CaMPDB :: Substrate

SB0138 : Antiapoptotic Bfl-1 (BCL2A1)

* Basic Information

Organism	Homo sapiens (human)
Protein Names	bcl-2-related protein A1 isoform 2 [Homo sapiens]; bcl-2-related protein A1 isoform 2; hematopoietic BCL2-related protein A1; bcl2-L-5; protein BFL-1; bcl-2-like protein 5; hemopoietic-specific early response protein; Bcl-2-related protein A1; Bcl-2-like protein 5; Bcl2-L-5; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
Gene Names	BCL2A1; BCL2L5, BFL1, GRS, HBPA1; BCL2L5; BFL1; GRS; HBPA1; BCL2-related protein A1
Gene Locus	15q24.3; chromosome 15
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
NP_001108207	NM_001114735	597	Q16548	601056	HGNC:991	N/A	hsa:597

* Information From OMIM

Function: D'Sa-Eipper et al. (1996) showed that the BFL1 protein suppresses apoptosis induced by the p53 tumor suppressor protein in a manner similar to other BCL2 family members. The BFL1 gene showed a dominant cooperating oncogenic activity with the E1A oncogene in transformation of primary rodent epithelial cells.

* Structure Information

1. Primary Information

Length: 163 aa

Average Mass: 18.745 kDa

Monoisotopic Mass: 18.734 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
--- cleavage 21 ---
--- cleavage 22 ---
DDE_Tnp_1-associated 1.	46	86	46.0	0.0
--- cleavage 71 (inside DDE_Tnp_1-associated 46..86) ---
DDE_Tnp_1-associated 2.	116	124	39.0	0.0

3. Sequence Information

Fasta Sequence: SB0138.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2VM6 (X-ray; 220 A; A=1-149), 3I1H (X-ray; 220 A; A=1-151), 3MQP (X-ray; 224 A; A=1-151), 4ZEQ (X-ray; 180 A; A=1-151)

* Cleavage Information

3 [sites] cleaved by Calpain 1

Source Reference: [PubMed ID: 22745672] Valero JG, Cornut-Thibaut A, Juge R, Debaud AL, Gimenez D, Gillet G, Bonnefoy-Berard N, Salgado J, Salles G, Aouacheria A, Kucharczak J, micro-Calpain conversion of antiapoptotic Bfl-1 (BCL2A1) into a prodeath factor reveals two distinct alpha-helices inducing mitochondria-mediated apoptosis. PLoS One. 2012;7(6):e38620. doi: 10.1371/journal.pone.0038620. Epub 2012 Jun 20.

Cleavage sites (±10aa)

[Site 1] LAQDYLQCVL²¹-QIPQPGSGPS

Leu²¹ Gln

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Leu¹²	Ala¹³	Gln¹⁴	Asp¹⁵	Tyr¹⁶	Leu¹⁷	Gln¹⁸	Cys¹⁹	Val²⁰	Leu²¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Gln²²	Ile²³	Pro²⁴	Gln²⁵	Pro²⁶	Gly²⁷	Ser²⁸	Gly²⁹	Pro³⁰	Ser³¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKN

#	organism	max score	hits	top seq
1	Homo sapiens	110.00	4	BCL2-related protein A1 isoform 2
2	synthetic construct	109.00	1	Homo sapiens BCL2-related protein A1
3	Canis familiaris	82.80	1	PREDICTED: similar to Bcl-2-related protein A1 (B
4	Rattus norvegicus	80.90	1	B-cell leukemia/lymphoma 2 related protein A1
5	Mus musculus	69.30	8	Bcl2a1a
6	Gallus gallus	49.30	1	BCL2-related protein A1

