CaMPDB :: Substrate

XSB0174 : beta I spectrin form betaI sigma3 [Homo sapiens]

This entry is computationally expanded from SB0078

* Basic Information

Organism	Homo sapiens (human)
Protein Names	beta I spectrin form betaI sigma3
Gene Names	Not available
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
AAL73492	N/A	N/A	Q8WX82	N/A	N/A	N/A	hsa:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1028 aa

Average Mass: 117.549 kDa

Monoisotopic Mass: 117.477 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
Spectrin 1.	46	141	28.3	3.2e-05
Spectrin 2.	143	247	77.7	4.2e-20
Spectrin 3.	249	353	98.3	2.6e-26
Spectrin 4.	355	460	114.3	4e-31
Spectrin 5.	462	566	86.4	9.9e-23
Spectrin 6.	568	672	100.6	5.3e-27
Spectrin 7.	674	760	17.6	0.0011
--- cleavage 723 (inside Spectrin 674..760) ---
PH 1.	844	988	52.9	1.2e-12

3. Sequence Information

Fasta Sequence: XSB0174.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] KRHEAFEKST⁷²³-ASWAERFAAL

Thr⁷²³ Ala

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Lys⁷¹⁴	Arg⁷¹⁵	His⁷¹⁶	Glu⁷¹⁷	Ala⁷¹⁸	Phe⁷¹⁹	Glu⁷²⁰	Lys⁷²¹	Ser⁷²²	Thr⁷²³

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ala⁷²⁴	Ser⁷²⁵	Trp⁷²⁶	Ala⁷²⁷	Glu⁷²⁸	Arg⁷²⁹	Phe⁷³⁰	Ala⁷³¹	Ala⁷³²	Leu⁷³³

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELKERQIAERPAEE

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	122.00	61	AF465439_1 beta I spectrin form betaI sigma3
2	N/A	122.00	16	-
3	Mus musculus	114.00	47	mKIAA4219 protein
4	Danio rerio	79.30	9	spectrin, beta, erythrocytic
5	Drosophila melanogaster	76.30	8	beta Spectrin CG5870-PA
6	Gallus gallus	76.30	5	PREDICTED: similar to spectrin, beta, non-erythroc
7	Aedes aegypti	76.30	3	beta chain spectrin
8	Drosophila pseudoobscura	76.30	3	GA19192-PA
9	Anopheles gambiae str. PEST	75.50	3	ENSANGP00000012507
10	Canis familiaris	75.10	18	PREDICTED: similar to spectrin, beta, non-erythroc
11	Pan troglodytes	75.10	14	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
12	Rattus norvegicus	75.10	13	Spnb2 protein
13	Macaca mulatta	75.10	5	PREDICTED: spectrin, beta, non-erythrocytic 1 isof
14	Bos taurus	75.10	5	PREDICTED: similar to spectrin, beta, non-erythroc
15	Macaca fascicularis	75.10	2	unnamed protein product
16	mice, brain, Peptide Partial, 332 aa	75.10	1	beta-spectrin subunit
17	Apis mellifera	73.90	3	PREDICTED: similar to Spectrin beta chain
18	Tribolium castaneum	71.60	4	PREDICTED: similar to Spectrin beta chain isoform
19	Tetraodon nigroviridis	69.30	8	unnamed protein product
20	Caenorhabditis briggsae	64.70	3	Hypothetical protein CBG19038
21	Strongylocentrotus purpuratus	64.30	5	PREDICTED: similar to spectrin beta 2
22	Caenorhabditis elegans	63.20	5	UNCoordinated family member (unc-70)
23	Brugia malayi	63.20	1	beta-G spectrin
24	Sus scrofa	43.90	1	spectrin alpha non-erythrocytic 1
25	Monodelphis domestica	36.60	4	PREDICTED: similar to spectrin, alpha, erythrocyti
26	Xenopus tropicalis	35.80	1	hypothetical protein LOC100036647
27	Mus sp.	34.70	1	SPTB1_MOUSE Spectrin beta chain, erythrocyte (Beta

