XSB0553 : tyrosine hydroxylase [Canis lupus familiaris]
[ CaMP Format ]
This entry is computationally expanded from SB0059
* Basic Information
| Organism | Canis lupus familiaris (dog) |
| Protein Names | Tyrosine 3-monooxygenase; 1.14.16.2; Tyrosine 3-hydroxylase; TH; tyrosine hydroxylase |
| Gene Names | TH; tyrosine hydroxylase |
| Gene Locus | 18; chromosome 18 |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 495 aa
Average Mass: 55.679 kDa
Monoisotopic Mass: 55.644 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
| --- cleavage 22 --- |
| --- cleavage 30 --- |
| ACT 1. | 80 | 151 | 5.8 | 2 |
| Biopterin_H 1. | 162 | 493 | 976.4 | 1.3e-290 |
3. Sequence Information
Fasta Sequence: XSB0553.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] GFRRAVSELD22-AKQAEAIMSP
Asp22 
Ala
 |
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Gly13 | Phe14 | Arg15 | Arg16 | Ala17 | Val18 | Ser19 | Glu20 | Leu21 | Asp22 |
 |
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ala23 | Lys24 | Gln25 | Ala26 | Glu27 | Ala28 | Ile29 | Met30 | Ser31 | Pro32 |
Sequence conservation (by blast)
Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
MPTPNTASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKA
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Canis lupus familiaris |
103.00 |
1 |
tyrosine hydroxylase |
| 2 |
Canis familiaris |
103.00 |
1 |
PREDICTED: tyrosine hydroxylase |
| 3 |
N/A |
100.00 |
12 |
T |
| 4 |
Bos taurus |
100.00 |
2 |
tyrosine hydroxylase |
| 5 |
Homo sapiens |
94.70 |
18 |
Tyrosine hydroxylase |
| 6 |
Gallus gallus |
90.10 |
1 |
tyrosine hydroxylase |
| 7 |
Rattus norvegicus |
88.60 |
2 |
tyrosine hydroxylase |
| 8 |
Mus musculus |
87.80 |
3 |
tyrosine hydroxylase |
| 9 |
synthetic construct |
87.80 |
1 |
chimeric tyrosine hydroxylase |
| 10 |
Xenopus laevis |
81.60 |
1 |
tyrosine hydroxylase |
| 11 |
Monodelphis domestica |
78.60 |
1 |
PREDICTED: similar to tyrosine hydroxylase, partia |
| 12 |
Macaca mulatta |
62.40 |
1 |
tyrosine hydroxylase type 1 |
| 13 |
Anguilla anguilla |
60.50 |
1 |
TY3H_ANGAN Tyrosine 3-monooxygenase (Tyrosine 3-hy |
| 14 |
Lates calcarifer |
59.70 |
1 |
tyrosine hydroxylase 1 |
| 15 |
Danio rerio |
55.80 |
2 |
PREDICTED: tyrosine hydroxylase |
| 16 |
Takifugu rubripes |
53.90 |
1 |
tyrosine 3-monooxygenase |
| 17 |
Pan troglodytes |
45.40 |
1 |
PREDICTED: tyrosine hydroxylase |
| 18 |
Tetraodon nigroviridis |
40.00 |
1 |
unnamed protein product |
Top-ranked sequences
| organism | matching |
|---|
| Canis lupus familiaris |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|
| Canis familiaris |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||||||||||||||||||||#||||||||||||||||||||||||||||||
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|
| N/A |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||| ||||||||||||||||#||||||||||||+|||||||+|||||||||
Sbjct 1 MPTPNAASPQAKGFRRAVSELD#AKQAEAIMSPRFVGRRQSLIQDARKEREKA 52
|
| Bos taurus |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||| ||||||||||||||||#||||||||||||+|||||||+|||||||||
Sbjct 1 MPTPNAASPQAKGFRRAVSELD#AKQAEAIMSPRFVGRRQSLIQDARKEREKA 52
|
| Homo sapiens |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||+ +||||||||||||||#|||||||||||||||||||||||||||| |
Sbjct 1 MPTPDATTPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREAA 52
|
| Gallus gallus |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||| ++ ||||||||||||#+||||||||||||||||||||||||||| |
Sbjct 1 MPTPNISTSAAKGFRRAVSELD#SKQAEAIMSPRFIGRRQSLIEDARKEREAA 52
|
| Rattus norvegicus |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||+ ||| ||||||||| |#||||||+ |||||||||||||||||||| |
Sbjct 1 MPTPSAPSPQPKGFRRAVSEQD#AKQAEAVTSPRFIGRRQSLIEDARKEREAA 52
|
