTTGRQRTSHSESTDSEVHSGGS#HRPHSREHTYGQAGSQHEEPEFTVHERHGTT 1620 Query 1771 H 1771 | Query 1771 H 1771 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#H-THSG-HTHGQARSQHGESESIVHERHGTI 1770 +|||||||+||+ ||+ +||| +||||#| || || || |||||||| ||||| | Sbjct 1332 STQTGSRTSGRQRFSHSDATDSEVHSGVS#HRPHSQEQTHSQAGSQHGESESTVHERHETT 1391 Query 1771 H 1771 + Sbjct 1392 Y 1392 Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSGHTHGQARSQHGESESIVHERHGTIH 1771 +||||||||||+ | ||| |||| +| |# ||||||| || |+||+| | | | || | Sbjct 2165 STQTGSRTTGRQRSSHSESSDSEVHSEAS#PTHSGHTHSQAGSRHGQSGSSGHGRQGTTH 2223 |
| Mus musculus | Query 1713 TTQTGSRTTGRRGSGHSEYSDSEGYSGVS#HTHSG------HTHGQARSQHGES 1759 +|+| + || | |||+ | +| ||# ||| | ||||| | || Sbjct 1030 PSQSGYGRSPRRSQVHPEYSEGEAHSEVS#QRHSGSSHCHCHCHGQARHQQRES 1082 |
[Site 3] IVHERHGTIH1771-GQTGDTTRHA
His1771 Gly
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile1762 | Val1763 | His1764 | Glu1765 | Arg1766 | His1767 | Gly1768 | Thr1769 | Ile1770 | His1771 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gly1772 | Gln1773 | Thr1774 | Gly1775 | Asp1776 | Thr1777 | Thr1778 | Arg1779 | His1780 | Ala1781 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| HTHSGHTHGQARSQHGESESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 43.50 | 1 | filaggrin family member 2 |
| 2 | N/A | 33.10 | 5 | profilaggrin |
| 3 | Homo sapiens | 32.30 | 1 | filaggrin |
| 4 | Plasmodium falciparum 3D7 | 31.20 | 1 | hypothetical protein MAL8P1.152 |
| 5 | Mus musculus | 30.80 | 1 | filaggrin family member 2 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 |||||| |||| |||||| | ||||||| |#||||||||||||||||||| |||| ||| | Sbjct 2044 HTHSGHAHGQAGSQHGESGSSVHERHGTTH#GQTGDTTRHAHSGHGQSTQRGSRTAGRRGS 2103 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRR 1799 |||||||+|||||||||| | +| | ||||#||||||||| ||||||||||||||||+ Sbjct 2119 HTHSGHTYGQARSQHGESGSAIHGRQGTIH#GQTGDTTRHGQSGHGQSTQTGSRTTGRQ 2176 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 |||+||||||| ||||+||||| ||||| |#||||||||||| || +||||||||||| | Sbjct 1667 HTHTGHTHGQAGSQHGQSESIVPERHGTTH#GQTGDTTRHAHYHHGLTTQTGSRTTGRRGS 1726 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 |||||||| ||||||||||| ||+|| | |#||||||| | | |||+ |||||||||| | Sbjct 1894 HTHSGHTHSQARSQHGESESTVHKRHQTTH#GQTGDTTEHGHPSHGQTIQTGSRTTGRRGS 1953 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRR 1799 ||||||||||+ |||||||||+|+|| |#|||||||||++||| |+||||||||||+ Sbjct 1515 HTHSGHTHGQSGSQHGESESIIHDRHRITH#GQTGDTTRHSYSGHEQTTQTGSRTTGRQ 1572 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 ||||||||||| | + || | ||||||| |#||| ||||| ||||||||| ||||||||+| Sbjct 1969 HTHSGHTHGQAGSHYPESGSSVHERHGTTH#GQTADTTRHGHSGHGQSTQRGSRTTGRRAS 2028 Query 1746 GHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 ||||||| |||||||||| ||||| |#||||||+ |+ ||||||||+|| ||||| | Sbjct 1823 GHTHGQAGSQHGESESIVDERHGTTH#GQTGDTSGHSQSGHGQSTQSGSSTTGRRRS 1878 Query 1743 THSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 ||||||| || |+||+| | | | || |#||||||||||| |+||||| |||||||| | Sbjct 2195 THSGHTHSQAGSRHGQSGSSGHGRQGTTH#GQTGDTTRHAHYGYGQSTQRGSRTTGRRGS 2253 Query 1747 HTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRR 1799 ||+||| ||| | | ||||||| |#|| |||| |+||||||||| |||||||+ Sbjct 1597 HTYGQAGSQHEEPEFTVHERHGTTH#GQIGDTTGHSHSGHGQSTQRGSRTTGRQ 1649 Query 1748 THGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 || || |||||||| ||||| | +#||||+ | | ||||||||| |||||||| | Sbjct 1369 THSQAGSQHGESESTVHERHETTY#GQTGEATGHGHSGHGQSTQRGSRTTGRRGS 1422 Query 1748 THGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRSS 1801 ||||| |||||| | || |||| |#||||||||||| ||+||| || ||||| | Sbjct 1446 THGQAGSQHGESGSTVHGRHGTTH#GQTGDTTRHAHYHHGKSTQRGSSTTGRRGS 1499 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRR 1799 | || | | || | + +| | | | || |#|| |||||| ||||||||||||||+||+ Sbjct 1286 HRHSEHIHTQAGSHYPKSGSTVRRRQGTTH#GQRGDTTRHGHSGHGQSTQTGSRTSGRQ 1343 Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTT 1796 |||||| ||| || + | || | | |#||||||||| |||+|||||||||++ Sbjct 2269 HTHSGHIQGQAGSQQRQPGSTVHGRLETTH#GQTGDTTRHGHSGYGQSTQTGSRSS 2323 Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTG 1792 || || || | || | | |#||| +||||+ || ||||||| Sbjct 1219 GQGESQQVESGSTVHGRQETTH#GQTINTTRHSQSGQGQSTQTG 1261 |
| N/A | Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 ||| | | ++ | ||||+ |# |+ |++||+ ||||++ Sbjct 632 GQAASSHEQARSSAGERHGSHH#QQSADSSRHSGIGHGQAS 671 |
| Homo sapiens | Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 ||| | | ++ | ||||+ |# |+ |++||+ ||||++ Sbjct 2313 GQAASSHEQARSSAGERHGSHH#QQSADSSRHSGIGHGQAS 2352 Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 ||| | | ++ | ||||+ |# |+ |++||+ ||||++ Sbjct 2637 GQAASSHEQARSSAGERHGSHH#QQSADSSRHSGIGHGQAS 2676 Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 ||| | | ++ | ||||+ |# |+ |++||+ ||||++ Sbjct 2961 GQAASSHEQARSSAGERHGSHH#QQSADSSRHSGIGHGQAS 3000 Query 1750 GQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 ||| | | ++ | ||||+ |# |+ |++||+ ||||++ Sbjct 3609 GQAASSHEQARSSAGERHGSHH#QQSADSSRHSGIGHGQAS 3648 Query 1748 THGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQST 1789 +|||| | | ++ | ||||+ |# |+ |++||+ || |++ Sbjct 1338 SHGQAVSSHEQARSSPGERHGSRH#QQSADSSRHSGIGHRQAS 1379 |
| Plasmodium falciparum 3D7 | Query 1742 HTHSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQT 1791 | +| | | | | +||++| +|# | || + | |++ | Sbjct 490 HEQNGKLHEQNGDLH-EQNGKLHEQNGKLH#EQNGDLHDQSGDLHEQNSLT 538 |
| Mus musculus | Query 1747 HTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGR 1798 | ||||| | || || + | #| + |++|| +| || +|+||| + | Sbjct 1070 HCHGQARHQQRES---VHGQRGRPQ#GPSQDSSRHPQAGPGQPSQSGSRRSPR 1118 Query 1744 HSGHTHGQARSQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRS 1800 +||+ ||| ++ | + || +| | #| + |++| +|||| +|+| + ||| Sbjct 987 YSGYGHGQGQAGHQQRESGYGQR-GRPQ#GPSQDSSRQPQAGHGQPSQSGYGRSPRRS 1042 Query 1742 HTHSGHTHGQAR--SQHGESESIVHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRR 1799 |+ |||+||| + ++| + || || + | #| + |++| +| || + +|| + || Sbjct 1685 HSGSGHSHGQGQVHAEHQQRES-VHGQRGRPQ#GPSQDSSRQPQAGQGQPSLSGSGRSPRR 1743 Query 1800 S 1800 | Query 1800 S 1800 Query 1763 VHERHGTIH#GQTGDTTRHAHSGHGQSTQTGSRTTGRRS 1800 || + | #| | |++| +| || +|+|| + ||| Sbjct 1473 VHGQRGRPQ#GPTQDSSRQPQAGQGQPSQSGSGRSPRRS 1510 |
[Site 4] RHAHSGHGQS1788-TQTGSRTTGR
Ser1788 Thr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg1779 | His1780 | Ala1781 | His1782 | Ser1783 | Gly1784 | His1785 | Gly1786 | Gln1787 | Ser1788 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr1789 | Gln1790 | Thr1791 | Gly1792 | Ser1793 | Arg1794 | Thr1795 | Thr1796 | Gly1797 | Arg1798 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| SESIVHERHGTIHGQTGDTTRHAHSGHGQSTQTGSRTTGRRSSGHSEYSDSEGHSGFSQR |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 40.40 | 1 | filaggrin family member 2 |
