SB0141 : Ataxin-3, Machado-Joseph disease (spinocerebellar ataxia 3)
[ CaMP Format ]
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | MJD1 protein [Homo sapiens]; MJD1 protein |
| Gene Names | MJD1 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| AAB33571 | N/A | N/A | N/A | N/A | N/A | N/A | N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 360 aa
Average Mass: 41.531 kDa
Monoisotopic Mass: 41.505 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Ubiquitin interaction motif 1. | 41 | 49 | 1.0 | 0.9 |
| --- cleavage 55 --- | ||||
| --- cleavage 62 --- | ||||
| Uncharacterized conserved protein (DUF2215) 1. | 76 | 96 | 126.0 | 0.0 |
| --- cleavage 187 --- | ||||
| --- cleavage 208 --- | ||||
| Gene regulated by oestrogen in breast cancer 1. | 226 | 318 | 1094.0 | 11.8 |
| --- cleavage 256 (inside Gene regulated by oestrogen in breast cancer 226..318) --- | ||||
| --- cleavage 317 (inside Gene regulated by oestrogen in breast cancer 226..318) --- | ||||
3. Sequence Information
Fasta Sequence: SB0141.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
6 [sites] cleaved by Calpain 2
Source Reference: [PubMed ID: 17488727] Haacke A, Hartl FU, Breuer P, Calpain inhibition is sufficient to suppress aggregation of polyglutamine-expanded ataxin-3. J Biol Chem. 2007 Jun 29;282(26):18851-6. Epub 2007 May 8.
Cleavage sites (±10aa)
[Site 1] MRMAEGGVTS55-EDYRTFLQQP
Ser55 
Glu
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Met46 | Arg47 | Met48 | Ala49 | Glu50 | Gly51 | Gly52 | Val53 | Thr54 | Ser55 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Glu56 | Asp57 | Tyr58 | Arg59 | Thr60 | Phe61 | Leu62 | Gln63 | Gln64 | Pro65 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EYFSPVELSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALK |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 127.00 | 10 | MJD1 protein |
| 2 | Canis familiaris | 126.00 | 4 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 3 | N/A | 126.00 | 3 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
| 4 | Mus musculus | 125.00 | 3 | ATX3_MOUSE Ataxin-3 (Machado-Joseph disease prote |
| 5 | Bos taurus | 125.00 | 1 | ataxin 3 |
| 6 | Rattus norvegicus | 125.00 | 1 | ataxin 3 |
| 7 | Tetraodon nigroviridis | 118.00 | 1 | unnamed protein product |
| 8 | Xenopus tropicalis | 116.00 | 1 | ataxin 3 |
| 9 | Gallus gallus | 115.00 | 1 | ataxin 3 |
| 10 | Apis mellifera | 97.40 | 1 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 11 | Danio rerio | 79.70 | 1 | ataxin 3 |
| 12 | Tetrahymena thermophila SB210 | 48.10 | 1 | Josephin family protein |
| 13 | Arabidopsis thaliana | 36.60 | 1 | josephin family protein |
| 14 | Ustilago maydis 521 | 35.00 | 1 | hypothetical protein UM03353.1 |
| 15 | Cryptosporidium hominis TU502 | 33.50 | 1 | hypothetical protein Chro.10044 |
| 16 | Cryptosporidium parvum Iowa II | 33.50 | 1 | N-terminal machado-Joseph disease protein like do |
