SB0130 : tau
[ CaMP Format ]
* Basic Information
| Organism | Rattus norvegicus (Norway rat) |
| Protein Names | rCG32645, isoform CRA_d [Rattus norvegicus]; rCG32645, isoform CRA_d |
| Gene Names | Not available |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| EDM06300 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 432 aa
Average Mass: 45.113 kDa
Monoisotopic Mass: 45.086 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 120 --- | ||||
| --- cleavage 209 --- | ||||
| Predicted transmembrane and coiled-coil 2 protein 1. | 244 | 292 | 104.0 | 0.1 |
| Predicted transmembrane and coiled-coil 2 protein 2. | 317 | 389 | 109.0 | 0.3 |
| --- cleavage 380 (inside Predicted transmembrane and coiled-coil 2 protein 317..389) --- | ||||
3. Sequence Information
Fasta Sequence: SB0130.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 21359008] Liu MC, Kobeissy F, Zheng W, Zhang Z, Hayes RL, Wang KK, Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions. ASN Neuro. 2011 Feb 16;3(1):e00051. doi: 10.1042/AN20100012.
Cleavage sites (±10aa)
[Site 1] VTQARVAGVS120-KDRTGNDEKK
Ser120 
Lys
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val111 | Thr112 | Gln113 | Ala114 | Arg115 | Val116 | Ala117 | Gly118 | Val119 | Ser120 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Lys121 | Asp122 | Arg123 | Thr124 | Gly125 | Asn126 | Asp127 | Glu128 | Lys129 | Lys130 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| TAEEAGIGDTPNMEDQAAGHVTQARVAGVSKDRTGNDEKKAKGADGKTGAKIATPRGAAT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Rattus norvegicus | 117.00 | 1 | microtubule associated protein |
| 2 | Rattus norvegicus | 116.00 | 1 | microtubule-associated protein TAU |
| 3 | Mus musculus | 106.00 | 6 | microtubule-associated protein tau isoform a |
| 4 | N/A | 104.00 | 6 | tau microtubule binding protein |
| 5 | Canis familiaris | 95.10 | 6 | PREDICTED: similar to microtubule-associated prot |
| 6 | Spermophilus citellus | 89.70 | 1 | TAU_SPECI Microtubule-associated protein tau gi |
| 7 | Homo sapiens | 88.60 | 3 | microtubule-associated protein tau isoform 2 |
| 8 | Capra hircus | 88.20 | 1 | TAU_CAPHI Microtubule-associated protein tau (Neu |
| 9 | Bos taurus | 87.00 | 8 | tau protein |
| 10 | Papio hamadryas | 86.70 | 1 | TAU_PAPHA Microtubule-associated protein tau (Neu |
| 11 | synthetic construct | 86.70 | 1 | Homo sapiens microtubule-associated protein tau |
| 12 | rats, spinal cord, Peptide Partial, 102 aa | 57.40 | 1 | HMW tau isoform SC2=high-molecular-weight tau pro |
| 13 | rats, dorsal root ganglia, Peptide, 686 aa | 51.20 | 1 | high molecular weight tau, HMW |
| 14 | human, Alzheimer's disease brain, Peptide Partial, 28 aa, segment 2 of 11 | 48.10 | 1 | paired helical filament-tau, PHF-tau |
| 15 | Canis lupus familiaris | 39.70 | 1 | microtubule-associated protein tau |
| 16 | Pongo pygmaeus | 32.70 | 1 | TAU_PONPY Microtubule-associated protein tau gi |
| 17 | Gorilla gorilla | 32.70 | 1 | TAU_GORGO Microtubule-associated protein tau gi |
| 18 | Hylobates lar | 32.70 | 1 | TAU_HYLLA Microtubule-associated protein tau gi |
| 19 | Pan troglodytes | 32.70 | 1 | microtubule-associated protein tau |
Top-ranked sequences
| organism | matching |
|---|---|
| Rattus norvegicus | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 |