| 2 | N/A | 35.40 | 7 | profilaggrin |
| 3 | Hordeum vulgare subsp. vulgare | 35.40 | 2 | nicotianamine aminotransferase |
| 4 | Mus musculus | 35.40 | 1 | filaggrin family member 2 |
| 5 | Homo sapiens | 31.20 | 1 | filaggrin |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 | | ||||||| |||| ||||| |||||||#|| ||||||||+|||||||||||||| | Sbjct 1986 SGSSVHERHGTTHGQTADTTRHGHSGHGQS#TQRGSRTTGRRASGHSEYSDSEGHSGVS 2043 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 ||||| ||||| |||||||||||| || +#||||||||||| |||||||||||+|| | Sbjct 1684 SESIVPERHGTTHGQTGDTTRHAHYHHGLT#TQTGSRTTGRRGSGHSEYSDSEGYSGVS 1741 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 | | ||||||| ||||||||||||||||||#|| |||| ||| ||||| |||| ||| | Sbjct 2061 SGSSVHERHGTTHGQTGDTTRHAHSGHGQS#TQRGSRTAGRRGSGHSESSDSEVHSGVS 2118 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 ||| ||+|| | |||||||| | | |||+# |||||||||| ||||||||||| || | Sbjct 1911 SESTVHKRHQTTHGQTGDTTEHGHPSHGQT#IQTGSRTTGRRGSGHSEYSDSEGPSGVS 1968 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 ||||| ||||| |||||||+ |+ ||||||#||+|| ||||| ||||| |||| ||| | Sbjct 1836 SESIVDERHGTTHGQTGDTSGHSQSGHGQS#TQSGSSTTGRRRSGHSESSDSEVHSGGS 1893 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 ||| ||||| | +||||+ | | |||||||#|| |||||||| ||||| |||| ||| | | Sbjct 1380 SESTVHERHETTYGQTGEATGHGHSGHGQS#TQRGSRTTGRRGSGHSESSDSEVHSGGSHR 1439 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 ||||+|+|| ||||||||||++||| |+#||||||||||+ + ||| +||| ||| | | Sbjct 1532 SESIIHDRHRITHGQTGDTTRHSYSGHEQT#TQTGSRTTGRQRTSHSESTDSEVHSGGSHR 1591 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFS 1816 | | || |||| |||||||||||| ||+|#|| || ||||| ||||| |||| ||| | Sbjct 1457 SGSTVHGRHGTTHGQTGDTTRHAHYHHGKS#TQRGSSTTGRRGSGHSESSDSEVHSGGS 1514 Query 1764 HERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 | | || |||||||||||| |+|||#|| |||||||| ||||| |||| || Sbjct 2216 HGRQGTTHGQTGDTTRHAHYGYGQS#TQRGSRTTGRRGSGHSESSDSEVHS 2265 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 | | | | || ||| |||||| |||||||#|||||||+||+ ||+ +||| ||| | | Sbjct 1303 SGSTVRRRQGTTHGQRGDTTRHGHSGHGQS#TQTGSRTSGRQRFSHSDATDSEVHSGVSHR 1362 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRR 1799 | | +| | ||||||||||||| ||||||#||||||||||+ Sbjct 2136 SGSAIHGRQGTIHGQTGDTTRHGQSGHGQS#TQTGSRTTGRQ 2176 Query 1760 ESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRR 1799 | ||||||| ||| |||| |+|||||||#|| |||||||+ Sbjct 1610 EFTVHERHGTTHGQIGDTTGHSHSGHGQS#TQRGSRTTGRQ 1649 Query 1761 SIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTT 1796 | || | | |||||||||| |||+|||#||||||++ Sbjct 2288 STVHGRLETTHGQTGDTTRHGHSGYGQS#TQTGSRSS 2323 Query 1759 SESIVHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 | | || | | |||| +||||+ || |||#|||||| | || | || |||| || | | Sbjct 1228 SGSTVHGRQETTHGQTINTTRHSQSGQGQS#TQTGSRVTRRRRSSQSENSDSEVHSKVSHR 1287 |
| N/A | Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||| ||||+#+ + | +| | |+ +|||||| Sbjct 36 ERHGSHHQQSADSSRHAGIGHGQA#S-SAVRDSGHRGYRGSQATDSEGHS 83 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ + |+ |++||+ ||||+#+ + | +| | | |+ ||+|||| Sbjct 360 ERHGSHYQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDNEGHS 407 |
| Hordeum vulgare subsp. vulgare | Query 1767 HGTIHGQTGDTTRHAHS---GHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 || | + || + |||++#| | | |+||+| +|+ | | Sbjct 54 HGVAADANGKSNGHAEATANGHGEA#TANGKTNGHRESNGHAEAADANGES 103 |