Top-ranked sequences

organism	matching
Homo sapiens	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753
N/A	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753
Mus musculus	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|\| Sbjct 618 EPYLASRDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQTPERPTEE 677
Danio rerio	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|+\|\| \| \| \|\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\|\|#\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2048 EPYVASKDVGQTVDEVEKLLKRHEAFEKST#ATWEERFSALERLTTLELLE 2097
Drosophila melanogaster	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLLSSELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQELAEE 2097
Gallus gallus	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|\|\|\|\|+ \|\|\|\|\| \| Sbjct 2036 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFAALERLTTLELLE 2085
Aedes aegypti	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLMSTELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQEAAEE 2097
Drosophila pseudoobscura	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLLSSELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQELAEE 2097
Anopheles gambiae str. PEST	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|\|\| + + \|\|\| Sbjct 2038 EPYLMSTELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALERLTTFELKEMKRRQDAAEE 2097
Canis familiaris	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2037 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2086
Pan troglodytes	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2037 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2086
Rattus norvegicus	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 190 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 239
Macaca mulatta	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2024 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2073
Bos taurus	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 2036 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 2085
Macaca fascicularis	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 367 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 416
mice, brain, Peptide Partial, 332 aa	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \|\|\|\|+\| + \| +\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|\|\|\| \| Sbjct 163 EPYLSSREIGQSVDEVEKLIKRHEAFEKSA#ATWDERFSALERLTTLELLE 212
Apis mellifera	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\| + \|\| \|\|\|\| + \|+ \|\| Sbjct 2036 EPYLMSQELGHTIDEVENLIKKHEAFEKSA#AAQEERFSALHRLTTFELKEMKRREQEREE 2095
Tribolium castaneum	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 745 \|\|\|\| \| + \|\|\|+\| \|\| \|\|\|+\|\|\|\|\|\|\| #\|+ \|\|\|+\|\|\|+ \|\| \|\|+\| \| Sbjct 2037 EPYLMSTELGHTIDDVENLIKKHEAFEKSA#AAQEERFSALERLTTFELREIQ 2088
Tetraodon nigroviridis	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 745 \|\|\|\|+\| + \| +\|\| \|\|\|\|+\|\|\|\|\|\|\|\|\| #\|+\| \|\|\|+\|\|\|+ \|\|+ \|+ Sbjct 1937 EPYLSSREVGRSVDQVEKLLKRHEAFEKSA#ATWEERFSALERLTTVSAGPRR 1988
Caenorhabditis briggsae	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| \| ++ Sbjct 2024 EPYLISREYGRNLEETIKLIKKHEAFEKSA#LAQEERFLALEKLTTFELKENQHREEETQK 2083
Strongylocentrotus purpuratus	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKE 743 \| \|\| \| \|+\| ++\| \|\|\|\|\|\|\|\|\|\|\|\|\|+ # \|\|\| \|\|\|\| \|\| \|\|+\| Sbjct 2026 EQYLRSDDYGDSLDEVEKLIKRHEAFEKAL#YCQEERFTALEKLTTFELRE 2075
Caenorhabditis elegans	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAE 748 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| \| Sbjct 2027 EPYLISKEYGRNLEETIKLIKKHEAFEKSA#FAQEERFLALEKLTTFELKETQHRE 2081
Brugia malayi	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQ 745 \|\|\|\| \| ++\| ++ \|\|\|\|+\|\|\|\|\|\|\| # + \|\|\| \|\|\|\| \|\| \|\|\|\| \| Sbjct 2033 EPYLVSKEYGRNLEETIKLIKKHEAFEKSA#NAQEERFLALEKLTTFELKEMQ 2084
Sus scrofa	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIA 747 \| +\| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| #++ \|+ \|\|++ \| ++ \| Sbjct 24 EAFLLNEDLGDSLDSVEALLKKHEDFEKSL#SAQEEKITALDEFVTKLIQNNHYA 77
Monodelphis domestica	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTT 738 \| +\| + \| \|+++ +\|\| \|+++\|\| \|\|++ # + \|+ \|+\| \| Sbjct 487 EAFLENEDLGNSLGTVEALLQKHEDFEEAF#GAQEEKITTLDKTAT 531
Xenopus tropicalis	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAE 748 \| +\| + \| \| ++\|\|\|\| \|+\|+\|\| \|\|\|\| #++ \|+ \|\|++ \| ++ \|+ Sbjct 487 EAFLLNEDLGDSLDSVEALLKKHEDFEKSL#SAQEEKITALDEFATKLIQNNHYAK 541 Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALE 734 \| +\| \| \| \| ++\|\|\|\| \|\|\|+\|\| \|+\|+ # \|+ \|\|\|+ Sbjct 1464 EAFLNSEDKGDSLDSVEALIKKHEDFDKAI#NVQEEKIAALQ 1504 Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAAL 733 \| +\|\| \|\|\| + \|\|+ \|+++\|\| \|+ #\|+ \|+ \|\| Sbjct 275 EQLMASDDFGRDLASVQALLRKHEGLERDL#AALEEKVKAL 314
Mus sp.	Query 694 EPYLASGDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQIAERPAEE 753 \|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|\|\| \|\| Sbjct 2020 EPYLASRDFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALEKPTTLELKERQTPERPTEE 2079 Query 701 DFGHTVDSVEKLIKRHEAFEKST#ASWAERFAALE 734 +\|\|+ + +\|\| \|+\|\|\| \| \|#\|++ \|\| \|\|\| Sbjct 441 NFGYDLAAVEAAKKKHEAIETDT#AAYEERVKALE 474

* References

None.