logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2259 : calpain 3 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismMus musculus (house mouse)
Protein Namescalpain 3
Gene NamesCapn3; RP23-432M14.2-005
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAM24142 N/A N/A A2AVV5_MOUSE N/A N/A N/A mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 737 aa

Average Mass: 85.105 kDa

Monoisotopic Mass: 85.051 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Cementoin 1. 22387.74
Peptidase_C2 1. 50349763.81.2e-226
--- cleavage 274 (inside Peptidase_C2 50..349) ---
--- cleavage 296 (inside Peptidase_C2 50..349) ---
--- cleavage 322 (inside Peptidase_C2 50..349) ---
Calpain_III 1. 360514370.82.5e-108
efhand 1. 5415680.618
efhand 2. 61264028.52.6e-05
efhand 3. 64267027.45.8e-05
efhand 4. 7077349.91.8

3. Sequence Information

Fasta Sequence: XSB2259.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE274-EALFKGEKVK

Glu274 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly265His266Ala267Tyr268Ser269Val270Thr271Gly272Leu273Glu274
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu275Ala276Leu277Phe278Lys279Gly280Glu281Lys282Val283Lys284

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE296-WNGSWSDGWK

Glu296 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg287Leu288Arg289Asn290Pro291Trp292Gly293Gln294Val295Glu296
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp297Asn298Gly299Ser300Trp301Ser302Asp303Gly304Trp305Lys306

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ322-VTEDGEFWMS

Gln322 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys313Asp314Glu315Lys316Ala317Arg318Leu319Gln320His321Gln322
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val323Thr324Glu325Asp326Gly327Glu328Phe329Trp330Met331Ser332

Sequence conservation (by blast)

* References

None.