| Rattus norvegicus | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 |
| Mus musculus | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 |||||||||||| |||||||||||||| |#|||||||||||||||||||||||||||||+ Sbjct 91 TAEEAGIGDTPNQEDQAAGHVTQARVA--S#KDRTGNDEKKAKGADGKTGAKIATPRGAAS 148 |
| N/A | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 ||||||||||| |||||||||||||| |#|||||||||||||||||||||||||||||+ Sbjct 34 AEEAGIGDTPNQEDQAAGHVTQARVA--S#KDRTGNDEKKAKGADGKTGAKIATPRGAAS 90 |
| Canis familiaris | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGA 148 ||||||||||||+||||||||||||+ #|| || |+||||||||||| |||||||| Sbjct 101 TAEEAGIGDTPNLEDQAAGHVTQARMVSKG#KDGTGTDDKKAKGADGKTGTKIATPRGA 158 |
| Spermophilus citellus | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 |||||||||||||||||||||||||+ #|+ ||++++|||||| ||| ||||||| | Sbjct 89 TAEEAGIGDTPNMEDQAAGHVTQARMVSKG#KEGTGSEDRKAKGADSKTGTKIATPRGTA 147 |
| Homo sapiens | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 |||||||||||++||+|||||||||+ |#|| ||+|+|||||||||| ||||||||| Sbjct 102 TAEEAGIGDTPSLEDEAAGHVTQARMVSKS#KDGTGSDDKKAKGADGKT--KIATPRGAA 158 |
| Capra hircus | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 ||||||||| |+||||||||||||+ #|| || |+||||||||| | ||||||||| Sbjct 63 AEEAGIGDTSNLEDQAAGHVTQARMVSKG#KDGTGPDDKKAKGADGKPGTKIATPRGAA 120 |
| Bos taurus | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 ||||||||| |+||||||||||||+ #|| || |+|| |||||| | ||||||||| Sbjct 92 AEEAGIGDTSNLEDQAAGHVTQARMVSKG#KDGTGPDDKKTKGADGKPGTKIATPRGAA 149 |
| Papio hamadryas | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 ||||||||||++||+|||||||||+ |#|| ||+|+|||||||||| ||||||||| Sbjct 45 AEEAGIGDTPSLEDEAAGHVTQARMVSKS#KDGTGSDDKKAKGADGKT--KIATPRGAA 100 |
| synthetic construct | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAA 149 ||||||||||++||+|||||||||+ |#|| ||+|+|||||||||| ||||||||| Sbjct 45 AEEAGIGDTPSLEDEAAGHVTQARMVSKS#KDGTGSDDKKAKGADGKT--KIATPRGAA 100 |
| rats, spinal cord, Peptide Partial, 102 aa | Query 106 QAAGHVTQARVAGVS#KDRTGNDEKKAK 132 |||||||||||||||#|||||||||||| Query 106 QAAGHVTQARVAGVS#KDRTGNDEKKAK 132 |
| rats, dorsal root ganglia, Peptide, 686 aa | Query 113 QARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 150 +|||||||#|||||||||||||||||||||||||||||| Sbjct 367 KARVAGVS#KDRTGNDEKKAKGADGKTGAKIATPRGAAT 404 Query 91 TAEEAGIGDTPNMEDQAAGHVTQ 113 ||||||||||||||||||||||| Query 91 TAEEAGIGDTPNMEDQAAGHVTQ 113 |
| human, Alzheimer's disease brain, Peptide Partial, 28 aa, segment 2 of 11 | Query 92 AEEAGIGDTPNMEDQAAGHVTQARVAGVS#K 121 ||||||||||++||+|||||||||+ ||#| Sbjct 1 AEEAGIGDTPSLEDEAAGHVTQARM--VS#K 28 |
| Canis lupus familiaris | Query 91 TAEEAGIGDTPNMEDQAAGHVTQ 113 ||||||||||||+|||||||||| Sbjct 101 TAEEAGIGDTPNLEDQAAGHVTQ 123 Query 124 TGNDEKKAKGADGKTGAKIATPRGA 148 +| | |||||||||| |||||||| Sbjct 458 SGAKEMKAKGADGKTGTKIATPRGA 482 |
| Pongo pygmaeus | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAG 118 |||||||||||++||+||||||| +| Sbjct 102 TAEEAGIGDTPSLEDEAAGHVTQEPESG 129 Query 124 TGNDEKKAKGADGKTGAKIATPRGAA 149 +| | | ||||||| ||||||||| Sbjct 452 SGAKEMKLKGADGKT--KIATPRGAA 475 |
| Gorilla gorilla | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAG 118 |||||||||||++||+||||||| +| Sbjct 102 TAEEAGIGDTPSLEDEAAGHVTQEPESG 129 Query 124 TGNDEKKAKGADGKTGAKIATPRGAA 149 +| | | ||||||| ||||||||| Sbjct 452 SGAKEMKLKGADGKT--KIATPRGAA 475 |
