SB0136 : [beta]-Catenin
[ CaMP Format ]
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | catenin beta-1 [Mus musculus]; catenin beta-1; beta-catenin; Catenin beta-1; Beta-catenin |
| Gene Names | Ctnnb1; Catnb; catenin (cadherin associated protein), beta 1 |
| Gene Locus | 9 72.19 cM; chromosome 9 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_001159374 | NM_001165902 | 12387 | Q02248 | N/A | N/A | N/A | mmu:12387 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 781 aa
Average Mass: 85.470 kDa
Monoisotopic Mass: 85.416 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| --- cleavage 28 --- | ||||
| --- cleavage 29 --- | ||||
| --- cleavage 30 --- | ||||
| --- cleavage 95 --- | ||||
| Kinesin-associated protein (KAP) 1. | 153 | 208 | 578.0 | 0.1 |
| Domain of unknown function (DUF3361) 1. | 233 | 264 | 95.0 | 0.3 |
| Armadillo/beta-catenin-like repeat 1. | 272 | 303 | 7.0 | 0.0 |
| Armadillo/beta-catenin-like repeat 2. | 308 | 328 | 1.0 | 0.0 |
| Kinesin-associated protein (KAP) 2. | 335 | 466 | 305.0 | 0.0 |
| Kinesin-associated protein (KAP) 3. | 508 | 591 | 308.0 | 0.0 |
| Armadillo-like 1. | 594 | 647 | 134.0 | 0.0 |
3. Sequence Information
Fasta Sequence: SB0136.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1DOW (X-ray; 180 A; B=118-149), 1I7W (X-ray; 200 A; A/C=134-671), 1I7X (X-ray; 300 A; A/C=134-671), 1JPP (X-ray; 310 A; A/B=134-671), 1M1E (X-ray; 210 A; A=134-671), 1V18 (X-ray; 210 A; A=134-671), 2BCT (X-ray; 290 A; A=150-665), 3BCT (X-ray; 210 A; A=193-661), 3OUW (X-ray; 291 A; A=134-671), 3OUX (X-ray; 240 A; A=134-671), 4EV8 (X-ray; 190 A; A=134-671), 4EV9 (X-ray; 210 A; A=134-671), 4EVA (X-ray; 200 A; A/C=134-671), 4EVP (X-ray; 226 A; A=134-671), 4EVT (X-ray; 234 A; A=134-671), 4ONS (X-ray; 280 A; B/D=78-151)
* Cleavage Information
4 [sites] cleaved by Calpain 1
Source Reference: [PubMed ID: 17270735] Abe K, Takeichi M, NMDA-receptor activation induces calpain-mediated beta-catenin cleavages for triggering gene expression. Neuron. 2007 Feb 1;53(3):387-97.
Cleavage sites (±10aa)
[Site 1] KAAVSHWQQQ28-SYLDSGIHSG
Gln28 
Ser
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Lys19 | Ala20 | Ala21 | Val22 | Ser23 | His24 | Trp25 | Gln26 | Gln27 | Gln28 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ser29 | Tyr30 | Leu31 | Asp32 | Ser33 | Gly34 | Ile35 | His36 | Ser37 | Gly38 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVD |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 123.00 | 6 | beta-catenin |
| 2 | Mus musculus | 122.00 | 4 | catenin (cadherin associated protein), beta 1, 88 |
| 3 | Rattus norvegicus | 122.00 | 2 | beta-catenin |
| 4 | Sus scrofa | 122.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 5 | Gallus gallus | 122.00 | 1 | catenin (cadherin-associated protein), beta 1, 88 |
| 6 | Meriones unguiculatus | 122.00 | 1 | beta-catenin |
| 7 | N/A | 120.00 | 7 | CTNB_XENLA Catenin beta (Beta-catenin) gi |
| 8 | Xenopus tropicalis | 120.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 9 | Xenopus laevis | 120.00 | 1 | beta-catenin protein |
| 10 | Xenopus laevis | 119.00 | 3 | catenin |
| 11 | Carassius auratus | 117.00 | 1 | beta-catenin |
| 12 | Danio rerio | 116.00 | 4 | catenin, beta 2 |
| 13 | Tetraodon nigroviridis | 113.00 | 2 | unnamed protein product |
| 14 | Branchiostoma belcheri | 50.80 | 1 | beta-catenin |
| 15 | Anopheles gambiae str. PEST | 47.40 | 1 | AGAP001043-PA |
| 16 | Gryllus bimaculatus | 47.40 | 1 | armadillo protein |
| 17 | Apis mellifera | 47.00 | 2 | PREDICTED: similar to Armadillo segment polarity |
| 18 | Drosophila melanogaster | 46.20 | 2 | armadillo CG11579-PC, isoform C |
| 19 | Bos taurus | 45.80 | 1 | junction plakoglobin |
| 20 | Drosophila pseudoobscura | 45.80 | 1 | GA11077-PA |
| 21 | Chaetopterus variopedatus | 44.70 | 1 | AF408420_1 beta-catenin |
| 22 | Canis familiaris | 44.30 | 9 | PREDICTED: similar to junction plakoglobin isofor |
