XSB0218 : FLJ00343 protein [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0090
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Filamin-A; Alpha-filamin; Filamin-1; Endothelial actin-binding protein; Actin-binding protein 280; ABP-280; Non-muscle filamin; FLJ00343 protein |
| Gene Names | FLJ00343; FLN, FLN1; FLN; FLN1 |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| BAC03408 |
N/A |
N/A |
Q8NF52 |
N/A |
N/A |
N/A |
hsa:2316 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2651 aa
Average Mass: 281.430 kDa
Monoisotopic Mass: 281.254 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| CH 1. | 56 | 161 | 108.9 | 1.7e-29 |
| CH 2. | 179 | 281 | 99.6 | 1.1e-26 |
| Filamin 1. | 290 | 383 | 120.4 | 5.9e-33 |
| Filamin 2. | 390 | 483 | 128.7 | 1.9e-35 |
| Filamin 3. | 489 | 579 | 133.3 | 7.9e-37 |
| Filamin 4. | 585 | 672 | 107.3 | 5e-29 |
| Filamin 5. | 681 | 772 | 143.6 | 6.3e-40 |
| Filamin 6. | 778 | 875 | 123.9 | 5.4e-34 |
| Filamin 7. | 881 | 974 | 129.4 | 1.1e-35 |
| Filamin 8. | 980 | 1070 | 102.9 | 1.1e-27 |
| Filamin 9. | 1076 | 1163 | 158.5 | 2e-44 |
| Filamin 10. | 1169 | 1258 | 134.1 | 4.5e-37 |
| Filamin 11. | 1264 | 1358 | 118.3 | 2.6e-32 |
| Filamin 12. | 1364 | 1451 | 151.8 | 2e-42 |
| Filamin 13. | 1457 | 1548 | 152.9 | 9.8e-43 |
| Filamin 14. | 1554 | 1645 | 147.1 | 5.4e-41 |
| Filamin 15. | 1651 | 1741 | 126.0 | 1.2e-34 |
| --- cleavage 1765 --- |
| Filamin 16. | 1777 | 1861 | 38.8 | 2.2e-08 |
| Filamin 17. | 1866 | 1953 | 155.8 | 1.3e-43 |
| Filamin 18. | 1954 | 2040 | 25.5 | 6.3e-05 |
| Filamin 19. | 2048 | 2135 | 146.4 | 8.8e-41 |
| Filamin 20. | 2154 | 2231 | 19.0 | 0.00025 |
| Filamin 21. | 2239 | 2326 | 139.8 | 8.6e-39 |
| Filamin 22. | 2333 | 2421 | 91.0 | 4.1e-24 |
| Filamin 23. | 2430 | 2517 | 127.2 | 5.4e-35 |
| Filamin 24. | 2558 | 2647 | 115.3 | 2e-31 |
3. Sequence Information
Fasta Sequence: XSB0218.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB:
2AAV (NMR; -; A=1863-1955), 2BP3 (X-ray; 232 A; A/B=1863-1956), 2BRQ (X-ray; 210 A; A/B=2236-2329), 2J3S (X-ray; 250 A; A/B=2045-2329), 2JF1 (X-ray; 220 A; A=2236-2329), 2K3T (NMR; -; A=2427-2522), 2W0P (X-ray; 190 A; A/B=2236-2329), 3CNK (X-ray; 165 A; A/B=2559-2647)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] LRSQQLAPQY1765-TYAQGGQQTW
Tyr1765 
Thr
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Leu1756 | Arg1757 | Ser1758 | Gln1759 | Gln1760 | Leu1761 | Ala1762 | Pro1763 | Gln1764 | Tyr1765 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Thr1766 | Tyr1767 | Ala1768 | Gln1769 | Gly1770 | Gly1771 | Gln1772 | Gln1773 | Thr1774 | Trp1775 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
PNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPERPLVGVNGLDVTSLRPF
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Homo sapiens |
127.00 |
13 |
FLJ00343 protein |
| 2 |
Macaca mulatta |
126.00 |
