SB0139 : Cytoplasmic polyadenylation element-binding protein 3 (CPEB3)
[ CaMP Format ]
* Basic Information
Organism | Homo sapiens (human) |
Protein Names | cytoplasmic polyadenylation element-binding protein 3 isoform 2 [Homo sapiens]; cytoplasmic polyadenylation element-binding protein 3 isoform 2; cytoplasmic polyadenylation element-binding protein 3; CPE-BP3; hCPEB-3; CPE-binding protein 3; Cytoplasmic polyadenylation element-binding protein 3 |
Gene Names | CPEB3; KIAA0940; cytoplasmic polyadenylation element binding protein 3 |
Gene Locus | 10q23.32; chromosome 10 |
GO Function | Not available |
Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
---|---|---|---|---|---|---|---|
NP_001171608 | NM_001178137 | 22849 | Q8NE35 | 610606 | HGNC:21746 | N/A | hsa:22849 |
* Information From OMIM
Function:
* Structure Information
1. Primary Information
Length: 684 aa
Average Mass: 74.440 kDa
Monoisotopic Mass: 74.394 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
domain name | begin | end | score | e-value |
---|---|---|---|---|
--- cleavage 427 --- | ||||
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) 1. | 429 | 492 | 1.0 | 0.0 |
RNA recognition motif 1. | 536 | 555 | 3.0 | 0.0 |
B-box zinc finger 1. | 620 | 666 | 4.0 | 6.2 |
3. Sequence Information
Fasta Sequence: SB0139.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
1 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 22711986] Wang CF, Huang YS, Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun
Cleavage sites (±10aa)
[Site 1] NGERVERYSR427-KVFVGGLPPD
Arg427 Lys
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Asn418 | Gly419 | Glu420 | Arg421 | Val422 | Glu423 | Arg424 | Tyr425 | Ser426 | Arg427 |
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Lys428 | Val429 | Phe430 | Val431 | Gly432 | Gly433 | Leu434 | Pro435 | Pro436 | Asp437 |
Sequence conservation (by blast)
* References
[PubMed ID: 22711986] Wang CF, Huang YS, Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun