XSB0298 : unnamed protein product [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0073
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Dystrophin |
| Gene Names | DMD |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3685 aa
Average Mass: 426.592 kDa
Monoisotopic Mass: 426.327 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 16 | 119 | 108.8 | 1.9e-29 |
| CH 2. | 135 | 240 | 100.9 | 4.3e-27 |
| Spectrin 1. | 339 | 447 | 79.5 | 1.2e-20 |
| Spectrin 2. | 448 | 556 | 69.0 | 1.8e-17 |
| DUF802 1. | 628 | 677 | -21.9 | 5 |
| Spectrin 3. | 719 | 827 | 13.5 | 0.0025 |
| Spectrin 4. | 830 | 934 | 40.8 | 5.3e-09 |
| Spectrin 5. | 943 | 1045 | 8.5 | 0.0065 |
| Spectrin 6. | 1048 | 1154 | 89.1 | 1.6e-23 |
| Spectrin 7. | 1157 | 1263 | 60.1 | 8.2e-15 |
| Spectrin 8. | 1266 | 1367 | 16.4 | 0.0014 |
| DUF1136 1. | 1413 | 1436 | -5.0 | 6.4 |
| Spectrin 9. | 1459 | 1568 | 0.4 | 0.031 |
| Spectrin 10. | 1571 | 1676 | 53.2 | 1e-12 |
| Spectrin 11. | 1679 | 1779 | 60.3 | 7.3e-15 |
| Involucrin 1. | 1849 | 1858 | 2.3 | 1.3e |
| Spectrin 12. | 1877 | 1979 | 47.1 | 6.8e-11 |
| --- cleavage 1992 --- | ||||
| Spectrin 13. | 2104 | 2208 | 80.2 | 7.7e-21 |
| Spectrin 14. | 2211 | 2318 | 63.3 | 9.2e-16 |
| Involucrin 2. | 2330 | 2339 | 3.7 | 58 |
| VitD-bind_III 1. | 2390 | 2451 | -24.8 | 6 |
| Spectrin 15. | 2470 | 2577 | 20.2 | 0.00068 |
| Spectrin 16. | 2580 | 2686 | 57.2 | 6.4e-14 |
| Spectrin 17. | 2689 | 2802 | 22.7 | 0.00042 |
| Spectrin 18. | 2934 | 3040 | 76.9 | 7.2e-20 |
| WW 1. | 3057 | 3086 | 48.9 | 2e-11 |
| efhand_1 1. | 3087 | 3207 | 274.7 | 2.1e-79 |
| efhand_2 1. | 3211 | 3302 | 230.0 | 6.1e-66 |
| ZZ 1. | 3307 | 3352 | 93.3 | 8.6e-25 |
| M 1. | 3501 | 3521 | 9.4 | 8.3 |
| M 2. | 3567 | 3587 | 5.1 | 31 |
3. Sequence Information
Fasta Sequence: XSB0298.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] MVMTEDMPLE1992-ISYVPSTYLT
Glu1992 
Ile
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Met1983 | Val1984 | Met1985 | Thr1986 | Glu1987 | Asp1988 | Met1989 | Pro1990 | Leu1991 | Glu1992 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile1993 | Ser1994 | Tyr1995 | Val1996 | Pro1997 | Ser1998 | Thr1999 | Tyr2000 | Leu2001 | Thr2002 |
Sequence conservation (by blast)
* References
[PubMed ID: 2668885] Rosenthal A, Speer A, Billwitz H, Cross GS, Forrest SM, Davies KE, Two human cDNA molecules coding for the Duchenne muscular dystrophy (DMD) locus are highly homologous. Nucleic Acids Res. 1989 Jul 11;17(13):5391.