| Hylobates lar | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAG 118 |||||||||||++||+||||||| +| Sbjct 102 TAEEAGIGDTPSLEDEAAGHVTQEPESG 129 Query 124 TGNDEKKAKGADGKTGAKIATPRGAA 149 +| | | ||||||| ||||||||| Sbjct 452 SGAKEMKLKGADGKT--KIATPRGAA 475 |
| Pan troglodytes | Query 91 TAEEAGIGDTPNMEDQAAGHVTQARVAG 118 |||||||||||++||+||||||| +| Sbjct 102 TAEEAGIGDTPSLEDEAAGHVTQEPESG 129 Query 124 TGNDEKKAKGADGKTGAKIATPRGAA 149 +| | | ||||||| ||||||||| Sbjct 452 SGAKEMKLKGADGKT--KIATPRGAA 475 |
[Site 2] RSRTPSLPTP209-PTREPKKVAV
Pro209 Pro
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Arg200 | Ser201 | Arg202 | Thr203 | Pro204 | Ser205 | Leu206 | Pro207 | Thr208 | Pro209 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Pro210 | Thr211 | Arg212 | Glu213 | Pro214 | Lys215 | Lys216 | Val217 | Ala218 | Val219 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| PKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPV |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 114.00 | 10 | tau microtubule binding protein |
| 2 | Mus musculus | 114.00 | 9 | unnamed protein product |
| 3 | Rattus norvegicus | 114.00 | 1 | microtubule associated protein |
| 4 | rats, dorsal root ganglia, Peptide, 686 aa | 113.00 | 1 | high molecular weight tau, HMW |
| 5 | Homo sapiens | 111.00 | 7 | microtubule-associated protein tau isoform 3 |
| 6 | Canis familiaris | 110.00 | 11 | PREDICTED: similar to microtubule-associated prot |
| 7 | synthetic construct | 110.00 | 1 | Homo sapiens microtubule-associated protein tau |
| 8 | Papio hamadryas | 109.00 | 1 | TAU_PAPHA Microtubule-associated protein tau (Neu |
| 9 | Hylobates lar | 108.00 | 1 | TAU_HYLLA Microtubule-associated protein tau gi |
| 10 | Gorilla gorilla | 108.00 | 1 | TAU_GORGO Microtubule-associated protein tau gi |
| 11 | Canis lupus familiaris | 108.00 | 1 | microtubule-associated protein tau |
| 12 | Pongo pygmaeus | 108.00 | 1 | TAU_PONPY Microtubule-associated protein tau gi |
| 13 | Spermophilus citellus | 108.00 | 1 | TAU_SPECI Microtubule-associated protein tau gi |
| 14 | Pan troglodytes | 108.00 | 1 | microtubule-associated protein tau |
| 15 | Bos taurus | 106.00 | 10 | microtubule-associated protein tau |
| 16 | Capra hircus | 106.00 | 1 | TAU_CAPHI Microtubule-associated protein tau (Neu |
| 17 | human, Alzheimer's disease brain, Peptide Partial, 64 aa, segment 4 of 11 | 101.00 | 1 | paired helical filament-tau, PHF-tau |
| 18 | Xenopus laevis | 75.90 | 6 | tau-like protein-2 |
| 19 | Xenopus laevis | 75.90 | 1 | tau-like protein-2 |
| 20 | Tetraodon nigroviridis | 40.40 | 2 | unnamed protein product |
| 21 | Rattus norvegicus | 35.40 | 4 | MAP2d |
| 22 | Mus musculus | 35.00 | 1 | Microtubule-associated protein 2 |
| 23 | Rattus sp. | 34.70 | 2 | HMW MAP2 |
| 24 | Homo sapiens | 34.30 | 2 | microtubule-associated protein 2 |
| 25 | Rattus rattus | 34.30 | 1 | microtubule-associated protein 2 |
| 26 | Macaca fascicularis | 34.30 | 1 | hypothetical protein |
| 27 | Danio rerio | 32.70 | 1 | hypothetical protein LOC555420 |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |
| Mus musculus | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |
| Rattus norvegicus | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |
| rats, dorsal root ganglia, Peptide, 686 aa | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |
| Homo sapiens | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 131 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 190 |
| Canis familiaris | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |||+|||||||||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 190 KSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSAAKSRLQTAPV 248 |
| synthetic construct | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 131 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 190 |
| Papio hamadryas | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#| |||||||||||||||||++||||||||| Sbjct 131 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PAREPKKVAVVRTPPKSPSSAKSRLQTAPV 190 |
| Hylobates lar | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 524 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 583 |
| Gorilla gorilla | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 524 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 583 |
| Canis lupus familiaris | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |||+|||||||||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 514 KSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSAAKSRLQTAPV 572 |
| Pongo pygmaeus | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 506 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 565 |
| Spermophilus citellus | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 |||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 179 KSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSTKSRLQTAPV 237 |
| Pan troglodytes | Query 180 PKSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 524 PKSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 583 |
| Bos taurus | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAP 238 |||+|||||||||||||||||||||||||#||||||||||||||||||||+||||| || Sbjct 197 KSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSAAKSRLQAAP 254 |
| Capra hircus | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAP 238 |||+|||||||||||||||||||||||||#||||||||||||||||||||+||||| || Sbjct 152 KSGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSAAKSRLQAAP 209 |
| human, Alzheimer's disease brain, Peptide Partial, 64 aa, segment 4 of 11 | Query 182 SGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQTAPV 239 ||+|||||||||||||||||||||||||#|||||||||||||||||||++||||||||| Sbjct 1 SGDRSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSSAKSRLQTAPV 58 |
| Xenopus laevis | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQ 235 ||||||||||||||||| || | ||# |||||+||+|||||||+++||||| Sbjct 424 KSGERSGYSSPGSPGTPTGRS---SSQTP#TNREPKKIAVIRTPPKSPASAKSRLQ 475 |
| Xenopus laevis | Query 181 KSGERSGYSSPGSPGTPGSRSRTPSLPTP#PTREPKKVAVVRTPPKSPSASKSRLQ 235 ||||||||||||||||| || | ||# |||||+||+|||||||+++||||| Sbjct 424 KSGERSGYSSPGSPGTPTGRS---SSQTP#TNREPKKIAVIRTPPKSPASAKSRLQ 475 |
| Tetraodon nigroviridis | Query 185 RSGYSSPGSPGTPGS---------RSRTPSLPTP#PT---REPKKVAVVRTPPKSPSASKS 232 ||| |+| | |||+ |||| ||# + + |||||+||||||||+++ Sbjct 688 RSGTSTPASAITPGTPPSYSCRSPGSRTPGSHTP#KSFSVLQEKKVAVIRTPPKSPSSAQR 747 Query 233 RLQT 236 +|+ Sbjct 748 QLKV 751 |
| Rattus norvegicus | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTREP--KKVAVVRTPPKSPSASKS-RLQTAPV 239 ||| ||+|||| | ||| | # | ||||++|||||||+ | || |+ Sbjct 252 YSSRTPGTPGTP-SYPRTPGTPKS#GILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 307 |
| Mus musculus | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTREP--KKVAVVRTPPKSPSASKS-RLQTAPV 239 ||| ||+|||| | ||| | # | ||||++|||||||+ | || |+ Sbjct 251 YSSRTPGTPGTP-SYPRTPGTPKS#GILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 306 |
| Rattus sp. | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTREP--KKVAVVRTPPKSPSASKS-RLQTAPV 239 ||| ||+|||| | ||| | # | ||||++|||||||+ | || |+ Sbjct 182 YSSRTPGTPGTP-SYPRTPGTPKS#GILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 237 |
| Homo sapiens | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTR-----EPKKVAVVRTPPKSP 227 ||| ||+|||| | ||| | #| ||||++||||||| Sbjct 1605 YSSRTPGTPGTP-SYPRTPHTPGT#PKSAILVPSEKKVAIIRTPPKSP 1650 |
| Rattus rattus | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTREP-KKVAVVRTPPKSPSASKS-RLQTAPV 239 ||| ||+|||| | ||| | # | +|||++|||||||+ | || |+ Sbjct 1614 YSSRTPGTPGTP-SYPRTPGTPKS#GILVPSEKVAIIRTPPKSPATPKQLRLINQPL 1668 |
| Macaca fascicularis | Query 188 YSS--PGSPGTPGSRSRTPSLPTP#PTR-----EPKKVAVVRTPPKSPSASKS-RLQTAPV 239 ||| ||+|||| | ||| | #| ||||++|||||||+ | || |+ Sbjct 518 YSSRTPGTPGTP-SYPRTPHTPGT#PKSAILVPSEKKVAIIRTPPKSPATPKQLRLINQPL 576 |
| Danio rerio | Query 185 RSGYSSPGSPG----TPGS----RSRTPSLPTP#P--------TREPKKVAVVRTPPKSPS 228 ||| |+| +|| |||+ ||| | #| + ||||++|||||||+ Sbjct 60 RSGTSTPHTPGSTAITPGTPPSYSCRTPGTPRT#PGTPKSLSLLSQEKKVAIIRTPPKSPA 119 Query 229 ASKSRLQT 236 + +|+ Sbjct 120 TTPKQLRV 127 |
[Site 3] ENAKAKTDHG380-AEIVYKSPVV
Gly380 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Glu371 | Asn372 | Ala373 | Lys374 | Ala375 | Lys376 | Thr377 | Asp378 | His379 | Gly380 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala381 | Glu382 | Ile383 | Val384 | Tyr385 | Lys386 | Ser387 | Pro388 | Val389 | Val390 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| ITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDM |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Canis familiaris | 126.00 | 21 | PREDICTED: similar to Microtubule-associated prot |
| 2 | N/A | 126.00 | 14 | TAU_MACMU Microtubule-associated protein tau (Neu |
| 3 | Bos taurus | 126.00 | 10 | microtubule-associated protein tau |
| 4 | Canis lupus familiaris | 126.00 | 1 | microtubule-associated protein tau |
| 5 | rats, dorsal root ganglia, Peptide, 686 aa | 126.00 | 1 | high molecular weight tau, HMW |
| 6 | Hylobates lar | 126.00 | 1 | TAU_HYLLA Microtubule-associated protein tau gi |
| 7 | Pan troglodytes | 126.00 | 1 | microtubule-associated protein tau |
| 8 | Gorilla gorilla | 126.00 | 1 | TAU_GORGO Microtubule-associated protein tau gi |
| 9 | Mus musculus | 125.00 | 14 | microtubule-associated protein tau isoform a |
| 10 | Homo sapiens | 125.00 | 13 | microtubule-associated protein tau isoform 2 |
| 11 | synthetic construct | 125.00 | 1 | Homo sapiens microtubule-associated protein tau |
| 12 | Capra hircus | 125.00 | 1 | TAU_CAPHI Microtubule-associated protein tau (Neu |
| 13 | Papio hamadryas | 125.00 | 1 | TAU_PAPHA Microtubule-associated protein tau (Neu |