| Mus musculus | Query 1768 GTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 | | + |++| +|||| #+|+| + ||| | |||+ | || ||| Sbjct 1010 GRPQGPSQDSSRQPQAGHGQP#SQSGYGRSPRRSQVHPEYSEGEAHSEVSQR 1060 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | | |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1473 VHGQRGRPQGPTQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1528 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++|| +| || #+|+||| + | | | |+ | || || Sbjct 1083 VHGQRGRPQGPSQDSSRHPQAGPGQP#SQSGSRRSPRSQPVHPESSEGEEHSVVPQR 1138 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1161 VHGQQGRPQGPSQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1216 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1629 VHGQRGRPQGPSQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVIPQR 1684 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1553 VHGQRGRPQGPSQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1608 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1865 VHGQRGRPQGPSQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1920 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+ +|| + ||| | | |+ | || || Sbjct 1707 VHGQRGRPQGPSQDSSRQPQAGQGQP#SLSGSGRSPRRSPVHPESSEGEEHSVVPQR 1762 Query 1769 TIHGQ-------TGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 ++||| | |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1318 SVHGQPVRPEVPTQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1374 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | | + |++| +| || #+|+|| + || | | |+ | || || Sbjct 1787 VHGQRGRPQGPSQDSSRQPQAGQGQP#SQSGSGRSPGRSPVHPESSEGEEHSVVPQR 1842 Query 1763 VHERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 || + | |++| +| || #+|+|| + ||| | | |+ | || || Sbjct 1241 VHGQRSRPQGPFQDSSRQPQAGQGQP#SQSGSGRSPRRSPVHPESSEGEEHSVVPQR 1296 |
| Homo sapiens | Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ ||||+#+ + | +| | | |+ ||||||| Sbjct 2328 ERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDSEGHS 2375 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ ||||+#+ + | +| | | |+ ||||||| Sbjct 3624 ERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGSSGSQASDSEGHS 3671 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ ||||+#+ + | +| | |+ ||+|||| Sbjct 2652 ERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGYSGSQASDNEGHS 2699 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ ||||+#+ + | +| | |+ ||+|||| Sbjct 2976 ERHGSHHQQSADSSRHSGIGHGQA#S-SAVRDSGHRGYSGSQASDNEGHS 3023 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ +| ||+#+ | | ||| |+ ||||||| Sbjct 382 ERHGSGHQQSADSSRHSATGRGQA#SSAVSDRGHRGSSG-SQASDSEGHS 429 Query 1765 ERHGTIHG-QTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ +||||+#+ + | +| | | |+ +|||||| Sbjct 706 ERHGSRHQLQSADSSRHSGTGHGQA#S-SAVRDSGHRGSSGSQATDSEGHS 754 Query 1765 ERHGTIHGQTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ || |+#+ + | +| | | |+ ++||||| Sbjct 1355 ERHGSRHQQSADSSRHSGIGHRQA#S-SAVRDSGHRGSSGSQVTNSEGHS 1402 Query 1776 DTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHSGFSQR 1818 | +||+ +| |||# ||||+ |+ | |+ ||||||| |+| Sbjct 921 DISRHSQAGQGQS#E--GSRTSRRQGSSVSQDSDSEGHSEDSER 961 Query 1765 ERHGTIHG-QTGDTTRHAHSGHGQS#TQTGSRTTGRRSSGHSEYSDSEGHS 1813 ||||+ | |+ |++||+ ||||+#+ + | +| | |+ ||||||| Sbjct 2003 ERHGSHHQLQSADSSRHSGIGHGQA#S-SAVRDSGHRGYSGSQASDSEGHS 2051 |
* References
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