| 23 | Ciona savignyi | 39.70 | 1 | beta-catenin |
| 24 | Achaearanea tepidariorum | 37.70 | 1 | Armadillo |
| 25 | Ciona intestinalis | 35.40 | 2 | beta-catenin |
| 26 | Urechis caupo | 33.10 | 1 | CTNB_URECA Catenin beta (Beta-catenin) gi |
| 27 | Trypanosoma cruzi strain CL Brener | 31.20 | 1 | mucin-associated surface protein (MASP), putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| Mus musculus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| Rattus norvegicus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| Sus scrofa | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| Gallus gallus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| Meriones unguiculatus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |
| N/A | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||+|||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEDEDVD 58 |
| Xenopus tropicalis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||+|||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEDEDVD 58 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||+|||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEDEDVD 58 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||#|||||||||||||||||||||||||++||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Carassius auratus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||+|||||||||||||||||||||||#|||||||||||||||||||||||||++||| Sbjct 1 MATQSDLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Danio rerio | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||+|||||||||||| ||||||||||||#||||||||||||||||||||||||||||+| Sbjct 1 MASQADLMELDMAMEQDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDLD 58 |
| Tetraodon nigroviridis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||#||||||||||||||||||||||||||+||| Sbjct 1 ADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEDDVD 54 |
| Branchiostoma belcheri | Query 4 QADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNP 52 | + |+| | | ||||#||||||| ||||| ||||| + | Sbjct 27 QGNYMDLSGMPAMDPKQQTMEWQQQ#SYLDSGIQSGATTQAPSLSSRQGP 75 |
| Anopheles gambiae str. PEST | Query 16 PDRKAAVSHWQQQ#SYL-DSGIHSGATTTAPSLSGKGNPEEED 56 | | ||| #||| |||||||| | |||||| + |+| Sbjct 4 PSAKEQTLMWQQN#SYLGDSGIHSGAVTQVPSLSGKDDDMEDD 45 |
| Gryllus bimaculatus | Query 25 WQQQ#SYL-DSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||| #||| |||||||||| ||||+|| |||++ Sbjct 36 WQQN#SYLGDSGIHSGATTQAPSLTGK----EEDME 66 |
| Apis mellifera | Query 25 WQQQ#SYL-DSGIHSGATTTAPSLSGKGNPEEE 55 ||| #||| |||||||| | ||||||| + | | Sbjct 36 WQQN#SYLGDSGIHSGAVTQAPSLSGKEDDEME 67 |
| Drosophila melanogaster | Query 25 WQQQ#SYL-DSGIHSGATTTAPSLSGKGNPEEE 55 ||| #||| |||||||| | |||||| + | | Sbjct 35 WQQN#SYLGDSGIHSGAVTQVPSLSGKEDEEME 66 |
| Bos taurus | Query 22 VSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | |||| || ||++ Sbjct 13 VTEWQQT#YTYDSGIHSGANTCVPSLSSKGLIEEDE 47 |
| Drosophila pseudoobscura | Query 25 WQQQ#SYL-DSGIHSGATTTAPSLSGK------GNPEEEDVD 58 ||| #||| |||||||| | |||||| |+| |+| Sbjct 32 WQQN#SYLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLD 72 |
| Chaetopterus variopedatus | Query 6 DLMELDMAMEPDRKAAVSHWQQQ#SYL-DSGIHSGATTTAPSLSGKGNPEEED 56 + +++|| |+ ||| # |+ |||||||||| |||+| + | +| Sbjct 22 NYLDMDMQQPMDQNQKTMMWQQN#QYMADSGIHSGATTQAPSISSRQGDEMDD 73 |
| Canis familiaris | Query 22 VSHWQQQ#SYLDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | ||+| || ||++ Sbjct 13 VTEWQQT#YTYDSGIHSGANTCVPSVSSKGIMEEDE 47 |
| Ciona savignyi | Query 5 ADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSG 48 |||| | || || | | # |||| ||||| ||+|| Sbjct 2 ADLMMNRNEMVPDAKAQVRMWN--#--WDSGIQSGATTATPSISG 41 |
| Achaearanea tepidariorum | Query 25 WQQQ#SYL-DSGIHSGATTTAP-SLSGK 49 ||| #||+ ||||||||+| || +| || Sbjct 39 WQQN#SYMGDSGIHSGASTHAPGTLCGK 65 |
