XSB0258 : Talin 1 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0081
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Talin-1; talin 1 |
| Gene Names | TLN1; KIAA1027, TLN; KIAA1027; TLN |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Description: Talin serves a function of linking vinculin (OMIM:193065) to the integrins, and, thus, the cytoskeleton to extracellular matrix (ECM) receptors. It has a mass of 270 kD and shares 23% N-terminal identity with ezrin (OMIM:123900), which has similar functions.
* Structure Information
1. Primary Information
Length: 2541 aa
Average Mass: 269.797 kDa
Monoisotopic Mass: 269.629 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| FERM_N 1. | 90 | 199 | 99.6 | 1.1e-26 |
| FERM_M 1. | 201 | 313 | 144.7 | 2.8e-40 |
| --- cleavage 433 --- | ||||
| Talin_middle 1. | 491 | 652 | 370.4 | 3.2e-108 |
| Stork_head 1. | 728 | 795 | -14.0 | 3.2 |
| Inhibitor_I34 1. | 840 | 905 | -11.3 | 7.9 |
| PMEI 1. | 946 | 1104 | -11.7 | 0.16 |
| DUF1707 1. | 1160 | 1204 | -23.6 | 3.1 |
| XhlA 1. | 1360 | 1411 | -17.4 | 7 |
| Mucin 1. | 1476 | 1614 | -38.4 | 9.2 |
| WSK 1. | 1635 | 1664 | 0.9 | 8 |
| HHH 1. | 1805 | 1834 | 0.1 | 6.9 |
| VBS 1. | 1849 | 1973 | 286.8 | 4.7e-83 |
| Vir_act_alpha_C 1. | 2184 | 2262 | -16.6 | 0.79 |
| Wos2 1. | 2277 | 2322 | -3.6 | 3.1 |
| I_LWEQ 1. | 2341 | 2533 | 371.9 | 1.2e-108 |
3. Sequence Information
Fasta Sequence: XSB0258.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1SYQ (X-ray; 242 A; B=607-631)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VSPKKSTVLQ433-QQYNRVGKVE
Gln433 
Gln
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val424 | Ser425 | Pro426 | Lys427 | Lys428 | Ser429 | Thr430 | Val431 | Leu432 | Gln433 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln434 | Gln435 | Tyr436 | Asn437 | Arg438 | Val439 | Gly440 | Lys441 | Val442 | Glu443 |
Sequence conservation (by blast)
* References
[PubMed ID: 12477932] Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.