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SB0145 : Troponin T3, fast skeletal muscle, TnTf

[ CaMP Format ]

* Basic Information

OrganismSus scrofa (pig)
Protein Namestroponin T fast skeletal muscle type [Sus scrofa]; troponin T fast skeletal muscle type
Gene Namestnnt3
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAD15378 N/A N/A N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 266 aa

Average Mass: 31.547 kDa

Monoisotopic Mass: 31.528 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Troponin 1. 72719.02.7
--- cleavage 22 (inside Troponin 7..27) ---
--- cleavage 38 ---
--- cleavage 52 ---
Tetratricopeptide repeat 1. 9911411.00.8
Tetratricopeptide repeat 2. 13314120.01.4
Tetratricopeptide repeat 3. 1641986.00.0
Troponin 2. 20025145.01.8

3. Sequence Information

Fasta Sequence: SB0145.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites] cleaved by Calpain 2

Source Reference: [PubMed ID: 15884856] Kitamura S, Muroya S, Tanabe S, Okumura T, Chikuni K, Nishimura T, Mechanism of production of troponin T fragments during postmortem aging of porcine muscle. J Agric Food Chem. 2005 May 18;53(10):4178-81.

Cleavage sites (±10aa)

[Site 1] YEEEEEAQEE22-APPPPAEVHE

Glu22 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Tyr13Glu14Glu15Glu16Glu17Glu18Ala19Gln20Glu21Glu22
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala23Pro24Pro25Pro26Pro27Ala28Glu29Val30His31Glu32

Sequence conservation (by blast)

[Site 2] EVHEVHEEVH38-EVHEPEEKPR

His38 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu29Val30His31Glu32Val33His34Glu35Glu36Val37His38
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu39Val40His41Glu42Pro43Glu44Glu45Lys46Pro47Arg48

Sequence conservation (by blast)

[Site 3] PEEKPRPKLT52-APKIPEGEKV

Thr52 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Pro43Glu44Glu45Lys46Pro47Arg48Pro49Lys50Leu51Thr52
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala53Pro54Lys55Ile56Pro57Glu58Gly59Glu60Lys61Val62

Sequence conservation (by blast)

* References

[PubMed ID: 16556993] Kitamura S, Muroya S, Nakajima I, Chikuni K, Nishimura T, Amino acid sequences of porcine fast and slow troponin T isoforms. Biosci Biotechnol Biochem. 2006 Mar;70(3):726-8.