| 17 | Caenorhabditis briggsae AF16 | 33.10 | 1 | Hypothetical protein CBG18600 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| Canis familiaris | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| N/A | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| Mus musculus | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||+|||||||||#|||||||||||||||||||||||||||||| Sbjct 26 EYFSPVELSSIAHQLDEEERLRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| Bos taurus | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| Rattus norvegicus | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 ||||||||||||||||||||+|||||||||#|||||||||||||||||||||||||||||| Sbjct 26 EYFSPVELSSIAHQLDEEERLRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |
| Tetraodon nigroviridis | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |||+||+||||||||||||||||||||+ |#|+|||||||||||||||||||||||||||| Sbjct 19 EYFTPVDLSSIAHQLDEEERMRMAEGGMAS#EEYRTFLQQPSGNMDDSGFFSIQVISNALK 78 |
| Xenopus tropicalis | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNAL 84 |||||||||||| ||||+||||||||||||#||||||+|||||||||||||||||||+|| Sbjct 26 EYFSPVELSSIAMQLDEQERMRMAEGGVTS#EDYRTFVQQPSGNMDDSGFFSIQVISDAL 84 |
| Gallus gallus | Query 26 EYFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |||||||||||| |||||||||||||||+|#|+||||||||| |||||||||||||||||| Sbjct 26 EYFSPVELSSIAQQLDEEERMRMAEGGVSS#EEYRTFLQQPSVNMDDSGFFSIQVISNALK 85 |
| Apis mellifera | Query 27 YFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 |++ |+|+|+ ||+|||||+|||| || |#|||+ ||+||||||||||+||+||||+||| Sbjct 27 YYNAVDLASLGHQMDEEERIRMAESGVDS#EDYKLFLEQPSGNMDDSGYFSVQVISSALK 85 |
| Danio rerio | Query 46 MRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNAL 84 |||||||| +#|+||||||||||||||||||||||||||| Sbjct 1 MRMAEGGVQT#EEYRTFLQQPSGNMDDSGFFSIQVISNAL 39 |
| Tetrahymena thermophila SB210 | Query 27 YFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 +|+ ++|+ | +||++|++ + +|| |#+|+ |+ | |++| | +||||+ ||| Sbjct 28 FFNEIDLALYAQELDKQEKILLEQGGTDS#KDFLEFVAGDSHNVEDGGNYSIQVLERALK 86 |
| Arabidopsis thaliana | Query 27 YFSPVELSSIAHQLDEEERMRMAEG-GVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 +|| +|+++| || +|| | || | # || + | |+ | |||||+ ||+ Sbjct 33 FFSEFDLAAVAADLDGKERQVMLEGAAVGG#FAPGDFLAEESHNVSLGGDFSIQVLQKALE 92 |
| Ustilago maydis 521 | Query 26 EYFSPVELSSIAHQLDEEE--RMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNA 83 +|+ +|+ || +||+ | + +++ + +# | + ||||+|||| |+ | Sbjct 38 QYYDASQLAQIATELDQLEATELGLSQADIAA#RDRSSL------NMDDTGFFSASVLERA 91 Query 84 LK 85 |+ Sbjct 92 LQ 93 |
| Cryptosporidium hominis TU502 | Query 27 YFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 || || ||+++|+ || + + | # ++| | | ||||| |+ |+ Sbjct 33 YFDEAFLSKIAYEIDDMERRLLEKSNST-#--FKTISDNNSQNASYDGFFSIMVLQECLQ 88 |
| Cryptosporidium parvum Iowa II | Query 27 YFSPVELSSIAHQLDEEERMRMAEGGVTS#EDYRTFLQQPSGNMDDSGFFSIQVISNALK 85 || || ||+++|+ || + + | # ++| | | ||||| |+ |+ Sbjct 33 YFDEAFLSKIAYEIDDMERRLLEKSNST-#--FKTISDNNSQNASYDGFFSIMVLQECLQ 88 |
| Caenorhabditis briggsae AF16 | Query 66 SGNMDDSGFFSIQVISNALK 85 | ||+|||||||||| ||+ Sbjct 65 SENMNDSGFFSIQVIEKALE 84 |
[Site 2] VTSEDYRTFL62-QQPSGNMDDS
Leu62 Gln
