logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB1001 : dystrophin (muscular dystrophy, Duchenne and Becker types), isoform CRA_f [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0073

* Basic Information

OrganismHomo sapiens (human)
Protein Namesdystrophin (muscular dystrophy; Duchenne and Becker types); isoform CRA_f
Gene NamesDMD
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EAW99066 N/A 1756 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 3685 aa

Average Mass: 426.720 kDa

Monoisotopic Mass: 426.454 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
CH 1. 16119108.81.9e-29
CH 2. 135240100.94.3e-27
Spectrin 1. 33944779.51.2e-20
Spectrin 2. 44855669.01.8e-17
--- cleavage 690 ---
Spectrin 3. 71982711.90.0034
Spectrin 4. 83093440.85.3e-09
Spectrin 5. 94310458.50.0065
Spectrin 6. 1048115489.11.6e-23
Spectrin 7. 1157126358.91.9e-14
Spectrin 8. 1266136716.40.0014
DUF1136 1. 14131436-5.06.4
Spectrin 9. 145915680.40.031
Spectrin 10. 1571167653.21e-12
Spectrin 11. 1679177960.37.4e-15
Involucrin 1. 184918582.31.3e
Spectrin 12. 1877197947.16.8e-11
--- cleavage 1992 ---
Spectrin 13. 2104220880.27.7e-21
Spectrin 14. 2211231863.39.2e-16
Involucrin 2. 233023393.758
VitD-bind_III 1. 23902451-24.86
Spectrin 15. 2470257720.20.00068
Spectrin 16. 2580268657.26.4e-14
Spectrin 17. 2689280222.70.00042
Spectrin 18. 2934304075.22.4e-19
WW 1. 3057308648.92e-11
efhand_1 1. 30873207274.72.1e-79
efhand_2 1. 32113302230.06.1e-66
ZZ 1. 3307335293.38.6e-25
M 1. 350135219.48.3
M 2. 356735875.131

3. Sequence Information

Fasta Sequence: XSB1001.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

2 [sites]

Cleavage sites (±10aa)

[Site 1] MVMTEDMPLE1992-ISYVPSTYLT

Glu1992 Ile

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Met1983Val1984Met1985Thr1986Glu1987Asp1988Met1989Pro1990Leu1991Glu1992
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ile1993Ser1994Tyr1995Val1996Pro1997Ser1998Thr1999Tyr2000Leu2001Thr2002

Sequence conservation (by blast)

[Site 2] VMETVTTVTT690-REQILVKHAQ

Thr690 Arg

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Val681Met682Glu683Thr684Val685Thr686Thr687Val688Thr689Thr690
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Arg691Glu692Gln693Ile694Leu695Val696Lys697His698Ala699Gln700

Sequence conservation (by blast)

* References

[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.