CaMPDB :: Substrate

XSB0383 : plasma membrane calcium ATPase isoform 1 [Homo sapiens]

This entry is computationally expanded from SB0056

* Basic Information

Organism	Homo sapiens (human)
Protein Names	Plasma membrane calcium-transporting ATPase 1; PMCA1; 3.6.3.8; Plasma membrane calcium pump isoform 1; Plasma membrane calcium ATPase isoform 1
Gene Names	ATP2B1; PMCA1
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
AAD09924	N/A	N/A	P20020	N/A	N/A	N/A	hsa:490

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 1084 aa

Average Mass: 119.831 kDa

Monoisotopic Mass: 119.755 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
E1-E2_ATPase 1.	22	329	231.8	1.7e-66
Hydrolase 1.	333	682	63.7	7.1e-16
Cation_ATPase_C 1.	743	925	204.3	3.3e-58

3. Sequence Information

Fasta Sequence: XSB0383.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] GQILWFRGLN⁹⁷⁶-RIQTQIRVVN

Asn⁹⁷⁶ Arg

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Gly⁹⁶⁷	Gln⁹⁶⁸	Ile⁹⁶⁹	Leu⁹⁷⁰	Trp⁹⁷¹	Phe⁹⁷²	Arg⁹⁷³	Gly⁹⁷⁴	Leu⁹⁷⁵	Asn⁹⁷⁶

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Arg⁹⁷⁷	Ile⁹⁷⁸	Gln⁹⁷⁹	Thr⁹⁸⁰	Gln⁹⁸¹	Ile⁹⁸²	Arg⁹⁸³	Val⁹⁸⁴	Val⁹⁸⁵	Asn⁹⁸⁶

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
EEELAEDVEEIDHAERELRRGQILWFRGLNRIQTQIRVVNAFRSSLYEGLEKPESRSSIH

Summary

#	organism	max score	hits	top seq
1	Canis familiaris	102.00	103	PREDICTED: similar to Plasma membrane calcium-tran
2	N/A	102.00	39	I
3	Homo sapiens	102.00	27	plasma membrane calcium ATPase isoform 1
4	Bos taurus	102.00	12	plasma membrane calcium ATPase 1
5	Mus musculus	102.00	12	plasma membrane calcium ATPase 1
6	Macaca mulatta	102.00	8	PREDICTED: similar to plasma membrane calcium ATPa
7	Monodelphis domestica	102.00	3	PREDICTED: similar to plasma membrane calcium ATPa
8	Sus scrofa	102.00	2	plasma membrane calcium ATPase 1
9	Rana catesbeiana	102.00	2	PMCA1bx
10	Gallus gallus	101.00	9	PREDICTED: similar to adenosine triphosphatase iso
11	Tetraodon nigroviridis	101.00	4	unnamed protein product
12	Danio rerio	101.00	4	PREDICTED: hypothetical protein, partial
13	Pan troglodytes	99.40	11	PREDICTED: plasma membrane calcium ATPase 2 isofor
14	Rattus norvegicus	99.40	6	ATPase, Ca++ transporting, plasma membrane 2
15	Oryctolagus cuniculus	96.30	1	Ca2+/Mg2+ ATPase
16	rats, ROS 17/2.8 osteosarcoma cells, Peptide Partial, 123 aa	92.40	1	plasma membrane Ca(2+)-ATPase PMCA1b isoform {alte
17	synthetic construct	82.00	2	hypothetical protein
18	Pongo pygmaeus	79.00	1	hypothetical protein
19	Procambarus clarkii	69.70	1	plasma membrane calcium ATPase PMCA3
20	Xenopus laevis	67.40	1	ATPase, Ca++ transporting, plasma membrane 3

Top-ranked sequences

organism	matching
Canis familiaris	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
N/A	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Homo sapiens	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Bos taurus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Mus musculus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Macaca mulatta	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Monodelphis domestica	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Sus scrofa	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Rana catesbeiana	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
Gallus gallus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\| Sbjct 1078 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPETRSSIH 1127
Tetraodon nigroviridis	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\| Sbjct 309 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPDSRSSIH 358
Danio rerio	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| Sbjct 314 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRTSIH 363
Pan troglodytes	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| Sbjct 1063 IDHAERELRRGQILWFRGLN#RIQTQIRVVKAFRSSLYEGLEKPESRTSIH 1112
Rattus norvegicus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\| Sbjct 1071 IDHAERELRRGQILWFRGLN#RIQTQIRVVKAFRSSLYEGLEKPESRTSIH 1120
Oryctolagus cuniculus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \| \|\|\|\|\|\|\|\| \|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 1093 IVHAERELRRWQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1142
rats, ROS 17/2.8 osteosarcoma cells, Peptide Partial, 123 aa	Query 962 RELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 962 RELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006
synthetic construct	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\| \|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|+\|\| \|\| \|\|\|+\| ++\|\| ++ \|\|\| Sbjct 1079 IDHAEMELRRGQILWFRGLN#RIQTQIKVVKAFHSSLHESIQKPYNQKSIH 1128
Pongo pygmaeus	Query 957 IDHAERELRRGQILWFRGLN#RIQTQ----------------------------------- 981 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\| Sbjct 171 IDHAERELRRGQILWFRGLN#RIQTQMDVVNAFQSGSSIQGALRRQPSIASQHHDVTNIST 230 Query 982 ----------------IRVVNAFRSSLYEGLEKPESRSSIH 1006 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 231 PTHVVFSSSTASTTVGIRVVNAFRSSLYEGLEKPESRSSIH 271
Procambarus clarkii	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFR--SSLYEGLEKPES 1001 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\| \|\|\|\|\|+ \|\|+ + +\| \| Sbjct 1119 IDHAERELRRGQILWFRGLN#RIQTQIEVVNAFKSGSSVQGAVRRPSS 1165
Xenopus laevis	Query 957 IDHAERELRRGQILWFRGLN#RIQTQIRVVNAFRS-SLYEGLEKPESRSS 1004 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\| \|\|\| \|+\| + ++\| + +\| ++ Sbjct 1119 IDHAERELRRGQILWFRGLN#RIQTQIEVVNTFKSGASFQGALRRQSSTT 1167

* References

None.