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val53 | Thr54 | Ser55 | Glu56 | Asp57 | Tyr58 | Arg59 | Thr60 | Phe61 | Leu62 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln63 | Gln64 | Pro65 | Ser66 | Gly67 | Asn68 | Met69 | Asp70 | Asp71 | Ser72 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LSSIAHQLDEEERMRMAEGGVTSEDYRTFLQQPSGNMDDSGFFSIQVISNALKVWGLELI |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 127.00 | 10 | MJD1 protein |
| 2 | N/A | 126.00 | 3 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
| 3 | Canis familiaris | 125.00 | 4 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 4 | Mus musculus | 125.00 | 3 | ataxin 3 |
| 5 | Bos taurus | 125.00 | 1 | ataxin 3 |
| 6 | Rattus norvegicus | 125.00 | 1 | ataxin 3 |
| 7 | Tetraodon nigroviridis | 119.00 | 1 | unnamed protein product |
| 8 | Gallus gallus | 116.00 | 1 | ataxin 3 |
| 9 | Xenopus tropicalis | 114.00 | 1 | ataxin 3 |
| 10 | Apis mellifera | 106.00 | 1 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 11 | Danio rerio | 92.80 | 1 | ataxin 3 |
| 12 | Tetrahymena thermophila SB210 | 46.20 | 1 | Josephin family protein |
| 13 | Arabidopsis thaliana | 40.80 | 1 | josephin family protein |
| 14 | Ustilago maydis 521 | 40.00 | 1 | hypothetical protein UM03353.1 |
| 15 | Caenorhabditis briggsae AF16 | 39.70 | 1 | Hypothetical protein CBG18600 |
| 16 | Cryptococcus neoformans var. neoformans JEC21 | 37.40 | 1 | Machado-Joseph disease protein 1 (Ataxin-3) |
| 17 | Oryza sativa Japonica Group | 35.80 | 1 | ATX3_ORYSJ Putative ataxin-3 homolog gi |
| 18 | Caenorhabditis elegans | 33.90 | 1 | human ATX (ataxin) related family member (atx-3) |
| 19 | Cryptosporidium hominis TU502 | 32.30 | 1 | hypothetical protein Chro.10044 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| N/A | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| Canis familiaris | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| Mus musculus | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |||||||||||||+||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 33 LSSIAHQLDEEERLRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| Bos taurus | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| Rattus norvegicus | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |||||||||||||+||||||||||||||||#|||||||||||||||||||||||||||||| Sbjct 33 LSSIAHQLDEEERLRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |
| Tetraodon nigroviridis | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||||||||||||||||||+ ||+|||||#||||||||||||||||||||||||||||+| Sbjct 26 LSSIAHQLDEEERMRMAEGGMASEEYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLEII 85 |
| Gallus gallus | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 ||||| |||||||||||||||+||+|||||#|||| ||||||||||||||||||||||||| Sbjct 33 LSSIAQQLDEEERMRMAEGGVSSEEYRTFL#QQPSVNMDDSGFFSIQVISNALKVWGLELI 92 |
| Xenopus tropicalis | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLEL 91 ||||| ||||+||||||||||||||||||+#|||||||||||||||||||+|| |||||| Sbjct 33 LSSIAMQLDEQERMRMAEGGVTSEDYRTFV#QQPSGNMDDSGFFSIQVISDALSVWGLEL 91 |