| Ciona intestinalis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQ#SYLDSGIHSGATTTAPSLSG 48 |++| | || |+ | | # |||| ||||| +||+|| Sbjct 2 AEMMMNRNEMVPDAKSQVRMWG--#--WDSGIQSGATTASPSISG 41 |
| Urechis caupo | Query 17 DRKAAVSHWQQQ#SYL-DSGIHSGATTTA-PSLSGK 49 | | ||| # |+ |||| ||||| | ||+| | Sbjct 33 DAKQQTMLWQQN#QYMGDSGIQSGATTQAPPSVSSK 67 |
| Trypanosoma cruzi strain CL Brener | Query 26 QQQ#SYLDSGIHSGATTTAPSL 46 |+ #++|++|+||| | |||| Sbjct 196 QKN#NFLETGVHSGTTPVAPSL 216 |
[Site 2] AAVSHWQQQS29-YLDSGIHSGA
Ser29 Tyr
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala20 | Ala21 | Val22 | Ser23 | His24 | Trp25 | Gln26 | Gln27 | Gln28 | Ser29 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Tyr30 | Leu31 | Asp32 | Ser33 | Gly34 | Ile35 | His36 | Ser37 | Gly38 | Ala39 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDT |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 125.00 | 6 | beta-catenin |
| 2 | Mus musculus | 124.00 | 4 | unnamed protein product |
| 3 | Rattus norvegicus | 124.00 | 2 | beta-catenin |
| 4 | Sus scrofa | 124.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 5 | Gallus gallus | 124.00 | 1 | catenin (cadherin-associated protein), beta 1, 88 |
| 6 | Meriones unguiculatus | 124.00 | 1 | beta-catenin |
| 7 | N/A | 122.00 | 7 | CTNB_XENLA Catenin beta (Beta-catenin) gi |
| 8 | Xenopus tropicalis | 122.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 9 | Xenopus laevis | 122.00 | 1 | beta-catenin protein |
| 10 | Xenopus laevis | 119.00 | 3 | catenin |
| 11 | Carassius auratus | 117.00 | 1 | beta-catenin |
| 12 | Danio rerio | 116.00 | 4 | catenin, beta 2 |
| 13 | Tetraodon nigroviridis | 113.00 | 2 | unnamed protein product |
| 14 | Branchiostoma belcheri | 50.80 | 1 | beta-catenin |
| 15 | Drosophila melanogaster | 48.10 | 2 | armadillo CG11579-PC, isoform C |
| 16 | Drosophila pseudoobscura | 47.80 | 1 | GA11077-PA |
| 17 | Gryllus bimaculatus | 47.40 | 1 | armadillo protein |
| 18 | Anopheles gambiae str. PEST | 47.40 | 1 | AGAP001043-PA |
| 19 | Apis mellifera | 47.00 | 2 | PREDICTED: similar to Armadillo segment polarity |
| 20 | Bos taurus | 45.80 | 1 | junction plakoglobin |
| 21 | Chaetopterus variopedatus | 45.10 | 1 | AF408420_1 beta-catenin |
| 22 | Canis familiaris | 44.30 | 9 | PREDICTED: similar to junction plakoglobin isofor |
| 23 | Ciona savignyi | 39.70 | 1 | beta-catenin |
| 24 | Achaearanea tepidariorum | 37.70 | 1 | Armadillo |
| 25 | Ciona intestinalis | 35.40 | 2 | beta-catenin |
| 26 | Urechis caupo | 33.10 | 1 | CTNB_URECA Catenin beta (Beta-catenin) gi |
| 27 | Trypanosoma cruzi strain CL Brener | 31.20 | 1 | mucin-associated surface protein (MASP), putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| Mus musculus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| Rattus norvegicus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| Sus scrofa | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| Gallus gallus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| Meriones unguiculatus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |
| N/A | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#||||||||||||||||||||||||+||||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEDEDVDT 59 |
| Xenopus tropicalis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#||||||||||||||||||||||||+||||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEDEDVDT 59 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVDT 59 |||||||||||||||||||||||||||||#||||||||||||||||||||||||+||||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEDEDVDT 59 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |||||||||||||||||||||||||||||#||||||||||||||||||||||||++||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Carassius auratus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||+||||||||||||||||||||||||#||||||||||||||||||||||||++||| Sbjct 1 MATQSDLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Danio rerio | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||+|||||||||||| |||||||||||||#|||||||||||||||||||||||||||+| Sbjct 1 MASQADLMELDMAMEQDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDLD 58 |