| 14 | Pongo pygmaeus | 124.00 | 1 | TAU_PONPY Microtubule-associated protein tau gi |
| 15 | Spermophilus citellus | 123.00 | 1 | TAU_SPECI Microtubule-associated protein tau gi |
| 16 | Rattus norvegicus | 122.00 | 1 | microtubule associated protein |
| 17 | Xenopus laevis | 105.00 | 1 | tau-like protein-2 |
| 18 | Rattus norvegicus | 81.60 | 4 | microtubule-associated protein 2 |
| 19 | Rattus rattus | 81.60 | 1 | microtubule-associated protein 2 |
| 20 | Mus musculus | 81.30 | 3 | Microtubule-associated protein 2 |
| 21 | Rattus sp. | 80.90 | 1 | microtubule-associated protein 2c; MAP2c |
| 22 | Homo sapiens | 80.50 | 2 | microtubule-associated protein 2C |
| 23 | Macaca fascicularis | 80.10 | 2 | hypothetical protein |
| 24 | Xenopus laevis | 75.50 | 1 | microtubule-associated protein 2 |
| 25 | human, Alzheimer's disease brain, Peptide Partial, 56 aa, segment 11 of 11 | 71.60 | 1 | paired helical filament-tau, PHF-tau |
| 26 | Danio rerio | 70.10 | 1 | hypothetical protein LOC555420 |
| 27 | Tetraodon nigroviridis | 62.40 | 3 | unnamed protein product |
| 28 | human, Alzheimer's disease brain, Peptide Partial, 30 aa, segment 10 of 11 | 52.80 | 1 | paired helical filament-tau, PHF-tau |
| 29 | synthetic construct | 38.50 | 1 | microtubule-associated protein 4 |
| 30 | Anopheles gambiae | 37.40 | 1 | putative microtubule binding protein |
| 31 | Anopheles gambiae str. PEST | 37.00 | 1 | AGAP001570-PA |
| 32 | Drosophila melanogaster | 36.20 | 1 | tau CG31057-PA |
| 33 | Apis mellifera | 35.80 | 1 | PREDICTED: similar to tau CG31057-PA, partial |
| 34 | Drosophila pseudoobscura | 34.70 | 1 | GA15971-PA |
Top-ranked sequences
| organism | matching |
|---|---|
| Canis familiaris | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| N/A | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Bos taurus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Canis lupus familiaris | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| rats, dorsal root ganglia, Peptide, 686 aa | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Hylobates lar | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Pan troglodytes | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Gorilla gorilla | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Mus musculus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Homo sapiens | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| synthetic construct | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Capra hircus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Papio hamadryas | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Pongo pygmaeus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||+|||||||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 677 ITHVPGGGHKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 736 |
| Spermophilus citellus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||+| Sbjct 349 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSINM 408 |
| Rattus norvegicus | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||||||||||||||||||||||||||#||||+||||||||||||||||||||||||| Sbjct 293 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVHKSPVVSGDTSPRHLSNVSSTGSIDM 352 |