| Apis mellifera | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |+|+ ||+|||||+|||| || ||||+ ||#+||||||||||+||+||||+|||||||||| Sbjct 33 LASLGHQMDEEERIRMAESGVDSEDYKLFL#EQPSGNMDDSGYFSVQVISSALKVWGLELI 92 |
| Danio rerio | Query 46 MRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |||||||| +|+|||||#|||||||||||||||||||||| |||||++ Sbjct 1 MRMAEGGVQTEEYRTFL#QQPSGNMDDSGFFSIQVISNALGVWGLEIV 47 |
| Tetrahymena thermophila SB210 | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLE 90 |+ | +||++|++ + +|| |+|+ |+# | |++| | +||||+ ||| + |+ Sbjct 34 LALYAQELDKQEKILLEQGGTDSKDFLEFV#AGDSHNVEDGGNYSIQVLERALKRYNLK 91 |
| Arabidopsis thaliana | Query 33 LSSIAHQLDEEERMRMAEGG-VTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLEL 91 |+++| || +|| | || | ||# + | |+ | |||||+ ||+|| |++ Sbjct 39 LAAVAADLDGKERQVMLEGAAVGGFAPGDFL#AEESHNVSLGGDFSIQVLQKALEVWDLQV 98 Query 92 I 92 | Query 92 I 92 |
| Ustilago maydis 521 | Query 33 LSSIAHQLD--EEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLE 90 |+ || +|| | + +++ + + | + # ||||+|||| |+ ||+|||+ Sbjct 45 LAQIATELDQLEATELGLSQADIAARDRSSL-#-----NMDDTGFFSASVLERALQVWGIS 98 Query 91 L 91 + Sbjct 99 I 99 |
| Caenorhabditis briggsae AF16 | Query 66 SGNMDDSGFFSIQVISNALKVWGLELI 92 | ||+|||||||||| ||+ + |+|| Sbjct 65 SENMNDSGFFSIQVIEKALETFDLKLI 91 |
| Cryptococcus neoformans var. neoformans JEC21 | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 |+ || +||+ | + | |#++ | | ||+|+||| |+ ||+|| | ++ Sbjct 38 LADIAKRLDQAENATL--------DVNHQL#RK-SYNYDDTGYFSISVLERALEVWDLTMV 88 |
| Oryza sativa Japonica Group | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRT--FL#QQPSG--NMDDSGFFSIQVISNALKVWG 88 ||++| ||+ || |+|| + ||# + | |+ | |||||+ ||+|| Sbjct 42 LSALAVDLDQRERQVMSEGAAGAATTAAGDFL#AEGEGSHNVSLGGDFSIQVLQKALEVWD 101 Query 89 LELI 92 |++| Sbjct 102 LQVI 105 |
| Caenorhabditis elegans | Query 66 SGNMDDSGFFSIQVISNALKVWGLEL 91 | ||++||+|||||+ ||+ + |+| Sbjct 64 SENMNESGYFSIQVLEKALETFSLKL 89 |
| Cryptosporidium hominis TU502 | Query 33 LSSIAHQLDEEERMRMAEGGVTSEDYRTFL#QQPSGNMDDSGFFSIQVISNALKVWGLELI 92 || ||+++|+ || + + | ++| # | | ||||| |+ |+ | | Sbjct 39 LSKIAYEIDDMERRLLEKSNST---FKTIS#DNNSQNASYDGFFSIMVLQECLQRHGYSCI 95 |
[Site 3] LQMIRVQQMH187-RPKLIGEELA
His187 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu178 | Gln179 | Met180 | Ile181 | Arg182 | Val183 | Gln184 | Gln185 | Met186 | His187 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg188 | Pro189 | Lys190 | Leu191 | Ile192 | Gly193 | Glu194 | Glu195 | Leu196 | Ala197 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EGYSIFVVKGDLPDCEADQLLQMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERMLEAND |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 126.00 | 10 | MJD1 protein |
| 2 | N/A | 125.00 | 3 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
| 3 | Canis familiaris | 118.00 | 3 | PREDICTED: similar to ataxin 3 isoform 2 isoform |
| 4 | Bos taurus | 115.00 | 1 | ataxin 3 |
| 5 | Mus musculus | 107.00 | 3 | ataxin 3 |
| 6 | Rattus norvegicus | 107.00 | 1 | ataxin 3 |
