XSB0408 : talin 1 [Gallus gallus]
[ CaMP Format ]
This entry is computationally expanded from SB0081
* Basic Information
| Organism | Gallus gallus (chicken) |
| Protein Names | Talin-1; talin 1 |
| Gene Names | TLN1; TLN; talin 1 |
| Gene Locus | Z; chromosome Z |
| GO Function | Not available |
| Entrez Protein | Entrez Nucleotide | Entrez Gene | UniProt | OMIM | HGNC | HPRD | KEGG |
|---|---|---|---|---|---|---|---|
| NP_989854 | NM_204523 | 395194 | P54939 | N/A | N/A | N/A | gga:395194 |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 2541 aa
Average Mass: 271.842 kDa
Monoisotopic Mass: 271.672 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| FERM_N 1. | 90 | 199 | 93.2 | 9.4e-25 |
| FERM_M 1. | 201 | 313 | 138.7 | 1.8e-38 |
| --- cleavage 433 --- | ||||
| Talin_middle 1. | 491 | 652 | 366.8 | 3.8e-107 |
| dCMP_cyt_deam_1 1. | 662 | 746 | -30.6 | 0.33 |
| DUF2191 1. | 756 | 793 | -11.1 | 6.2 |
| HEAT_PBS 1. | 889 | 915 | 4.7 | 23 |
| PMEI 1. | 945 | 1097 | -17.9 | 0.51 |
| HEAT_PBS 2. | 1119 | 1156 | 4.3 | 26 |
| VBS 1. | 1233 | 1360 | 2.6 | 0.0048 |
| DUF1909 1. | 1467 | 1532 | -27.9 | 5.8 |
| Periviscerokin 1. | 1608 | 1618 | 4.1 | 36 |
| WSK 1. | 1634 | 1663 | 1.0 | 7.8 |
| HHH 1. | 1804 | 1833 | 0.1 | 6.9 |
| VBS 2. | 1848 | 1972 | 295.3 | 1.3e-85 |
| Swi5 1. | 2117 | 2210 | -20.8 | 2.4 |
| I_LWEQ 1. | 2340 | 2531 | 352.9 | 6.1e-103 |
3. Sequence Information
Fasta Sequence: XSB0408.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1MIX (X-ray; 175 A; A=196-400), 1MIZ (X-ray; 190 A; B=200-400), 1MK7 (X-ray; 220 A; B/D=209-400), 1MK9 (X-ray; 280 A; B/D/F/H=209-400), 1RKC (X-ray; 270 A; B=1944-1969), 1U6H (X-ray; 238 A; B=849-879), 1XWJ (X-ray; 260 A; B=1944-1969), 1ZVZ (X-ray; 180 A; B=820-844), 1ZW2 (X-ray; 210 A; B=2344-2368), 2H7D (NMR; -; A=309-405), 2H7E (NMR; -; A=309-405), 2HRJ (NMR; -; A=189-309), 2K00 (NMR; -; A=309-400)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] VSPKKSTVLQ433-QQFNRVGKAE
Gln433 
Gln
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val424 | Ser425 | Pro426 | Lys427 | Lys428 | Ser429 | Thr430 | Val431 | Leu432 | Gln433 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Gln434 | Gln435 | Phe436 | Asn437 | Arg438 | Val439 | Gly440 | Lys441 | Ala442 | Glu443 |
Sequence conservation (by blast)
* References
[PubMed ID: 19179532] del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP, Stretching single talin rod molecules activates vinculin binding. Science. 2009 Jan 30;323(5914):638-41.