XSB0679 : insulin-like growth factor binding protein 5 [Rattus norvegicus]
[ CaMP Format ]
This entry is computationally expanded from SB0023
* Basic Information
Organism | Rattus norvegicus (Norway rat) |
Protein Names | Insulin-like growth factor-binding protein 5; IGF-binding protein 5; IGFBP-5; IBP-5; insulin-like growth factor binding protein 5 |
Gene Names | Igfbp5; Igfbp-5; insulin-like growth factor binding protein 5 |
Gene Locus | 9q33; chromosome 9 |
GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 271 aa
Average Mass: 30.298 kDa
Monoisotopic Mass: 30.278 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
domain name | begin | end | score | e-value |
---|---|---|---|---|
--- cleavage 21 --- | ||||
IGFBP 1. | 26 | 84 | 102.7 | 1.3e-27 |
--- cleavage 160 --- | ||||
--- cleavage 171 --- | ||||
Thyroglobulin_1 1. | 191 | 262 | 130.3 | 6.3e-36 |
3. Sequence Information
Fasta Sequence: XSB0679.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
3 [sites]
Cleavage sites (±10aa)
[Site 1] ACAVPAQGLG21-SFVHCEPCDE
Gly21 Ser
![]() |
|||||||||
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Ala12 | Cys13 | Ala14 | Val15 | Pro16 | Ala17 | Gln18 | Gly19 | Leu20 | Gly21 |
![]() |
|||||||||
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Ser22 | Phe23 | Val24 | His25 | Cys26 | Glu27 | Pro28 | Cys29 | Asp30 | Glu31 |
Sequence conservation (by blast)
Sequence conservation (by blast)
Reference peptide (cleaved bond±30 residues) |
---|
MVISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPG |
Summary
# | organism | max score | hits | top seq |
---|---|---|---|---|
1 | Mus musculus | 79.70 | 12 | insulin-like growth factor binding protein 5 |
2 | Rattus norvegicus | 79.70 | 5 | insulin-like growth factor binding protein 5 |
3 | Sus scrofa | 79.70 | 5 | insulin-like growth factor binding protein 5 |
4 | Canis familiaris | 79.70 | 3 | PREDICTED: similar to insulin-like growth factor b |
5 | N/A | 78.60 | 9 | 2 |
6 | Homo sapiens | 77.40 | 8 | insulin-like growth factor binding protein 5 |
7 | synthetic construct | 77.40 | 6 | insulin-like growth factor binding protein 5 |
8 | Macaca mulatta | 77.40 | 4 | PREDICTED: similar to insulin-like growth factor b |
9 | Monodelphis domestica | 76.60 | 3 | PREDICTED: similar to insulin-like growth factor b |
10 | Xenopus tropicalis | 73.20 | 3 | Unknown (protein for MGC:144994) |
11 | Xenopus laevis | 73.20 | 3 | insulin-like growth factor binding protein 5 |
12 | chickens, eye, Peptide Partial, 51 aa | 66.60 | 1 | insulin-like growth factor binding protein-5, IGFB |
13 | Oncorhynchus mykiss | 64.70 | 1 | insulin-like growth factor binding protein 5 |
14 | Danio rerio | 64.30 | 6 | PREDICTED: similar to Igfbp5 protein |
15 | Tetraodon nigroviridis | 64.30 | 4 | unnamed protein product |
16 | Salmo salar | 63.20 | 1 | IGF binding protein 5 |
17 | Bos taurus | 44.30 | 3 | insulin-like growth factor binding protein 3 |
18 | Equus caballus | 39.30 | 1 | insulin-like growth factor binding protein-4 |
19 | Ovis aries | 39.30 | 1 | IBP4_SHEEP Insulin-like growth factor-binding prot |
20 | Pan troglodytes | 39.30 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
21 | Gallus gallus | 36.20 | 1 | insulin-like growth factor binding protein 1 |
22 | Spermophilus tridecemlineatus | 34.30 | 1 | IBP1_SPETR Insulin-like growth factor-binding prot |
Top-ranked sequences
organism | matching |
---|---|
Mus musculus | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||||||||||||||||||||||||||| Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |
Rattus norvegicus | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||||||||||||||||||||||||||| Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |
Sus scrofa | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||||||||||||||||||||||||||| Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |
Canis familiaris | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||||||||||||||||||||||||||| Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |
N/A | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||||||||||||||||||||||||+|| Sbjct 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKDPG 51 |
Homo sapiens | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 | ||#|||||||||||||||||||||||||||||| Sbjct 19 QSLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 52 |
synthetic construct | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 | ||#|||||||||||||||||||||||||||||| Sbjct 19 QSLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 52 |
Macaca mulatta | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 | ||#|||||||||||||||||||||||||||||| Sbjct 19 QSLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 52 |
Monodelphis domestica | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||||#|||||| ||||||||||||||||||||||| Sbjct 18 QGLG#SFVHCEACDEKALSMCPPSPLGCELVKEPG 51 |
Xenopus tropicalis | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 | ||#|||||||||+||+|||||+|+||||||||| Sbjct 19 QALG#SFVHCEPCDDKAMSMCPPTPVGCELVKEPG 52 |
Xenopus laevis | Query 18 QGLG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 | ||#|||||||||+||+|||||+|+||||||||| Sbjct 20 QALG#SFVHCEPCDDKAMSMCPPTPVGCELVKEPG 53 |
chickens, eye, Peptide Partial, 51 aa | Query 20 LG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||#||| ||||| ||||+||| ||||||||||| Sbjct 1 LG#SFVQCEPCDGKALSLCPPPPLGCELVKEPG 32 |
Oncorhynchus mykiss | Query 20 LG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||#|+| |||||+|||||||| |+||+|||||| Sbjct 19 LG#SYVPCEPCDQKALSMCPPVPVGCQLVKEPG 50 |
Danio rerio | Query 21 G#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |#||| |||||+|||||||| |+||+|||||| Sbjct 18 G#SFVPCEPCDQKALSMCPPVPVGCQLVKEPG 48 |
Tetraodon nigroviridis | Query 20 LG#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 ||#|+| |||||+|||||||| |+||+|+|||| Sbjct 13 LG#SYVPCEPCDQKALSMCPPVPVGCQLIKEPG 44 |
Salmo salar | Query 21 G#SFVHCEPCDEKALSMCPPSPLGCELVKEPG 51 |#|+| |||||+|||||||| |+||+|||||| Sbjct 20 G#SYVPCEPCDQKALSMCPPVPVGCQLVKEPG 50 |
Bos taurus | Query 19 GLG#SFVHCEPCDEKALSMC---PPSPLGCELVKEPG 51 | |# | ||||| +|++ | |||| |||+||| Sbjct 33 GAG#PVVRCEPCDARAVAQCAPPPPSPPCAELVREPG 68 |
Equus caballus | Query 24 VHCEPCDEKALSMCPPSPLGC-ELVKEPG 51 +|| || |+ |+ | | |+|| |||+||| Sbjct 4 IHCPPCSEEKLARCRP-PVGCEELVREPG 31 |
Ovis aries | Query 24 VHCEPCDEKALSMCPPSPLGC-ELVKEPG 51 +|| || |+ |+ | | |+|| |||+||| Sbjct 4 IHCPPCSEEKLARCRP-PVGCEELVREPG 31 |
Pan troglodytes | Query 24 VHCEPCDEKALSMCPPSPLGC-ELVKEPG 51 +|| || |+ |+ | | |+|| |||+||| Sbjct 25 IHCPPCSEEKLARCRP-PVGCEELVREPG 52 |
Gallus gallus | Query 24 VHCEPCDEKALSMCPPSPLGC-ELVKEPG 51 +|| || ++ |++||| || | ++|| Sbjct 32 LHCAPCTQEKLALCPPVEPGCPETARQPG 60 |
Spermophilus tridecemlineatus | Query 25 HCEPCDEKALSMCPPSPLGCELVKEP 50 || || + |++||| | | + | Sbjct 31 HCAPCSAEKLALCPPVPSSCPELSRP 56 |
[Site 2] VKKDRRKKLT160-QSKFVGGAEN
Thr160 Gln
![]() |
|||||||||
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Val151 | Lys152 | Lys153 | Asp154 | Arg155 | Arg156 | Lys157 | Lys158 | Leu159 | Thr160 |
![]() |
|||||||||
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Gln161 | Ser162 | Lys163 | Phe164 | Val165 | Gly166 | Gly167 | Ala168 | Glu169 | Asn170 |
Sequence conservation (by blast)
Sequence conservation (by blast)
Reference peptide (cleaved bond±30 residues) |
---|
YSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGP |
Summary
# | organism | max score | hits | top seq |
---|---|---|---|---|
1 | Rattus norvegicus | 124.00 | 1 | insulin-like growth factor binding protein 5 |
2 | Mus musculus | 122.00 | 3 | insulin-like growth factor binding protein 5 |
3 | Macaca mulatta | 119.00 | 3 | PREDICTED: similar to insulin-like growth factor b |
4 | Homo sapiens | 119.00 | 2 | insulin-like growth factor binding protein 5 |
