XSB0234 : D-MeAsp receptor:SUBUNIT=epsilon1
[ CaMP Format ]
This entry is computationally expanded from SB0072
* Basic Information
| Organism | Mus musculus (house mouse) |
| Protein Names | Not available |
| Gene Names | Not available |
| Gene Locus | Not available |
| GO Function | Not available |
| Entrez Protein |
Entrez Nucleotide |
Entrez Gene |
UniProt |
OMIM |
HGNC |
HPRD |
KEGG |
| 1809347A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
N/A |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 1464 aa
Average Mass: 0.000 kDa
Monoisotopic Mass: 0.000 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| HS1_rep 1. | 179 | 215 | 6.7 | 3.1 |
| Lig_chan-Glu_bd 1. | 439 | 502 | 73.1 | 1e-18 |
| Lig_chan 1. | 554 | 838 | 371.4 | 1.6e-108 |
| NMDAR2_C 1. | 839 | 1464 | 1140.0 | 0 |
| --- cleavage 1329 (inside NMDAR2_C 839..1464) --- |
| --- cleavage 1278 (inside NMDAR2_C 839..1464) --- |
3. Sequence Information
Fasta Sequence: XSB0234.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] LEGNLYGSLF1329-SVPSSKLLGN
Phe1329 
Ser
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Leu1320 | Glu1321 | Gly1322 | Asn1323 | Leu1324 | Tyr1325 | Gly1326 | Ser1327 | Leu1328 | Phe1329 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser1330 | Val1331 | Pro1332 | Ser1333 | Ser1334 | Lys1335 | Leu1336 | Leu1337 | Gly1338 | Asn1339 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
REIDLSRPSRSISLKDRERLLEGNLYGSLFSVPSSKLLGNKSSLFPQGLEDSKRSKSLLP
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
117.00 |
4 |
1 |
| 2 |
Rattus norvegicus |
117.00 |
4 |
N-methyl-D-aspartate receptor NMDAR2A subunit; NMD |
| 3 |
NMDA |
117.00 |
3 |
NMDE1_RAT Glutamate |
| 4 |
Mus musculus |
117.00 |
2 |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
| 5 |
Canis familiaris |
112.00 |
1 |
PREDICTED: similar to glutamate receptor, ionotrop |
| 6 |
Saimiri boliviensis |
111.00 |
1 |
glutamate receptor ionotropic N-methyl-D-aspartate |
| 7 |
Homo sapiens |
110.00 |
2 |
N-methyl-D-aspartate receptor subunit 2A precursor |
| 8 |
Pan troglodytes |
110.00 |
1 |
N-methyl-D-aspartate receptor subunit 2A |
| 9 |
Monodelphis domestica |
105.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 10 |
Bos taurus |
105.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 11 |
Gallus gallus |
85.90 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 12 |
Danio rerio |
72.00 |
2 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 13 |
Tetraodon nigroviridis |
50.40 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Rattus norvegicus |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| NMDA |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Mus musculus |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|
| Canis familiaris |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||+|||||||||||||||||||||||||||#||||||| ||||||||||||| ||||||||
Sbjct 1300 REMDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLSGNKSSLFPQGLEDRKRSKSLLP 1359
|
| Saimiri boliviensis |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
|||||||||||||||||||||||| |||||#||||||| | ||||||||||||||||||||
Sbjct 1224 REIDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1283
|
| Homo sapiens |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||+||||||||||||||||||||| |||||#||||||| | ||||||||||||||||||||
Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
|
| Pan troglodytes |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||+||||||||||||||||||||| |||||#||||||| | ||||||||||||||||||||
Sbjct 1300 RELDLSRPSRSISLKDRERLLEGNFYGSLF#SVPSSKLSGKKSSLFPQGLEDSKRSKSLLP 1359
|
| Monodelphis domestica |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||| ||||||||||+|||||||||||||#||||||||||| ||| | |||+|||||| |
Sbjct 1305 REIDLGRPSRSISLKDKERLLEGNLYGSLF#SVPSSKLLGNKGSLFSQALEDTKRSKSLFP 1364
|
| Bos taurus |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||+| |||||||||||||||||||||||||#||||||| ||| |||||||| ||||||||
Sbjct 1072 REVDPSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLAGNKGSLFPQGLEVGKRSKSLLP 1131
|
| Gallus gallus |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
||||| ||||||||||+|+ |+ + | |+|#|||||||| ||+|| |||||||||| |
Sbjct 1294 REIDLGRPSRSISLKDKEKFLQSSPYASMF#SVPSSKLLSNKASLLTHALEDSKRSKSLYP 1353
|
| Danio rerio |
Query 1300 REIDLSRPSRSISLKDRERLLEGNLYGSLF#SVPSSKLLGNKSSLFPQGLEDSKRSKSLLP 1359
+||||+||+||+|||+++| || + | ++|#++ + || |++| || + ||+||||||| |
Sbjct 1289 KEIDLNRPARSVSLKEKDRFLEDSPYANMF#NIKADKLFGSRSMLFNRNLEESKRSKSLYP 1348
|
| Tetraodon nigroviridis |
Query 1300 REIDLSRPSRSISLKDRERLLEGNL-YGSLF#SVP--SSKLLG--NKSSLFPQGLEDSKRS 1354
+++|+ ||+||+|||+++| + | +||#++ | +| | +|| +| ||+||||
Sbjct 1216 KDVDVGRPARSVSLKEKDRFATSDSHYANLF#NMRPYSGRLFGTSSKSMMFNHNLEESKRS 1275
Query 1355 KSLLP 1359
||| |
Sbjct 1276 KSLYP 1280
|
[Site 2] QDWSQNNALQ1278-FQKNKLKINR
Gln1278 Phe
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Gln1269 | Asp1270 | Trp1271 | Ser1272 | Gln1273 | Asn1274 | Asn1275 | Ala1276 | Leu1277 | Gln1278 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Phe1279 | Gln1280 | Lys1281 | Asn1282 | Lys1283 | Leu1284 | Lys1285 | Ile1286 | Asn1287 | Arg1288 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
DEDQMLQETGNPATREEAYQQDWSQNNALQFQKNKLKINRQNSYDNILDKPREIDLSRPS
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
N/A |
126.00 |
4 |
1 |
| 2 |
Mus musculus |
124.00 |
2 |
glutamate receptor, ionotropic, NMDA2A (epsilon 1) |
| 3 |
NMDA |
121.00 |
6 |
NMDE1_RAT Glutamate |
| 4 |
Rattus norvegicus |
121.00 |
3 |
N-methyl-D-aspartate receptor NMDAR2A subunit; NMD |
| 5 |
Saimiri boliviensis |
114.00 |
1 |
glutamate receptor ionotropic N-methyl-D-aspartate |
| 6 |
Homo sapiens |
110.00 |
4 |
N-methyl-D-aspartate receptor subunit 2A precursor |
| 7 |
Pan troglodytes |
110.00 |
1 |
N-methyl-D-aspartate receptor subunit 2A |
| 8 |
Canis familiaris |
107.00 |
1 |
PREDICTED: similar to glutamate receptor, ionotrop |
| 9 |
Bos taurus |
105.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 10 |
Monodelphis domestica |
99.00 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 11 |
Gallus gallus |
81.30 |
1 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 12 |
Danio rerio |
51.20 |
2 |
PREDICTED: similar to N-methyl-D-aspartate recepto |
| 13 |
Tetraodon nigroviridis |
46.20 |
1 |
unnamed protein product |
| 14 |
Tetrahymena thermophila SB210 |
33.90 |
2 |
TBC domain containing protein |
| 15 |
Paramecium tetraurelia |
33.50 |
3 |
hypothetical protein |
| 16 |
Plasmodium yoelii yoelii str. 17XNL |
32.70 |
1 |
myosin ij heavy chain |
| 17 |
Macaca mulatta |
32.30 |
1 |
PREDICTED: N-methyl-D-aspartate receptor subunit 2 |
Top-ranked sequences
| organism | matching |
|---|
| N/A |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
|
| Mus musculus |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||||||||||||||||||||#|||||||||||+||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQHSYDNILDKPREIDLSRPS 1308
|
| NMDA |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||||||| ||||||||||||#||||||+||||+||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
|