5 |
PREDICTED: filamin 1 (actin-binding protein-280) i |
| 3 |
Canis familiaris |
119.00 |
11 |
PREDICTED: similar to Filamin A (Alpha-filamin) (F |
| 4 |
Bos taurus |
115.00 |
1 |
PREDICTED: similar to filamin |
| 5 |
Mus musculus |
114.00 |
7 |
filamin, alpha |
| 6 |
N/A |
114.00 |
1 |
F |
| 7 |
Rattus norvegicus |
109.00 |
1 |
PREDICTED: similar to Filamin-A (Alpha-filamin) (F |
| 8 |
Tetraodon nigroviridis |
41.20 |
1 |
unnamed protein product |
| 9 |
Pan troglodytes |
38.90 |
2 |
PREDICTED: filamin B, beta (actin binding protein |
| 10 |
Danio rerio |
37.70 |
1 |
PREDICTED: similar to gamma-filamin |
| 11 |
Gallus gallus |
33.50 |
1 |
filamin |
Top-ranked sequences
| organism | matching |
|---|
| Homo sapiens |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|
| Macaca mulatta |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
||||||||||||||||||||||||||||||#|||||||||||||||||||||||+||||||
Sbjct 1732 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDMTSLRPF 1791
|
| Canis familiaris |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|||||||||||||||+ ||||| ||||| |#||||||||||||||||+|||||||||||||
Sbjct 1732 PNSPFQVTALAGDQPAAQPPLRPQQLAPPY#TYAQGGQQTWAPERPLMGVNGLDVTSLRPF 1791
|
| Bos taurus |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|||||||||||||||+ || || ||||| |#||||||||||||||||||||||||+|||||
Sbjct 2015 PNSPFQVTALAGDQPTAQPSLRPQQLAPPY#TYAQGGQQTWAPERPLVGVNGLDVSSLRPF 2074
|
| Mus musculus |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|||||||||||||||+|| |||||||||||# | || |||| ||||+||||||||||||||
Sbjct 1724 PNSPFQVTALAGDQPTVQTPLRSQQLAPQY#NYPQGSQQTWIPERPMVGVNGLDVTSLRPF 1783
|
| N/A |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|||||||||||||||+|| |||||||||||# | || |||| ||||+||||||||||||||
Sbjct 1732 PNSPFQVTALAGDQPTVQTPLRSQQLAPQY#NYPQGSQQTWIPERPMVGVNGLDVTSLRPF 1791
|
| Rattus norvegicus |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
|||||||||||||||+|| ||| ||| ||#|| || |||| ||||+||||||||||||||
Sbjct 1732 PNSPFQVTALAGDQPTVQTPLRPQQLPSQY#TYPQGSQQTWIPERPMVGVNGLDVTSLRPF 1791
|
| Tetraodon nigroviridis |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTW----APERPLVGVNGLDVTS 1791
|||||||| | ++ | + + | #+++ | | +||+ |+|||||
Sbjct 1674 PNSPFQVTVSVGQIYTLNPWEKKDKNCKQE#SHSSIGNPLTSVPQATDRPM-GMNGLDVAG 1732
Query 1792 LRPF 1795
||||
Query 1792 LRPF 1795
|
| Pan troglodytes |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
||||| | | | | + | + + ++#|+ + | || | | |+ ++ +||
Sbjct 1709 PNSPFTVMGL-GQYPGLSPGILKDNSSEKH#TFMKTKQLTWVTEEAYVPVSNMNGLGFKPF 1767
|
| Danio rerio |
Query 1736 PNSPFQVTALAGDQPSVQPPLRSQQLAPQY#TYAQGGQQTWAPERPLVGVNGLDVTSLRPF 1795
||||| | | + | ++ | || |# || || | |+ |+ ++ ||||
Sbjct 1263 PNSPFHVVA-SDTIPIIEEPCDKLQLQQPY#APYQGYSPHWATEEPVTAVDIIEPV-LRPF 1320
|
| Gallus gallus |
Query 1773 QTWAPERPLVGVNGLDVTSLRPF 1795
| | ||||+||||||| ||||
Sbjct 62 QVMATERPLLGVNGLDV-GLRPF 83
|
