XSB1002 : dystrophin (muscular dystrophy, Duchenne and Becker types), isoform CRA_a [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0073
* Basic Information
| Organism | Homo sapiens (human) |
| Protein Names | dystrophin (muscular dystrophy; Duchenne and Becker types); isoform CRA_a |
| Gene Names | DMD |
| Gene Locus | Not available |
| GO Function | Not available |
* Information From OMIM
Not Available.
* Structure Information
1. Primary Information
Length: 3681 aa
Average Mass: 425.971 kDa
Monoisotopic Mass: 425.706 kDa
2. Domain Information
Annotated Domains: Not Available.
Computationally Assigned Domains (Pfam+HMMER):
| domain name | begin | end | score | e-value |
|---|---|---|---|---|
| CH 1. | 12 | 115 | 108.8 | 1.9e-29 |
| CH 2. | 131 | 236 | 100.9 | 4.3e-27 |
| Spectrin 1. | 335 | 443 | 79.5 | 1.2e-20 |
| Spectrin 2. | 444 | 552 | 69.0 | 1.8e-17 |
| --- cleavage 686 --- | ||||
| Spectrin 3. | 715 | 823 | 11.9 | 0.0034 |
| Spectrin 4. | 826 | 930 | 40.8 | 5.3e-09 |
| Spectrin 5. | 939 | 1041 | 8.5 | 0.0065 |
| Spectrin 6. | 1044 | 1150 | 89.1 | 1.6e-23 |
| Spectrin 7. | 1153 | 1259 | 58.9 | 1.9e-14 |
| Spectrin 8. | 1262 | 1363 | 16.4 | 0.0014 |
| DUF1136 1. | 1409 | 1432 | -5.0 | 6.4 |
| Spectrin 9. | 1455 | 1564 | 0.4 | 0.031 |
| Spectrin 10. | 1567 | 1672 | 53.2 | 1e-12 |
| Spectrin 11. | 1675 | 1775 | 60.3 | 7.4e-15 |
| Involucrin 1. | 1845 | 1854 | 2.3 | 1.3e |
| Spectrin 12. | 1873 | 1975 | 47.1 | 6.8e-11 |
| --- cleavage 1988 --- | ||||
| Spectrin 13. | 2100 | 2204 | 80.2 | 7.7e-21 |
| Spectrin 14. | 2207 | 2314 | 63.3 | 9.2e-16 |
| Involucrin 2. | 2326 | 2335 | 3.7 | 58 |
| VitD-bind_III 1. | 2386 | 2447 | -24.8 | 6 |
| Spectrin 15. | 2466 | 2573 | 20.2 | 0.00068 |
| Spectrin 16. | 2576 | 2682 | 57.2 | 6.4e-14 |
| Spectrin 17. | 2685 | 2798 | 22.7 | 0.00042 |
| Spectrin 18. | 2930 | 3036 | 75.2 | 2.4e-19 |
| WW 1. | 3053 | 3082 | 48.9 | 2e-11 |
| efhand_1 1. | 3083 | 3203 | 274.7 | 2.1e-79 |
| efhand_2 1. | 3207 | 3298 | 230.0 | 6.1e-66 |
| ZZ 1. | 3303 | 3348 | 93.3 | 8.6e-25 |
| M 1. | 3497 | 3517 | 9.4 | 8.3 |
| M 2. | 3563 | 3583 | 5.1 | 31 |
3. Sequence Information
Fasta Sequence: XSB1002.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Not Available.
* Cleavage Information
2 [sites]
Cleavage sites (±10aa)
[Site 1] MVMTEDMPLE1988-ISYVPSTYLT
Glu1988 
Ile
 |
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Met1979 | Val1980 | Met1981 | Thr1982 | Glu1983 | Asp1984 | Met1985 | Pro1986 | Leu1987 | Glu1988 |
 |
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Ile1989 | Ser1990 | Tyr1991 | Val1992 | Pro1993 | Ser1994 | Thr1995 | Tyr1996 | Leu1997 | Thr1998 |
Sequence conservation (by blast)
[Site 2] VMETVTTVTT686-REQILVKHAQ
Thr686 Arg
|
|||||||||
| P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
|---|---|---|---|---|---|---|---|---|---|
| Val677 | Met678 | Glu679 | Thr680 | Val681 | Thr682 | Thr683 | Val684 | Thr685 | Thr686 |
|
|||||||||
| P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
| Arg687 | Glu688 | Gln689 | Ile690 | Leu691 | Val692 | Lys693 | His694 | Ala695 | Gln696 |
Sequence conservation (by blast)
* References
[PubMed ID: 11181995] Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X, The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51.