organism	matching
Homo sapiens	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51
synthetic construct	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51
Canis familiaris	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51 \|\|\|\|\|\|\|\| \|\|\|\|\|++ \|\|#\|\|\|\|\|\| \|\|+ \|\|\|\|\|+\|\|\|\|\|\| +\|\|\|\| Sbjct 64 MTDCEFGYTLALAQDYVRHVL#QIPQPGPAPSRASRVLQDVAFSVQGQVEKN 114
Rattus norvegicus	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51 \|\|\|\|\|\| \|\|+ \|\|++\|\|\| \|\|#\|+\| \| \|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MTDCEFMYIHSLAENYLQYVL#QVPAFESAPSKTSRVLQRVAFSVQKEVEKN 51
Mus musculus	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEKN 51 \|++ \|\| \|\|+ \|\|+ \|\|\| \|\|#\|+\| \| \|\|\| \|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MSEYEFMYIHSLAEHYLQYVL#QVPAFESAPSKACRVLQRVAFSVQKEVEKN 51
Gallus gallus	Query 1 MTDCEFGYIYRLAQDYLQCVL#QIPQPGSGPSKTSRVLQNVAFSVQKEVEK 50 \| \|\| \|+\| \|\|\|\|\|\|\| \|\|#\| \| ++ + \|\|+\|+\| \|+\| + \|+ Sbjct 1 METAEFYYVYYLAQDYLQYVL#QESHLGPAQTRVAHVLRNIASSLQDQTEE 50

[Site 2] AQDYLQCVLQ²²-IPQPGSGPSK

Gln²² Ile

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Ala¹³	Gln¹⁴	Asp¹⁵	Tyr¹⁶	Leu¹⁷	Gln¹⁸	Cys¹⁹	Val²⁰	Leu²¹	Gln²²

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ile²³	Pro²⁴	Gln²⁵	Pro²⁶	Gly²⁷	Ser²⁸	Gly²⁹	Pro³⁰	Ser³¹	Lys³²

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MTDCEFGYIYRLAQDYLQCVLQIPQPGSGPSKTSRVLQNVAFSVQKEVEKNL

#	organism	max score	hits	top seq
1	Homo sapiens	112.00	4	BCL2-related protein A1 isoform 2
2	synthetic construct	111.00	1	Homo sapiens BCL2-related protein A1
3	Canis familiaris	84.70	1	PREDICTED: similar to Bcl-2-related protein A1 (B
4	Rattus norvegicus	82.40	1	B-cell leukemia/lymphoma 2 related protein A1
5	Mus musculus	70.90	8	Bcl2a1a
6	Gallus gallus	50.40	1	BCL2-related protein A1

organism	matching
Homo sapiens	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52
synthetic construct	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52
Canis familiaris	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \|\|\|\|\|\|\|\| \|\|\|\|\|++ \|\|\|#\|\|\|\|\| \|\|+ \|\|\|\|\|+\|\|\|\|\|\| +\|\|\|\|\| Sbjct 64 MTDCEFGYTLALAQDYVRHVLQ#IPQPGPAPSRASRVLQDVAFSVQGQVEKNL 115
Rattus norvegicus	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \|\|\|\|\|\| \|\|+ \|\|++\|\|\| \|\|\|#+\| \| \|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MTDCEFMYIHSLAENYLQYVLQ#VPAFESAPSKTSRVLQRVAFSVQKEVEKNL 52
Mus musculus	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \|++ \|\| \|\|+ \|\|+ \|\|\| \|\|\|#+\| \| \|\|\| \|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1 MSEYEFMYIHSLAEHYLQYVLQ#VPAFESAPSKACRVLQRVAFSVQKEVEKNL 52
Gallus gallus	Query 1 MTDCEFGYIYRLAQDYLQCVLQ#IPQPGSGPSKTSRVLQNVAFSVQKEVEKNL 52 \| \|\| \|+\| \|\|\|\|\|\|\| \|\|\|# \| ++ + \|\|+\|+\| \|+\| + \|+ \| Sbjct 1 METAEFYYVYYLAQDYLQYVLQ#ESHLGPAQTRVAHVLRNIASSLQDQTEEAL 52

[Site 3] VSVDTARTLF⁷¹-NQVMEKEFED

Phe⁷¹ Asn

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Val⁶²	Ser⁶³	Val⁶⁴	Asp⁶⁵	Thr⁶⁶	Ala⁶⁷	Arg⁶⁸	Thr⁶⁹	Leu⁷⁰	Phe⁷¹

