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XSB2263 : mUp48 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesmUp48
Gene NamesCapn3; Ganc
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
BAD16653 N/A N/A Q762C4_MOUSE N/A N/A N/A mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 421 aa

Average Mass: 48.398 kDa

Monoisotopic Mass: 48.367 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 2293693.41.9e-205
--- cleavage 218 (inside Peptidase_C2 2..293) ---
--- cleavage 240 (inside Peptidase_C2 2..293) ---
--- cleavage 266 (inside Peptidase_C2 2..293) ---
Calpain_III 1. 304419136.39.9e-38

3. Sequence Information

Fasta Sequence: XSB2263.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE218-EALFKGEKVK

Glu218 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly209His210Ala211Tyr212Ser213Val214Thr215Gly216Leu217Glu218
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu219Ala220Leu221Phe222Lys223Gly224Glu225Lys226Val227Lys228

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE240-WNGSWSDGWK

Glu240 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg231Leu232Arg233Asn234Pro235Trp236Gly237Gln238Val239Glu240
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp241Asn242Gly243Ser244Trp245Ser246Asp247Gly248Trp249Lys250

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ266-VTEDGEFWMS

Gln266 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys257Asp258Glu259Lys260Ala261Arg262Leu263Gln264His265Gln266
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val267Thr268Glu269Asp270Gly271Glu272Phe273Trp274Met275Ser276

Sequence conservation (by blast)

* References

[PubMed ID: 14675785] Kawabata Y, Hata S, Ono Y, Ito Y, Suzuki K, Abe K, Sorimachi H, Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene. FEBS Lett. 2003 Dec 18;555(3):623-30.