5 | synthetic construct | 119.00 | 1 | insulin-like growth factor binding protein 5 |
6 | Canis familiaris | 119.00 | 1 | PREDICTED: similar to insulin-like growth factor b |
7 | Sus scrofa | 118.00 | 2 | insulin-like growth factor binding protein 5 |
8 | N/A | 118.00 | 1 | 2 |
9 | Bos taurus | 117.00 | 2 | PREDICTED: similar to Insulin-like growth factor-b |
10 | Monodelphis domestica | 103.00 | 2 | PREDICTED: similar to insulin-like growth factor b |
11 | Gallus gallus | 89.40 | 2 | PREDICTED: similar to insulin-like growth factor b |
12 | Coturnix japonica | 89.40 | 1 | AF293839_1 insulin-like growth factor binding prot |
13 | Oryza sativa (japonica cultivar-group) | 34.30 | 1 | retrotransposon protein, putative, Ty3-gypsy sub-c |
14 | Equus caballus | 33.90 | 1 | insulin-like growth factor binding protein-5 |
Top-ranked sequences
organism | matching |
---|---|
Rattus norvegicus | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 |
Mus musculus | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||||||||||||||||||||||||||||#||||||||||||||||||||||||||+||| Sbjct 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESEQGP 190 |
Macaca mulatta | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#||||||||||||||||| ||||||||+||| Sbjct 132 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVISAPEMRQESEQGP 191 |
Homo sapiens | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#|||||||||||||||+| ||||||||+||| Sbjct 132 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRIISAPEMRQESEQGP 191 |
synthetic construct | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#|||||||||||||||+| ||||||||+||| Sbjct 132 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRIISAPEMRQESEQGP 191 |
Canis familiaris | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#||||||||||||||||| ||||||||+||| Sbjct 131 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVISAPEMRQESEQGP 190 |
Sus scrofa | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#||||||||||||||||| ||||||||+||| Sbjct 131 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVILAPEMRQESEQGP 190 |
N/A | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#||||||||||||||||| ||||||||+||| Sbjct 131 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVILAPEMRQESEQGP 190 |
Bos taurus | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 ||||+|||||||||||||||||||||||||#||||||||||||||||| ||||||+|+||| Sbjct 136 YSPKIFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVISAPEMRQKSEQGP 195 |
Monodelphis domestica | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 |||||||||| +||+||||+|||||||||#|||||| ||||| ||| |||||||+||| Sbjct 131 YSPKVFRPKHVHLSEMKAEALKKDRRKKLT#QSKFVGAAENTAQSRVISVPEMRQESEQGP 190 |
Gallus gallus | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 | || +|||| |+|+|||||+|||||||||# +|||| |||||||||+ ||+||| + || Sbjct 45 YPPKAYRPKHGRLSDLKAEALKKDRRKKLT#LAKFVGMAENTAHPRVV-IPELRQEFELGP 103 |
Coturnix japonica | Query 131 YSPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 | || +|||| |+|+|||||+|||||||||# +|||| |||||||||+ ||+||| + || Sbjct 88 YPPKAYRPKHGRLSDLKAEALKKDRRKKLT#LAKFVGMAENTAHPRVV-IPELRQEFELGP 146 |
Oryza sativa (japonica cultivar-group) | Query 132 SPKVFRPKHTRISELKAEAVKKDRRKKLT#QSKFVGGAENTAHPRVIPAPEMRQESDQGP 190 | | | |+ + | |+ ||++| # || | + +| ||+ |+| +| + | | Sbjct 239 SMKTLVDKALRVESSEKEVVE-DRKRKWA#AKKFAGSSSST-RPRLAPSPAVRPMAPQPP 295 |
Equus caballus | Query 131 YSPKVFRPKHTRIS 144 |||||||||||||| Query 131 YSPKVFRPKHTRIS 144 |
[Site 3] SKFVGGAENT171-AHPRVIPAPE
Thr171 Ala
![]() |
|||||||||
P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
Ser162 | Lys163 | Phe164 | Val165 | Gly166 | Gly167 | Ala168 | Glu169 | Asn170 | Thr171 |
![]() |
|||||||||
P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Ala172 | His173 | Pro174 | Arg175 | Val176 | Ile177 | Pro178 | Ala179 | Pro180 | Glu181 |
Sequence conservation (by blast)
Sequence conservation (by blast)
