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XSB2338 : crystallin, beta B2 [Homo sapiens]

[ CaMP Format ]

This entry is computationally expanded from SB0082

* Basic Information

OrganismHomo sapiens (human)
Protein NamesBeta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp; crystallin; beta B2; eye lens structural protein
Gene NamesCRYBB2; CRYB2, CRYB2A; CRYB2; CRYB2A; crystallin, beta B2
Gene Locus22q11.23; chromosome 22
GO FunctionNot available
Entrez Protein Entrez Nucleotide Entrez Gene UniProt OMIM HGNC HPRD KEGG
NP_000487 NM_000496 1415 CRBB2_HUMAN 123620 2398 N/A hsa:1415

* Information From OMIM

Function: The alpha-crystallin subunits alpha-A (OMIM:123580) and alpha-B (OMIM:123590) each can form an oligomer by itself or with the other. Fu and Liang (2002) used a 2-hybrid system to study heterogeneous interactions among lens crystallins of different classes. They found interactions between alpha-A- (or alpha-B-) and beta-B2- or gamma-C-(OMIM:123680) crystallins, but the intensity of interaction was one-third that of alpha-A-alpha-B interactions. HSP27 (OMIM:602195), a member of the small heat-shock protein family, showed similar interaction properties with alpha-B-crystallin. Experiments with N- and C-terminal domain-truncated mutants demonstrated that both N- and C-terminal domains were important in alpha-A-crystallin self-interaction, but that only the C-terminal domain was important in alpha-B-crystallin self-interaction.

* Structure Information

1. Primary Information

Length: 205 aa

Average Mass: 23.380 kDa

Monoisotopic Mass: 23.365 kDa

2. Domain Information

Annotated Domains: interpro / pfam / smart / prosite

Computationally Assigned Domains (Pfam+HMMER):

domain namebeginendscoree-value
--- cleavage 8 ---
Crystall 1. 18100163.18.4e-46
Crystall 2. 108190164.33.5e-46

3. Sequence Information

Fasta Sequence: XSB2338.fasta

Amino Acid Sequence and Secondary Structures (PsiPred):

4. 3D Information

Known Structures in PDB: 1YTQ (X-ray; 170 A; A=2-205)

* Cleavage Information

1 [sites]

Cleavage sites (±10aa)

[Site 1] MASDHQTQ8-AGKPQSLNPK

Gln8 Ala

P10 P9 P8 P7 P6 P5 P4 P3 P2 P1
--Met1Ala2Ser3Asp4His5Gln6Thr7Gln8
P1' P2' P3' P4' P5' P6' P7' P8' P9' P10'
Ala9Gly10Lys11Pro12Gln13Ser14Leu15Asn16Pro17Lys18

Sequence conservation (by blast)

* References

[PubMed ID: 19321936] Wang L, Lin H, Gu J, Su H, Huang S, Qi Y, Autosomal-dominant cerulean cataract in a chinese family associated with gene conversion mutation in beta-B2-crystallin. Ophthalmic Res. 2009;41(3):148-53. Epub 2009 Mar 26.

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