XSB0448 : plasma membrane calcium ATPase 2 isoform 2 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0056
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | Plasma membrane calcium-transporting ATPase 2; PMCA2; 3.6.3.8; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium pump isoform 2; plasma membrane calcium ATPase 2 isoform 2; plasma membrane calcium pump; plasma membrane Ca(2+)-ATPase; plasma membrane Ca2+ pump 2 |
| Gene Names | ATP2B2; PMCA2; ATPase, Ca++ transporting, plasma membrane 2 |
| Gene Locus | 3p25.3; chromosome 3 |
| GO Function | Not available |
* Information From OMIM
Description: The Ca(2+)-ATPases are a family of plasma membrane pumps encoded by at least 4 genes: ATP2B1 (OMIM:108731) on chromosome 12q21; ATP2B2; ATP2B3 (OMIM:300014) on Xq28; and ATP2B4 (OMIM:108732) on 1q25.
* Structure Information
1. Primary Information
Length: 1198 aa
Average Mass: 132.594 kDa
Monoisotopic Mass: 132.509 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| Cation_ATPase_N 1. | 41 | 124 | 75.0 | 2.8e-19 |
| E1-E2_ATPase 1. | 156 | 444 | 224.6 | 2.6e-64 |
| Hydrolase 1. | 448 | 796 | 55.9 | 1.5e-13 |
| Cation_ATPase_C 1. | 857 | 1039 | 212.3 | 1.3e-60 |
3. Sequence Information
Fasta Sequence: XSB0448.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] GQILWFRGLN1090-RIQTQIRVVK
Asn1090 
Arg
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Gly1081 | Gln1082 | Ile1083 | Leu1084 | Trp1085 | Phe1086 | Arg1087 | Gly1088 | Leu1089 | Asn1090 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg1091 | Ile1092 | Gln1093 | Thr1094 | Gln1095 | Ile1096 | Arg1097 | Val1098 | Val1099 | Lys1100 |
Sequence conservation (by blast)
* References
[PubMed ID: 19043545] Gieger C, Geistlinger L, Altmaier E, Hrabe de Angelis M, Kronenberg F, Meitinger T, Mewes HW, Wichmann HE, Weinberger KM, Adamski J, Illig T, Suhre K, Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum. PLoS Genet. 2008 Nov;4(11):e1000282. Epub 2008 Nov 28.