CaMPDB :: Substrate

XSB2249 : PREDICTED: similar to gamma filamin isoform 3 [Bos taurus]

This entry is computationally expanded from SB0092

* Basic Information

Organism	Bos taurus (cattle)
Protein Names	similar to gamma filamin isoform 3
Gene Names	FLNC; Derived by automated computational analysis using gene prediction method: GNOMON. Supporting evidence includes similarity to: 1 mRNA, 37 ESTs, 12 Proteins
Gene Locus	Not available
GO Function	Not available

Entrez Protein	Entrez Nucleotide	Entrez Gene	UniProt	OMIM	HGNC	HPRD	KEGG
XP_606838	XM_606838	528415	N/A	N/A	N/A	N/A	N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 2693 aa

Average Mass: 287.395 kDa

Monoisotopic Mass: 287.216 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain name	begin	end	score	e-value
CH 1.	38	143	109.8	9.2e-30
CH 2.	161	263	103.1	9.5e-28
Filamin 1.	273	366	124.0	4.8e-34
Filamin 2.	373	466	123.9	5.4e-34
Filamin 3.	472	563	133.4	7.1e-37
Filamin 4.	569	656	116.1	1.2e-31
Filamin 5.	665	756	148.0	2.9e-41
Filamin 6.	762	859	142.0	1.8e-39
Filamin 7.	865	958	125.1	2.3e-34
Filamin 8.	964	1054	115.5	1.8e-31
Filamin 9.	1060	1147	151.5	2.5e-42
Filamin 10.	1153	1242	148.8	1.7e-41
Filamin 11.	1248	1342	125.1	2.3e-34
Filamin 12.	1348	1435	156.4	8.5e-44
Filamin 13.	1441	1531	147.1	5.5e-41
Filamin 14.	1537	1628	141.0	3.7e-39
Filamin 15.	1634	1732	100.1	7.5e-27
Filamin 16.	1740	1819	26.0	5.8e-05
Filamin 17.	1824	1911	156.4	8.4e-44
Filamin 18.	1912	1998	19.2	0.00024
Filamin 19.	2006	2093	149.6	9.6e-42
Filamin 20.	2184	2271	41.8	2.7e-09
Filamin 21.	2279	2366	137.9	3.2e-38
Filamin 22.	2373	2461	86.7	8.4e-23
Filamin 23.	2470	2557	123.1	9.1e-34
--- cleavage 2594 ---
Filamin 24.	2600	2689	116.6	8e-32

3. Sequence Information

Fasta Sequence: XSB2249.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] SSSSRGSSYS²⁵⁹⁴-SIPKFSSDAS

Ser²⁵⁹⁴ Ser

P10	P9	P8	P7	P6	P5	P4	P3	P2	P1

Ser²⁵⁸⁵	Ser²⁵⁸⁶	Ser²⁵⁸⁷	Ser²⁵⁸⁸	Arg²⁵⁸⁹	Gly²⁵⁹⁰	Ser²⁵⁹¹	Ser²⁵⁹²	Tyr²⁵⁹³	Ser²⁵⁹⁴

P1'	P2'	P3'	P4'	P5'	P6'	P7'	P8'	P9'	P10'
Ser²⁵⁹⁵	Ile²⁵⁹⁶	Pro²⁵⁹⁷	Lys²⁵⁹⁸	Phe²⁵⁹⁹	Ser²⁶⁰⁰	Ser²⁶⁰¹	Asp²⁶⁰²	Ala²⁶⁰³	Ser²⁶⁰⁴

Sequence conservation (by blast) Sequence conservation (by blast)

Reference peptide (cleaved bond±30 residues)
LSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAFVGQKNSF

Summary

#	organism	max score	hits	top seq
1	Homo sapiens	94.40	30	filamin, muscle isoform
2	Mus musculus	94.40	24	PREDICTED: similar to Filamin-C (Gamma-filamin) (F
3	Canis familiaris	94.40	21	PREDICTED: similar to Filamin C (Gamma-filamin) (F
4	N/A	94.40	16	F
5	Pan troglodytes	94.40	16	PREDICTED: gamma filamin
6	Bos taurus	94.40	6	PREDICTED: similar to filamin, muscle isoform 1
7	Rattus norvegicus	94.40	5	PREDICTED: similar to Filamin-C (Gamma-filamin) (F
8	Xenopus laevis	87.00	5	Unknown (protein for IMAGE:6940151)
9	Gallus gallus	80.50	4	cgABP260
10	Danio rerio	80.10	5	PREDICTED: similar to gamma-filamin
11	Tetraodon nigroviridis	66.20	4	unnamed protein product
12	Xenopus tropicalis	58.90	1	hypothetical protein LOC779840
13	Oryctolagus cuniculus	57.80	1	FLNB_RABIT Filamin-B (FLN-B) (Beta-filamin) (Actin
14	Macaca mulatta	56.20	8	PREDICTED: filamin B, beta (actin binding protein
15	Sus scrofa	56.20	2	filamin B beta
16	Drosophila melanogaster	54.30	8	cheerio CG3937-PD, isoform D
17	Monodelphis domestica	52.40	1	PREDICTED: similar to filamin B, beta (actin bindi
18	Anopheles gambiae str. PEST	48.90	1	ENSANGP00000003616
19	Aedes aegypti	48.90	1	filamin, putative
20	Apis mellifera	44.30	1	PREDICTED: similar to cheerio CG3937-PB, isoform B
21	Strongylocentrotus purpuratus	40.80	3	PREDICTED: similar to ENSANGP00000003616
22	Euprymna scolopes	40.00	1	filamin
23	Caenorhabditis briggsae	37.70	1	Hypothetical protein CBG10541
24	Caenorhabditis elegans	37.40	2	Y66H1B.2b

