CaMPDB :: Substrate

XSB0475 : p53 transformation suppressor [Homo sapiens]

This entry is computationally expanded from SB0053

* Basic Information

Organism	Homo sapiens (human)
Protein Names	p53 transformation suppressor
Gene Names	p53
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
CAA42625	N/A	N/A	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 245 aa

Average Mass: 27.066 kDa

Monoisotopic Mass: 27.048 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
P53_TAD 1.	5	29	46.4	1.1e-10
--- cleavage 25 (inside P53_TAD 5..29) ---
P53 1.	95	245	124.2	4.4e-34

3. Sequence Information

Fasta Sequence: XSB0475.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QETFSDLWKL²⁵-LPENNVLSPL

Leu²⁵ Leu

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Gln¹⁶	Glu¹⁷	Thr¹⁸	Phe¹⁹	Ser²⁰	Asp²¹	Leu²²	Trp²³	Lys²⁴	Leu²⁵

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Leu²⁶	Pro²⁷	Glu²⁸	Asn²⁹	Asn³⁰	Val³¹	Leu³²	Ser³³	Pro³⁴	Leu³⁵

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFT

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	117.00	44	p53 transformation suppressor
2	N/A	117.00	14	-
3	Pan troglodytes	117.00	5	PREDICTED: tumor protein p53 isoform 3
4	synthetic construct	117.00	3	tumor protein p53 (Li-Fraumeni syndrome)
5	Tupaia belangeri chinensis	117.00	1	P53_TUPGB Cellular tumor antigen p53 (Tumor suppre
6	Macaca mulatta	110.00	2	tumor protein p53
7	Chlorocebus aethiops	110.00	1	P53_CERAE Cellular tumor antigen p53 (Tumor suppre
8	Macaca fascicularis	108.00	1	P53
9	Marmota monax	89.40	1	P53_MARMO Cellular tumor antigen p53 (Tumor suppre
10	Spalax judaei	83.60	1	p53 protein
11	Cavia porcellus	82.40	1	P53_CAVPO Cellular tumor antigen p53 (Tumor suppre
12	Delphinapterus leucas	80.50	1	P53_DELLE Cellular tumor antigen p53 (Tumor suppre
13	Meriones unguiculatus	72.40	1	p53
14	Oryctolagus cuniculus	71.20	1	tumor protein p53
15	Cricetulus griseus	69.70	2	p53 tumour suppressor
16	Mesocricetus auratus	69.70	1	tumor supressor p53
17	Sus scrofa	68.20	3	tumor suppressor p53
18	Ovis aries	67.80	1	P53 protein
19	Canis familiaris	67.80	1	P53
20	Felis catus	66.20	2	tumor protein p53
21	Canis lupus familiaris	65.90	1	tumor protein p53
22	Bos taurus	64.30	2	tumor protein p53
23	Mus musculus	61.60	12	transformation related protein 53
24	Rattus norvegicus	52.00	5	AF209191_1 p53 alternative splice isoform p35/HAS
25	Bos primigenius	50.40	1	p53 gene product
26	Mastomys natalensis	47.00	1	p53
27	Xenopus tropicalis	44.70	1	tumor protein p53 (Li-Fraumeni syndrome)
28	Xenopus laevis	43.50	5	p53

