logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2269 : calpain 3, isoform CRA_a [Rattus norvegicus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismRattus norvegicus (Norway rat)
Protein Namescalpain 3; isoform CRA_a
Gene NamesCapn3
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
EDL79941 N/A 29155 N/A N/A N/A N/A N/A

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 516 aa

Average Mass: 58.604 kDa

Monoisotopic Mass: 58.567 kDa

2. Domain Information

Annotated Domains: Not Available.

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 74417939.02.3e-279
--- cleavage 342 (inside Peptidase_C2 74..417) ---
--- cleavage 364 (inside Peptidase_C2 74..417) ---
--- cleavage 390 (inside Peptidase_C2 74..417) ---
Calpain_III 1. 42851696.68.4e-26

3. Sequence Information

Fasta Sequence: XSB2269.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE342-EALFKGEKVK

Glu342 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly333His334Ala335Tyr336Ser337Val338Thr339Gly340Leu341Glu342
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu343Ala344Leu345Phe346Lys347Gly348Glu349Lys350Val351Lys352

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE364-WNGSWSDGWK

Glu364 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg355Leu356Arg357Asn358Pro359Trp360Gly361Gln362Val363Glu364
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp365Asn366Gly367Ser368Trp369Ser370Asp371Gly372Trp373Lys374

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ390-VTEDGEFWMS

Gln390 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys381Asp382Glu383Lys384Ala385Arg386Leu387Gln388His389Gln390
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val391Thr392Glu393Asp394Gly395Glu396Phe397Trp398Met399Ser400

Sequence conservation (by blast)

* References

[PubMed ID: 15632090] Florea L, Di Francesco V, Miller J, Turner R, Yao A, Harris M, Walenz B, Mobarry C, Merkulov GV, Charlab R, Dew I, Deng Z, Istrail S, Li P, Sutton G, Gene and alternative splicing annotation with AIR. Genome Res. 2005 Jan;15(1):54-66.