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XSB0476 : p53 transformation suppressor [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0053

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCellular tumor antigen p53; Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; p53 transformation suppressor
Gene Namesp53; P53
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAA42628 N/A N/A P04637 N/A 11998 N/A hsa:7157

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 393 aa

Average Mass: 43.682 kDa

Monoisotopic Mass: 43.654 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
P53_TAD 1. 52946.41.1e-10
--- cleavage 25 (inside P53_TAD 5..29) ---
P53 1. 95289506.04.8e-149
P53_tetramer 1. 31835985.51.9e-22

3. Sequence Information

Fasta Sequence: XSB0476.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1A1U (NMR; -; A/C=324-358), 1AIE (X-ray; 150 A; A=326-356), 1C26 (X-ray; 170 A; A=325-356), 1DT7 (NMR; -; X/Y=367-388), 1GZH (X-ray; 260 A; A=95-292, C=95-292), 1H26 (X-ray; 224 A; E=376-386), 1HS5 (NMR; -; A/B=324-357), 1JSP (NMR; -; A=367-386), 1KZY (X-ray; 250 A; A/B=95-289), 1MA3 (X-ray; 200 A; B=372-389), 1OLG (NMR; -; A/B/C/D=319-360), 1OLH (NMR; -; A/B/C/D=319-360), 1PES (NMR; -; A/B/C/D=325-355), 1PET (NMR; -; A/B/C/D=325-355), 1SAE (NMR; -; A/B/C/D=319-360), 1SAF (NMR; -; A/B/C/D=319-360), 1SAH (NMR; -; A/B/C/D=319-360), 1SAJ (NMR; -; A/B/C/D=319-360), 1SAK (NMR; -; A/B/C/D=319-360), 1SAL (NMR; -; A/B/C/D=319-360), 1TSR (X-ray; 220 A; A/B/C=94-312), 1TUP (X-ray; 220 A; A/B/C=94-312), 1UOL (X-ray; 190 A; A/B=94-312), 1XQH (X-ray; 175 A; B/F=369-377), 1YC5 (X-ray; 140 A; B=372-389), 1YCQ (X-ray; 230 A; B=13-29), 1YCR (X-ray; 260 A; B=15-29), 1YCS (X-ray; 220 A; A=94-292), 2AC0 (X-ray; 180 A; A/B/C/D=94-293), 2ADY (X-ray; 250 A; A/B=94-293), 2AHI (X-ray; 185 A; A/B/C/D=94-293), 2ATA (X-ray; 220 A; A/B/C/D=94-293), 2B3G (X-ray; 160 A; B=33-60), 2BIM (X-ray; 198 A; A/B=94-312), 2BIN (X-ray; 190 A; A=94-312), 2BIO (X-ray; 190 A; A=94-312), 2BIP (X-ray; 180 A; A=94-312), 2BIQ (X-ray; 180 A; A=94-312), 2F1X (X-ray; 230 A; A/B=360-368), 2FEJ (NMR; -; A=94-297), 2FOJ (X-ray; 160 A; B=363-367), 2FOO (X-ray; 220 A; B=358-363), 2GS0 (NMR; -; B=20-71), 2H1L (X-ray; 316 A; M/N/O/P/Q/R/S/T/U/V/W/X=92-292), 2H2D (X-ray; 170 A; B=372-389), 2H2F (X-ray; 220 A; B=372-389), 2H4F (X-ray; 200 A; D=372-389), 2H4H (X-ray; 199 A; B=372-389), 2H4J (X-ray; 210 A; D=372-389), 2H59 (X-ray; 190 A; D/E=372-389), 2J0Z (NMR; -; A/B/C/D=326-356), 2J10 (NMR; -; A/B/C/D=326-356), 2J11 (NMR; -; A/B/C/D=332-356), 2J1W (X-ray; 180 A; A/B=94-312), 2J1X (X-ray; 165 A; A/B=94-312), 2J1Y (X-ray; 169 A; A/B/C/D=94-293), 2J1Z (X-ray; 180 A; A/B=94-312), 2J20 (X-ray; 180 A; A/B=94-312), 2J21 (X-ray; 160 A; A/B=94-312), 2K8F (NMR; -; B=1-39), 2OCJ (X-ray; 205 A; A/B/C/D=94-312), 2PCX (X-ray; 154 A; A=94-292), 2QVQ (X-ray; 200 A; A=94-289), 2QXA (X-ray; 150 A; A/B/C/D=95-289), 2QXB (X-ray; 250 A; A/B/C/D=95-289), 2QXC (X-ray; 185 A; A/B/C/D=95-289), 2VUK (X-ray; 150 A; A/B=94-312), 2Z5S (X-ray; 230 A; P/Q/R=15-29), 2Z5T (X-ray; 230 A; P/Q/R=15-29), 3D05 (X-ray; 170 A; A=94-293), 3D06 (X-ray; 120 A; A=94-293), 3D07 (X-ray; 220 A; A/B=94-293), 3D08 (X-ray; 140 A; A=94-293), 3D09 (X-ray; 190 A; A=94-293), 3D0A (X-ray; 180 A; A/B/C/D=94-293), 3DAB (X-ray; 190 A; B/D/F/H=15-29), 3DAC (X-ray; 180 A; B/P=17-37), 3SAK (NMR; -; A/B/C/D=319-360)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] QETFSDLWKL25-LPENNVLSPL

Leu25 Leu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gln16Glu17Thr18Phe19Ser20Asp21Leu22Trp23Lys24Leu25
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Leu26Pro27Glu28Asn29Asn30Val31Leu32Ser33Pro34Leu35

Sequence conservation (by blast)

* References

[PubMed ID: 1915267] Farrell PJ, Allan GJ, Shanahan F, Vousden KH, Crook T, p53 is frequently mutated in Burkitt's lymphoma cell lines. EMBO J. 1991 Oct;10(10):2879-87.