logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB0646 : caspase-9 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0042

* Basic Information

OrganismHomo sapiens (human)
Protein NamesCaspase-9; CASP-9; 3.4.22.62; ICE-like apoptotic protease 6; ICE-LAP6; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; APAF-3; Caspase-9 subunit p35; Caspase-9 subunit p10
Gene NamesCASP9; MCH6
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAA87905 N/A N/A P55211 N/A N/A N/A hsa:842

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 266 aa

Average Mass: 30.115 kDa

Monoisotopic Mass: 30.096 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CARD 1. 69290.08.3e-24

3. Sequence Information

Fasta Sequence: XSB0646.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1JXQ (X-ray; 280 A; A/B/C/D=140-416), 1NW9 (X-ray; 240 A; B=140-416), 2AR9 (X-ray; 280 A; A/B/C/D=140-416), 3D9T (X-ray; 150 A; C/D=316-321), 3YGS (X-ray; 250 A; P=1-95)

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] EGLRTFDQLD180-AISSLPTPSD

Asp180 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Glu171Gly172Leu173Arg174Thr175Phe176Asp177Gln178Leu179Asp180
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala181Ile182Ser183Ser184Leu185Pro186Thr187Pro188Ser189Asp190

Sequence conservation (by blast)

[Site 2] LTPVVLRPEI115-RKPEVLRPET

Ile115 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Leu106Thr107Pro108Val109Val110Leu111Arg112Pro113Glu114Ile115
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg116Lys117Pro118Glu119Val120Leu121Arg122Pro123Glu124Thr125

Sequence conservation (by blast)

* References

None.