logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2274 : calpain 3 [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismMus musculus (house mouse)
Protein Namescalpain 3
Gene NamesCapn3; RP23-432M14.2-006
Gene LocusNot available
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
CAM24143 N/A N/A A2AVV6_MOUSE N/A N/A N/A mmu:

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 785 aa

Average Mass: 90.373 kDa

Monoisotopic Mass: 90.315 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Cementoin 1. 22387.74
Peptidase_C2 1. 50397904.07.8e-269
--- cleavage 322 (inside Peptidase_C2 50..397) ---
--- cleavage 344 (inside Peptidase_C2 50..397) ---
--- cleavage 370 (inside Peptidase_C2 50..397) ---
Calpain_III 1. 408562370.82.5e-108
efhand 1. 5896160.618
efhand 2. 66068828.52.6e-05
efhand 3. 69071827.45.8e-05
efhand 4. 7557829.91.8

3. Sequence Information

Fasta Sequence: XSB2274.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE322-EALFKGEKVK

Glu322 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly313His314Ala315Tyr316Ser317Val318Thr319Gly320Leu321Glu322
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu323Ala324Leu325Phe326Lys327Gly328Glu329Lys330Val331Lys332

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE344-WNGSWSDGWK

Glu344 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg335Leu336Arg337Asn338Pro339Trp340Gly341Gln342Val343Glu344
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp345Asn346Gly347Ser348Trp349Ser350Asp351Gly352Trp353Lys354

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ370-VTEDGEFWMS

Gln370 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys361Asp362Glu363Lys364Ala365Arg366Leu367Gln368His369Gln370
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val371Thr372Glu373Asp374Gly375Glu376Phe377Trp378Met379Ser380

Sequence conservation (by blast)

* References

None.