SB0128 : MEF2D
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | myocyte-specific enhancer factor 2D isoform 1 [Homo sapiens]; myocyte-specific enhancer factor 2D isoform 1; MADS box transcription enhancer factor 2, polypeptide D; myocyte-specific enhancer factor 2D; Myocyte-specific enhancer factor 2D |
| Gene Names | MEF2D; myocyte enhancer factor 2D |
| Gene Locus | 1q12-q23; chromosome 1 |
| GO Function | Not available |
* Information From OMIM
Function: Breitbart et al. (1993) found that recombinantly expressed MEF2D protein showed DNA binding to the MEF2 site.
* Structure Information
1. Primary Information
Length: 521 aa
Average Mass: 55.937 kDa
Monoisotopic Mass: 55.903 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| SRF-type transcription factor (DNA-binding and dimerisation domain) 1. | 10 | 57 | 1.0 | 0.4 |
| --- cleavage 78 --- | ||||
| Holliday junction regulator protein family C-terminal repeat 1. | 97 | 153 | 3.0 | 0.0 |
| Uncharacterized protein conserved in bacteria (DUF2076) 1. | 181 | 215 | 135.0 | 0.1 |
| Topoisomerase II-associated protein PAT1 1. | 365 | 404 | 272.0 | 4.6 |
3. Sequence Information
Fasta Sequence: SB0128.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 22215669] Wei G, Yin Y, Li W, Bito H, She H, Mao Z, Calpain-mediated degradation of myocyte enhancer factor 2D contributes to excitotoxicity by activation of extrasynaptic N-methyl-D-aspartate receptors. J Biol Chem. 2012 Feb 17;287(8):5797-805. doi: 10.1074/jbc.M111.260109. Epub 2012
Cleavage sites (±10aa)
[Site 1] YTEYNEPHES78-RTNADIIETL
Ser78 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Tyr69 | Thr70 | Glu71 | Tyr72 | Asn73 | Glu74 | Pro75 | His76 | Glu77 | Ser78 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg79 | Thr80 | Asn81 | Ala82 | Asp83 | Ile84 | Ile85 | Glu86 | Thr87 | Leu88 |
Sequence conservation (by blast)
* References
[PubMed ID: 23793025] Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U, McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimaki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schurks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Farkkila M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PA, Montgomery GW, Martin NG, Borck G, Gobel H, Heinze A, Heinze-Kuhn K, Williams FM, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkila K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor BJ, Trabzuni D, Rossin E, Lage K, Jacobs SB, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman DI, Palotie A, Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nat Genet. 2013 Aug;45(8):912-7. doi: 10.1038/ng.2676. Epub 2013 Jun 23.