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Asn⁷²	Gln⁷³	Val⁷⁴	Met⁷⁵	Glu⁷⁶	Lys⁷⁷	Glu⁷⁸	Phe⁷⁹	Glu⁸⁰	Asp⁸¹

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
FSVQKEVEKNLKSCLDNVNVVSVDTARTLFNQVMEKEFEDGIINWGRIVTIFAFEGILIK

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	122.00	23	BCL2-related protein A1 isoform 2
2	synthetic construct	121.00	4	Homo sapiens BCL2-related protein A1
3	Canis familiaris	112.00	2	PREDICTED: similar to Bcl-2-related protein A1 (B
4	Mus musculus	102.00	26	A1-b protein
5	Rattus norvegicus	101.00	8	B-cell leukemia/lymphoma 2 related protein A1
6	Gallus gallus	69.30	1	BCL2-related protein A1
7	Tetraodon nigroviridis	46.60	3	unnamed protein product
8	Bos taurus	40.40	7	BCL2_BOVIN Apoptosis regulator Bcl-2 gi
9	N/A	40.00	19	bcl2-beta protein gi
10	Danio rerio	40.00	8	bcl2-like
11	Rattus norvegicus	40.00	4	B-cell leukemia/lymphoma 2
12	Canis lupus familiaris	40.00	2	B-cell CLL/lymphoma 2
13	Felis catus	40.00	2	B-cell lymphoma protein 2
14	Cricetulus longicaudatus	40.00	2	AF404339_1 B-cell lymphoma protein 2
15	Felis catus	39.70	2	myeloid cell leukemia sequence 1
16	Canis lupus familiaris	39.70	1	myeloid cell leukemia sequence 1
17	Xenopus laevis	38.90	4	AR11_XENLA Apoptosis regulator R11 (XR11) gi
18	Rattus sp.	38.90	2	AAP21091.1
19	Homo sapiens	38.90	1	Bcl-2-related protein EAT/mcl1
20	synthetic construct	38.50	3	BCL2-associated X protein
21	Gallus gallus	38.10	6	bcl-x
22	Sus scrofa	38.10	3	BCL2-like 1
23	Mus musculus	38.10	1	B-cell leukemia/lymphoma x-gamma
24	Ovis aries	37.70	2	AF163774_1 Bcl2-associated protein Bax
25	Cervus elaphus	37.70	1	AF512030_1 bax
26	Macaca fascicularis	37.70	1	hypothetical protein
27	Oryctolagus cuniculus	37.70	1	BCL2-like 1
28	Xenopus tropicalis	37.00	1	BCL2-like 1
29	Xenopus tropicalis	37.00	1	BCL2-associated X protein
30	Xenopus laevis	36.60	1	BCL2-associated X protein
31	Danio rerio	34.70	1	bcl2-associated X protein
32	Ovis aries	33.50	1	AF144097_1 Bcl-2-related protein
33	Geodia cydonium	32.30	1	Bcl-x homologous protein, BHP2

