XSB0376 : c-Jun protein [Danio rerio]
[ CaMP Format ]
This entry is computationally expanded from SB0086
* Basic Information
| Organism | Danio rerio (zebrafish) |
| Protein Names | Novel protein (Zgc:65863); V-jun sarcoma virus 17 oncogene homolog (Avian); c-Jun protein; SubName: Full=Novel protein; Zgc:65863; Avian |
| Gene Names | jun; DKEY-86E18.3-001; DKEY-86E18.3; v-jun sarcoma virus 17 oncogene homolog (avian) |
| Gene Locus | 20; chromosome 20 |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_956281 | NM_199987 | 335916 | Q6NZT5 | N/A | N/A | N/A | dre:335916 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 308 aa
Average Mass: 33.876 kDa
Monoisotopic Mass: 33.854 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Jun 1. | 5 | 218 | 357.0 | 3.6e-104 |
| --- cleavage 89 (inside Jun 5..218) --- | ||||
| bZIP_1 1. | 227 | 290 | 85.6 | 1.7e-22 |
3. Sequence Information
Fasta Sequence: XSB0376.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] IQSSNGMITT89-TPTPTQFLCP
Thr89 
Thr
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Ile80 | Gln81 | Ser82 | Ser83 | Asn84 | Gly85 | Met86 | Ile87 | Thr88 | Thr89 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Thr90 | Pro91 | Thr92 | Pro93 | Thr94 | Gln95 | Phe96 | Leu97 | Cys98 | Pro99 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
| LTSPDVGLLKLASPELERLIIQSSNGMITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE |
Summary
| # | organism | max score | hits | top seq |
|---|---|---|---|---|
| 1 | Danio rerio | 121.00 | 5 | c-Jun |
| 2 | Xenopus laevis | 120.00 | 7 | c-Jun protein |
| 3 | N/A | 120.00 | 7 | J |
| 4 | Monodelphis domestica | 120.00 | 2 | PREDICTED: similar to fc49b10 G-protein coupled re |
| 5 | Ctenopharyngodon idella | 120.00 | 2 | c-Jun protein |
| 6 | Gallus gallus | 120.00 | 2 | jun oncogene |
| 7 | Serinus canaria | 120.00 | 1 | JUN_SERCA Transcription factor AP-1 (Proto-oncogen |
| 8 | Crocodylus niloticus | 120.00 | 1 | c-jun |
| 9 | Coturnix coturnix | 120.00 | 1 | JUN_COTJA Transcription factor AP-1 (Proto-oncogen |
| 10 | Alligator mississippiensis | 120.00 | 1 | c-jun |
| 11 | Pseudemys nelsoni | 120.00 | 1 | c-jun |
| 12 | Carassius auratus | 119.00 | 1 | c-Jun protein |
| 13 | Mus musculus | 118.00 | 11 | unnamed protein product |
| 14 | Homo sapiens | 118.00 | 10 | jun oncogene |
| 15 | Canis familiaris | 118.00 | 10 | PREDICTED: similar to Transcription factor AP-1 (A |
| 16 | Bos taurus | 118.00 | 5 | jun oncogene |
| 17 | synthetic construct | 118.00 | 5 | v-jun sarcoma virus 17 oncogene-like |
| 18 | Rattus norvegicus | 118.00 | 5 | v-jun sarcoma virus 17 oncogene homolog |
| 19 | Macaca mulatta | 118.00 | 2 | PREDICTED: similar to Transcription factor AP-1 (A |
| 20 | Sus scrofa | 118.00 | 1 | C-JUN protein |
| 21 | Macaca fuscata | 118.00 | 1 | transcription factor c-Jun |
| 22 | Oryctolagus cuniculus | 118.00 | 1 | c-jun transcription factor |
| 23 | Tetraodon nigroviridis | 117.00 | 6 | unnamed protein product |
| 24 | Oncorhynchus mykiss | 115.00 | 2 | transcription factor AP-1 |
| 25 | Takifugu rubripes | 114.00 | 6 | c-Jun protein |
| 26 | Xiphophorus maculatus | 105.00 | 2 | c-JUN |
| 27 | Ovis aries | 87.80 | 2 | c-Jun protein |
| 28 | Pan troglodytes | 82.80 | 2 | PREDICTED: jun D proto-oncogene |
| 29 | Cyprinus carpio | 79.30 | 1 | JUNB_CYPCA Transcription factor jun-B gb |
| 30 | Strongylocentrotus purpuratus | 77.40 | 1 | PREDICTED: similar to transcription factor AP-1 |
| 31 | Apis mellifera | 67.40 | 1 | PREDICTED: similar to c-Jun protein |
| 32 | Aedes aegypti | 58.50 | 1 | jun |