Top-ranked sequences

organism	matching
Homo sapiens	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55
N/A	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55
Pan troglodytes	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55
synthetic construct	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55
Tupaia belangeri chinensis	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55
Macaca mulatta	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|+ \|\| \| Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENNVLSPLPSQAVDDLMLSPDDLAQWLT 55
Chlorocebus aethiops	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|+ \|\| \| Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENNVLSPLPSQAVDDLMLSPDDLAQWLT 55
Macaca fascicularis	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWFT 55 \|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|+\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\|\|+ \|\| \| Sbjct 1 MEEPQSDPSIEPPLSQETFSDLWKL#LPENHVLSPLPSQAVDDLMLSPDDLAQWLT 55
Marmota monax	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWF 54 \|\|\| \|\|\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|\|\|\|\|+ \| \|\|\|\|+\|\| +\|+\| \|\| Sbjct 1 MEEAQSDLSIEPPLSQETFSDLWNL#LPENNVLSPVLSPPMDDLLLSSEDVENWF 54
Spalax judaei	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLS-PLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|\|\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|+\|\|\|\|\| \|\| +\|+\|\|+\|\|\|+\|+ \| Sbjct 1 MEEQQSDLSIEPPLSQETFSDLWKL#LPQNNVLSTPLSPNSMEDLLLSPEDVANW 54
Cavia porcellus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\|\| \|\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|\|\|\| \| \|\| \|+\|\|\|+++ \| Sbjct 1 MEEPHSDLSIEPPLSQETFSDLWKL#LPENNVLSDSLSPPMDHLLLSPEEVASW 53
Delphinapterus leucas	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|++ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|+\|\| \| \|+\|\|\|+\|\|\|+\|+ \| Sbjct 1 MEESQAELGVEPPLSQETFSDLWKL#LPENNLLSSELSPAVDDLLLSPEDVANW 53
Meriones unguiculatus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\|\|\|\|\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| \|+\|\| \| + \|+\|\|+\| \| \|+ \| Sbjct 1 MEEPQSDLSIEPPLSQETFSDLWKL#LPPKNLLSAL--EPMEDLLL-PQDVTSW 50
Oryctolagus cuniculus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|\|\| \|+\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|+\|+ + +\|\|\| \|\| +\|+ \| Sbjct 1 MEESQSDLSLEPPLSQETFSDLWKL#LPENNLLTTSLNPPVDDL-LSAEDVANW 52
Cricetulus griseus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLP-SQAMDDLMLSPDDIEQW 53 \|\|\|\|\|\|\| \|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| \|\|\|\|\| \|\| \| ++++\| \|\| +++ \| Sbjct 1 MEEPQSDLSIELPLSQETFSDLWKL#LPPNNVLSTLPSSDSIEELFLS-ENVTGW 53
Mesocricetus auratus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLP-SQAMDDLMLSPDDIEQW 53 \|\|\|\|\|\|\| \|+\| \|\|\|\|\|\|\|\|\|\|\|\|\|#\|\| \|\|\|\|\| \|\| \| ++++\| \|\| +++ \| Sbjct 1 MEEPQSDLSIELPLSQETFSDLWKL#LPPNNVLSTLPSSDSIEELFLS-ENVAGW 53
Sus scrofa	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVL-SPLPSQAMDDLMLSP 47 \|\|\| \|\|+ \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|#\|\|\|\|\|+\| \| \| \|++\|\|+\|\|\| Sbjct 1 MEESQSELGVEPPLSQETFSDLWKL#LPENNLLSSELSLAAVNDLLLSP 48
Ovis aries	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|++ \|\|\|\|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|+\|\| \| +\|\|\|+ +\|+ \| Sbjct 1 MEESQAELGVEPPLSQETFSDLWNL#LPENNLLSSELSAPVDDLLPYSEDVVTW 53
Canis familiaris	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|+\|\|\|\|+ +++\|\|\|\|\|\|\|\|\|+\|\| \|#\|\|\|\|\|\|\|\| \|+\|+\|+\| \|+ + \| Sbjct 1 MQEPQSELNIDPPLSQETFSELWNL#LPENNVLSSELCPAVDELLL-PESVVNW 52
Felis catus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|+\|\| + ++\|\|\|\|\|\|\|\|\|\|+\|\| \|#\|\|\|\|\|\|\|\| \| \|\|++\| \|\| +\|+ \| Sbjct 1 MQEPPLELTIEPPLSQETFSELWNL#LPENNVLSSELSSAMNELPLS-EDVANW 52
Canis lupus familiaris	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|\|+ +++\|\|\|\|\|\|\|\|\|+\|\| \|#\|\|\|\|\|\|\|\| \|+\|+\|+\| \|+ + \| Sbjct 1 MEESQSELNIDPPLSQETFSELWNL#LPENNVLSSELCPAVDELLL-PESVVNW 52
Bos taurus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\| \|++ +\|\|\|\|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|+\|\| \| +\|\|\| \| \|+ \| Sbjct 1 MEESQAELNVEPPLSQETFSDLWNL#LPENNLLSSELSAPVDDL-LPYTDVATW 52
Mus musculus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQWF 54 \|\|\| \|\|\| \|+\| \|\|\|\|\|\|\|\| \|\|\|\|#\|\| ++\|\| \|\|\|\|+\| \| \|+\|++\| Sbjct 4 MEESQSDISLELPLSQETFSGLWKL#LPPEDILS--SPHCMDDLLL-PQDVEEFF 54
Rattus norvegicus	Query 1 MEEPQSDPSVEPPLSQETFSDLWKL#LPENNVLSPLPS---QAMDDLMLSPDDIE 51 \|\|+ \|\|\| \|+\| \|\|\|\|\|\|\|\| \|\|\|\|#\|\| +++\| + +\|+\|\| \| \| \| Sbjct 1 MEDSQSDMSIELPLSQETFSCLWKL#LPPDDILPTTATGSPNSMEDLFLPQDVAE 54
Bos primigenius	Query 13 PLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPDDIEQW 53 \|\|\|\|\|\|\|\|\|\|\| \|#\|\|\|\|\|+\|\| \| +\|\|\| \| \|+ \| Sbjct 1 PLSQETFSDLWNL#LPENNLLSSELSAPVDDL-LPYTDVATW 40
Mastomys natalensis	Query 13 PLSQETFSDLWKL#LPENNVLSPLPSQAMDDLMLSPD 48 \|\|\|\|\|\|\| \|\|\|\|#\|\| \|\|\| +\|\|++ \|\|\|\| Sbjct 2 PLSQETFQRLWKL#LPPEAVLSEASPNSMDNMFLSPD 37
Xenopus tropicalis	Query 3 EPQSDPSVEPPLSQETFSDLWKL#LPE 28 \|\| \|+ +\|\|\|\|\|\|\|\|\| \|\|\| \|#\|\|+ Sbjct 2 EPSSETGMEPPLSQETFEDLWSL#LPD 27
Xenopus laevis	Query 3 EPQSDPSVEPPLSQETFSDLWKL#LPE 28 \|\| \|+ ++\|\|\|\|\|\|\|\| \|\|\| \|#\|\|+ Sbjct 2 EPSSETGMDPPLSQETFEDLWSL#LPD 27

* References

[PubMed ID: 1915267] Farrell PJ, Allan GJ, Shanahan F, Vousden KH, Crook T, p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J. 1991 Oct;10(10):2879-87.