| Mus musculus |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||+ +||| ||||||||| |# |||||+ |||||||||||||||||||| |
Sbjct 1 MPTPSASSPQPKGFRRAVSEQD#TKQAEAVTSPRFIGRRQSLIEDARKEREAA 52
|
| synthetic construct |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||+ +||| ||||||||| |# |||||+ |||||||||||||||||||| |
Sbjct 1 MPTPSASSPQPKGFRRAVSEQD#TKQAEAVTSPRFIGRRQSLIEDARKEREAA 52
|
| Xenopus laevis |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||| + | |||||||||# ||||||+||||+||||||||||||+|| |
Sbjct 1 MPTPNISGSAGKSFRRAVSELD#PKQAEAILSPRFLGRRQSLIEDARKDREVA 52
|
| Monodelphis domestica |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIM-----------------------------S 31
||||| ++| ||||||||||||#+||||||| |
Sbjct 1 MPTPNASAPSAKGFRRAVSELD#SKQAEAIMGTPGCSLVLSGGPGGMEPVAPLTPPPPVQS 60
Query 32 PRFIGRRQSLIEDARKEREKA 52
||||||||||||||||||| |
Sbjct 61 PRFIGRRQSLIEDARKEREAA 81
|
| Macaca mulatta |
Query 19 SELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
||||#||||||+ |||||||||||||||||||| |
Sbjct 1 SELD#AKQAEAVTSPRFIGRRQSLIEDARKEREAA 34
|
| Anguilla anguilla |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|| |++ | || ||||# +|++| ||||+||||||||||||||| |
Sbjct 1 MPISNSSGSSTKSITRAGSELD#--RADSITSPRFVGRRQSLIEDARKEREAA 50
|
| Lates calcarifer |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|| ++++ | ||| |||+# ++++| ||||+||||||||||||||| |
Sbjct 1 MPLSSSSTSSTKSIRRAASELE#--RSDSITSPRFVGRRQSLIEDARKEREAA 50
|
| Danio rerio |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|| ++++ | ||| |||+# ++++| | +|+||||||||||||||| |
Sbjct 1 MPNSSSSTSSTKSIRRAASELE#--RSDSITSQKFVGRRQSLIEDARKEREAA 50
|
| Takifugu rubripes |
Query 1 MPTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
|| + ++ | ||| |||+# +++++ | ||+||||||||||||||| |
Sbjct 1 MPQSSGSTSSTKSIRRAPSELE#--RSDSVTSQRFLGRRQSLIEDARKEREAA 50
|
| Pan troglodytes |
Query 2 PTPNTASPQAKGFRRAVSELD#AKQAEAIMSPRFIGRRQSLIEDARKEREKA 52
| | ||+| | # + |||||||||||||||||||| |
Sbjct 135 PWPGTAAPAAS----------#--YTPSPRSPRFIGRRQSLIEDARKEREAA 173
|
| Tetraodon nigroviridis |
Query 31 SPRFIGRRQSLIEDARKEREKA 52
| ||+||||||||||||||| |
Sbjct 2 SQRFLGRRQSLIEDARKEREAA 23
|
[Site 2] LDAKQAEAIM30-SPRFIGRRQS
Met30 Ser
|
| P10 | P9 | P8 | P7 | P6 |
P5 | P4 | P3 | P2 | P1 |
| Leu21 | Asp22 | Ala23 | Lys24 | Gln25 | Ala26 | Glu27 | Ala28 | Ile29 | Met30 |
|
| P1' | P2' | P3' | P4' | P5' |
P6' | P7' | P8' | P9' | P10' |
| Ser31 | Pro32 | Arg33 | Phe34 | Ile35 | Gly36 | Arg37 | Arg38 | Gln39 | Ser40 |
Sequence conservation (by blast) Sequence conservation (by blast)
| Reference peptide (cleaved bond±30 residues) |
|---|
|
MPTPNTASPQAKGFRRAVSELDAKQAEAIMSPRFIGRRQSLIEDARKEREKAEAASAASS
|
Summary
| # |
organism |
max score |
hits |
top seq |
| 1 |
Canis lupus familiaris |
89.00 |
1 |
tyrosine hydroxylase |
| 2 |
Canis familiaris |
89.00 |
1 |
PREDICTED: tyrosine hydroxylase |
| 3 |
N/A |
85.50 |
11 |
T |
| 4 |
Bos taurus |
85.50 |
2 |
tyrosine hydroxylase |
| 5 |
Homo sapiens |
82.40 |
18 |
Tyrosine hydroxylase |
| 6 |
Gallus gallus |
77.80 |
1 |
tyrosine hydroxylase |
| 7 |
Rattus norvegicus |
76.30 |
2 |
tyrosine hydroxylase |
| 8 |
Mus musculus |
75.50 |
3 |
tyrosine hydroxylase |
| 9 |
synthetic construct |
75.50 |
1 |
chimeric tyrosine hydroxylase |
| 10 |
Xenopus laevis |
70.90 |
1 |
tyrosine hydroxylase |
| 11 |
Monodelphis domestica |
66.20 |
1 |
PREDICTED: similar to tyrosine hydroxylase, partia |
| 12 |
Macaca mulatta |
50.10 |
1 |
tyrosine hydroxylase type 1 |
| 13 |
Anguilla anguilla |
48.10 |
1 |
TY3H_ANGAN Tyrosine 3-monooxygenase (Tyrosine 3-hy |
| 14 |
Lates calcarifer |
47.40 |
1 |
tyrosine hydroxylase 1 |
| 15 |
Danio rerio |
43.50 |
1 |
PREDICTED: tyrosine hydroxylase |
| 16 |
Takifugu rubripes |
41.60 |
1 |
tyrosine 3-monooxygenase |
| 17 |
Pan troglodytes |