| Tetraodon nigroviridis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEEDVD 58 |||||||||||||||||||||||||#|||||||||||||||||||||||||+||| Sbjct 1 ADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEDDVD 54 |
| Branchiostoma belcheri | Query 4 QADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSGKGNP 52 | + |+| | | |||||#|||||| ||||| ||||| + | Sbjct 27 QGNYMDLSGMPAMDPKQQTMEWQQQS#YLDSGIQSGATTQAPSLSSRQGP 75 |
| Drosophila melanogaster | Query 25 WQQQS#YL-DSGIHSGATTTAPSLSGK------GNPEEEDVDT 59 ||| |#|| |||||||| | |||||| |+| |+|| Sbjct 35 WQQNS#YLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDT 76 |
| Drosophila pseudoobscura | Query 25 WQQQS#YL-DSGIHSGATTTAPSLSGK------GNPEEEDVDT 59 ||| |#|| |||||||| | |||||| |+| |+|| Sbjct 32 WQQNS#YLGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDT 73 |
| Gryllus bimaculatus | Query 25 WQQQS#YL-DSGIHSGATTTAPSLSGKGNPEEEDVDT 59 ||| |#|| |||||||||| ||||+|| |||+++ Sbjct 36 WQQNS#YLGDSGIHSGATTQAPSLTGK----EEDMES 67 |
| Anopheles gambiae str. PEST | Query 16 PDRKAAVSHWQQQS#YL-DSGIHSGATTTAPSLSGKGNPEEED 56 | | ||| |#|| |||||||| | |||||| + |+| Sbjct 4 PSAKEQTLMWQQNS#YLGDSGIHSGAVTQVPSLSGKDDDMEDD 45 |
| Apis mellifera | Query 25 WQQQS#YL-DSGIHSGATTTAPSLSGKGNPEEE 55 ||| |#|| |||||||| | ||||||| + | | Sbjct 36 WQQNS#YLGDSGIHSGAVTQAPSLSGKEDDEME 67 |
| Bos taurus | Query 22 VSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | |||| || ||++ Sbjct 13 VTEWQQTY#TYDSGIHSGANTCVPSLSSKGLIEEDE 47 |
| Chaetopterus variopedatus | Query 6 DLMELDMAMEPDRKAAVSHWQQQS#YL-DSGIHSGATTTAPSLSGKGNPEEED 56 + +++|| |+ ||| #|+ |||||||||| |||+| + | +| Sbjct 22 NYLDMDMQQPMDQNQKTMMWQQNQ#YMADSGIHSGATTQAPSISSRQGDEMDD 73 |
| Canis familiaris | Query 22 VSHWQQQS#YLDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | ||+| || ||++ Sbjct 13 VTEWQQTY#TYDSGIHSGANTCVPSVSSKGIMEEDE 47 |
| Ciona savignyi | Query 5 ADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSG 48 |||| | || || | | # |||| ||||| ||+|| Sbjct 2 ADLMMNRNEMVPDAKAQVRMWN---#-WDSGIQSGATTATPSISG 41 |
| Achaearanea tepidariorum | Query 25 WQQQS#YL-DSGIHSGATTTAP-SLSGK 49 ||| |#|+ ||||||||+| || +| || Sbjct 39 WQQNS#YMGDSGIHSGASTHAPGTLCGK 65 |
| Ciona intestinalis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQS#YLDSGIHSGATTTAPSLSG 48 |++| | || |+ | | # |||| ||||| +||+|| Sbjct 2 AEMMMNRNEMVPDAKSQVRMWG---#-WDSGIQSGATTASPSISG 41 |
| Urechis caupo | Query 17 DRKAAVSHWQQQS#YL-DSGIHSGATTTA-PSLSGK 49 | | ||| #|+ |||| ||||| | ||+| | Sbjct 33 DAKQQTMLWQQNQ#YMGDSGIQSGATTQAPPSVSSK 67 |
| Trypanosoma cruzi strain CL Brener | Query 26 QQQS#YLDSGIHSGATTTAPSL 46 |+ +#+|++|+||| | |||| Sbjct 196 QKNN#FLETGVHSGTTPVAPSL 216 |
[Site 3] AVSHWQQQSY30-LDSGIHSGAT
Tyr30 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala21 | Val22 | Ser23 | His24 | Trp25 | Gln26 | Gln27 | Gln28 | Ser29 | Tyr30 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu31 | Asp32 | Ser33 | Gly34 | Ile35 | His36 | Ser37 | Gly38 | Ala39 | Thr40 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 127.00 | 6 | beta-catenin |
| 2 | Mus musculus | 125.00 | 4 | unnamed protein product |
| 3 | Rattus norvegicus | 125.00 | 2 | beta-catenin |
| 4 | Meriones unguiculatus | 125.00 | 1 | beta-catenin |
| 5 | Sus scrofa | 124.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 6 | Gallus gallus | 124.00 | 1 | catenin (cadherin-associated protein), beta 1, 88 |
| 7 | N/A | 123.00 | 7 | CTNB_XENLA Catenin beta (Beta-catenin) gi |
| 8 | Xenopus tropicalis | 123.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 9 | Xenopus laevis | 123.00 | 1 | beta-catenin protein |
| 10 | Xenopus laevis | 119.00 | 3 | catenin |
| 11 | Carassius auratus | 117.00 | 1 | beta-catenin |