Top-ranked sequences

organism	matching
Homo sapiens	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2564 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2623
Mus musculus	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2565 LSGGHSLHETSTVLVETVTKSSSSRGASYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624
Canis familiaris	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2565 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624
N/A	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2597 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2656
Pan troglodytes	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2443 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2502
Bos taurus	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2565 LSGGHSLHETSTVLVETVTKSSSSRGSSYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624
Rattus norvegicus	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| Sbjct 2565 LSGGHSLHETSTVLVETVTKSSSSRGASYS#SIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624
Xenopus laevis	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\|\| # \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|+\|\|\|\|\|\|\|+\| Sbjct 53 LSGGHSLHETSTVLVETVTKSSASVGEYGM#AGPKFSSDASKVVSRGPGLSKAFVGQKNTF 112
Gallus gallus	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|+ # +\|\|\|\|\|\|\|\|\|\|\| \|\|\|\|\|\| \|\|\|\|\|\|\| \| Sbjct 2531 LSGGHSLHETSSVLVETVTRGALGPPGFGT#-LPKFSSDASKVVARGPGLSTAFVGQKNHF 2589
Danio rerio	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|\|\|\|\|\|\|+\|\|\|\|\|\|\|\| # +\|\|\|\|\|\|\|\|\|\|\|+\|\| \|\|\|+\|\|+\|\|\|\|+\| Sbjct 2133 LSGGHSLHETSSVLVETVTKSSSVAGSFST#-LPKFSSDASKVVSRGAGLSKAFIGQKNTF 2191
Tetraodon nigroviridis	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\| \|\| \| \|\|\|+\|\|\|\|\|\|+\| # \|\|\|\|\|\|\|\|+\|+ \|\| \|\|\|+\|\|+ \|\|\|\|\| Sbjct 2744 LSSGHGLRETSSVLVETVSKSTAKGAAFAS#-FPKFSSDASQVLLRGAGLSKAFISQKNSF 2802
Xenopus tropicalis	Query 2569 HSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|+\|+\| \|++\|\|\| # \|+ +\|\|\|\|\|\|\| +\| \|\|++\|\|\|\|\|\|\|\|\| Sbjct 95 HSLHESSSVFVDSVTKSEAFTQHAAA#--PRIASDASKVVAKGLGLNKAFVGQKNSF 148
Oryctolagus cuniculus	Query 2565 LSGGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \| \| \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 168 LVGPGSTNETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 225
Macaca mulatta	Query 2570 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 2476 SANETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 2528
Sus scrofa	Query 2570 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \| +\|\|\|++\|\|\|+\|\|+ # \|\|\| \|\|\|\|\|\|\| ++\| \|\|\|+\|\|\|\|\|\|+\|\| Sbjct 131 SANETSSILVESVTRSSTETCYSA-#-IPKASSDASKVTSKGAGLSKAFVGQKSSF 183
Drosophila melanogaster	Query 2573 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|\|\|+\|\|\|\| \| # +\| \| \|\|\|\|\|\|\|++\| \|\| +\|++\|++\| \| Sbjct 2421 ETSTVIVETVQKVAKGGKNTGV#HLPTFKSDASKVVSKGMGLKKAYIGKQNQF 2472
Monodelphis domestica	Query 2570 SLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \| +\|\|\|++\|\|\|+\|\|+ # +\|\| \|\|\|\|\|\|\| ++\| \|\| +\|\|\|\|\|\|++\| Sbjct 37 SANETSSILVESVTRSSTETCYSA-#-VPKASSDASKVTSKGAGLVKAFVGQKSTF 89
Anopheles gambiae str. PEST	Query 2573 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|+\|+\|\|\|\| \| # +\| \| \|\|\|\|\|+ ++\| \|\| +\|++\|++\| \| Sbjct 2293 ETSSVIVETVAKVSKGGNRTGV#ILPIFKSDASKIQSKGMGLKKAYMGKQNQF 2344
Aedes aegypti	Query 2573 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|+\|+\|\|\|\| \| # +\| \| \|\|\|\|\|\| ++\| \|\| +\|++\|++\| \| Sbjct 2235 ETSSVVVETVAKVSKGGNRTGV#ILPIFKSDASKVQSKGMGLKKAYLGKQNQF 2286
Apis mellifera	Query 2573 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|\|+++\|\|\|\| \| # +\| \| \|\|\|\|\|\| ++\| \|\| +\|++\|++\| \| Sbjct 683 ETSSIVVETVQKISKAKQVGPV#-LPLFKSDASKVTSKGMGLKKAYLGKQNVF 733
Strongylocentrotus purpuratus	Query 2573 ETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|+ \|+\|\|\|+ \| # \| \|+\|\|\|\|\|\|\|+ \| \|\| ++\|+ +\|+ \| Sbjct 2168 ETAQVMVETIVKTTTTTGFQA-#--PVFTSDASKVVSSGMGLKKSFLNKKSQF 2216
Euprymna scolopes	Query 2568 GHS--LHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVG 2619 \|\|+ \|\| ++\|+\|\|\|\|\|\| # \| \| \|\|\|\|\|\|\| \| \|\| \|+ \| Sbjct 78 GHASGFHEQASVVVETVTKTSTTTRFSG-#-IQNFQSDASKVVANGAGLKTAYPG 129
Caenorhabditis briggsae	Query 2567 GGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|+ +\|\|\| \| ++ \| \| # +\|+++ \|\|+\|\| +\| \|\|++ \| \|+ +\| Sbjct 1241 GGNGYNETSHVKIDAVAKTSKGTVAV--#-VPEYAGDAAKVTAKGAGLNKFFPGRPAAF 1295
Caenorhabditis elegans	Query 2567 GGHSLHETSTVLVETVTKXXXXXXXXXX#XIPKFSSDASKVVTRGPGLSQAFVGQKNSF 2624 \|\|+ +\|\|\| \| ++ \| \| # +\|++ \|\|+\|\| +\| \|\|++ \| \|+ +\| Sbjct 777 GGNGYNETSHVKIDAVAKTSKGTVAV--#-VPEYQGDAAKVTAKGAGLNKFFPGRPAAF 831

* References

None.