logo CaMPDB: Calpain for Modulatory Proteolysis Database

XSB2275 : calpain 3 isoform a [Mus musculus]

[ CaMP Format ]

This entry is computationally expanded from SB0104

* Basic Information

OrganismMus musculus (house mouse)
Protein NamesCalpain-3; 3.4.22.54; Calpain L3; Calpain p94; Calcium-activated neutral proteinase 3; CANP 3; Muscle-specific calcium-activated neutral protease 3; calpain 3 isoform a; skeletal muscle specific calpain p94
Gene NamesCapn3; calpain 3
Gene Locus2 67.2 cM; chromosome 2
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_031627 NM_007601 12335 CAN3_MOUSE N/A N/A N/A mmu:12335

* Information From OMIM

Not Available.

* Structure Information

1. Primary Information

Length: 821 aa

Average Mass: 94.242 kDa

Monoisotopic Mass: 94.182 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
Peptidase_C2 1. 74417938.43.3e-279
--- cleavage 342 (inside Peptidase_C2 74..417) ---
--- cleavage 364 (inside Peptidase_C2 74..417) ---
--- cleavage 390 (inside Peptidase_C2 74..417) ---
Calpain_III 1. 428582370.82.5e-108
efhand 1. 6536800.618
efhand 2. 69672428.52.6e-05
efhand 3. 72675427.45.8e-05
efhand 4. 7918189.91.8

3. Sequence Information

Fasta Sequence: XSB2275.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Not Available.

* Cleavage Information

3 [sites]

Cleavage sites (±10aa)

[Site 1] GHAYSVTGLE342-EALFKGEKVK

Glu342 Glu

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Gly333His334Ala335Tyr336Ser337Val338Thr339Gly340Leu341Glu342
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Glu343Ala344Leu345Phe346Lys347Gly348Glu349Lys350Val351Lys352

Sequence conservation (by blast)

[Site 2] RLRNPWGQVE364-WNGSWSDGWK

Glu364 Trp

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Arg355Leu356Arg357Asn358Pro359Trp360Gly361Gln362Val363Glu364
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Trp365Asn366Gly367Ser368Trp369Ser370Asp371Gly372Trp373Lys374

Sequence conservation (by blast)

[Site 3] KDEKARLQHQ390-VTEDGEFWMS

Gln390 Val

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
Lys381Asp382Glu383Lys384Ala385Arg386Leu387Gln388His389Gln390
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Val391Thr392Glu393Asp394Gly395Glu396Phe397Trp398Met399Ser400

Sequence conservation (by blast)

* References

[PubMed ID: 19143834] Laure L, Suel L, Roudaut C, Bourg N, Ouali A, Bartoli M, Richard I, Daniele N, Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling. FEBS J. 2009 Feb;276(3):669-84.

» More (9)