33.10 |
1 |
PREDICTED: tyrosine hydroxylase |
| 18 |
Tetrahymena thermophila SB210 |
32.70 |
1 |
phage head-tail adaptor, putative family protein |
Top-ranked sequences
| organism | matching |
|---|
| Canis lupus familiaris |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||||||||||||||||||||||||||||#||||||||||||||
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|
| Canis familiaris |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||||||||||||||||||||||||||||#||||||||||||||
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|
| N/A |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||| ||||||||||||||||||||||||#||||+|||||||+|
Sbjct 1 MPTPNAASPQAKGFRRAVSELDAKQAEAIM#SPRFVGRRQSLIQD 44
|
| Bos taurus |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||| ||||||||||||||||||||||||#||||+|||||||+|
Sbjct 1 MPTPNAASPQAKGFRRAVSELDAKQAEAIM#SPRFVGRRQSLIQD 44
|
| Homo sapiens |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||+ +||||||||||||||||||||||#||||||||||||||
Sbjct 1 MPTPDATTPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|
| Gallus gallus |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||| ++ ||||||||||||+|||||||#||||||||||||||
Sbjct 1 MPTPNISTSAAKGFRRAVSELDSKQAEAIM#SPRFIGRRQSLIED 44
|
| Rattus norvegicus |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||+ ||| ||||||||| |||||||+ #||||||||||||||
Sbjct 1 MPTPSAPSPQPKGFRRAVSEQDAKQAEAVT#SPRFIGRRQSLIED 44
|
| Mus musculus |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||+ +||| ||||||||| | |||||+ #||||||||||||||
Sbjct 1 MPTPSASSPQPKGFRRAVSEQDTKQAEAVT#SPRFIGRRQSLIED 44
|
| synthetic construct |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||+ +||| ||||||||| | |||||+ #||||||||||||||
Sbjct 1 MPTPSASSPQPKGFRRAVSEQDTKQAEAVT#SPRFIGRRQSLIED 44
|
| Xenopus laevis |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
||||| + | ||||||||| ||||||+#||||+|||||||||
Sbjct 1 MPTPNISGSAGKSFRRAVSELDPKQAEAIL#SPRFLGRRQSLIED 44
|
| Monodelphis domestica |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM-----------------------------#S 31
||||| ++| ||||||||||||+||||||| #|
Sbjct 1 MPTPNASAPSAKGFRRAVSELDSKQAEAIMGTPGCSLVLSGGPGGMEPVAPLTPPPPVQ#S 60
Query 32 PRFIGRRQSLIED 44
|||||||||||||
Query 32 PRFIGRRQSLIED 44
|
| Macaca mulatta |
Query 19 SELDAKQAEAIM#SPRFIGRRQSLIED 44
||||||||||+ #||||||||||||||
Sbjct 1 SELDAKQAEAVT#SPRFIGRRQSLIED 26
|
| Anguilla anguilla |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|| |++ | || |||| +|++| #||||+|||||||||
Sbjct 1 MPISNSSGSSTKSITRAGSELD--RADSIT#SPRFVGRRQSLIED 42
|
| Lates calcarifer |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|| ++++ | ||| |||+ ++++| #||||+|||||||||
Sbjct 1 MPLSSSSTSSTKSIRRAASELE--RSDSIT#SPRFVGRRQSLIED 42
|
| Danio rerio |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|| ++++ | ||| |||+ ++++| #| +|+|||||||||
Sbjct 1 MPNSSSSTSSTKSIRRAASELE--RSDSIT#SQKFVGRRQSLIED 42
|
| Takifugu rubripes |
Query 1 MPTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
|| + ++ | ||| |||+ +++++ #| ||+|||||||||
Sbjct 1 MPQSSGSTSSTKSIRRAPSELE--RSDSVT#SQRFLGRRQSLIED 42
|
| Pan troglodytes |
Query 2 PTPNTASPQAKGFRRAVSELDAKQAEAIM#SPRFIGRRQSLIED 44
| | ||+| | + #||||||||||||||
Sbjct 135 PWPGTAAPAAS------------YTPSPR#SPRFIGRRQSLIED 165
|
| Tetrahymena thermophila SB210 |
Query 3 TPNTASPQAKGFRRAVS-ELDAKQAEAIM#SPRFIGRRQSLIE 43
| + | ||| +| | | || |++ ++#+|| ||++ |+|+
Sbjct 115 TDSMNSIQAKSIQRTSSAERDANQSDRLI#TPRLIGQKSSMIK 156
|
* References
[PubMed ID: 16210796] Takeuchi Y, Hashizume C, Chon EM, Momozawa Y, Masuda K, Kikusui T, Mori Y, Canine tyrosine hydroxylase (TH) gene and dopamine beta -hydroxylase (DBH) gene: their sequences, genetic polymorphisms, and diversities among five different dog breeds. J Vet Med Sci. 2005 Sep;67(9):861-7.