| 12 | Danio rerio | 116.00 | 4 | catenin, beta 2 |
| 13 | Tetraodon nigroviridis | 113.00 | 2 | unnamed protein product |
| 14 | Branchiostoma belcheri | 50.80 | 1 | beta-catenin |
| 15 | Drosophila melanogaster | 48.10 | 2 | armadillo CG11579-PC, isoform C |
| 16 | Drosophila pseudoobscura | 47.80 | 1 | GA11077-PA |
| 17 | Gryllus bimaculatus | 47.40 | 1 | armadillo protein |
| 18 | Anopheles gambiae str. PEST | 47.40 | 1 | AGAP001043-PA |
| 19 | Apis mellifera | 47.00 | 2 | PREDICTED: similar to Armadillo segment polarity |
| 20 | Bos taurus | 45.80 | 1 | junction plakoglobin |
| 21 | Chaetopterus variopedatus | 45.10 | 1 | AF408420_1 beta-catenin |
| 22 | Canis familiaris | 44.30 | 9 | PREDICTED: similar to junction plakoglobin isofor |
| 23 | Ciona savignyi | 39.70 | 1 | beta-catenin |
| 24 | Achaearanea tepidariorum | 37.70 | 1 | Armadillo |
| 25 | Ciona intestinalis | 35.40 | 2 | beta-catenin |
| 26 | Urechis caupo | 33.10 | 1 | CTNB_URECA Catenin beta (Beta-catenin) gi |
| 27 | Trypanosoma cruzi strain CL Brener | 31.20 | 1 | mucin-associated surface protein (MASP), putative |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 |
| Mus musculus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 |
| Rattus norvegicus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 |
| Meriones unguiculatus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 |
| Sus scrofa | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTT 60 |
| Gallus gallus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||+ Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTT 60 |
| N/A | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||+|||||+ Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEDEDVDTN 60 |
| Xenopus tropicalis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||+|||||+ Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEDEDVDTN 60 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVDTS 60 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||+|||||+ Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEDEDVDTN 60 |
| Xenopus laevis | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||++||| Sbjct 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Carassius auratus | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||+|||||||||||||||||||||||||#|||||||||||||||||||||||++||| Sbjct 1 MATQSDLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEDDDVD 58 |
| Danio rerio | Query 1 MATQADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||+|||||||||||| ||||||||||||||#||||||||||||||||||||||||||+| Sbjct 1 MASQADLMELDMAMEQDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDLD 58 |
| Tetraodon nigroviridis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEEDVD 58 ||||||||||||||||||||||||||#||||||||||||||||||||||||+||| Sbjct 1 ADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEDDVD 54 |
| Branchiostoma belcheri | Query 4 QADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSGKGNP 52 | + |+| | | ||||||#||||| ||||| ||||| + | Sbjct 27 QGNYMDLSGMPAMDPKQQTMEWQQQSY#LDSGIQSGATTQAPSLSSRQGP 75 |
| Drosophila melanogaster | Query 25 WQQQSY#L-DSGIHSGATTTAPSLSGK------GNPEEEDVDT 59 ||| ||#| |||||||| | |||||| |+| |+|| Sbjct 35 WQQNSY#LGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDT 76 |
| Drosophila pseudoobscura | Query 25 WQQQSY#L-DSGIHSGATTTAPSLSGK------GNPEEEDVDT 59 ||| ||#| |||||||| | |||||| |+| |+|| Sbjct 32 WQQNSY#LGDSGIHSGAVTQVPSLSGKEDEEMEGDPLMFDLDT 73 |
| Gryllus bimaculatus | Query 25 WQQQSY#L-DSGIHSGATTTAPSLSGKGNPEEEDVDT 59 ||| ||#| |||||||||| ||||+|| |||+++ Sbjct 36 WQQNSY#LGDSGIHSGATTQAPSLTGK----EEDMES 67 |
| Anopheles gambiae str. PEST | Query 16 PDRKAAVSHWQQQSY#L-DSGIHSGATTTAPSLSGKGNPEEED 56 | | ||| ||#| |||||||| | |||||| + |+| Sbjct 4 PSAKEQTLMWQQNSY#LGDSGIHSGAVTQVPSLSGKDDDMEDD 45 |
| Apis mellifera | Query 25 WQQQSY#L-DSGIHSGATTTAPSLSGKGNPEEE 55 ||| ||#| |||||||| | ||||||| + | | Sbjct 36 WQQNSY#LGDSGIHSGAVTQAPSLSGKEDDEME 67 |
