logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2267 : calpain 3, isoform CRA_f [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namescalpain 3; isoform CRA_f
Gene NamesCapn3
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EDL79946 N/A 29155 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 496 aa

Average Mass: 56.835 kDa

Monoisotopic Mass: 56.799 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Cementoin 1. 22387.74
Peptidase_C2 1. 50397906.01.9e-269
--- cleavage 322 (inside Peptidase_C2 50..397) ---
--- cleavage 344 (inside Peptidase_C2 50..397) ---
--- cleavage 370 (inside Peptidase_C2 50..397) ---
Calpain_III 1. 40849696.68.4e-26

3. Sequence Information

Fasta Sequence: XSB2267.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE322-EALFKGEKVK

Glu322 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly313His314Ala315Tyr316Ser317Val318Thr319Gly320Leu321Glu322
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu323Ala324Leu325Phe326Lys327Gly328Glu329Lys330Val331Lys332

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE344-WNGSWSDGWK

Glu344 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg335Leu336Arg337Asn338Pro339Trp340Gly341Gln342Val343Glu344
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp345Asn346Gly347Ser348Trp349Ser350Asp351Gly352Trp353Lys354

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ370-VTEDGEFWMS

Gln370 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys361Asp362Glu363Lys364Ala365Arg366Leu367Gln368His369Gln370
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val371Thr372Glu373Asp374Gly375Glu376Phe377Trp378Met379Ser380

Sequence conservation (by blast)

* References

[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.