logo CaMPDB: Calpain for Modulatory Proteolysis Database

SB0139 : Cytoplasmic polyadenylation element-binding protein 3 (CPEB3)

[ CaMP Format ]

* Basic Information

OrganismHomo sapiens (human)
Protein Namescytoplasmic polyadenylation element-binding protein 3 isoform 2 [Homo sapiens]; cytoplasmic polyadenylation element-binding protein 3 isoform 2; cytoplasmic polyadenylation element-binding protein 3; CPE-BP3; hCPEB-3; CPE-binding protein 3; Cytoplasmic polyadenylation element-binding protein 3
Gene NamesCPEB3; KIAA0940; cytoplasmic polyadenylation element binding protein 3
Gene Locus10q23.32; chromosome 10
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_001171608 NM_001178137 22849 Q8NE35 610606 HGNC:21746 N/A hsa:22849

* Information From OMIM

Function: CPEB3 Ribozyme

* Structure Information

1. Primary Information

Length: 684 aa

Average Mass: 74.440 kDa

Monoisotopic Mass: 74.394 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 427 ---
RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) 1. 4294921.00.0
RNA recognition motif 1. 5365553.00.0
B-box zinc finger 1. 6206664.06.2

3. Sequence Information

Fasta Sequence: SB0139.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 2DNL (NMR; -; A=440-540), 2RUG (NMR; -; A=440-540)

* Cleavage Information

1 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 22711986] Wang CF, Huang YS, Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun

Cleavage sites (±10aa)

[Site 1] NGERVERYSR427-KVFVGGLPPD

Arg427 Lys

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Asn418Gly419Glu420Arg421Val422Glu423Arg424Tyr425Ser426Arg427
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Lys428Val429Phe430Val431Gly432Gly433Leu434Pro435Pro436Asp437

Sequence conservation (by blast)

* References

[PubMed ID: 22711986] Wang CF, Huang YS, Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons. Mol Cell Biol. 2012 Aug;32(16):3321-32. doi: 10.1128/MCB.00296-12. Epub 2012 Jun

» More (7)