Top-ranked sequences

organism	matching
Homo sapiens	Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101
synthetic construct	Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101
Canis familiaris	Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|\|\| +\|\|\|\|\|\| \|\|\|+ +\|\|\|\|\|\|\|\|\|+\|#\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\| \| Sbjct 105 FSVQGQVEKNLKPCLDSFDVVSVDTARTIF#NQVMEKEFEDGVINWGRIVTVFAFEGILTK 164
Mus musculus	Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|\|\|\|\|\|\|\|\|\|\|\| \|\|+ +\| \|+\|\|\|\| +\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|+\| Sbjct 42 FSVQKEVEKNLKSYLDDFHVESIDTARIIF#NQVMEKEFEDGIINWGRIVTIFAFGGVLLK 101
Rattus norvegicus	Query 42 FSVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|\|\|\|\|\|\|\|\|\|\| \|\|+ +\| \|+\|\|\|\| +\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|+\|+\| Sbjct 42 FSVQKEVEKNLKPYLDDFHVESIDTARIIF#NQVMEKEFEDGIINWGRIVTIFAFGGVLLK 101
Gallus gallus	Query 43 SVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|+\| + \|+ \|+ \|\| +++ \|\|\| \|+ +\|#\| \|\|\|++\| \|\| \|\|\|\|\|+\|\|\| \| \|+\| \| Sbjct 43 SLQDQTEEALRPFLDRIDITSVDVAKRIF#NGVMEEKFADGNTNWGRIMTIFTFGGLLTK 101
Tetraodon nigroviridis	Query 61 VVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|++ \|\|\| \|# \|\|++ \|+\|\|+ \|\|\|\|\|\| +\|\|\| \|+\| Sbjct 97 VITPDTAYQSF#KNVMDEVFKDGV-NWGRIVGLFAFGGVL 134
Bos taurus	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 115 TARERF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 147
N/A	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 125 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 157
Danio rerio	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\| \|# \|\|++ \| \|\|+ \|\|\|\|\|\| +\|\|\| \| \| Sbjct 121 TAYQSF#ESVMDEVFRDGV-NWGRIVGLFAFGGAL 153
Rattus norvegicus	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 122 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 154
Canis lupus familiaris	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 125 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 157
Felis catus	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 121 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 153
Cricetulus longicaudatus	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 122 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 154
Felis catus	Query 44 VQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|+ \| + \| +++ + + ++\| #++\|\| \| \|\|+ \|\|\|\|\|\|\|+ +\| + \| Sbjct 220 VQRNHETAFQGMLRKLDIKNENDVKSL-#SRVMVHVFSDGVTNWGRIVTLISFGAFVAK 276
Canis lupus familiaris	Query 44 VQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 \|\|+ \| + \| +++ + \| ++\| #++\|+ \| \|\|+ \|\|\|\|\|\|\|+ +\| + \| Sbjct 220 VQRNHETAFQGMLRKLDIKNEDDVKSL-#SRVIVHVFSDGVTNWGRIVTLISFGAFVAK 276
Xenopus laevis	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAF 95 ++ \|\|\|+ \|# \|\|\| + \| \|\| \|\|\|\|\|\| \|+\| Sbjct 86 ITQDTAQQSF#QQVMGELFRDG-TNWGRIVAFFSF 118
Rattus sp.	Query 66 TARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 \|\|\| \|# \|+\|+ \| \|\|+ \|\|\|\|\|\| \| \| \|++ Sbjct 104 TARGRF#ATVVEELFRDGV-NWGRIVAFFEFGGVM 136
Homo sapiens	Query 43 SVQKEVEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAF 95 \|\|+ \| + \| +++ + \| ++\| #++\|\| \| \|\|+ \|\|\|\|\|\|\|+ +\| Sbjct 38 GVQRNHETAFQGMLRKLDIKNEDDVKSL-#SRVMIHVFSDGVTNWGRIVTLISF 89
synthetic construct	Query 59 VNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILI 100 + \| \|+ \| +\|# +\| \| \|\| \|\|\|\|+\| +\| \| \|+ Sbjct 80 IAAVDTDSPREVF#FRVAADMFSDGNFNWGRVVALFYFASKLV 121