| Bos taurus | Query 22 VSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | |||| || ||++ Sbjct 13 VTEWQQTYT#YDSGIHSGANTCVPSLSSKGLIEEDE 47 |
| Chaetopterus variopedatus | Query 6 DLMELDMAMEPDRKAAVSHWQQQSY#L-DSGIHSGATTTAPSLSGKGNPEEED 56 + +++|| |+ ||| |#+ |||||||||| |||+| + | +| Sbjct 22 NYLDMDMQQPMDQNQKTMMWQQNQY#MADSGIHSGATTQAPSISSRQGDEMDD 73 |
| Canis familiaris | Query 22 VSHWQQQSY#LDSGIHSGATTTAPSLSGKGNPEEED 56 |+ ||| # |||||||| | ||+| || ||++ Sbjct 13 VTEWQQTYT#YDSGIHSGANTCVPSVSSKGIMEEDE 47 |
| Ciona savignyi | Query 5 ADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSG 48 |||| | || || | | # |||| ||||| ||+|| Sbjct 2 ADLMMNRNEMVPDAKAQVRMWN----#WDSGIQSGATTATPSISG 41 |
| Achaearanea tepidariorum | Query 25 WQQQSY#L-DSGIHSGATTTAP-SLSGK 49 ||| ||#+ ||||||||+| || +| || Sbjct 39 WQQNSY#MGDSGIHSGASTHAPGTLCGK 65 |
| Ciona intestinalis | Query 5 ADLMELDMAMEPDRKAAVSHWQQQSY#LDSGIHSGATTTAPSLSG 48 |++| | || |+ | | # |||| ||||| +||+|| Sbjct 2 AEMMMNRNEMVPDAKSQVRMWG----#WDSGIQSGATTASPSISG 41 |
| Urechis caupo | Query 17 DRKAAVSHWQQQSY#L-DSGIHSGATTTA-PSLSGK 49 | | ||| |#+ |||| ||||| | ||+| | Sbjct 33 DAKQQTMLWQQNQY#MGDSGIQSGATTQAPPSVSSK 67 |
| Trypanosoma cruzi strain CL Brener | Query 26 QQQSY#LDSGIHSGATTTAPSL 46 |+ ++#|++|+||| | |||| Sbjct 196 QKNNF#LETGVHSGTTPVAPSL 216 |
[Site 4] YAMTRAQRVR95-AAMFPETLDE
Arg95 Ala
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Tyr86 | Ala87 | Met88 | Thr89 | Arg90 | Ala91 | Gln92 | Arg93 | Val94 | Arg95 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ala96 | Ala97 | Met98 | Phe99 | Pro100 | Glu101 | Thr102 | Leu103 | Asp104 | Glu105 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| WEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPTNVQRL |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 130.00 | 2 | beta-catenin |
| 2 | Mus musculus | 129.00 | 3 | unnamed protein product |
| 3 | Sus scrofa | 129.00 | 1 | catenin (cadherin-associated protein), beta 1, 88 |
| 4 | Rattus norvegicus | 129.00 | 1 | beta-catenin |
| 5 | Meriones unguiculatus | 129.00 | 1 | beta-catenin |
| 6 | N/A | 126.00 | 4 | CTNB_XENLA Catenin beta (Beta-catenin) gi |
| 7 | Xenopus tropicalis | 126.00 | 2 | catenin (cadherin-associated protein), beta 1, 88 |
| 8 | Xenopus laevis | 126.00 | 1 | beta-catenin protein |
| 9 | Xenopus laevis | 125.00 | 3 | catenin |
| 10 | Gallus gallus | 125.00 | 1 | catenin (cadherin-associated protein), beta 1, 88 |
| 11 | Danio rerio | 124.00 | 4 | catenin (cadherin-associated protein), beta 1 |
| 12 | Carassius auratus | 123.00 | 1 | beta-catenin |
| 13 | Tetraodon nigroviridis | 112.00 | 4 | unnamed protein product |
| 14 | Lytechinus variegatus | 91.70 | 1 | beta-catenin |
| 15 | Tripneustes gratilla=sea urchins, Peptide, 820 aa | 91.70 | 1 | CTNB_TRIGR Catenin beta (Beta-catenin) gi |
| 16 | Branchiostoma belcheri | 89.00 | 1 | beta-catenin |
| 17 | Anopheles gambiae str. PEST | 87.80 | 1 | AGAP001043-PA |
| 18 | Gryllus bimaculatus | 86.30 | 1 | armadillo protein |
| 19 | Achaearanea tepidariorum | 85.10 | 1 | Armadillo |
| 20 | Apis mellifera | 84.70 | 2 | PREDICTED: similar to Armadillo segment polarity |
| 21 | Drosophila melanogaster | 84.00 | 2 | armadillo CG11579-PC, isoform C |
| 22 | Chaetopterus variopedatus | 84.00 | 1 | AF408420_1 beta-catenin |
| 23 | Drosophila pseudoobscura | 83.60 | 1 | GA11077-PA |
| 24 | Urechis caupo | 82.00 | 1 | CTNB_URECA Catenin beta (Beta-catenin) gi |
| 25 | Ciona savignyi | 64.70 | 1 | beta-catenin |
| 26 | Ciona intestinalis | 49.30 | 2 | beta-catenin |
| 27 | Oryctolagus cuniculus | 40.80 | 1 | beta-catenin |
| 28 | Hydra vulgaris | 35.00 | 1 | U38624_1 beta-catenin |
| 29 | Enterococcus faecalis V583 | 33.10 | 1 | hypothetical protein EF0857 |
