logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2260 : calpain 3 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismMus musculus (house mouse)
Protein Namescalpain 3
Gene NamesCapn3; RP23-432M14.2-002
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAM24139 N/A N/A A2AVV2_MOUSE N/A N/A N/A mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 729 aa

Average Mass: 84.096 kDa

Monoisotopic Mass: 84.043 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 74369798.15.7e-237
--- cleavage 294 (inside Peptidase_C2 74..369) ---
--- cleavage 316 (inside Peptidase_C2 74..369) ---
--- cleavage 342 (inside Peptidase_C2 74..369) ---
Calpain_III 1. 380534370.82.5e-108
efhand 1. 5615880.618
efhand 2. 60463228.52.6e-05
efhand 3. 63466227.45.8e-05
efhand 4. 6997269.91.8

3. Sequence Information

Fasta Sequence: XSB2260.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE294-EALFKGEKVK

Glu294 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly285His286Ala287Tyr288Ser289Val290Thr291Gly292Leu293Glu294
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu295Ala296Leu297Phe298Lys299Gly300Glu301Lys302Val303Lys304

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE316-WNGSWSDGWK

Glu316 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg307Leu308Arg309Asn310Pro311Trp312Gly313Gln314Val315Glu316
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp317Asn318Gly319Ser320Trp321Ser322Asp323Gly324Trp325Lys326

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ342-VTEDGEFWMS

Gln342 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys333Asp334Glu335Lys336Ala337Arg338Leu339Gln340His341Gln342
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val343Thr344Glu345Asp346Gly347Glu348Phe349Trp350Met351Ser352

Sequence conservation (by blast)

* References

None.