Gallus gallus	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 ++ \|\| \|# \|\|+ + \| \|\|+ \|\|\|\|\|\| \|+\| \| \| Sbjct 110 ITPGTAYQSF#EQVVNELFHDGV-NWGRIVAFFSFGGAL 146
Sus scrofa	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 ++ \|\| \|# \|\|+ + \| \|\|+ \|\|\|\|\|\| \|+\| \| \| Sbjct 114 ITPGTAYQSF#EQVLNELFRDGV-NWGRIVAFFSFGGAL 150
Mus musculus	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 ++ \|\| \|# \|\|+ + \| \|\|+ \|\|\|\|\|\| \|+\| \| \| Sbjct 98 ITPGTAYQSF#EQVVNELFRDGV-NWGRIVAFFSFGGAL 134
Ovis aries	Query 59 VNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILI 100 + \| \|+ \| +\|# +\| + \| \|\| \|\|\|\|+\| +\| \| \|+ Sbjct 52 IAAVDTDSPREVF#FRVAAEMFSDGNFNWGRVVALFYFASKLV 93
Cervus elaphus	Query 59 VNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILI 100 + \| \|+ \| +\|# +\| + \| \|\| \|\|\|\|+\| +\| \| \|+ Sbjct 7 IAAVDTDSPREVF#FRVAAEMFSDGNFNWGRVVALFYFASKLV 48
Macaca fascicularis	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 ++ \|\| \|# \|\|+ + \| \|\|+ \|\|\|\|\|\| \|+\| \| \| Sbjct 70 ITPGTAYQSF#EQVVNELFRDGV-NWGRIVAFFSFGGAL 106
Oryctolagus cuniculus	Query 62 VSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGIL 99 ++ \|\| \|# \|\|+ + \| \|\|+ \|\|\|\|\|\| \|+\| \| \| Sbjct 114 ITPGTAYQSF#EQVVNELFRDGV-NWGRIVAFFSFGGAL 150
Xenopus tropicalis	Query 65 DTARTLF#NQVMEKEFEDGIINWGRIVTIFAF 95 \|\|\|+ \|# \|\|+ + \| \|\| \|\|\|\|\|\| \|+\| Sbjct 85 DTAQQSF#QQVVGELFRDGT-NWGRIVAFFSF 114
Xenopus tropicalis	Query 59 VNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILI 100 + \| ++ + +\|# \| ++ \| \|\|+ \|\|\|\|+\| +\| \| \|+ Sbjct 110 IECVPCNSPKQVF#FHVAKELFADGVFNWGRVVALFYFACKLV 151
Xenopus laevis	Query 44 VQKEVEKN--LKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAFEGILI 100 + \|++ \| \|+ +\|\|\| \| + +\|# \| ++ \| \|\|+ \|\|\|\|+\| +\| \| \|+ Sbjct 96 IGDELDANMELQRRIDNVPCTS---PKQVF#FHVAKELFADGVFNWGRVVALFYFACKLV 151
Danio rerio	Query 52 LKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAF 95 \|+\| \|+\| \|+ + +\|# +\| + \| \|\| \|\|\|\|+\| +\| \| Sbjct 78 LQSMLNNSNL---QPTQDVF#IRVAREIFSDGKFNWGRVVALFYF 118
Ovis aries	Query 72 NQVMEKEFEDGIINWGRIVTIFAFEGILIK 101 ++\|\| \| \|\|+ \|\|\|\|\|\|\|+ +\| + \| Sbjct 1 SRVMIHVFSDGVTNWGRIVTLISFGAFVAK 30
Geodia cydonium	Query 48 VEKNLKSCLDNVNVVSVDTARTLF#NQVMEKEFEDGIINWGRIVTIFAF 95 \|\|+\|++ \|+ \| + \|# +\| + \| \|\|+ +\|\|\|++ \|\| Sbjct 96 VERNVRDFRRGGWDVTPDNVESEF#REVERRTFSDGV-HWGRVIAFLAF 142

* References

[PubMed ID: 24810636] Medina-Echeverz J, Haile LA, Zhao F, Gamrekelashvili J, Ma C, Metais JY, Dunbar CE, Kapoor V, Manns MP, Korangy F, Greten TF, IFN-gamma regulates survival and function of tumor-induced CD11b+ Gr-1high myeloid derived suppressor cells by modulating the anti-apoptotic molecule Bcl2a1. Eur J Immunol. 2014 Aug;44(8):2457-67. doi: 10.1002/eji.201444497. Epub 2014 Jun

» More (9) « Hide Below

[PubMed ID: 23480177] ... Turpeinen H, Ojala PJ, Ojala K, Miettinen M, Volin L, Partanen J, Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. Int J Immunogenet. 2013 Dec;40(6):495-501. doi: 10.1111/iji.12051. Epub 2013 Mar

[PubMed ID: 23841872] ... You G, Feng L, Yan W, Zhang W, Wang YZ, Li SW, Li SW, Li GL, Song YJ, Kang CS, You YP, Jiang T, BCL2A1 is a potential biomarker for postoperative seizure control in patients with low-grade gliomas. CNS Neurosci Ther. 2013 Nov;19(11):882-8. doi: 10.1111/cns.12148. Epub 2013 Jul

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