| 30 | Crocosphaera watsonii WH 8501 | 31.20 | 1 | pilus assembly protein, membrane protein, require |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| Mus musculus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| Sus scrofa | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| Rattus norvegicus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| Meriones unguiculatus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| N/A | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||||||||+||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 66 WEQGFSQSFTQDQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 125 |
| Xenopus tropicalis | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||||||||+||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 66 WEQGFSQSFTQDQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 125 |
| Xenopus laevis | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||||||||+||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 66 WEQGFSQSFTQDQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 125 |
| Xenopus laevis | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||+|||||+||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 66 WEQGFTQSFTQDQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 125 |
| Gallus gallus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ||||||||||||||||||||||||||||| #+||||||||||||||||||||||||||||| Sbjct 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVL#SAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |
| Danio rerio | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||+||| ||||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 65 WEQGFNQSFNQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 124 |
| Carassius auratus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||+||| |+||||||||||||||||||#||||||||||||||||||||+||||||||| Sbjct 65 WEQGFNQSFNQDQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDSAHPTNVQRL 124 |
| Tetraodon nigroviridis | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |||||+|+|+|+|| |||||||||||||||#||||||||+||+||||||+|| +||||||| Sbjct 61 WEQGFNQNFSQDQVQDIDGQYAMTRAQRVR#AAMFPETLEEGVQIPSTQYDATNPTNVQRL 120 |
| Lytechinus variegatus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |+ |+ |++||||| +++ | ||+||||#||||||||+||+|||||||| |||| |||| Sbjct 83 WDAGYGQAYTQEQVDEMNQQLTQTRSQRVR#AAMFPETLEEGVQIPSTQFDPAHPTAVQRL 142 |
| Tripneustes gratilla=sea urchins, Peptide, 820 aa | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |+ |+ |++||||| +++ | ||+||||#||||||||+||+|||||||| |||| |||| Sbjct 82 WDAGYGQAYTQEQVDEMNQQLTQTRSQRVR#AAMFPETLEEGVQIPSTQFDPAHPTAVQRL 141 |
| Branchiostoma belcheri | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 | ||| + |||||| +++ | ||+||||#||||||||||| |||||||| || |||| Sbjct 92 WNQGFQEGFTQEQVNEMNQQLIQTRSQRVR#AAMFPETLDEGTQIPSTQFDPNQPTAVQRL 151 |
| Anopheles gambiae str. PEST | Query 67 EQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 +|||||+|||+|| |++ | + ||+||||#||||||||+||++||||||| || |||| Sbjct 52 DQGFSQNFTQDQVDDMNQQLSQTRSQRVR#AAMFPETLEEGIEIPSTQFDPQQPTAVQRL 110 |
| Gryllus bimaculatus | Query 67 EQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 +|||+| |||+|| +++ | + ||+||||#||||||||+||++||||||| | || |||| Sbjct 75 DQGFTQGFTQDQVDEMNQQLSQTRSQRVR#AAMFPETLEEGIEIPSTQFDPAQPTAVQRL 133 |
| Achaearanea tepidariorum | Query 66 WEQ-GFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQR 124 |+| || | |||||| +++ | ||+||||#||||||||+||++||||||| || ||| Sbjct 78 WDQPGFGQGFTQEQVDEMNQQLNQTRSQRVR#AAMFPETLEEGLEIPSTQFDPTQPTAVQR 137 Query 125 L 125 | Query 125 L 125 |
| Apis mellifera | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 +|||+| |||+|| +++ | ||+||||#||||||||+||++|||||+| | || |||| Sbjct 75 LDQGFAQGFTQDQVDEMNQQLNHTRSQRVR#AAMFPETLEEGIEIPSTQYDPAQPTAVQRL 134 |
| Drosophila melanogaster | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 + || |+|||+|| |++ | + ||+||||#||||||||+||++||||||| || |||| Sbjct 74 LDTGFPQNFTQDQVDDMNQQLSQTRSQRVR#AAMFPETLEEGIEIPSTQFDPQQPTAVQRL 133 |
