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XSB0679 : insulin-like growth factor binding protein 5 [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0023

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein NamesInsulin-like growth factor-binding protein 5; IGF-binding protein 5; IGFBP-5; IBP-5; insulin-like growth factor binding protein 5
Gene NamesIgfbp5; Igfbp-5; insulin-like growth factor binding protein 5
Gene Locus9q33; chromosome 9
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_036949 NM_012817 25285 P24594 N/A N/A N/A rno:25285

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 271 aa

Average Mass: 30.298 kDa

Monoisotopic Mass: 30.278 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 21 ---
IGFBP 1. 2684102.71.3e-27
--- cleavage 160 ---
--- cleavage 171 ---
Thyroglobulin_1 1. 191262130.36.3e-36

3. Sequence Information

Fasta Sequence: XSB0679.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] ACAVPAQGLG21-SFVHCEPCDE

Gly21 Ser

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ala12Cys13Ala14Val15Pro16Ala17Gln18Gly19Leu20Gly21
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ser22Phe23Val24His25Cys26Glu27Pro28Cys29Asp30Glu31

Sequence conservation (by blast)

[Site 2] VKKDRRKKLT160-QSKFVGGAEN

Thr160 Gln

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val151Lys152Lys153Asp154Arg155Arg156Lys157Lys158Leu159Thr160
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Gln161Ser162Lys163Phe164Val165Gly166Gly167Ala168Glu169Asn170

Sequence conservation (by blast)

[Site 3] SKFVGGAENT171-AHPRVIPAPE

Thr171 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Ser162Lys163Phe164Val165Gly166Gly167Ala168Glu169Asn170Thr171
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala172His173Pro174Arg175Val176Ile177Pro178Ala179Pro180Glu181

Sequence conservation (by blast)

* References

[PubMed ID: 16672690] Berfield AK, Hansen KM, Abrass CK, Rat glomerular mesangial cells require laminin-9 to migrate in response to insulin-like growth factor binding protein-5. Am J Physiol Cell Physiol. 2006 Oct;291(4):C589-99. Epub 2006 May 3.

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