| 33 | Anopheles gambiae str. PEST | 53.10 | 1 | ENSANGP00000020405 |
| 34 | Xenopus tropicalis | 47.00 | 1 | jun B proto-oncogene |
| 35 | Ciona intestinalis | 43.90 | 1 | transcription factor protein |
| 36 | Tribolium castaneum | 41.20 | 1 | PREDICTED: similar to Transcription factor AP-1 (J |
| 37 | Poecilia reticulata | 37.40 | 1 | transcription factor JunB |
| 38 | Drosophila pseudoobscura | 35.00 | 1 | GA15338-PA |
| 39 | Schistosoma japonicum | 33.90 | 1 | SJCHGC07787 protein |
Top-ranked sequences
| organism | matching |
|---|---|
| Danio rerio | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Xenopus laevis | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||||||#|||||||||||||||||||||+|||||||| Sbjct 59 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFADGFVRALAE 118 |
| N/A | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Monodelphis domestica | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Ctenopharyngodon idella | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Gallus gallus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 57 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 116 |
| Serinus canaria | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Crocodylus niloticus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Coturnix coturnix | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |
| Alligator mississippiensis | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Pseudemys nelsoni | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Carassius auratus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||| ||||| Sbjct 56 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFARALAE 115 |
| Mus musculus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Homo sapiens | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Canis familiaris | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Bos taurus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| synthetic construct | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Rattus norvegicus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Macaca mulatta | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Sus scrofa | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Macaca fuscata | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 61 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 120 |
| Oryctolagus cuniculus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||||||||||||||||||||||| |||#|||||||||||||||||||||||||||||| Sbjct 8 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 67 |
| Tetraodon nigroviridis | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||+||||||+||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFICPKNVTEEQEGFAEGFVRALAE 119 |
| Oncorhynchus mykiss | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |||||| |||||||||||||||||||+|||#||||||||||+||||||||||||||||||| Sbjct 59 LTSPDVQLLKLASPELERLIIQSSNGLITT#TPTPTQFLCPRNVTDEQEGFAEGFVRALAE 118 |
| Takifugu rubripes | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||||||+|||#|||||||+ |||||+||||||||||||||| Sbjct 60 LTSPDVGLLKLASPELERLIIQSSNGLITT#TPTPTQFISPKNVTEEQEGFAEGFVRALAE 119 |
| Xiphophorus maculatus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 ||||||||||||||||||||||| +|+ |#|||||||+|||||+|||||||||||||||| Sbjct 62 LTSPDVGLLKLASPELERLIIQSCSGL--T#TPTPTQFICPKNVSDEQEGFAEGFVRALAE 119 |
| Ovis aries | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVT 103 |||||||||||||||||||||||||| |||#|||||||||||||| Sbjct 47 LTSPDVGLLKLASPELERLIIQSSNGHITT#TPTPTQFLCPKNVT 90 |