| Rattus norvegicus |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||||||| ||||||||||||#||||||+||||+||||||||||||||||||
Sbjct 1249 DEDQMLQETGNPATREEVYQQDWSQNNALQ#FQKNKLRINRQHSYDNILDKPREIDLSRPS 1308
|
| Saimiri boliviensis |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||||||+ |||||+||||||# |||||+|+||+|||||+||||||||||||
Sbjct 1173 DEDQMLQETGNPATREQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPREIDLSRPS 1232
|
| Homo sapiens |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
|||||||||||||| |+ |||||+||||||# |||||+|+||+|||||+|||||+||||||
Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
|
| Pan troglodytes |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
|||||||||||||| |+ |||||+||||||# |||||+|+||+|||||+|||||+||||||
Sbjct 1249 DEDQMLQETGNPATGEQVYQQDWAQNNALQ#LQKNKLRISRQHSYDNIVDKPRELDLSRPS 1308
|
| Canis familiaris |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||+|| +|| |||||+||+ ||#||||||+|+||+|||||+|||||+||||||
Sbjct 1249 DEDQMLQETGSPAAQEEVYQQDWAQNSTLQ#FQKNKLRISRQHSYDNIVDKPREMDLSRPS 1308
|
| Bos taurus |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPREIDLSRPS 1308
||||||||||||| +|| |||||+ |+|||# |||||+|+||+|||||||||||+| ||||
Sbjct 1021 DEDQMLQETGNPAAQEEVYQQDWAPNSALQ#LQKNKLRISRQHSYDNILDKPREVDPSRPS 1080
|
| Monodelphis domestica |
Query 1249 DEDQMLQET-GNPATREEAYQQDWSQNNALQ#FQK-NKLKINRQNSYDNILDKPREIDLSR 1306
||||||||| ||| || |+|||+||||||#||| |||+|+||+|||||||||||||| |
Sbjct 1252 DEDQMLQETTANPAHPEETYEQDWAQNNALQ#FQKKNKLRISRQHSYDNILDKPREIDLGR 1311
Query 1307 PS 1308
||
Query 1307 PS 1308
|
| Gallus gallus |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#F-QKNKLKINRQNSYDNILDKPREIDLSRP 1307
+||||||+| | + || | ||||||||#+ +||||+|+||+|+||| || ||||| ||
Sbjct 1242 EEDQMLQDTTNLSLPEEIYGHSWSQNNALQ#YHKKNKLRISRQHSFDNIADKSREIDLGRP 1301
Query 1308 S 1308
|
Query 1308 S 1308
|
| Danio rerio |
Query 1250 EDQMLQETG-NPATR-EEAYQQDWSQNNALQ#FQK-NKLKINRQNSYDNI-LDKPREIDLS 1305
||||||| +|+ ++ + | | + # |+ |+||++||+|+||| |+||+||||+
Sbjct 1235 EDQMLQEAMISPSMHHDDMFSHYWPQTDGPH#VQRRNRLKLSRQHSFDNIMLEKPKEIDLN 1294
Query 1306 RPS 1308
||+
Sbjct 1295 RPA 1297
|
| Tetraodon nigroviridis |
Query 1249 DEDQMLQET-GNPATREEAYQQD-------WSQNNALQ#FQK-NKLKINRQNSYDNI-LDK 1298
+|||+| + |+| + || | | + # || |+|+++||+|+||| |+|
Sbjct 1155 NEDQLLTDPLGSPTLHHQQQQQADEMFGLYWPQTDGPH#VQKRNRLRLSRQHSFDNIMLEK 1214
Query 1299 PREIDLSRPS 1308
|+++|+ ||+
Sbjct 1215 PKDVDVGRPA 1224
|
| Tetrahymena thermophila SB210 |
Query 1249 DEDQMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKIN 1287
+|+|++|+ |||+|| | |+ |# || |+|
Sbjct 648 NENQLIQQQKPPATQEEDYSVPQELQNSFQ#MNKNMSKLN 686
|
| Paramecium tetraurelia |
Query 1253 MLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSY--DNILDKPREIDLS 1305
+||+ | ++ + || ||#||+|+ +|+| + ++|++| ++||||
Sbjct 165 ILQKQVNDLHKDNIFLGSEKQNLLLQ#FQQNQQFVNQQQNILEEDIINKTQQIDLS 219
|
| Plasmodium yoelii yoelii str. 17XNL |
Query 1252 QMLQETGNPATREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNI 1295
++++ | || + + ++| || +# +||| + || |+ +||
Sbjct 460 KIMKNEKNKKTRNKRKKTEFSNNNTEE#TEKNKYEKNRTNNLENI 503
|
| Macaca mulatta |
Query 1250 EDQMLQETGNPA------TREEAYQQDWSQNNALQ#FQKNKLKINRQNSYDNILDKPRE 1301
|| ||| || + + | |+ # +||+ |+ ||+||| +| +|
Sbjct 1256 EDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKA#QKKNRNKLRRQHSYDTFVDLQKE 1313
|
* References
[PubMed ID: 1374164] Meguro H, Mori H, Araki K, Kushiya E, Kutsuwada T, Yamazaki M, Kumanishi T, Arakawa M, Sakimura K, Mishina M, Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature. 1992 May 7;357(6373):70-4.