Reference peptide (cleaved bond±30 residues) |
---|
RISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQE |
Summary
# | organism | max score | hits | top seq |
---|---|---|---|---|
1 | Rattus norvegicus | 122.00 | 1 | insulin-like growth factor binding protein 5 |
2 | Mus musculus | 121.00 | 3 | insulin-like growth factor binding protein 5 |
3 | Macaca mulatta | 118.00 | 3 | PREDICTED: similar to insulin-like growth factor b |
4 | Canis familiaris | 118.00 | 2 | PREDICTED: similar to insulin-like growth factor b |
5 | Sus scrofa | 117.00 | 2 | insulin-like growth factor binding protein 5 |
6 | Homo sapiens | 117.00 | 2 | insulin-like growth factor binding protein 5 |
7 | N/A | 117.00 | 1 | 2 |
8 | synthetic construct | 117.00 | 1 | insulin-like growth factor binding protein 5 |
9 | Bos taurus | 116.00 | 1 | PREDICTED: similar to Insulin-like growth factor-b |
10 | Monodelphis domestica | 103.00 | 2 | PREDICTED: similar to insulin-like growth factor b |
11 | Gallus gallus | 95.10 | 2 | PREDICTED: similar to insulin-like growth factor b |
12 | Coturnix japonica | 95.10 | 1 | AF293839_1 insulin-like growth factor binding prot |
13 | Xenopus laevis | 40.40 | 1 | insulin-like growth factor binding protein 5 |
14 | Xenopus tropicalis | 39.70 | 1 | Unknown (protein for MGC:144994) |
15 | Oryza sativa (japonica cultivar-group) | 32.70 | 2 | retrotransposon protein, putative, Ty3-gypsy sub-c |
16 | Salmo salar | 32.30 | 2 | IGF binding protein 5 |
17 | Oncorhynchus mykiss | 32.30 | 1 | insulin-like growth factor binding protein 5 |
18 | Aquifex pyrophilus | 32.30 | 1 | NAD-dependent DNA ligase |
Top-ranked sequences
organism | matching |
---|---|
Rattus norvegicus | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||||||||||||||||||||||||||| Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 |
Mus musculus | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||||||||||||+|||||||||||||| Sbjct 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESEQGPCRRHMEASLQE 201 |
Macaca mulatta | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||| ||||||||+|||||||||||||| Sbjct 143 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVISAPEMRQESEQGPCRRHMEASLQE 202 |
Canis familiaris | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||| ||||||||+|||||||||||||| Sbjct 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVISAPEMRQESEQGPCRRHMEASLQE 201 |
Sus scrofa | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||| ||||||||+|||||||||||||| Sbjct 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVILAPEMRQESEQGPCRRHMEASLQE 201 |
Homo sapiens | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#||||+| ||||||||+|||||||||||||| Sbjct 143 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRIISAPEMRQESEQGPCRRHMEASLQE 202 |
N/A | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||| ||||||||+|||||||||||||| Sbjct 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVILAPEMRQESEQGPCRRHMEASLQE 201 |
synthetic construct | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#||||+| ||||||||+|||||||||||||| Sbjct 143 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRIISAPEMRQESEQGPCRRHMEASLQE 202 |
Bos taurus | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 ||||||||||||||||||||||||||||||#|||||| ||||||+|+|||||||||||||| Sbjct 147 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVISAPEMRQKSEQGPCRRHMEASLQE 206 |
Monodelphis domestica | Query 143 ISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 +||+||||+||||||||||||||| ||||#| ||| |||||||+|||||||||||||| Sbjct 143 LSEMKAEALKKDRRKKLTQSKFVGAAENT#AQSRVISVPEMRQESEQGPCRRHMEASLQE 201 |
Gallus gallus | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 |+|+|||||+||||||||| +|||| ||||#|||||+ ||+||| + ||||||||||||| Sbjct 56 RLSDLKAEALKKDRRKKLTLAKFVGMAENT#AHPRVV-IPELRQEFELGPCRRHMEASLQE 114 |