| Pan troglodytes | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 | |||+||||||||||||||||| ||++||#||| +||| || |++ ||||||+|| + Sbjct 88 LASPDLGLLKLASPELERLIIQS-NGLVTT#TPTSSQFLYPKVAASEEQEFAEGFVKALED 146 |
| Cyprinus carpio | Query 64 DVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 | | ||||||||||||||+|||++||# ||| |+| + +||||||||||||+|| Sbjct 58 DSGSLKLASPELERLIIQTSNGVLTT#-PTPGQYLYSRGITDEQEGFAEGFVKAL 110 |
| Strongylocentrotus purpuratus | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 |++||| +|||||||||++|| | | | |#|||| ||+ |||||+|| ||+||| || Sbjct 38 LSTPDVQMLKLASPELEKMII-SQQGNICT#TPTPGQFISPKNVTEEQAAFAQGFVEAL 94 |
| Apis mellifera | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRALAE 119 |+|||+ +|||+|||||+ || + ++| # |||| | || ||+ || +| ||| || | Sbjct 61 LSSPDLNMLKLSSPELEKFIIAQQDSLVTN#LVTPTQILFPKAVTEAQELYARGFVDALNE 120 |
| Aedes aegypti | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 +||||+ +||| |||||++|| |+ #||||+ | | | ||| ||+|| || Sbjct 65 ITSPDLQVLKLVSPELEKIIINSA---ALP#TPTPSSILYPTKATTEQEQFAKGFDEAL 119 |
| Anopheles gambiae str. PEST | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 | |||+ +||| |||||++| | #||||+ + | + | ||+ ||+|| || Sbjct 14 LPSPDLQMLKLVSPELEKII---STNATLP#TPTPSAIIFPPSATSEQQQFAKGFEDAL 68 |
| Xenopus tropicalis | Query 63 PDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPK--NVTDEQEGFAEGFVRAL 117 | ||+|+|||||+|| | |+|+ # + + +|+||||| +|||+|| Sbjct 61 PAPSSLKMAAPELERMIIHSGPGVISG#PSGGQLYYSSRGNGITEEQEGFVDGFVKAL 117 |
| Ciona intestinalis | Query 60 LTSPD-VGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 |++|| | +||+ ||+ +|+++ || #| +|| +| | ||| +|+|||| | Sbjct 134 LSTPDLVNMLKVGSPDFDRMLVHSSQA---N#TQNNSQFF-QRNATQEQEIYAQGFVREL 188 |
| Tribolium castaneum | Query 62 SPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAEGFVRAL 117 +|| |||+ +| +| +|+ ++ |+ #||+|+ + |++|| ||| || ||| || Sbjct 32 TPD--LLKVDTPTIENIILANN---ISH#TPSPS-LIFPRDVTVEQEKFAGGFVEAL 81 |
| Poecilia reticulata | Query 95 QFLCPKNVTDEQEGFAEGFVRALAE 119 |+ + +||||||||||||+|| | Sbjct 1 QYFYNRGITDEQEGFAEGFVKALDE 25 |
| Drosophila pseudoobscura | Query 60 LTSPDVGLLKLASPELERLIIQSSNGMITT#TPTPTQFLCPK--NVTDEQEGFAEGFVRAL 117 + |||+ + +|+||++++ || |+ |# | | + | || ||| | +|| || Sbjct 82 INSPDLQAKTVNTPDLEKILL--SNHMMQT#-PQPGKVFPTKVGPVTSEQEAFGKGFEEAL 138 |
| Schistosoma japonicum | Query 74 ELERLIIQSSNGMITT#TPTPTQFLCPKNVTDEQEGFAE 111 | |+|+ | +|# ||| || | |+|++|| ||| Sbjct 46 EFEKLLGHLGNNG-ST#PVTPTSFLNPNNITEDQELFAE 82 |
* References
[PubMed ID: 18716208] Zearfoss NR, Alarcon JM, Trifilieff P, Kandel E, Richter JD, A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus. J Neurosci. 2008 Aug 20;28(34):8502-9.
[PubMed ID: 18347071] ... Gan XQ, Wang JY, Xi Y, Wu ZL, Li YP, Li L, Nuclear Dvl, c-Jun, beta-catenin, and TCF form a complex leading to stabilization of beta-catenin-TCF interaction. J Cell Biol. 2008 Mar 24;180(6):1087-100. Epub 2008 Mar 17.
[PubMed ID: 16799861] ... Gonzalez P, Baudrimont M, Boudou A, Bourdineaud JP, Comparative effects of direct cadmium contamination on gene expression in gills, liver, skeletal muscles and brain of the zebrafish (Danio rerio). Biometals. 2006 Jun;19(3):225-35.
[PubMed ID: 16033799] ... Fong SH, Emelyanov A, Teh C, Korzh V, Wnt signalling mediated by Tbx2b regulates cell migration during formation of the neural plate. Development. 2005 Aug;132(16):3587-96. Epub 2005 Jul 20.
[PubMed ID: 15984772] ... Gonzalez P, Dominique Y, Massabuau JC, Boudou A, Bourdineaud JP, Comparative effects of dietary methylmercury on gene expression in liver, skeletal muscle, and brain of the zebrafish (Danio rerio). Environ Sci Technol. 2005 Jun 1;39(11):3972-80.