| 7 | Gallus gallus | 93.20 | 1 | ataxin 3 |
| 8 | Danio rerio | 67.40 | 1 | ataxin 3 |
| 9 | Xenopus tropicalis | 57.80 | 1 | ataxin 3 |
| 10 | Caenorhabditis elegans | 34.70 | 1 | human ATX (ataxin) related family member (atx-3) |
| 11 | Apis mellifera | 33.90 | 1 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 |
| N/A | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 |
| Canis familiaris | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||||||| #||||||||||||||||| ||||||+||||| Sbjct 60 EGYSIFVVKGDLPDCEADQLLQMIRVQQMQ#RPKLIGEELAQLKEQRVQKTDLERVLEAND 119 |
| Bos taurus | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||||||||#||||||||||||||||| ||||| +|| || Sbjct 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVQKTDLEHVLEVND 217 |
| Mus musculus | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||+|||||#|||||||||| |||| | ||||+||| | Sbjct 158 EGYSIFVVKGDLPDCEADQLLQMIKVQQMH#RPKLIGEELAHLKEQSALKADLERVLEAAD 217 |
| Rattus norvegicus | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAND 217 ||||||||||||||||||||||||+|||||#|||||||||| |||| | ||||+||| | Sbjct 158 EGYSIFVVKGDLPDCEADQLLQMIKVQQMH#RPKLIGEELAHLKEQSALKADLERVLEAAD 217 |
| Gallus gallus | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTDLERMLEAN 216 ||||||||||||||||||||||||||||+ #|||||||| || ++||+ ++|+++ +| + Sbjct 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQVQ#RPKLIGEETAQSRDQRLPRSDVDQAIEVS 216 |
| Danio rerio | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQ 198 |||||||++|+||+|||||+|+++||+| #|||||||| | Sbjct 113 EGYSIFVIRGNLPECEADQILRIMRVEQQQ#RPKLIGEEETQ 153 |
| Xenopus tropicalis | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHKTD 208 |||||||||||||+|||||||||++|||| #||+||||+ | ++||| +++ Sbjct 158 EGYSIFVVKGDLPECEADQLLQMVQVQQMQ#RPRLIGEDAA-ARDQRVQRSE 207 |
| Caenorhabditis elegans | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#RPKLIGEELAQLKEQRVHK 206 ||||||||+| || +|| |+ + | # + ++ |||++ | Sbjct 156 EGYSIFVVQGVLPRSDADDLISLCPV----#----VPPKVTPKKEQKLEK 196 |
| Apis mellifera | Query 158 EGYSIFVVKGDLPDCEADQLLQMIRVQQMH#R 188 ||||||+| | || | || +| ++ | #+ Sbjct 160 EGYSIFIVIGALPQCPADDILMKNPIEPMS#K 190 |
[Site 4] LKEQRVHKTD208-LERMLEANDG
Asp208 Leu
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Leu199 | Lys200 | Glu201 | Gln202 | Arg203 | Val204 | His205 | Lys206 | Thr207 | Asp208 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Leu209 | Glu210 | Arg211 | Met212 | Leu213 | Glu214 | Ala215 | Asn216 | Asp217 | Gly218 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| QMIRVQQMHRPKLIGEELAQLKEQRVHKTDLERMLEANDGSGMLDEDEEDLQRALALSRQ |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | N/A | 121.00 | 2 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
| 2 | Homo sapiens | 120.00 | 10 | MJD1 protein |
| 3 | Canis familiaris | 112.00 | 3 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 4 | Bos taurus | 108.00 | 1 | ataxin 3 |
| 5 | Mus musculus | 97.80 | 3 | ATX3_MOUSE Ataxin-3 (Machado-Joseph disease prote |
| 6 | Rattus norvegicus | 96.30 | 1 | ataxin 3 |
