logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0274 : Actin, cytoplasmic 1

[ CaMP Format ]

This entry is computationally expanded from SB0071

* Basic Information

OrganismHomo sapiens (human)
Protein NamesBeta-actin; Actin, cytoplasmic 1, N-terminally processed; mutant beta-actin (beta'-actin)
Gene NamesACTB
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA45026 N/A N/A P60709 N/A 132 N/A hsa:60

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 375 aa

Average Mass: 41.813 kDa

Monoisotopic Mass: 41.786 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Actin 1. 2375822.72.3e-244
--- cleavage 37 (inside Actin 2..375) ---

3. Sequence Information

Fasta Sequence: XSB0274.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 3BYH (EM; 1200 A; A=2-375), 3D2U (X-ray; 221 A; C/G=170-178)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] RAVFPSIVGR37-PRHQGVMVGM

Arg37 Pro

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg28Ala29Val30Phe31Pro32Ser33Ile34Val35Gly36Arg37
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Pro38Arg39His40Gln41Gly42Val43Met44Val45Gly46Met47

Sequence conservation (by blast)

* References

[PubMed ID: 6322116] Ponte P, Ng SY, Engel J, Gunning P, Kedes L, Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA. Nucleic Acids Res. 1984 Feb 10;12(3):1687-96.

» More (1)