| Xenopus laevis | Query 351 ITHVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 +||||||| ||||+|||+||||||||||||#|||||||| ||+|||| ||||||+|||+| Sbjct 592 VTHVPGGGAKKIESHKLSFRENAKAKTDHG#AEIVYKSPGHSGETSPRRLSNVSSSGSINM 651 |
| Rattus norvegicus | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 1746 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPSRSSVASPRRLSNVSSSGSINL 1803 |
| Rattus rattus | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 1749 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPSRSSVASPRRLSNVSSSGSINL 1806 |
| Mus musculus | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 387 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPSRSSVASPRRLSNVSSSGSINL 444 |
| Rattus sp. | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 141 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPSRSSVASPRRLSNVSSSGSINL 198 |
| Homo sapiens | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 393 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPGRSSVASPRRLSNVSSSGSINL 450 |
| Macaca fascicularis | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||||| ||++ || |||+|||+ |||#|||+ +|| | ||| ||||||+|||++ Sbjct 657 HVPGGGNVKIDSQKLNFREHAKARVDHG#AEIITQSPGRSSVASPRRLSNVSSSGSINL 714 |
| Xenopus laevis | Query 352 THVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 +|+||||| ||++ || ||+ |||+ |||#|||+ +|| | || ||||||+|||++ Sbjct 349 SHMPGGGNIKIDSQKLNFRDQAKARVDHG#AEIITQSPGRSSAASPHRLSNVSSSGSINL 407 |
| human, Alzheimer's disease brain, Peptide Partial, 56 aa, segment 11 of 11 | Query 377 TDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ||||#|||||||||||||||||||||||||||||| Query 377 TDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 |
| Danio rerio | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 | |||| +||+|||+||+ |||+ |||#|||| ++ +|| ||| |++||+|||+| Sbjct 213 HTPGGGQIQIESHKLSFRDAAKARVDHG#AEIVIETLGLSGGTSPHRHSHMSSSGSINM 270 |
| Tetraodon nigroviridis | Query 360 KKIETHKLTFRENAKAKTDHG#AEIVYKSPVVSGDTSPRHLSNVSSTGSIDM 410 ++||+||||||| |||+||||#||| || + ||+ || |||+|||+| Sbjct 385 RQIESHKLTFRETAKARTDHG#AEI------VSLEDSPQQLSTVSSSGSINM 429 |
| human, Alzheimer's disease brain, Peptide Partial, 30 aa, segment 10 of 11 | Query 351 ITHVPGGGNKKIETHKLTFRENAK 374 |||||||||||||||||||||||| Query 351 ITHVPGGGNKKIETHKLTFRENAK 374 |
| synthetic construct | Query 351 ITHVPGGGNKKIETHKLTFRENAKAK 376 | | ||||+ |||+ || |+| |+|| Sbjct 872 IKHKPGGGDVKIESQKLNFKEKAQAK 897 |
| Anopheles gambiae | Query 352 THVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYK 386 +| ||||+|+||+ | |+| || | # | || Sbjct 732 SHKPGGGDKRIESIKTDFKERAKPKIGSK#DNITYK 766 |
| Anopheles gambiae str. PEST | Query 352 THVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYK 386 +| ||||+|+||+ | |+| || | # | || Sbjct 732 SHKPGGGDKRIESIKTDFKERAKPKIGSK#DNITYK 766 |
| Drosophila melanogaster | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYK 386 | ||||+||||| |+ |++ || | #| + ++ Sbjct 249 HKPGGGDKKIETLKMDFKDKAKPKVGST#ANVKHQ 282 |
| Apis mellifera | Query 352 THVPGGGNKKIETHKLTFRENAKAK 376 |+ ||||+||||| || |++ || | Sbjct 229 TYKPGGGDKKIETVKLDFKDKAKPK 253 |
| Drosophila pseudoobscura | Query 353 HVPGGGNKKIETHKLTFRENAKAKTDHG#AEIVYK 386 + ||||+||||| |+ |++ || | # + |+ Sbjct 168 YKPGGGDKKIETLKMDFKDKAKPKVGSK#DNVKYQ 201 |
* References
[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.