| 7 | Gallus gallus | 80.90 | 1 | ataxin 3 |
| 8 | Danio rerio | 44.70 | 1 | ataxin 3 |
| 9 | Xenopus tropicalis | 43.50 | 1 | ataxin 3 |
Top-ranked sequences
| organism | matching |
|---|---|
| N/A | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |
| Homo sapiens | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |
| Canis familiaris | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |||||||| ||||||||||||||||| |||#|||+|||||||||||||||||||||||||| Sbjct 179 QMIRVQQMQRPKLIGEELAQLKEQRVQKTD#LERVLEANDGSGMLDEDEEDLQRALALSRQ 238 |
| Bos taurus | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |||||||||||||||||||||||||| |||#|| +|| |||+||||||||+|||||||||| Sbjct 179 QMIRVQQMHRPKLIGEELAQLKEQRVQKTD#LEHVLEVNDGTGMLDEDEEELQRALALSRQ 238 |
| Mus musculus | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |||+||||||||||||||| |||| | |#|||+||| ||||+ ||||+|||||||+||| Sbjct 179 QMIKVQQMHRPKLIGEELAHLKEQSALKAD#LERVLEAADGSGIFDEDEDDLQRALAISRQ 238 |
| Rattus norvegicus | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 |||+||||||||||||||| |||| | |#|||+||| || || |+||+|||||||+||| Sbjct 179 QMIKVQQMHRPKLIGEELAHLKEQSALKAD#LERVLEAADGPGMFDDDEDDLQRALAMSRQ 238 |
| Gallus gallus | Query 179 QMIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEAN---DGSGMLDEDEEDLQRALAL 235 |||||||+ |||||||| || ++||+ ++|#+++ +| + ||+||||||||+ |||||| Sbjct 179 QMIRVQQVQRPKLIGEETAQSRDQRLPRSD#VDQAIEVSHPFDGTGMLDEDEENFQRALAL 238 Query 236 SRQ 238 ||| Query 236 SRQ 238 |
| Danio rerio | Query 180 MIRVQQMHRPKLIGEELAQLKEQRVHKTD#LERMLEANDGSGMLDEDEEDLQRALALSRQ 238 ++||+| |||||||| | + | ++# | +||||||+|++||||||| Sbjct 135 IMRVEQQQRPKLIGEEETQ-RMSAPHASE#TTHTAEEP----VLDEDEEELRKALALSRQ 188 |
| Xenopus tropicalis | Query 188 RPKLIGEELAQLKEQRVHKTD#LERMLEAN---DGSGMLDEDEEDLQRALALSRQ 238 ||+||||+ | ++||| ++ # | +| + + | |+|||+++||+||||||| Sbjct 188 RPRLIGEDAAA-RDQRVQRS-#-EAGVEGDRLYNSSAMVDEDDDNLQKALALSRQ 238 |
[Site 5] ADLRRAIQLS256-MQGSSRNISQ
Ser256 Met
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ala247 | Asp248 | Leu249 | Arg250 | Arg251 | Ala252 | Ile253 | Gln254 | Leu255 | Ser256 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Met257 | Gln258 | Gly259 | Ser260 | Ser261 | Arg262 | Asn263 | Ile264 | Ser265 | Gln266 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| EDLQRALALSRQEIDMEDEEADLRRAIQLSMQGSSRNISQDMTQTSGTNLTSEELRKRRE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 117.00 | 9 | MJD1 protein |
| 2 | N/A | 117.00 | 2 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
| 3 | Canis familiaris | 106.00 | 3 | PREDICTED: similar to ataxin 3 isoform 1 isoform |
| 4 | Bos taurus | 100.00 | 1 | ataxin 3 |
| 5 | Rattus norvegicus | 96.70 | 1 | ataxin 3 |
| 6 | Mus musculus | 91.70 | 3 | ATX3_MOUSE Ataxin-3 (Machado-Joseph disease prote |
| 7 | Gallus gallus | 75.50 | 1 | ataxin 3 |
| 8 | Xenopus tropicalis | 72.40 | 1 | ataxin 3 |
| 9 | Danio rerio | 61.60 | 1 | ataxin 3 |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 |
| N/A | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 |
