XSB2338 : crystallin, beta B2 [Homo sapiens]
[ CaMP Format ]
This entry is computationally expanded from SB0082
* Basic Information
Organism | Homo sapiens (human) |
Protein Names | Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp; crystallin; beta B2; eye lens structural protein |
Gene Names | CRYBB2; CRYB2, CRYB2A; CRYB2; CRYB2A; crystallin, beta B2 |
Gene Locus | 22q11.23; chromosome 22 |
GO Function | Not available |
* Information From OMIM
Function: The alpha-crystallin subunits alpha-A (OMIM:123580) and alpha-B (OMIM:123590) each can form an oligomer by itself or with the other. Fu and Liang (2002) used a 2-hybrid system to study heterogeneous interactions among lens crystallins of different classes. They found interactions between alpha-A- (or alpha-B-) and beta-B2- or gamma-C-(OMIM:123680) crystallins, but the intensity of interaction was one-third that of alpha-A-alpha-B interactions. HSP27 (OMIM:602195), a member of the small heat-shock protein family, showed similar interaction properties with alpha-B-crystallin. Experiments with N- and C-terminal domain-truncated mutants demonstrated that both N- and C-terminal domains were important in alpha-A-crystallin self-interaction, but that only the C-terminal domain was important in alpha-B-crystallin self-interaction.
* Structure Information
1. Primary Information
Length: 205 aa
Average Mass: 23.380 kDa
Monoisotopic Mass: 23.365 kDa
2. Domain Information
Annotated Domains: interpro / pfam / smart / prosite
Computationally Assigned Domains (Pfam+HMMER):
domain name | begin | end | score | e-value |
---|---|---|---|---|
--- cleavage 8 --- | ||||
Crystall 1. | 18 | 100 | 163.1 | 8.4e-46 |
Crystall 2. | 108 | 190 | 164.3 | 3.5e-46 |
3. Sequence Information
Fasta Sequence: XSB2338.fasta
Amino Acid Sequence and Secondary Structures (PsiPred):
4. 3D Information
Known Structures in PDB: 1YTQ (X-ray; 170 A; A=2-205)
* Cleavage Information
1 [sites]
Cleavage sites (±10aa)
[Site 1] MASDHQTQ8-AGKPQSLNPK
Gln8 Ala
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P10 | P9 | P8 | P7 | P6 | P5 | P4 | P3 | P2 | P1 |
---|---|---|---|---|---|---|---|---|---|
- | - | Met1 | Ala2 | Ser3 | Asp4 | His5 | Gln6 | Thr7 | Gln8 |
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P1' | P2' | P3' | P4' | P5' | P6' | P7' | P8' | P9' | P10' |
Ala9 | Gly10 | Lys11 | Pro12 | Gln13 | Ser14 | Leu15 | Asn16 | Pro17 | Lys18 |
Sequence conservation (by blast)
* References
[PubMed ID: 19321936] Wang L, Lin H, Gu J, Su H, Huang S, Qi Y, Autosomal-dominant cerulean cataract in a chinese family associated with gene conversion mutation in beta-B2-crystallin. Ophthalmic Res. 2009;41(3):148-53. Epub 2009 Mar 26.