| Chaetopterus variopedatus | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 ++|||+| |||||| |++ | ||+||||#||||||||+||+|||||| + || |||| Sbjct 83 FDQGFNQGFTQEQVDDMNQQLNQTRSQRVR#AAMFPETLEEGIQIPSTQMHSDQPTAVQRL 142 |
| Drosophila pseudoobscura | Query 66 WEQGFSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 + || |+|||+|| |++ | + ||+||||#||||||||+||++||||||| || |||| Sbjct 71 LDTGFPQNFTQDQVDDMNQQLSQTRSQRVR#AAMFPETLEEGIEIPSTQFDPQQPTAVQRL 130 |
| Urechis caupo | Query 66 WEQGFS-QSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQR 124 ++|||| |+|||||| +++ | ||+||||#||||||||+||+|||||| | || ||| Sbjct 88 FDQGFSTQAFTQEQVDEMNQQLNQTRSQRVR#AAMFPETLEEGVQIPSTQLDPGQPTAVQR 147 Query 125 L 125 | Query 125 L 125 |
| Ciona savignyi | Query 74 FTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 || |+| | |+ ||| |||# +||||+|+| |||||||| |+|||| Sbjct 63 FTMEEVDQIHDQFVRTRADRVR#DVLFPETMDDGTQIPSTQFDDGTTTSVQRL 114 |
| Ciona intestinalis | Query 74 FTQEQVADIDGQYAMTRAQRVR#AAMFPET-LDEGMQIPSTQFDAAHPTNVQRL 125 || |+ | |+ ||| |||# +|||| ++| +||||+++ |+|||| Sbjct 63 FTMEEANQIHDQFVRTRADRVR#DVLFPETMMEESGPVPSTQYESNTATSVQRL 115 |
| Oryctolagus cuniculus | Query 109 IPSTQFDAAHPTNVQRL 125 ||||||||||||||||| Query 109 IPSTQFDAAHPTNVQRL 125 |
| Hydra vulgaris | Query 82 IDGQYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDAAHPTNVQRL 125 |+ |+ |+|| |# |||| + | |++ | + ||| Sbjct 140 INDQFNNNRSQRAR#TGMFPEAMHENMELSHAQIHNNNSAVPQRL 183 |
| Enterococcus faecalis V583 | Query 70 FSQSFTQEQVADIDGQYAMTRAQRVR#AAMFPETLDEGMQIPS 111 ++ | ++| +| | ||+| ++ #| + || +|| |+ | Sbjct 28 LAEMFERQQTGKLDKMYLMTKAPKLL#AYLKPEAIDEVKQVVS 69 |
| Crocosphaera watsonii WH 8501 | Query 85 QYAMTRAQRVR#AAMFPETLDEGMQIPSTQFDA 116 | |++|| + #|+ || | +|| || ||||+ Sbjct 71 QNALSRAMNLP#ASRNPEIL-QGMTIPVTQFDS 101 |
* References
[PubMed ID: 24590964] Cai SX, Liu AR, He HL, Chen QH, Yang Y, Guo FM, Huang YZ, Liu L, Qiu HB, Stable genetic alterations of beta-catenin and ROR2 regulate the Wnt pathway, affect the fate of MSCs. J Cell Physiol. 2014 Jun;229(6):791-800. doi: 10.1002/jcp.24500.
[PubMed ID: 24637293] ... Sarin S, Boivin F, Li A, Lim J, Svajger B, Rosenblum ND, Bridgewater D, beta-Catenin overexpression in the metanephric mesenchyme leads to renal dysplasia genesis via cell-autonomous and non-cell-autonomous mechanisms. Am J Pathol. 2014 May;184(5):1395-410. doi: 10.1016/j.ajpath.2014.01.018. Epub
[PubMed ID: 24653033] ... Deschene ER, Myung P, Rompolas P, Zito G, Sun TY, Taketo MM, Saotome I, Greco V, beta-Catenin activation regulates tissue growth non-cell autonomously in the hair stem cell niche. Science. 2014 Mar 21;343(6177):1353-6. doi: 10.1126/science.1248373.
[PubMed ID: 24561244] ... Wang J, Han F, Lee SW, Wu J, Chan CH, Zhang X, Gao Y, Su HK, Feng ZZ, Xu DZ, Lin HK, E3-ligase Skp2 regulates beta-catenin expression and maintains hematopoietic stem cell homing. Biochem Biophys Res Commun. 2014 Mar 14;445(3):566-71. doi:
[PubMed ID: 24637233] ... ,
[PubMed ID: 7626889] ... Guenet JL, Simon-Chazottes D, Ringwald M, Kemler R, The genes coding for alpha and beta catenin (Catna1 and Catnb) and plakoglobin (Jup) map to mouse chromosomes 18, 9, and 11, respectively. Mamm Genome. 1995 May;6(5):363-6.
[PubMed ID: 1509266] ... Butz S, Stappert J, Weissig H, Kemler R, Plakoglobin and beta-catenin: distinct but closely related. Science. 1992 Aug 21;257(5073):1142-4.
[PubMed ID: 1639851] ... Peifer M, McCrea PD, Green KJ, Wieschaus E, Gumbiner BM, The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form a multigene family with similar properties. J Cell Biol. 1992 Aug;118(3):681-91.
[PubMed ID: 2349235] ... Ozawa M, Ringwald M, Kemler R, Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule. Proc Natl Acad Sci U S A. 1990 Jun;87(11):4246-50.
[PubMed ID: 2788574] ... Ozawa M, Baribault H, Kemler R, The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7.