| Canis familiaris | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 ||||||||||||||||||||||||||||||#||||||+|||| |||| +||||||||||| Sbjct 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRSISQDTPQTSGIHLTSEELRKRRE 286 |
| Bos taurus | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 |+||||||||||||||||||||||||||||#|||+||| ||+ ||||++ |||||||||| Sbjct 227 EELQRALALSRQEIDMEDEEADLRRAIQLS#MQGTSRNRCQDIPQTSGSHPTSEELRKRRE 286 |
| Rattus norvegicus | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 +|||||||+|||||||||||||||||||||#|||||| + +| ||| |+|+||||||||| Sbjct 227 DDLQRALAMSRQEIDMEDEEADLRRAIQLS#MQGSSRGMCEDSPQTSSTDLSSEELRKRRE 286 |
| Mus musculus | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSGTNLTSEELRKRRE 286 +|||||||+|||||||||||||||||||||#||||||++ ++ ||| +|+|||||+||| Sbjct 227 DDLQRALAISRQEIDMEDEEADLRRAIQLS#MQGSSRSMCENSPQTSSPDLSSEELRRRRE 286 |
| Gallus gallus | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGS-----SRNISQDMTQTSGT----NLT 277 |+ |||||||||||||||||||||||||||#|||| | ++ |+ +| | +|+ Sbjct 230 ENFQRALALSRQEIDMEDEEADLRRAIQLS#MQGSRQSEFSNSLPQNASQPPHTSQTDSLS 289 Query 278 SEELRKRRE 286 ||+||+||+ Sbjct 290 SEDLRRRRQ 298 |
| Xenopus tropicalis | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRN-----ISQDMTQTSGTN----LT 277 ++||+|||||||+|||||||||||||||||#||| ++ + + |+|| + || Sbjct 227 DNLQKALALSRQQIDMEDEEADLRRAIQLS#MQGGHQSDITEPLVSNTPQSSGNSEPEPLT 286 Query 278 SEELRKRRE 286 |||||+||+ Sbjct 287 SEELRQRRQ 295 |
| Danio rerio | Query 227 EDLQRALALSRQEIDMEDEEADLRRAIQLS#MQGSSRNISQDMTQTSG--TNLTSEELRKR 284 |+|++|||||||++ +||||||||||||+|#||||| | | |++||||+| Sbjct 177 EELRKALALSRQDLQVEDEEADLRRAIQMS#MQGSSDAGSSAPAGGSSEKQTLSAEELRRR 236 Query 285 RE 286 |+ Sbjct 237 RQ 238 |
[Site 6] QQQQQQQQQQ317-RDLSGQSSHP
Gln317 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gln308 | Gln309 | Gln310 | Gln311 | Gln312 | Gln313 | Gln314 | Gln315 | Gln316 | Gln317 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg318 | Asp319 | Leu320 | Ser321 | Gly322 | Gln323 | Ser324 | Ser325 | His326 | Pro327 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| YFEKQQQKQQQQQQQQQQQQQQQQQQQQQQRDLSGQSSHPCERPATSSGALGSDLGKACS |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Homo sapiens | 108.00 | 8 | MJD1 protein |
| 2 | N/A | 108.00 | 1 | ATX3_HUMAN Ataxin-3 (Machado-Joseph disease prote |
Top-ranked sequences
| organism | matching |
|---|---|
| Homo sapiens | Query 288 YFEKQQQKQQQQQQQQQQQQQQQQQQQQQQ#RDLSGQSSHPCERPATSSGALGSDLGKACS 347 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 288 YFEKQQQKQQQQQQQQQQQQQQQQQQQQQQ#RDLSGQSSHPCERPATSSGALGSDLGKACS 347 |
| N/A | Query 288 YFEKQQQKQQQQQQQQQQQQQQQQQQQQQQ#RDLSGQSSHPCERPATSSGALGSDLGKACS 347 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 288 YFEKQQQKQQQQQQQQQQQQQQQQQQQQQQ#RDLSGQSSHPCERPATSSGALGSDLGKACS 347 |
* References
[PubMed ID: 7874163] Kawaguchi Y, Okamoto T, Taniwaki M, Aizawa M, Inoue M, Katayama S, Kawakami H, Nakamura S, Nishimura M, Akiguchi I, et al., CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Nat Genet. 1994 Nov;8(3):221-8.