Coturnix japonica | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 |+|+|||||+||||||||| +|||| ||||#|||||+ ||+||| + ||||||||||||| Sbjct 99 RLSDLKAEALKKDRRKKLTLAKFVGMAENT#AHPRVV-IPELRQEFELGPCRRHMEASLQE 157 |
Xenopus laevis | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 |+|+ || |+ |+|| +||+ | | # | || | | ||||| +| +|| Sbjct 140 RLSDQKAIALNTFRQKKHSQSRIVS-VEKV#QSPST---PEHSIEIDMGPCRRQVETLMQE 195 |
Xenopus tropicalis | Query 142 RISELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQE 201 |+++ || |+ |+|| +||+ | | # | || | | ||||| +| +|| Sbjct 136 RLTDQKAIALNTFRQKKQSQSRIVS-VEKV#QSPST---PEHSIEIDMGPCRRQVETLMQE 191 |
Oryza sativa (japonica cultivar-group) | Query 145 ELKAEAVKKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGP 190 | + | +||++| || | + +|# ||+ |+| +| + | | Sbjct 251 ESSEKEVVEDRKRKWAAKKFAGSSSST#-RPRLAPSPAVRPMAPQPP 295 |
Salmo salar | Query 143 ISELKAEAVKKDRRKKLTQSKF--VGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQ 200 |+ | +|++||+ +| |+| +| + +# | | + | + ||||| ++ +| Sbjct 145 INSKKIQAMRKDKDRKRAQAKLRSIGPMDYS#------PLPIDKHEPEFGPCRRKLDGIIQ 198 |
Oncorhynchus mykiss | Query 143 ISELKAEAVKKDRRKKLTQSKF--VGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEASLQ 200 |+ | +|++||+ +| |+| +| + +# | | + | + ||||| ++ +| Sbjct 145 INSKKIQAMRKDKDRKRAQAKLRSIGPMDYS#------PLPIDKHEPEFGPCRRKLDGIIQ 198 |
Aquifex pyrophilus | Query 142 RISELKAEAV-KKDRRKKLTQSKFVGGAENT#AHPRVIPAPEMRQESDQGPCRRHMEA 197 +++|++ | | |+ ||| | + | #|+|| | +||+ + +| +|| Sbjct 194 KLAEIRGEVVINKEEFKKLNQERIEEGLPPF#ANPRNAAAGSIRQKDPKEVAKRRLEA 250 |
* References
[PubMed ID: 16672690] Berfield AK, Hansen KM, Abrass CK, Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. Am J Physiol Cell Physiol. 2006 Oct;291(4):C589-99. Epub 2006 May 3.
[PubMed ID: 16339387] ... Lang CH, Krawiec BJ, Huber D, McCoy JM, Frost RA, Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism. Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R963-72. Epub 2005
[PubMed ID: 16204335] ... Kiepe D, Ciarmatori S, Haarmann A, Tonshoff B, Differential expression of IGF system components in proliferating vs. differentiating growth plate chondrocytes: the functional role of IGFBP-5. Am J Physiol Endocrinol Metab. 2006 Feb;290(2):E363-71. Epub 2005 Oct 4.
[PubMed ID: 15845624] ... Kiepe D, Ciarmatori S, Hoeflich A, Wolf E, Tonshoff B, Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology. 2005 Jul;146(7):3096-104. Epub 2005 Apr 21.
[PubMed ID: 15589207] ... Durant D, Pereira RM, Canalis E, Overexpression of insulin-like growth factor binding protein-5 decreases osteoblastic function in vitro. Bone. 2004 Dec;35(6):1256-62.
[PubMed ID: 12397024] ... Spangenburg EE, Abraha T, Childs TE, Pattison JS, Booth FW, Skeletal muscle IGF-binding protein-3 and -5 expressions are age, muscle, and load dependent. Am J Physiol Endocrinol Metab. 2003 Feb;284(2):E340-50. Epub 2002 Oct 22.
[PubMed ID: 12193414] ... Chamoun D, Choi D, Tavares AB, Udoff LC, Levitas E, Resnick CE, Rosenfeld RG, Adashi EY, Regulation of granulosa cell-derived insulin-like growth factor binding proteins (IGFBPs): role for protein kinase-C in the pre- and posttranslational modulation of IGFBP-4 and IGFBP-5. Biol Reprod. 2002 Sep;67(3):1003-12.
[PubMed ID: 12006713] ... Gonzalez-Parra S, Rosato RR, Chowen JA, Argente J, Groffen C, Dits N, Drop SL, Inverse correlation between insulin-like growth factor (IGF)-binding protein-5 and IGF-I and II during postnatal development of the anterior pituitary gland. Horm Res. 2002;57(1-2):10-4.
[PubMed ID: 7679898] ... Zhu X, Ling N, Shimasaki S, Cloning of the rat insulin- like growth factor binding protein-5 gene and DNA sequence analysis of its promoter region. Biochem Biophys Res Commun. 1993 Feb 15;190(3):1045-52.
[PubMed ID: 1709938] ... Shimasaki S, Shimonaka M, Zhang HP, Ling N, Identification of five different insulin-like growth factor binding proteins (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human. J Biol Chem. 1991 Jun 5;266(16):10646-53.